valproic acid has been researched along with Alopecia Cicatrisata in 30 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We systematically reviewed studies to provide current evidence about the incidence and risk of alopecia in patients undergoing valproic acid (VPA) therapy." | 9.01 | Risk of valproic acid-related alopecia: A systematic review and meta-analysis. ( Liu, L; Wang, H; Wang, X; Xu, D; Zhu, L, 2019) |
| "No statistical differences in age, hair loss duration and total hair count at baseline were found between the groups." | 6.79 | Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis. ( Jeong, YS; Jo, SJ; Kwon, O; Paik, SH; Park, WS; Park, YW; Shin, H; Shin, HJ, 2014) |
| "Valproic acid (VPA) is a widely used and well-tolerable antiepileptic drug in epileptic patients." | 5.35 | The effects of biotin supplementation on serum and liver tissue biotinidase enzyme activity and alopecia in rats which were administrated to valproic acid. ( Akin, R; Arslan, M; Balamtekin, N; Kurt, I; Ozcan, O; Unay, B; Vurucu, S, 2009) |
| "We systematically reviewed studies to provide current evidence about the incidence and risk of alopecia in patients undergoing valproic acid (VPA) therapy." | 5.01 | Risk of valproic acid-related alopecia: A systematic review and meta-analysis. ( Liu, L; Wang, H; Wang, X; Xu, D; Zhu, L, 2019) |
| "Alopecia is a common side effect in patients managed on the mood stabilizers lithium, valproate, and carbamazepine." | 4.79 | Alopecia and mood stabilizer therapy. ( DeVane, CL; Finkenbine, RD; McKinney, PA, 1996) |
| " VPA induced ALP in human dermal papilla cells by up-regulating the Wnt/β-catenin pathway, whereas minoxidil (MNX), a drug commonly used to treat alopecia, did not significantly affect the Wnt/β-catenin pathway." | 3.78 | Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells. ( Choi, KY; Kim, HJ; Kim, HY; Lee, SH; Min, do S; Park, PJ; Park, WS; Shin, SH; Yoon, J; Zahoor, M, 2012) |
| "No statistical differences in age, hair loss duration and total hair count at baseline were found between the groups." | 2.79 | Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis. ( Jeong, YS; Jo, SJ; Kwon, O; Paik, SH; Park, WS; Park, YW; Shin, H; Shin, HJ, 2014) |
| " A review of the literature associated with our personal experience since 1976 has shown VPA to be a remarkably safe and effective antiepileptic drug in a wide range of epileptic conditions in children and adults." | 2.39 | [Tolerance to and unwanted effects of valproate sodium]. ( Despland, PA, 1994) |
| "Valproic acid was related to the highest risk." | 1.48 | Severe hair loss associated with psychotropic drugs in psychiatric inpatients-Data from an observational pharmacovigilance program in German-speaking countries. ( Bleich, S; Burda, K; Druschky, K; Frieling, H; Grohmann, R; Hillemacher, T; Neyazi, A; Stübner, S; Toto, S, 2018) |
| "Weight gain and alopecia were the most common patient-reported CSEs in this study, and weight gain was the most likely cosmetic side effect to result in dosage adjustment or medication discontinuation." | 1.42 | Cosmetic side effects of antiepileptic drugs in adults with epilepsy. ( Buchsbaum, R; Chen, B; Choi, H; Detyniecki, K; Hirsch, LJ; Javed, A; Kato, K; Legge, A; Moeller, J, 2015) |
