valproic acid has been researched along with Alcohol Drinking in 15 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because BD-II and alcohol dependence are neurodegenerative disorders, agents with anti-inflammatory and neurotrophic effects might provide effective therapy." | 2.87 | Add-On Memantine Treatment for Bipolar II Disorder Comorbid with Alcohol Dependence: A 12-Week Follow-Up Study. ( Chang, YH; Chen, KC; Chen, PS; Chen, SL; Hong, JS; Huang, SY; Lee, IH; Lee, SY; Lu, RB; Tzeng, NS; Wang, LJ; Wang, TY; Yang, YK, 2018) |
| " Patients treated with lithium or divalproex (ongoing or assigned at screening) were randomized to receive quetiapine (dosed up to 400 mg/d over 7 days, followed by 300 to 800 mg/d flexible dosing until study end) or placebo." | 2.75 | A double-blind, placebo-controlled study with quetiapine as adjunct therapy with lithium or divalproex in bipolar I patients with coexisting alcohol dependence. ( Brown, ES; Calabrese, JR; Kotz, M; Pettinati, HM; Raines, S; Stedman, M, 2010) |
| "Additional marijuana abuse may impact on the clinical presentation of bipolar illness and may potentially act as mediator of treatment response in this population." | 2.71 | Patient characteristics and treatment implications of marijuana abuse among bipolar alcoholics: results from a double blind, placebo-controlled study. ( Cornelius, JR; Daley, DC; Douaihy, A; Kelly, TM; Kirisci, L; Salloum, IM, 2005) |
| " Similarly, 5 days of oral dosing with VAL (400 and 600 mg/kg) reliably reduced the intake of ethanol without affecting the intake of water." | 1.30 | Valproate reduces intake of alcoholic beverage among rats. ( Boswell, KJ; Chambers, MD; Gardell, LR; Hubbell, CL; Reid, LD; Whalen, CA, 1998) |
| "Juvenile myoclonic epilepsy is a common, under-recognised form of epilepsy which is best treated with sodium valproate." | 1.29 | Juvenile myoclonic epilepsy: diagnosis, management and outcome. ( Buchanan, N; Sharpe, C, 1995) |
| " During EEG recording of wake-sleep cycle valporoic acid was shown to produce hypnotic action dependent on drug dosage in high active and low active animals." | 1.28 | [The effect of valproic acid on sleep structure and ethanol consumption in rats with various types of individual reactivity before and after stress exposure]. ( Mdzinarishvili, AL; Molodavkin, GA; Voronina, TA, 1989) |
| "Treatment with carbamazepine or phenytoin was effective, but haloperidol increased the severity of the choreoathetoid attacks." | 1.27 | Therapeutic aspects of kinesiogenic paroxysmal choreoathetosis and familial paroxysmal choreoathetosis of the Mount and Reback type. ( Monninger, P; Przuntek, H, 1983) |
| "Most patients with mild withdrawal symptoms do not require hospitalization and respond to non-pharmacologic supportive care." | 1.27 | Clinical assessment and pharmacotherapy of the alcohol withdrawal syndrome. ( Naranjo, CA; Sellers, EM, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Metruccio, F | 3 |
| Battistoni, M | 3 |
| Di Renzo, F | 3 |
| Moretto, A | 3 |
| Menegola, E | 3 |
| Hagesaether, E | 1 |
| Lee, SY | 1 |
| Wang, TY | 1 |
| Chen, SL | 1 |
| Chang, YH | 1 |
| Chen, PS | 1 |
| Huang, SY | 1 |
| Tzeng, NS | 1 |
| Wang, LJ | 1 |
| Lee, IH | 1 |
| Chen, KC | 1 |
| Yang, YK | 1 |
| Hong, JS | 1 |
| Lu, RB | 1 |
| Hesemann, J | 1 |
| Lauer, E | 1 |
| Ziska, S | 1 |
| Noonan, K | 1 |
| Nemeth, B | 1 |
| Scott-Schwoerer, J | 1 |
| McCarty, C | 1 |
| Rasmussen, K | 1 |
| Goldberg, JM | 1 |
| Sund, S | 1 |
| Eickhoff, J | 1 |
| Raggio, CL | 1 |
| Giampietro, PF | 1 |
| Al Ameri, M | 1 |
| Al Mansouri, S | 1 |
| Al Maamari, A | 1 |
| Bahi, A | 1 |
| Stedman, M | 1 |
| Pettinati, HM | 1 |
| Brown, ES | 1 |
| Kotz, M | 1 |
| Calabrese, JR | 1 |
| Raines, S | 1 |
| Polifka, JE | 1 |
| Friedman, JM | 1 |
| Salloum, IM | 2 |
| Cornelius, JR | 2 |
| Daley, DC | 2 |
| Kirisci, L | 2 |
| Himmelhoch, JM | 1 |
| Thase, ME | 1 |
| Douaihy, A | 1 |
| Kelly, TM | 1 |
| Przuntek, H | 1 |
| Monninger, P | 1 |
| Sharpe, C | 1 |
| Buchanan, N | 1 |
| Gardell, LR | 1 |
| Whalen, CA | 1 |
| Chambers, MD | 1 |
| Boswell, KJ | 1 |
| Hubbell, CL | 1 |
| Reid, LD | 1 |
| Hillbom, ME | 1 |
| Mdzinarishvili, AL | 1 |
| Molodavkin, GA | 1 |
| Voronina, TA | 1 |
| Naranjo, CA | 1 |
| Sellers, EM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Efficacy of Valproate Maintenance in Bipolar Alcoholics[NCT00000439] | Phase 2 | 72 participants (Actual) | Interventional | 2000-10-31 | Completed | ||
| Imaging Framework for Testing GABAergic/Glutamatergic Drugs in Bipolar Alcoholics[NCT03220776] | Phase 2 | 54 participants (Actual) | Interventional | 2017-08-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Concentrations of GABA+, referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy (i.e., MEGA-PRESS). (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 3.90 |
| Gabapentin | 3.93 |
| Placebo Oral Tablet | 3.73 |
Concentrations of Glx (i.e., glutamate + glutamine), referenced to unsuppressed water and corrected for within-voxel CSF proportion, in dorsal anterior cingulate cortex measured via Proton Magnetic Resonance Spectroscopy. (NCT03220776)
Timeframe: Day 5 of each experimental condition
| Intervention | mmol/kg (Mean) |
|---|---|
| N-Acetylcysteine | 21.59 |
| Gabapentin | 21.69 |
| Placebo Oral Tablet | 22.25 |
1 review available for valproic acid and Alcohol Drinking
| Article | Year |
|---|---|
Medical genetics: 1. Clinical teratology in the age of genomics.
