valproic acid has been researched along with Allergy, Drug in 32 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly in epilepsy and psychiatric disorders." | 4.89 | Adverse drug reactions induced by valproic acid. ( Nanau, RM; Neuman, MG, 2013) |
| " With carbamazepine and phenytoin, hepatotoxicity may be due to drug hypersensitivity." | 4.77 | Hepatic considerations in the use of antiepileptic drugs. ( Dreifuss, FE; Langer, DH, 1987) |
| "Aromatic anticonvulsant agents such as carbamazepine and phenytoin can induce anticonvulsant hypersensitivity syndrome (AHS) at a frequency of 1 in 10,000 to 1 in 1,000 treated patients." | 3.73 | Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents. ( Bröcker, EB; Pfeuffer, P; Raith, P; Seitz, CS; Trautmann, A, 2006) |
| " We report a drug hypersensitivity syndrome in a 6-year-old Tunisian child treated for epileptic absences with sodium valproate and ethosuximide." | 3.70 | Hypersensitivity syndrome due to 2 anticonvulsant drugs. ( Conilleau, V; Dompmartin, A; Leroy, D; Michel, M; Verneuil, L, 1999) |
| " The adverse effect (AE) profile of this combination needs clarification." | 2.69 | Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group. ( Faught, E; French, J; Harden, C; Jacobson, M; Montouris, G; Morris, G; Rosenfeld, W, 1999) |
| "Valproic acid has clear efficacy in the treatment of partial epilepsies." | 2.42 | The efficacy of divalproex for partial epilepsies. ( Smith, MC, 2003) |
| "This syndrome is accompanied by fever, rash, lymphadenopathy, eosinophilia and affects parenchymal organs." | 1.32 | [Anticonvulsant hypersensitivity syndrome]. ( Papp, Z; Török, L, 2004) |
| " In addition, there was a significant dose-response association between the development of procarbazine hypersensitivity and the presence of therapeutic anticonvulsant serum levels (p = 0." | 1.30 | Anticonvulsant usage is associated with an increased risk of procarbazine hypersensitivity reactions in patients with brain tumors. ( Coyle, TE; Hurteau, TE; Lehmann, DF; Newman, N, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.25) | 18.7374 |
| 1990's | 12 (37.50) | 18.2507 |
| 2000's | 12 (37.50) | 29.6817 |
| 2010's | 6 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Papadavid, E | 1 |
| Evangelia, P | 1 |
| Panayiotides, I | 1 |
| Ioannis, P | 1 |
| Makris, M | 1 |
| Michael, M | 1 |
| Giatrakou, S | 1 |
| Sophia, G | 1 |
| Dalamaga, M | 1 |
| Maria, D | 1 |
| Stavrianeas, N | 2 |
| Rigopoulos, D | 1 |
| Dimitrios, R | 1 |
| Nanau, RM | 1 |
| Neuman, MG | 1 |
| Franciotta, D | 2 |
| Kwan, P | 1 |
| Perucca, E | 2 |
| Dreesman, A | 1 |
| Hoorens, A | 1 |
| Hachimi-Idrissi, S | 1 |
| Ioseliani, M | 1 |
| Lekishvili, M | 1 |
| Lin, YH | 1 |
| Chien, YL | 1 |
| van Zoelen, MA | 1 |
| de Graaf, M | 1 |
| van Dijk, MR | 1 |
| Bogte, A | 1 |
| van Erpecum, KJ | 1 |
| Rockmann, H | 1 |
| Maarschalk-Ellerbroek, LJ | 1 |
| Arévalo-Lorido, JC | 1 |
| Carretero-Gómez, J | 1 |
| Bureo-Dacal, JC | 1 |
| Montero-Leal, C | 1 |
| Bureo-Dacal, P | 1 |
| Huang, YL | 1 |
| Hong, HS | 1 |
| Wang, ZW | 1 |
| Kuo, TT | 1 |
| Roepke, S | 1 |