| "Valproic acid (VPA) is a widely used and well-tolerable antiepileptic drug in epileptic patients." | 1.35 | The effects of biotin supplementation on serum and liver tissue biotinidase enzyme activity and alopecia in rats which were administrated to valproic acid. ( Akin, R; Arslan, M; Balamtekin, N; Kurt, I; Ozcan, O; Unay, B; Vurucu, S, 2009) |
| "Our findings suggest that hair loss in patients can be attributed to zinc and BA depletion within the first 3 months, and to zinc depletion only by the 6th month." | 1.35 | The influence of valproic acid treatment on hair and serum zinc levels and serum biotinidase activity. ( Paksu, MS; Tasdemir, HA; Yilmaz, Y, 2009) |
| "Valproic acid (VPA) is an antiepileptic drug widely used and well-tolerated by most of patients." | 1.33 | Serum and liver tissue biotinidase enzyme activity in rats which were administrated to valproic acid. ( Akin, R; Demirkaya, E; Gokcay, E; Korkmazer, N; Kul, M; Unay, B; Vurucu, S, 2006) |
| " Twenty-three patients complained of various long-term adverse effects, while the other 17 remained symptom-free." | 1.27 | Long-term treatment with sodium valproate: monitoring of venous ammonia concentrations and adverse effects. ( Arnetoli, G; Campostrini, R; Messori, A; Paganini, M; Valenza, T; Zaccara, G; Zappoli, R, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (13.33) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 6 (20.00) | 29.6817 |
| 2010's | 12 (40.00) | 24.3611 |
| 2020's | 3 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, P | 1 |
| Sun, Y | 1 |
| Nie, L | 1 |
| Shavandi, A | 1 |
| Yunusov, KE | 1 |
| Hua, Y | 1 |
| Jiang, G | 1 |
| Yang, G | 1 |
| Chen, G | 1 |
| Gu, Z | 1 |
| Govindan, K | 1 |
| Mandadi, GD | 1 |
| Grootens, KP | 1 |
| Hartong, EGTM | 1 |
| Kim, D | 1 |
| Garza, LA | 1 |
| Agrawal, AK | 1 |
| Das, S | 1 |
| Druschky, K | 1 |
| Bleich, S | 1 |
| Grohmann, R | 1 |
| Burda, K | 1 |
| Frieling, H | 1 |
| Hillemacher, T | 1 |
| Neyazi, A | 1 |
| Stübner, S | 1 |
| Toto, S | 1 |
| Wang, X | 1 |
| Wang, H | 1 |
| Xu, D | 1 |
| Zhu, L | 1 |
| Liu, L | 1 |
| Choi, SY | 1 |
| Kim, HD | 1 |
| Kim, BJ | 1 |
| Kim, MN | 1 |
| Han, DH | 1 |
| Markovic, J | 1 |
| Plestic, S | 1 |
| Kostic, J | 1 |
| Jo, SJ | 1 |
| Shin, H | 1 |
| Park, YW | 1 |
| Paik, SH | 1 |
| Park, WS | 2 |
| Jeong, YS | 1 |
| Shin, HJ | 1 |
| Kwon, O | 1 |
| Chen, B | 1 |
| Choi, H | 1 |
| Hirsch, LJ | 1 |
| Moeller, J | 1 |
| Javed, A | 1 |
| Kato, K | 1 |
| Legge, A | 1 |
| Buchsbaum, R | 1 |
| Detyniecki, K | 1 |
| Guzmán-Sánchez, D | 1 |
| Asz-Sigall, D | 1 |
| Watanabe, S | 1 |
| Kuwabara, Y | 1 |
| Suehiro, S | 1 |
| Yamashita, D | 1 |
| Tanaka, M | 1 |
| Tanaka, A | 1 |
| Ohue, S | 1 |
| Araki, H | 1 |
| Arslan, M | 1 |
| Vurucu, S | 2 |
| Balamtekin, N | 1 |
| Unay, B | 2 |
| Akin, R | 2 |
| Kurt, I | 1 |
| Ozcan, O | 1 |
| Yilmaz, Y | 1 |
| Tasdemir, HA | 1 |
| Paksu, MS | 1 |
| Lee, SH | 1 |
| Yoon, J | 1 |
| Shin, SH | 1 |
| Zahoor, M | 1 |
| Kim, HJ | 1 |
| Park, PJ | 1 |
| Min, do S | 1 |
| Kim, HY | 1 |
| Choi, KY | 1 |
| Patrizi, A | 1 |
| Savoia, F | 1 |
| Negosanti, F | 1 |
| Posar, A | 1 |
| Santucci, M | 1 |
| Neri, I | 1 |
| Korkmazer, N | 1 |
| Demirkaya, E | 1 |
| Kul, M | 1 |
| Gokcay, E | 1 |
