valproic acid has been researched along with Alpers Diffuse Degeneration of Cerebral Gray Matter with Hepatic Cirrhosis in 15 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Children with refractory epilepsy who suffered from severe liver function impairment during valproic acid (VPA) treatment at routine dosage were studied." | 3.78 | [Valproic acid-induced idiosyncratic liver injury in 4 cases]. ( Bao, XH; Jiang, YW; Liu, CT; Qin, J; Wu, XP; Xiong, H; Zhang, YH; Zhao, H, 2012) |
| " In 5 pediatric patients with severe myoclonic epilepsy and valproic acid-induced liver failure, we identified 1 novel and 4 previously described pathogenic mutations in the linker region of this enzyme." | 3.74 | Clonally expanded mitochondrial DNA mutations in epileptic individuals with mutated DNA polymerase gamma. ( Baron, M; Bös, M; Chinnery, PF; Elger, CE; Kornblum, C; Kunz, WS; Sassen, R; Stewart, JD; Taylor, RW; Zsurka, G, 2008) |
| "Alpers syndrome was not clearly defined until the link between brain and liver disease was described." | 2.43 | Alpers syndrome: progressive neuronal degeneration of children with liver disease. ( Gordon, N, 2006) |
| "To review our clinical experience and determine if there are appropriate signs and symptoms to consider POLG sequencing prior to valproic acid (VPA) dosing in patients with seizures." | 1.36 | POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders. ( Bao, X; Koenig, MK; Lee, IC; Naviaux, RK; Saneto, RP; Weng, SW; Wong, LJ, 2010) |
| "He developed coma and acute liver failure that were attributed to VPA toxicity, and underwent emergency orthotopic liver transplantation (OLTx)." | 1.31 | Inappropriate liver transplantation in a child with Alpers-Huttenlocher syndrome misdiagnosed as valproate-induced acute liver failure. ( Camboulives, J; Delarue, A; Guys, JM; Lethel, V; Montfort, MF; Paut, O; Pellissier, JF; Roquelaure, B; Sarles, J, 2000) |
| "We report 2 siblings with Alpers disease who were discordant for exposure to valproate (VPA)." | 1.30 | Valproate-induced liver failure in one of two siblings with Alpers disease. ( Armstrong, DL; Burke, B; Dobyns, WB; Schwabe, MJ, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Finsterer, J | 1 |
| Li, S | 1 |
| Guo, J | 1 |
| Ying, Z | 1 |
| Chen, S | 1 |
| Yang, L | 1 |
| Chen, K | 1 |
| Long, Q | 1 |
| Qin, D | 1 |
| Pei, D | 1 |
| Liu, X | 1 |
| London, F | 1 |
| Hadhoum, N | 1 |
| Outteryck, O | 1 |
| Vermersch, P | 1 |
| Zéphir, H | 1 |
| Zsurka, G | 1 |
| Baron, M | 1 |
| Stewart, JD | 2 |
| Kornblum, C | 1 |
| Bös, M | 1 |
| Sassen, R | 1 |
| Taylor, RW | 1 |
| Elger, CE | 1 |
| Chinnery, PF | 2 |
| Kunz, WS | 1 |
| Saneto, RP | 1 |
| Lee, IC | 1 |
| Koenig, MK | 1 |
| Bao, X | 1 |
| Weng, SW | 1 |
| Naviaux, RK | 1 |
| Wong, LJ | 1 |
| Horvath, R | 1 |
| Baruffini, E | 1 |
| Ferrero, I | 1 |
| Bulst, S | 1 |
| Watkins, PB | 1 |
| Fontana, RJ | 1 |
| Day, CP | 1 |
| Pronicka, E | 1 |
| Weglewska-Jurkiewicz, A | 1 |
| Pronicki, M | 1 |
| Sykut-Cegielska, J | 1 |
| Kowalski, P | 1 |
| Pajdowska, M | 1 |
| Jankowska, I | 1 |
| Kotulska, K | 1 |
| Kalicinski, P | 1 |
| Jakobkiewicz-Banecka, J | 1 |
| Wegrzyn, G | 1 |
| Xiong, H | 1 |
| Liu, CT | 1 |
| Zhang, YH | 1 |
| Bao, XH | 1 |
| Jiang, YW | 1 |
| Zhao, H | 1 |
| Wu, XP | 1 |
| Qin, J | 1 |
| Gordon, N | 1 |
| Schwabe, MJ | 1 |
| Dobyns, WB | 1 |
| Burke, B | 1 |
| Armstrong, DL | 1 |
| Delarue, A | 1 |
| Paut, O | 1 |
| Guys, JM | 1 |
| Montfort, MF | 1 |
| Lethel, V | 1 |
| Roquelaure, B | 1 |
| Pellissier, JF | 1 |
| Sarles, J | 1 |
| Camboulives, J | 1 |
| Rasmussen, M | 1 |
| Sanengen, T | 1 |
| Skullerud, K | 1 |
| Kvittingen, EA | 1 |
| Skjeldal, OH | 1 |
| Kelly, DA | 1 |
| Kayihan, N | 1 |
| Nennesmo, I | 1 |
| Ericzon, BG | 1 |
| Németh, A | 1 |
| Bicknese, AR | 1 |
| May, W | 1 |
| Hickey, WF | 1 |
| Dodson, WE | 1 |
1 review available for valproic acid and Alpers Diffuse Degeneration of Cerebral Gray Matter with Hepatic Cirrhosis
| Article | Year |
|---|---|
Alpers syndrome: progressive neuronal degeneration of children with liver disease.
