valproic acid has been researched along with Altered Level of Consciousness in 17 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 5-year-old female developed alteration of consciousness during 3 days of long-term treatment with valproic acid for localization-related epilepsy." | 7.72 | Reversible altered consciousness with brain atrophy caused by valproic acid. ( Eguchi, M; Imataka, G; Nakagawa, E; Ota, T; Yamanouchi, H, 2003) |
| "We report the case of an aborted awake craniotomy for a left frontotemporoinsular glioma due to ammonia encephalopathy on a patient taking Levetiracetam, valproic acid and clobazam." | 3.81 | Ammonia encephalopathy and awake craniotomy for brain language mapping: cause of failed awake craniotomy. ( Arroyo Pérez, R; Fernández-Candil, JL; León Jorba, A; Pacreu Terradas, S; Villalba Martínez, G; Vivanco-Hidalgo, RM, 2015) |
| "A 5-year-old female developed alteration of consciousness during 3 days of long-term treatment with valproic acid for localization-related epilepsy." | 3.72 | Reversible altered consciousness with brain atrophy caused by valproic acid. ( Eguchi, M; Imataka, G; Nakagawa, E; Ota, T; Yamanouchi, H, 2003) |
| "VPA is widely used for the treatment of generalized epilepsy." | 2.61 | [Valproic acid-induced hyperammonemic encephalopathy in a patient receiving valproic acid monotherapy]. ( Araki, M; Mukai, T; Naka, H; Shishido, T; Tokinobu, H; Yamada, H, 2019) |
| " In children under 2 years old, serious adverse effects are appear to be more frequent." | 1.51 | Adverse Effects of Treatment with Valproic Acid during the Neonatal Period. ( Baudou, E; Benevent, J; Hachon LeCamus, C; Montastruc, JL; Touati, G, 2019) |
| "This was followed by a tonic-clonic seizure." | 1.48 | [Two cases of photosensitive seizure induced by barcode readers with red flashing lights]. ( Kawamata, J; Shimohama, S; Toyama, Y, 2018) |
| " All these patients were receiving the usual dosage (1000 to 1500 mg per day) of Valproic acid (VPA)." | 1.29 | Impairment of consciousness induced by valproate treatment following neurosurgical operation. ( Baulac, M; de Billy, A; Durand, G; Landau, J; Philippon, J, 1993) |
| "Valproic acid (VPA) was given to 24 epileptic patients who were already being treated with other antiepileptic drugs." | 1.27 | Acute changes of blood ammonia may predict short-term adverse effects of valproic acid. ( Arnetoli, G; Baruzzi, A; Campostrini, R; Moroni, F; Paganini, M; Targioni, G; Valenza, T; Zaccara, G; Zappoli, R, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 6 (35.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Toyama, Y | 1 |
| Kawamata, J | 1 |
| Shimohama, S | 1 |
| Camilleri, L | 1 |
| Baudou, E | 1 |
| Benevent, J | 1 |
| Montastruc, JL | 1 |
| Touati, G | 1 |
| Hachon LeCamus, C | 1 |
| Yamada, H | 1 |
| Shishido, T | 1 |
| Mukai, T | 1 |
| Araki, M | 1 |
| Naka, H | 1 |
| Tokinobu, H | 1 |
| Villalba Martínez, G | 1 |
| Fernández-Candil, JL | 1 |
| Vivanco-Hidalgo, RM | 1 |
| Pacreu Terradas, S | 1 |
| León Jorba, A | 1 |
| Arroyo Pérez, R | 1 |
| Johannsen, J | 1 |
| Nickel, M | 1 |
| Schulz, A | 1 |
| Denecke, J | 1 |
| Yamanouchi, H | 1 |
| Ota, T | 1 |
| Imataka, G | 1 |
| Nakagawa, E | 1 |
| Eguchi, M | 1 |
| McCall, M | 1 |
| Bourgeois, JA | 1 |
| Williams, JA | 1 |
| Barreiro, CJ | 1 |
| Nwakanma, LU | 1 |
| Lange, MS | 1 |
| Kratz, LE | 1 |
| Blue, ME | 1 |
| Berrong, J | 1 |
| Patel, ND | 1 |
| Gott, VL | 1 |
| Troncoso, JC | 1 |
| Johnston, MV | 1 |
| Baumgartner, WA | 1 |
| Meinardi, MC | 1 |
| van den Berg, GB | 1 |
| Groenhuijzen, A | 1 |
| Driessen, JT | 1 |
| Maas, HA | 1 |
| Wolfhagen, FH | 1 |
| Nakazato, Y | 1 |
| Tamura, N | 1 |
| Shimazu, K | 1 |
| Skjødt, T | 1 |
| Sørensen, T | 1 |
| Zaccara, G | 1 |
| Campostrini, R | 1 |
| Paganini, M | 1 |
| Moroni, F | 1 |
| Valenza, T | 1 |
| Targioni, G | 1 |
| Arnetoli, G | 1 |
| Zappoli, R | 1 |
| Baruzzi, A | 1 |
| Marescaux, C | 1 |
| Warter, JM | 1 |
| Micheletti, G | 1 |
| Rumbach, L | 1 |
| Coquillat, G | 1 |
| Kurtz, D | 1 |
| Landau, J | 1 |
| Baulac, M | 1 |
| Durand, G | 1 |
| de Billy, A | 1 |
| Philippon, J | 1 |
| Katsumori, H | 1 |
| Nagaki, S | 1 |
| Matsuzaki, M | 1 |
| Funatsuka, M | 1 |
| Fukuyama, Y | 1 |
| Kido, H | 1 |
| Mizuno, Y | 1 |
| Yamaguchi, N | 1 |
| Kurata, K | 1 |
2 reviews available for valproic acid and Altered Level of Consciousness
| Article | Year |
|---|---|
Lesson of the month 1: Sodium valproate-induced encephalopathy.