| Treudler, R | 1 |
| Anghelescu, I | 1 |
| Orfanos, CE | 1 |
| Tebbe, B | 1 |
| Smith, MC | 1 |
| Marsden, D | 1 |
| Libretto, SE | 1 |
| Papp, Z | 1 |
| Török, L | 1 |
| Rahman, M | 1 |
| Haider, N | 1 |
| Seitz, CS | 1 |
| Pfeuffer, P | 1 |
| Raith, P | 1 |
| Bröcker, EB | 1 |
| Trautmann, A | 1 |
| Zaccara, G | 1 |
| Periole, B | 2 |
| el Sayed, F | 1 |
| Moreau-Cabarrot, A | 1 |
| Bazex, J | 1 |
| Alldredge, BK | 1 |
| Knutsen, AP | 1 |
| Ferriero, D | 1 |
| Nevoral, J | 1 |
| Janda, J | 1 |
| Hanika, J | 1 |
| Svec, M | 1 |
| Honzová, S | 1 |
| Plantin, P | 1 |
| Cartier, H | 1 |
| Le Bihan, G | 1 |
| Clouard, P | 1 |
| Lellouche, F | 1 |
| Leroy, JP | 1 |
| Park, BK | 1 |
| Pirmohamed, M | 1 |
| Kitteringham, NR | 1 |
| Tennis, P | 1 |
| Stern, RS | 1 |
| Lehmann, DF | 1 |
| Hurteau, TE | 1 |
| Newman, N | 1 |
| Coyle, TE | 1 |
| Ciernik, IF | 1 |
| Thiel, M | 1 |
| Widmer, U | 1 |
| Schlienger, RG | 1 |
| Oh, PI | 1 |
| Knowles, SR | 1 |
| Shear, NH | 1 |
| Hamer, HM | 1 |
| Morris, HH | 1 |
| Faught, E | 1 |
| Morris, G | 1 |
| Jacobson, M | 1 |
| French, J | 1 |
| Harden, C | 1 |
| Montouris, G | 1 |
| Rosenfeld, W | 1 |
| Conilleau, V | 1 |
| Dompmartin, A | 1 |
| Verneuil, L | 1 |
| Michel, M | 1 |
| Leroy, D | 1 |
| Schaub, N | 1 |
| Bircher, AJ | 1 |
| Picart, N | 1 |
| Mazereeuw, J | 1 |
| Bonafé, JL | 1 |
| Dreifuss, FE | 1 |
| Langer, DH | 1 |
| Hicks, RA | 1 |
| Murphy, JV | 1 |
| Jackson, MA | 1 |
6 reviews available for valproic acid and Allergy, Drug
| Article | Year |
|---|---|
Adverse drug reactions induced by valproic acid.
Topics: Anticonvulsants; Antipsychotic Agents; Drug Hypersensitivity; Endocrine System; Epilepsy; Humans; Hy | 2013 |
Genetic basis for idiosyncratic reactions to antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Epile | 2009 |
The efficacy of divalproex for partial epilepsies.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Hypersensitivi | 2003 |
Idiosyncratic adverse reactions to antiepileptic drugs.
Topics: Age Factors; Anemia, Aplastic; Anticonvulsants; B-Lymphocytes; Central Nervous System Diseases; Chem | 2007 |
The role of cytochrome P450 enzymes in hepatic and extrahepatic human drug toxicity.
Topics: Abnormalities, Drug-Induced; Acetaminophen; Chemical and Drug Induced Liver Injury; Cytochrome P-450 | 1995 |
Hepatic considerations in the use of antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Hypersensitivity; Humans; Liv | 1987 |
1 trial available for valproic acid and Allergy, Drug
| Article | Year |
|---|---|
Adding lamotrigine to valproate: incidence of rash and other adverse effects. Postmarketing Antiepileptic Drug Survey (PADS) Group.
Topics: Adolescent; Adult; Child; Dizziness; Drug Eruptions; Drug Hypersensitivity; Drug Therapy, Combinatio | 1999 |
25 other studies available for valproic acid and Allergy, Drug
| Article | Year |
|---|---|
Pityriasis rosea-like eruption associated with lamotrigine.
Topics: Adult; Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Lamotrigine; Myocloni | 2013 |
Multiple organ dysfunction syndrome: infection or hypersensitivity reaction?
