valproic acid has been researched along with Agranulocytosis in 11 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Agranulocytosis: A decrease in the number of GRANULOCYTES; (BASOPHILS; EOSINOPHILS; and NEUTROPHILS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " We report an infant with SCAD deficiency who unexpectedly exhibited an extremely high blood concentration of valproic acid (VPA) and agranulocytosis." | 8.02 | Unexpected elevation in valproic acid concentration and agranulocytosis in a patient with short-chain acyl-CoA dehydrogenase deficiency. ( Eto, K; Hara, K; Ito, S; Nagata, S; Nishikawa, A; Oguni, H; Otani, Y; Suzuki, Y, 2021) |
| " We report an infant with SCAD deficiency who unexpectedly exhibited an extremely high blood concentration of valproic acid (VPA) and agranulocytosis." | 4.02 | Unexpected elevation in valproic acid concentration and agranulocytosis in a patient with short-chain acyl-CoA dehydrogenase deficiency. ( Eto, K; Hara, K; Ito, S; Nagata, S; Nishikawa, A; Oguni, H; Otani, Y; Suzuki, Y, 2021) |
| "This case suggests that rufinamide may induce the potentially serious adverse effect of agranulocytosis." | 3.81 | A granulocytosis associated with rufinamide: A case report. ( Awaya, T; Heike, T; Ide, M; Kato, T; Nakata, M; Saito, K; Yoshida, T, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Suzuki, Y | 1 |
| Ito, S | 1 |
| Otani, Y | 1 |
| Nishikawa, A | 1 |
| Eto, K | 1 |
| Hara, K | 1 |
| Oguni, H | 1 |
| Nagata, S | 1 |
| Roméo, B | 1 |
| Petillion, A | 1 |
| Martelli, C | 1 |
| Benyamina, A | 1 |
| Ide, M | 1 |
| Kato, T | 1 |
| Nakata, M | 1 |
| Saito, K | 1 |
| Yoshida, T | 1 |
| Awaya, T | 1 |
| Heike, T | 1 |
| Madeb, R | 1 |
| Hirschmann, S | 1 |
| Kurs, R | 1 |
| Turkie, A | 1 |
| Modai, I | 1 |
| Symon, DN | 1 |
| Russell, G | 1 |
| Pantelis, C | 1 |
| Adesanya, A | 1 |
| Védrine, L | 1 |
| Biance, N | 1 |
| Souleau, B | 1 |
| Nedellec, G | 1 |
| de Revel, T | 1 |
| Jaeken, J | 1 |
| van Goethem, C | 1 |
| Casaer, P | 1 |
| Devlieger, H | 1 |
| Eggermont, E | 1 |
| Pilet, M | 1 |
| Watts, RG | 1 |
| Emanuel, PD | 1 |
| Zuckerman, KS | 1 |
| Howard, TH | 1 |
| Jensen, NB | 1 |
| Storm, K | 1 |
11 other studies available for valproic acid and Agranulocytosis
| Article | Year |
|---|---|
Unexpected elevation in valproic acid concentration and agranulocytosis in a patient with short-chain acyl-CoA dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase; Agranulocytosis; Anticonvulsants; Female; Humans; Infant; Lipid Metabolism, | 2021 |
Failure of rechallenge clozapine after agranulocytosis: A case report.
Topics: Adult; Agranulocytosis; Antipsychotic Agents; Clopenthixol; Clozapine; Drug Resistance; Drug Substit | 2019 |
A granulocytosis associated with rufinamide: A case report.
Topics: Agranulocytosis; Anticonvulsants; Child; Clonazepam; Epilepsy; Humans; Male; Triazoles; Valproic Aci | 2015 |
Combined clozapine and valproic acid treatment-induced agranulocytosis.
Topics: Agranulocytosis; Anticonvulsants; Chronic Disease; Clozapine; Drug Therapy, Combination; Humans; Mal | 2002 |
Sodium valproate and neutropenia.
Topics: Agranulocytosis; Child; Female; Humans; Neutropenia; Valproic Acid | 1983 |
Adverse Drug Reactions Advisory Committee: ADRAC report for 1980.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Australia; Bronchial Spasm; Chemical and Drug Induced Live | 1982 |
Increased risk of neutropaenia and agranulocytosis with sodium valproate used adjunctively with clozapine.
Topics: Adult; Agranulocytosis; Anticonvulsants; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; | 2001 |
[Agranulocytosis and simultaneous cholestatic jaundice induced by sodium valproate in an elderly woman].
Topics: Age Factors; Aged; Agranulocytosis; Anticonvulsants; Cholestasis; Female; Humans; Valproic Acid | 2001 |
Neutropenia during sodium valproate treatment.
Topics: Agranulocytosis; Humans; Infant; Male; Neutropenia; Seizures; Valproic Acid | 1979 |
Valproic acid-induced cytopenias: evidence for a dose-related suppression of hematopoiesis.
Topics: Adolescent; Agranulocytosis; Dose-Response Relationship, Drug; Hematopoiesis; Hematopoietic Stem Cel | 1990 |
[Neutropenia during treatment with valproate].
Topics: Agranulocytosis; Child; Epilepsy, Tonic-Clonic; Female; Humans; Neutropenia; Valproic Acid | 1987 |