Topics: Adult; Alcohol Drinking; Anticonvulsants; Environmental Exposure; Epilepsy; Female; Genetic Counseli | 2002 |
4 trials available for valproic acid and Alcohol Drinking
| Article | Year |
|---|---|
Add-On Memantine Treatment for Bipolar II Disorder Comorbid with Alcohol Dependence: A 12-Week Follow-Up Study.
Topics: Alcohol Drinking; Alcoholism; Antimanic Agents; Bipolar Disorder; Brain-Derived Neurotrophic Factor; | 2018 |
A double-blind, placebo-controlled study with quetiapine as adjunct therapy with lithium or divalproex in bipolar I patients with coexisting alcohol dependence.
Topics: Adult; Alcohol Drinking; Alcoholism; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Diagn | 2010 |
Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study.
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Anticonvulsants; Bipolar Disorder; Comorbidit | 2005 |
Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study.
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Anticonvulsants; Bipolar Disorder; Comorbidit | 2005 |
Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study.
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Anticonvulsants; Bipolar Disorder; Comorbidit | 2005 |
Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study.
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Alcoholism; Anticonvulsants; Bipolar Disorder; Comorbidit | 2005 |
Patient characteristics and treatment implications of marijuana abuse among bipolar alcoholics: results from a double blind, placebo-controlled study.
Topics: Adolescent; Adult; Affect; Aged; Alcohol Drinking; Alcoholism; Antimanic Agents; Bipolar Disorder; D | 2005 |
10 other studies available for valproic acid and Alcohol Drinking
| Article | Year |
|---|---|
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Moderate alcohol consumption during pregnancy increases potency of two different drugs (the antifungal fluconazole and the antiepileptic valproate) in inducing craniofacial defects: prediction by the in vitro rat whole embryo culture.
Topics: Alcohol Drinking; Animals; Anticonvulsants; Antifungal Agents; Ethanol; Female; Fluconazole; Humans; | 2023 |
Altered drug release from Orfiril
Topics: Alcohol Drinking; Anticonvulsants; Central Nervous System Depressants; Computer Simulation; Drug Int | 2018 |
Analysis of maternal risk factors associated with congenital vertebral malformations.
Topics: Abnormalities, Multiple; Adolescent; Adult; Alcohol Drinking; Child; Clomiphene; Diabetes Mellitus, | 2013 |
The histone deacetylase (HDAC) inhibitor valproic acid reduces ethanol consumption and ethanol-conditioned place preference in rats.
Topics: Alcohol Drinking; Animals; Central Nervous System Depressants; Choice Behavior; Conditioning, Psycho | 2014 |
Therapeutic aspects of kinesiogenic paroxysmal choreoathetosis and familial paroxysmal choreoathetosis of the Mount and Reback type.
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Athetosis; Carbamazepine; Child; Chorea; Female; Haloperi | 1983 |
Juvenile myoclonic epilepsy: diagnosis, management and outcome.
Topics: Adolescent; Adult; Alcohol Drinking; Anticonvulsants; Carbamazepine; Epilepsies, Myoclonic; Female; | 1995 |
Valproate reduces intake of alcoholic beverage among rats.
Topics: Administration, Oral; Alcohol Drinking; Animals; Conditioning, Psychological; Ethanol; Injections, I | 1998 |
The prevention of ethanol withdrawal seizures in rats by dipropylacetate.
Topics: Alcohol Drinking; Analgesia; Animals; Ethanol; Humans; Male; Rats; Seizures; Substance Withdrawal Sy | 1975 |
[The effect of valproic acid on sleep structure and ethanol consumption in rats with various types of individual reactivity before and after stress exposure].
Topics: Alcohol Drinking; Animals; Electroencephalography; Individuality; Male; Rats; Sleep; Sleep Deprivati | 1989 |
Clinical assessment and pharmacotherapy of the alcohol withdrawal syndrome.
Topics: Adrenergic beta-Antagonists; Alcohol Drinking; Alcoholism; Anti-Anxiety Agents; Benzodiazepines; Chl | 1986 |