valproic acid has been researched along with Ambulation Disorders, Neurologic in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) has been reported to cause cognitive decline and parkinsonism that are reversed with cessation of medication." | 5.37 | Reversible dementia and gait disturbance after prolonged use of valproic acid. ( Evans, MD; Shinar, R; Yaari, R, 2011) |
| "The goal of this study was to determine if manifestations of agitation (ie, physical aggression, physically nonaggressive behavior, and verbally agitated behaviors) show different degrees of response to divalproex sodium (extended release or sprinkles) alone or in combination with second-generation antipsychotic agents." | 2.73 | Report on an open-label prospective study of divalproex sodium for the behavioral and psychological symptoms of dementia as monotherapy and in combination with second-generation antipsychotic medication. ( Adkison, L; Ahokpossi, C; Forester, B; Hyde, J; Perez, R; Sribney, W; Vanelli, M, 2007) |
| "We report five adult patients with frontal lobe epilepsy (FLE) who were treated with VPA and in whom a primary adverse effect was unstable gait and falls." | 1.46 | Gait instability in valproate-treated patients: Call to measure ammonia levels. ( Elger, CE; Kipervasser, S; Korczyn, AD; Nass, RD; Neufeld, MY; Quesada, CM, 2017) |
| "Valproic acid (VPA) has been reported to cause cognitive decline and parkinsonism that are reversed with cessation of medication." | 1.37 | Reversible dementia and gait disturbance after prolonged use of valproic acid. ( Evans, MD; Shinar, R; Yaari, R, 2011) |
| "Whilst post-ictal psychosis is rarely reported prior to the age of 16, NPC in adolescents and adults is particularly psychotogenic and may increase the risk for post-ictal psychosis in the pediatric population." | 1.36 | Post-ictal psychosis in adolescent Niemann-Pick disease type C. ( Adams, S; Fietz, M; Kornberg, A; Velakoulis, D; Walterfang, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Sharma, A | 1 |
| Sinha, S | 1 |
| Narang, A | 1 |
| Chouhan, DK | 1 |
| Gupta, S | 1 |
| Kipervasser, S | 1 |
| Elger, CE | 1 |
| Korczyn, AD | 1 |
| Nass, RD | 1 |
| Quesada, CM | 1 |
| Neufeld, MY | 1 |
| Walterfang, M | 1 |
| Kornberg, A | 1 |
| Adams, S | 1 |
| Fietz, M | 1 |
| Velakoulis, D | 1 |
| Evans, MD | 1 |
| Shinar, R | 1 |
| Yaari, R | 1 |
| Brownstone, E | 1 |
| Voigtländer, T | 1 |
| Baumhackl, U | 1 |
| Finsterer, J | 1 |
| Forester, B | 1 |
| Vanelli, M | 1 |
| Hyde, J | 1 |
| Perez, R | 1 |
| Ahokpossi, C | 1 |
| Sribney, W | 1 |
| Adkison, L | 1 |
1 trial available for valproic acid and Ambulation Disorders, Neurologic
| Article | Year |
|---|---|
Report on an open-label prospective study of divalproex sodium for the behavioral and psychological symptoms of dementia as monotherapy and in combination with second-generation antipsychotic medication.
Topics: Aged; Aged, 80 and over; Aggression; Antimanic Agents; Antipsychotic Agents; Behavioral Symptoms; De | 2007 |
5 other studies available for valproic acid and Ambulation Disorders, Neurologic
| Article | Year |
|---|---|
Waddling Gait: A complication of valproate therapy and a thought beyond vitamin D deficiency.
Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Drug Therapy, Combination; Epilepsy, Absence; Fem | 2020 |
Gait instability in valproate-treated patients: Call to measure ammonia levels.
Topics: Accidental Falls; Adult; Ammonia; Anticonvulsants; Disease Progression; Epilepsy, Frontal Lobe; Fema | 2017 |
Post-ictal psychosis in adolescent Niemann-Pick disease type C.
Topics: Adolescent; Age Factors; Anticonvulsants; Cells, Cultured; Cholesterol Esters; Esterification; Fibro | 2010 |
Reversible dementia and gait disturbance after prolonged use of valproic acid.
Topics: Aged; Anticonvulsants; Cerebral Ventricles; Dementia; Female; Gait Disorders, Neurologic; Hearing Lo | 2011 |
Epilepsy in adult X-linked adrenoleucodystrophy due to the deletion c.1415-1416delAG in exon 5 of the ABCD1-gene.
Topics: Adrenoleukodystrophy; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP- | 2013 |