| Koch-Weser, J | 1 |
| Browne, TR | 1 |
| Herranz, JL | 1 |
| Arteaga, R | 1 |
| Armijo, JA | 1 |
| Despland, PA | 1 |
| Fatemi, SH | 1 |
| Calabrese, JR | 1 |
| McKinney, PA | 1 |
| Finkenbine, RD | 1 |
| DeVane, CL | 1 |
| Khan, TA | 1 |
| Sheng, H | 2 |
| Mercke, YK | 1 |
| Lippmann, SB | 1 |
| Mercke, Y | 1 |
| Khan, T | 1 |
| Lippmann, S | 1 |
| Zoran, DL | 1 |
| Boeckh, A | 1 |
| Boothe, DM | 1 |
| Hassan, MN | 1 |
| Laljee, HC | 1 |
| Parsonage, MJ | 1 |
| Uehlinger, C | 1 |
| Barrelet, L | 1 |
| Touabi, M | 1 |
| Baumann, P | 1 |
| Zaccara, G | 1 |
| Campostrini, R | 1 |
| Paganini, M | 1 |
| Messori, A | 1 |
| Valenza, T | 1 |
| Arnetoli, G | 1 |
| Zappoli, R | 1 |
8 reviews available for valproic acid and Alopecia Cicatrisata
| Article | Year |
|---|---|
Transdermal Drug Delivery for Hair Regrowth.
Topics: Acrylates; Administration, Cutaneous; Alopecia; Drug Carriers; Finasteride; Hair Follicle; Humans; J | 2021 |
Valproic acid and alopecia: A two-edged sword.
Topics: Alopecia; Animals; Anticonvulsants; Humans; Mice; Valproic Acid | 2017 |
Risk of valproic acid-related alopecia: A systematic review and meta-analysis.
Topics: Alopecia; Anticonvulsants; Epilepsy; Humans; Incidence; Prospective Studies; Valproic Acid | 2019 |
Alopecias due to drugs and other skin and systemic disorders.
Topics: Alopecia; Anticonvulsants; Antidepressive Agents; Antineoplastic Agents; Dermatologic Agents; Dermat | 2015 |
Drug therapy: Valproic acid.
Topics: Adult; Alopecia; Behavior; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chil | 1980 |
[Tolerance to and unwanted effects of valproate sodium].
Topics: Adolescent; Adult; Aged; Alopecia; Body Weight; Child; Drug Tolerance; Humans; Mental Processes; Val | 1994 |
Alopecia and mood stabilizer therapy.
Topics: Adult; Alopecia; Antimanic Agents; Bipolar Disorder; Case Management; Diethylcarbamazine; Female; Hu | 1996 |
Hair loss in psychopharmacology.
Topics: Adolescent; Adult; Alopecia; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antipsychotic | 2000 |
2 trials available for valproic acid and Alopecia Cicatrisata
| Article | Year |
|---|---|
Topical valproic acid increases the hair count in male patients with androgenetic alopecia: a randomized, comparative, clinical feasibility study using phototrichogram analysis.
Topics: Administration, Topical; Adult; Alopecia; Dermatologic Agents; Double-Blind Method; Feasibility Stud | 2014 |
Drug therapy: Valproic acid.
Topics: Adult; Alopecia; Behavior; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chil | 1980 |
21 other studies available for valproic acid and Alopecia Cicatrisata
| Article | Year |
|---|---|
Fabrication of carboxymethyl cellulose/hyaluronic acid/polyvinylpyrrolidone composite pastes incorporation of minoxidil-loaded ferulic acid-derived lignin nanoparticles and valproic acid for treatment of androgenetic alopecia.
Topics: Alopecia; Animals; Carboxymethylcellulose Sodium; Hyaluronic Acid; Lignin; Mice; Minoxidil; Nanopart | 2023 |
Alopecia in Breastfed Infant Possibly Due to Mother Getting Valproate.
Topics: Alopecia; Breast Feeding; Female; Humans; Infant; Infant Nutritional Physiological Phenomena; Mother | 2021 |
A Case Report of Biotin Treatment for Valproate-Induced Hair Loss.