Topics: Anticonvulsants; Child; Drug Hypersensitivity; Drug Therapy, Combination; Humans; Hypersensitivity, | 2010 |
Pediatric drug induced hypersensitivity syndrome: case report.
Topics: Child; Drug Hypersensitivity; Female; Glucocorticoids; Humans; Prednisolone; Valproic Acid | 2011 |
Valproic Acid-related anticonvulsant hypersensitivity syndrome and subsequent olanzapine-related neutropenia and thrombocytopenia: a case report.
Topics: Adult; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; C | 2012 |
Valproic acid-induced DRESS syndrome with acute liver failure.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Eosinophilia; | 2012 |
Antiepileptic drug hypersensitivity syndrome in a patient treated with valproate.
Topics: Adult; Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Epilepsy; Humans; Hyperplasia; Lymph | 2003 |
Fatal sodium valproate-induced hypersensitivity syndrome with lichenoid dermatitis and fulminant hepatitis.
Topics: Anticonvulsants; Child, Preschool; Drug Hypersensitivity; Fatal Outcome; Female; Humans; Lichenoid E | 2003 |
Valproic Acid and hypersensitivity syndrome.
Topics: Anticonvulsants; Bipolar Disorder; Drug Eruptions; Drug Hypersensitivity; Drug Therapy, Combination; | 2004 |
Hypersensitivity to topiramate sprinkle capsules does not preclude the use of topiramate tablets.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Benzodiazepines; Capsules; Carbamazepine; Clobaza | 2004 |
[Anticonvulsant hypersensitivity syndrome].
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Eruptions; Drug | 2004 |
Anticonvulsant hypersensitivity syndrome from addition of lamotrigine to divalproex.
Topics: Anticonvulsants; Bipolar Disorder; Drug Hypersensitivity; Drug Therapy, Combination; Exanthema; Fema | 2005 |
Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Amitriptyline; Anticonvulsants; Antidepressive A | 2006 |
[A case for diagnosis: syndrome of hypersensitivity to carbamazepine].
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Skin T | 1995 |
Antiepileptic drug hypersensitivity syndrome: in vitro and clinical observations.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cross Reactions; Drug Hypersens | 1994 |
[Acute reversible liver necrosis after valproate therapy (immunologic hypersensitivity)].
Topics: Child; Drug Hypersensitivity; Epilepsy; Humans; Liver; Liver Cirrhosis; Male; Necrosis; Transaminase | 1993 |
[Drug hypersensitivity syndrome during treatment with valproic acid].
Topics: Adult; Anticonvulsants; Drug Hypersensitivity; Female; Humans; Syndrome; Valproic Acid | 1995 |
Risk of serious cutaneous disorders after initiation of use of phenytoin, carbamazepine, or sodium valproate: a record linkage study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Hypersensitivity; Female; Hospitaliza | 1997 |
Anticonvulsant usage is associated with an increased risk of procarbazine hypersensitivity reactions in patients with brain tumors.
Topics: Adult; Anticonvulsants; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain | 1997 |
Anterior uveitis and the anticonvulsant hypersensitivity syndrome.
Topics: Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Humans; Male; Middle Aged; Syndrome; Uveitis, | 1998 |
Quantifying the costs of serious adverse drug reactions to antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Direct Service Costs; Drug Costs; Drug Hypersensitivity; Epileps | 1998 |
Successful treatment with gabapentin in the presence of hypersensitivity syndrome to phenytoin and carbamazepine: a report of three cases.
Topics: Acetates; Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Hypersens | 1999 |
Hypersensitivity syndrome due to 2 anticonvulsant drugs.
Topics: Antibodies, Viral; Anticonvulsants; Child; Drug Hypersensitivity; Ethosuximide; Herpesvirus 6, Human | 1999 |
Severe hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro.
Topics: Adult; Anticonvulsants; Drug Hypersensitivity; Drug Therapy, Combination; Humans; Immunologic Tests; | 2000 |
[Drug hypersensitivity syndrome to valproic acid].
Topics: Adult; Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Patch Tests; Valproic | 2000 |
Kawasaki-like syndrome caused by carbamazepine.
Topics: Carbamazepine; Child, Preschool; Drug Hypersensitivity; Epilepsy; Humans; Male; Mucocutaneous Lymph | 1988 |