valproic acid has been researched along with Amenorrhea in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Amenorrhea: Absence of menstruation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Women with untreated epilepsy are more likely to have irregular menstrual cycles than are nonepileptic controls, indicating that the disease itself plays a role in the etiology of these reproductive abnormalities." | 2.44 | Menstrual cycle dysfunction associated with neurologic and psychiatric disorders: their treatment in adolescents. ( Hayes, FJ; Joffe, H, 2008) |
| "A possible role of the seizure disorder or, alternatively, of the use of antiepileptic drugs (AEDs) has been suggested as the pathogenic mechanism." | 1.31 | Characterization of reproductive endocrine disorders in women with epilepsy. ( Bilo, L; Di Carlo, C; Meo, R; Nappi, C; Striano, S; Valentino, R, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Joffe, H | 2 |
| Hayes, FJ | 1 |
| Cohen, LS | 1 |
| Suppes, T | 1 |
| McLaughlin, WL | 1 |
| Lavori, P | 1 |
| Adams, JM | 1 |
| Hwang, CH | 1 |
| Hall, JE | 1 |
| Sachs, GS | 1 |
| Bauer, J | 1 |
| Jarre, A | 1 |
| Klingmüller, D | 1 |
| Elger, CE | 1 |
| Bilo, L | 1 |
| Meo, R | 1 |
| Valentino, R | 1 |
| Di Carlo, C | 1 |
| Striano, S | 1 |
| Nappi, C | 1 |
| Jones, TH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)[NCT00012558] | 5,000 participants | Interventional | 1998-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for valproic acid and Amenorrhea
| Article | Year |
|---|---|
Menstrual cycle dysfunction associated with neurologic and psychiatric disorders: their treatment in adolescents.
Topics: Adolescent; Amenorrhea; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Bone and Bones; Epi | 2008 |
1 trial available for valproic acid and Amenorrhea
| Article | Year |
|---|---|
Valproate is associated with new-onset oligoamenorrhea with hyperandrogenism in women with bipolar disorder.
Topics: Adolescent; Adult; Amenorrhea; Antimanic Agents; Bipolar Disorder; Cohort Studies; Comorbidity; Fema | 2006 |
3 other studies available for valproic acid and Amenorrhea
| Article | Year |
|---|---|
Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women.
Topics: Adult; Amenorrhea; Anticonvulsants; Carbamazepine; Cohort Studies; Drug Therapy, Combination; Epilep | 2000 |
Characterization of reproductive endocrine disorders in women with epilepsy.
Topics: Adolescent; Adult; Amenorrhea; Anticonvulsants; Endocrine System Diseases; Epilepsy; Female; Humans; | 2001 |
Sodium valproate-induced menstrual disturbance in young women.
Topics: Adolescent; Amenorrhea; Epilepsy; Female; Gonadotropin-Releasing Hormone; Humans; Luteinizing Hormon | 1991 |