valproic acid has been researched along with Allergic Encephalomyelitis in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is a short-chain branched fatty acid with anti-epileptic, neuro-protective and anti-inflammatory effects." | 5.46 | Valproic acid attenuates inflammation of optic nerve and apoptosis of retinal ganglion cells in a rat model of optic neuritis. ( Li, H; Liu, Q; Niu, X; Wang, Z; Yang, J; Zhao, C; Zhao, L, 2017) |
| "Valproic acid (VPA) is a short-chain branched fatty acid with anti-inflammatory, neuro-protective and axon remodeling effects." | 5.38 | Valproic acid ameliorates inflammation in experimental autoimmune encephalomyelitis rats. ( Schluesener, HJ; Wu, Y; Zhang, Z; Zhang, ZY, 2012) |
| "Valproic acid (VPA) is a short-chain branched fatty acid with anti-epileptic, neuro-protective and anti-inflammatory effects." | 1.46 | Valproic acid attenuates inflammation of optic nerve and apoptosis of retinal ganglion cells in a rat model of optic neuritis. ( Li, H; Liu, Q; Niu, X; Wang, Z; Yang, J; Zhao, C; Zhao, L, 2017) |
| "Valproic acid (VPA) is a short-chain branched fatty acid with anti-inflammatory, neuro-protective and axon remodeling effects." | 1.38 | Valproic acid ameliorates inflammation in experimental autoimmune encephalomyelitis rats. ( Schluesener, HJ; Wu, Y; Zhang, Z; Zhang, ZY, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Q | 1 |
| Li, H | 1 |
| Yang, J | 1 |
| Niu, X | 1 |
| Zhao, C | 1 |
| Zhao, L | 1 |
| Wang, Z | 1 |
| Pazhoohan, S | 1 |
| Satarian, L | 1 |
| Asghari, AA | 1 |
| Salimi, M | 1 |
| Kiani, S | 1 |
| Mani, AR | 1 |
| Javan, M | 1 |
| Castelo-Branco, G | 1 |
| Stridh, P | 1 |
| Guerreiro-Cacais, AO | 1 |
| Adzemovic, MZ | 1 |
| Falcão, AM | 1 |
| Marta, M | 1 |
| Berglund, R | 1 |
| Gillett, A | 1 |
| Hamza, KH | 1 |
| Lassmann, H | 1 |
| Hermanson, O | 1 |
| Jagodic, M | 1 |
| Azuchi, Y | 1 |
| Kimura, A | 1 |
| Guo, X | 1 |
| Akiyama, G | 1 |
| Noro, T | 1 |
| Harada, C | 1 |
| Nishigaki, A | 1 |
| Namekata, K | 1 |
| Harada, T | 1 |
| Lv, J | 1 |
| Du, C | 1 |
| Wei, W | 1 |
| Wu, Z | 1 |
| Zhao, G | 1 |
| Li, Z | 1 |
| Xie, X | 1 |
| Zhang, Z | 1 |
| Zhang, ZY | 1 |
| Wu, Y | 1 |
| Schluesener, HJ | 1 |
1 trial available for valproic acid and Allergic Encephalomyelitis
| Article | Year |
|---|---|
The antiepileptic drug valproic acid restores T cell homeostasis and ameliorates pathogenesis of experimental autoimmune encephalomyelitis.
Topics: Animals; Anticonvulsants; Caspase 3; Caspase 8; Drug Evaluation, Preclinical; Encephalomyelitis, Aut | 2012 |
5 other studies available for valproic acid and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Valproic acid attenuates inflammation of optic nerve and apoptosis of retinal ganglion cells in a rat model of optic neuritis.
Topics: Animals; Apoptosis; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; In Situ Nic | 2017 |
Valproic Acid attenuates disease symptoms and increases endogenous myelin repair by recruiting neural stem cells and oligodendrocyte progenitors in experimental autoimmune encephalomyelitis.
Topics: Animals; Central Nervous System Agents; Encephalomyelitis, Autoimmune, Experimental; Female; Fluores | 2014 |
Acute treatment with valproic acid and l-thyroxine ameliorates clinical signs of experimental autoimmune encephalomyelitis and prevents brain pathology in DA rats.
Topics: Analysis of Variance; Animals; Brain; CD11b Antigen; CD4-Positive T-Lymphocytes; Disease Models, Ani | 2014 |
Valproic acid and ASK1 deficiency ameliorate optic neuritis and neurodegeneration in an animal model of multiple sclerosis.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; MAP Kinase Kin | 2017 |
Valproic acid ameliorates inflammation in experimental autoimmune encephalomyelitis rats.
Topics: Animals; Anti-Inflammatory Agents; CD11b Antigen; CD3 Complex; Cell Proliferation; Cytokines; Diseas | 2012 |