Topics: Alopecia; Biotin; Humans; Male; Middle Aged; Valproic Acid | 2017 |
The Negative Regulator CXXC5: Making WNT Look a Little Less Dishevelled.
Topics: Alopecia; Animals; beta Catenin; Carrier Proteins; DNA-Binding Proteins; Gene Expression Regulation; | 2017 |
Severe hair loss associated with psychotropic drugs in psychiatric inpatients-Data from an observational pharmacovigilance program in German-speaking countries.
Topics: Adult; Alopecia; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Austria; Bipolar Dis | 2018 |
A case of androgenetic alopecia treated with valproic acid.
Topics: Alopecia; Anticonvulsants; Hair; Humans; Male; Middle Aged; Valproic Acid | 2014 |
Concordant response to pharmacotherapy in monozygotic twins with schizoaffective disorder.
Topics: Affect; Alopecia; Antipsychotic Agents; Diseases in Twins; Drug Therapy, Combination; Emotions; Huma | 2013 |
Cosmetic side effects of antiepileptic drugs in adults with epilepsy.
Topics: Acne Vulgaris; Adult; Alopecia; Anticonvulsants; Epilepsy; Female; gamma-Aminobutyric Acid; Gingival | 2015 |
Valproic acid reduces hair loss and improves survival in patients receiving temozolomide-based radiation therapy for high-grade glioma.
Topics: Adult; Aged; Aged, 80 and over; Alopecia; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemor | 2017 |
The effects of biotin supplementation on serum and liver tissue biotinidase enzyme activity and alopecia in rats which were administrated to valproic acid.
Topics: Alopecia; Animals; Anticonvulsants; Avitaminosis; Biotin; Biotinidase; Biotinidase Deficiency; Dieta | 2009 |
The influence of valproic acid treatment on hair and serum zinc levels and serum biotinidase activity.
Topics: Alopecia; Anticonvulsants; Biotinidase; Child; Child, Preschool; Epilepsy; Female; Hair; Humans; Mal | 2009 |
Valproic acid induces hair regeneration in murine model and activates alkaline phosphatase activity in human dermal papilla cells.
Topics: Alkaline Phosphatase; Alopecia; Animals; beta Catenin; Cell Differentiation; Cells, Cultured; Dermis | 2012 |
Telogen effluvium caused by magnesium valproate and lamotrigine.
Topics: Acute Disease; Adolescent; Adult; Alopecia; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; | 2005 |
Serum and liver tissue biotinidase enzyme activity in rats which were administrated to valproic acid.
Topics: Alopecia; Analysis of Variance; Animals; Anticonvulsants; Biotinidase; Dose-Response Relationship, D | 2006 |
Change in hair colour induced by valproic acid.
Topics: Alopecia; Child; Hair Color; Humans; Male; Valproic Acid | 1981 |
Treatment of valproate-induced alopecia.
Topics: Adult; Alopecia; Antimanic Agents; Female; Humans; Selenium; Valproic Acid; Zinc | 1995 |
Divalproex-induced alopecia: a case report.
Topics: Adult; Alopecia; Anticonvulsants; Antimanic Agents; Dose-Response Relationship, Drug; Female; Humans | 1999 |
Hyperactivity and alopecia associated with ingestion of valproic acid in a cat.
Topics: Alopecia; Animals; Anticonvulsants; Behavior, Animal; Cat Diseases; Cats; Hyperkinesis; Male; Valpro | 2001 |
Sodium valproate in the treatment of resistant epilepsy.
Topics: Adolescent; Adult; Alopecia; Anticonvulsants; Body Weight; Diarrhea; Drug Interactions; Epilepsies, | 1976 |
Alopecia and mood stabilizers: two case reports.
Topics: Adult; Alopecia; Carbamazepine; Clorazepate Dipotassium; Depressive Disorder; Female; Fluvoxamine; H | 1992 |
Long-term treatment with sodium valproate: monitoring of venous ammonia concentrations and adverse effects.
Topics: Adolescent; Adult; Alopecia; Ammonia; Body Weight; Child; Epilepsy; Female; Gastrointestinal Disease | 1987 |