Topics: Anticonvulsants; Child; Contraindications; Diffuse Cerebral Sclerosis of Schilder; Humans; Liver Fai | 2006 |
14 other studies available for valproic acid and Alpers Diffuse Degeneration of Cerebral Gray Matter with Hepatic Cirrhosis
| Article | Year |
|---|---|
Valproic acid for myoclonic epilepsy in POLG1 carriers can be fatal.
Topics: Acute Disease; Anticonvulsants; Child; Diffuse Cerebral Sclerosis of Schilder; DNA Polymerase gamma; | 2021 |
Valproic acid-induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening-dependent apoptotic sensitivity in an induced pluripotent stem cell model.
Topics: Anticonvulsants; Apoptosis; Cells, Cultured; Chemical and Drug Induced Liver Injury; Diffuse Cerebra | 2015 |
Late-onset of Alpers-Huttenlocher syndrome: an unusual cause of refractory epilepsy and liver failure.
Topics: Adolescent; Anticonvulsants; Diffuse Cerebral Sclerosis of Schilder; Diffusion Magnetic Resonance Im | 2017 |
Clonally expanded mitochondrial DNA mutations in epileptic individuals with mutated DNA polymerase gamma.
Topics: Adolescent; Anticonvulsants; Brain; Child; Child, Preschool; Diffuse Cerebral Sclerosis of Schilder; | 2008 |
POLG DNA testing as an emerging standard of care before instituting valproic acid therapy for pediatric seizure disorders.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diffuse Cerebral Sclerosis of Schilder; DNA Mu | 2010 |
Polymerase γ gene POLG determines the risk of sodium valproate-induced liver toxicity.
Topics: Adolescent; Adult; Amino Acid Substitution; Bipolar Disorder; Child; Child, Preschool; Diffuse Cereb | 2010 |
Drug-resistant epilepsia and fulminant valproate liver toxicity. Alpers-Huttenlocher syndrome in two children confirmed post mortem by identification of p.W748S mutation in POLG gene.
Topics: Amino Acid Substitution; Child; Diffuse Cerebral Sclerosis of Schilder; DNA Polymerase gamma; DNA-Di | 2011 |
[Valproic acid-induced idiosyncratic liver injury in 4 cases].
Topics: Anticonvulsants; Biomarkers; Carnitine; Chemical and Drug Induced Liver Injury; Child; Child, Presch | 2012 |
Valproate-induced liver failure in one of two siblings with Alpers disease.
Topics: Anticonvulsants; Child, Preschool; Diffuse Cerebral Sclerosis of Schilder; Fatal Outcome; Female; Hu | 1997 |
Inappropriate liver transplantation in a child with Alpers-Huttenlocher syndrome misdiagnosed as valproate-induced acute liver failure.
Topics: Anticonvulsants; Brain; Child, Preschool; Diagnosis, Differential; Diagnostic Errors; Diffuse Cerebr | 2000 |
Evidence that Alpers-Huttenlocher syndrome could be a mitochondrial disease.
Topics: Cerebral Cortex; Child; Child, Preschool; Diffuse Cerebral Sclerosis of Schilder; Epilepsy, Absence; | 2000 |
Liver transplantation: to do or not to do?
Topics: Anticonvulsants; Child; Contraindications; Diffuse Cerebral Sclerosis of Schilder; Epilepsy; Female; | 2000 |
Fatal deterioration of neurological disease after orthotopic liver transplantation for valproic acid-induced liver damage.
Topics: Adolescent; Anticonvulsants; Diffuse Cerebral Sclerosis of Schilder; Electroencephalography; Epileps | 2000 |
Early childhood hepatocerebral degeneration misdiagnosed as valproate hepatotoxicity.
Topics: Brain; Chemical and Drug Induced Liver Injury; Diagnostic Errors; Diffuse Cerebral Sclerosis of Schi | 1992 |