Topics: Aged; Ammonia; Anticonvulsants; Brain Diseases; Carnitine; Consciousness Disorders; Epilepsy; Humans | 2018 |
[Valproic acid-induced hyperammonemic encephalopathy in a patient receiving valproic acid monotherapy].
Topics: Aged; Ammonia; Anticonvulsants; Biomarkers; Cardiomyopathies; Carnitine; Consciousness Disorders; Ep | 2019 |
15 other studies available for valproic acid and Altered Level of Consciousness
| Article | Year |
|---|---|
[Two cases of photosensitive seizure induced by barcode readers with red flashing lights].
Topics: Adult; Anticonvulsants; Consciousness Disorders; Durable Medical Equipment; Electroencephalography; | 2018 |
Adverse Effects of Treatment with Valproic Acid during the Neonatal Period.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Consciousness Disorders; Female; Hematologi | 2019 |
Ammonia encephalopathy and awake craniotomy for brain language mapping: cause of failed awake craniotomy.
Topics: Anesthesia, General; Anesthesia, Local; Anticonvulsants; Aphasia; Benzodiazepines; Brain Diseases; B | 2015 |
Considering Valproate as a Risk Factor for Rapid Exacerbation of Complex Movement Disorder in Progressed Stages of Late-Infantile CLN2 Disease.
Topics: Anticonvulsants; Child; Child, Preschool; Consciousness Disorders; Creatine Kinase; Deprescriptions; | 2016 |
Reversible altered consciousness with brain atrophy caused by valproic acid.
Topics: Atrophy; Brain; Child, Preschool; Consciousness Disorders; Electroencephalography; Epilepsy; Female; | 2003 |
Valproic acid-induced hyperammonemia: a case report.
Topics: Ammonia; Anticonvulsants; Blood Urea Nitrogen; Consciousness Disorders; Diagnosis, Differential; Dru | 2004 |
Valproic acid prevents brain injury in a canine model of hypothermic circulatory arrest: a promising new approach to neuroprotection during cardiac surgery.
Topics: Animals; Apoptosis; Aspartic Acid; Behavior, Animal; Biomarkers; Brain; Brain Chemistry; Brain Damag | 2006 |
[Metabolic encephalopathy can be a potentially life-threatening complication from valproic acid].
Topics: Aged, 80 and over; Ammonia; Brain Diseases, Metabolic; Consciousness Disorders; Diagnosis, Different | 2008 |
An adult case of cyclic vomiting syndrome successfully responding to valproic acid.
Topics: Anti-Anxiety Agents; Anticonvulsants; Antiemetics; Consciousness Disorders; Diazepam; Female; Humans | 2008 |
[Stupor associated with the treatment of epilepsy with valproate].
Topics: Anticonvulsants; Cognition Disorders; Consciousness Disorders; Epilepsy, Tonic-Clonic; Female; Human | 1984 |
Acute changes of blood ammonia may predict short-term adverse effects of valproic acid.
Topics: Adolescent; Adult; Ammonia; Child; Consciousness Disorders; Epilepsy; Female; Humans; Male; Middle A | 1984 |
Stuporous episodes during treatment with sodium valproate: report of seven cases.
Topics: Anticonvulsants; Cognition Disorders; Consciousness Disorders; Electroencephalography; Epilepsy; Fem | 1982 |
Impairment of consciousness induced by valproate treatment following neurosurgical operation.
Topics: Adolescent; Adult; Arousal; Brain Neoplasms; Cerebral Hemorrhage; Coma; Consciousness Disorders; Del | 1993 |
[A case of acute intoxication with massive overdosage of slow-release sodium valproate tablets].
Topics: Acute Disease; Adolescent; Adult; Consciousness Disorders; Delayed-Action Preparations; Humans; Male | 1994 |
Episodic twilight state with severe autonomic symptoms in an epileptic patient.
Topics: Amygdala; Autonomic Nervous System; Carbamazepine; Child; Cognition Disorders; Consciousness Disorde | 1988 |