valproic acid has been researched along with Alexander Disease in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Alexander Disease: Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although most patients with infantile Alexander disease have epilepsy, infantile spasms are rare." | 1.39 | Alexander disease with mild dorsal brainstem atrophy and infantile spasms. ( Hara, T; Ishizaki, Y; Sanefuji, M; Sawaishi, Y; Torisu, H; Yamaguchi-Takada, Y; Yano, T; Yoshikawa, Y, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Torisu, H | 1 |
| Yoshikawa, Y | 1 |
| Yamaguchi-Takada, Y | 1 |
| Yano, T | 1 |
| Sanefuji, M | 1 |
| Ishizaki, Y | 1 |
| Sawaishi, Y | 1 |
| Hara, T | 1 |
| Sechi, GP | 1 |
| Conti, M | 1 |
| Sau, GF | 1 |
| Cocco, GA | 1 |
2 other studies available for valproic acid and Alexander Disease
| Article | Year |
|---|---|
Alexander disease with mild dorsal brainstem atrophy and infantile spasms.
Topics: Alexander Disease; Anticonvulsants; Atrophy; Brain Stem; Brain Waves; Corpus Callosum; DNA Mutationa | 2013 |
Valproate-induced parkinsonism, glial cells and Alexander's disease.
Topics: Adult; Alexander Disease; Anticonvulsants; Female; Humans; Magnetic Resonance Imaging; Neuroglia; Pa | 2008 |