valproic acid has been researched along with Adult Fanconi Syndrome in 31 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effects of valproic acid (VPA) on renal tubular function, we examined 15 ambulatory children with epilepsy who received VPA for at least 6 months." | 5.09 | Renal tubular dysfunction in epileptic children on valproic acid therapy. ( Altunbaşak, S; Anarat, A; Burgut, HR; Yildizaş, D, 2001) |
| "Two severely disabled children with epilepsy, a 6-year-old boy and a 15-year-old girl, had been treated with valproic acid from the ages of 5 and 6 months, respectively, and developed Fanconi syndrome." | 3.76 | Fanconi syndrome caused by valproic acid. ( Endo, A; Fuchigami, T; Fujita, Y; Mugishima, H; Takahashi, S, 2010) |
| " In addition, the chemotherapeutic agent ifosfamide caused a decrease in plasma GPx activity in pediatric osteosarcoma patients." | 3.70 | Plasma glutathione peroxidase and its relationship to renal proximal tubule function. ( Avissar, N; Bhamre, S; Cohen, HJ; Ornt, DB; Salvatierra, O; Scandling, JD; Tham, DM; Tune, BM; Whitin, JC, 1998) |
| "Valproic acid-treated animals developed biochemical evidence of FS as judged by elevated serum gamma-glutamyl transferase (γ-GT), alkaline phosphatase (ALP), creatinine (Cr), and blood urea nitrogen (BUN) along with hypokalaemia, hypophosphataemia, and a decrease in serum uric acid." | 1.48 | Mechanism of valproic acid-induced Fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney. ( Heidari, R; Jafari, F; Khodaei, F; Niknahad, H; Shirazi Yeganeh, B, 2018) |
| "Although Fanconi syndrome is rare in patients with epilepsy treated with sodium valproate (VPA), the prevalence might be higher in children with severe motor and intellectual disabilities (SMID)." | 1.43 | Outcome of renal proximal tubular dysfunction with Fanconi syndrome caused by sodium valproate. ( Sato, S; Watanabe, T; Yamazaki, S; Yoshikawa, H, 2016) |
| "Valproate-induced Fanconi syndrome is a rare adverse effect of valproate." | 1.40 | Fever of unknown origin as the initial manifestation of valproate-induced Fanconi syndrome. ( Fujii, T; Kumada, T; Kusunoki, T; Murayama, K; Nozaki, F; Ohtake, A, 2014) |
| "Although nephrocalcinosis is not a common feature in patients with proximal tubulopathy, the patient presented also with this condition, and the concomitant use of another anticonvulsant might have potentiated this condition." | 1.38 | Anticonvulsant-induced rickets and nephrocalcinosis. ( Lau, KK; Papneja, K, 2012) |
| "Recently, renal Fanconi syndrome associated with VPA treatment has occasionally been reported." | 1.37 | [Three cases of Fanconi syndrome associated with valproate sodium treatment]. ( Inoue, T; Itabashi, H; Murakami, N; Nagai, T; Otani, R; Sakuta, R; Tanaka, Y, 2011) |
| "Although renal Fanconi syndrome resulting from valproate (VPA) has occasionally been reported, the detailed clinical characteristics of this disease remain unclear." | 1.33 | Secondary renal Fanconi syndrome caused by valproate therapy. ( Abe, T; Abe, Y; Watanabe, T; Yamazaki, S; Yoshikawa, H, 2005) |
| "Since Fanconi syndrome was considered to be caused by sodium valproate, it was stopped." | 1.31 | Fanconi syndrome caused by sodium valproate: report of three severely disabled children. ( Abe, T; Watanabe, T; Yoshikawa, H, 2002) |
| " In those patients who use these drugs at increased dosage levels or for long periods, the possibility of tubular dysfunction may be increased, and these dysfunctions may manifest in clinical symptoms." | 1.30 | N-acetyl-beta-glucosaminidase and beta-galactosidase activity in children receiving antiepileptic drugs. ( Cenani, A; Cengiz, M; Cengiz, S; Seven, M; Yüksel, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.23) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 10 (32.26) | 29.6817 |
| 2010's | 13 (41.94) | 24.3611 |
| 2020's | 2 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Sturla Álvarez, DA | 1 |
| Sánchez Marcos, E | 1 |
| de Lucas Collantes, C | 1 |
| Cantarín Extremera, V | 1 |
| Soto Insuga, V | 1 |
| Aparicio López, C | 1 |
| Morton, A | 1 |
| Ono, H | 3 |
| Knights, MJ | 1 |
| Finlay, E | 2 |
| Hayashi, A | 1 |
| Kawakita, R | 1 |
| Kumada, T | 2 |
| Nozaki, F | 2 |
| Hiejima, I | 1 |
| Miyajima, T | 1 |
| Kusunoki, T | 2 |
| Fujii, T | 2 |
| Murayama, K | 1 |
| Ohtake, A | 1 |
| Hanley, P | 1 |
| Cunningham, RJ | 1 |
| Lou, L | 1 |
| Vog, B | 1 |
| Raina, R | 1 |
| Knights, M | 1 |
| Thekkekkara, T | 1 |
| Morris, A | 1 |
| Yamazaki, S | 2 |
| Watanabe, T | 5 |
| Sato, S | 1 |
| Yoshikawa, H | 4 |
| Heidari, R | 1 |
| Jafari, F | 1 |
| Khodaei, F | 1 |
| Shirazi Yeganeh, B | 1 |
| Niknahad, H | 1 |
| Endo, A | 1 |
| Fujita, Y | 1 |
| Fuchigami, T | 1 |
| Takahashi, S | 1 |
| Mugishima, H | 1 |
| Patel, SM | 1 |
| Graff-Radford, J | 1 |
| Wieland, ML | 1 |
| Inoue, T | 1 |
| Tanaka, Y | 1 |
| Otani, R | 1 |
| Itabashi, H | 1 |
| Murakami, N | 1 |
| Nagai, T | 1 |
| Sakuta, R | 1 |
| Dhillon, N | 1 |
| Högler, W | 1 |
| Lau, KK | 1 |
| Papneja, K | 1 |
| Abe, T | 3 |
| Zaki, EL | 1 |
| Springate, JE | 1 |
| Knorr, M | 1 |
| Schaper, J | 1 |
| Harjes, M | 1 |
| Mayatepek, E | 1 |
| Rosenbaum, T | 1 |
| Nakayasu, K | 1 |
| Nagayama, Y | 1 |
| Abe, Y | 1 |
| Jaffe, SL | 1 |
| Sanford, M | 1 |
| Lenoir, GR | 1 |
| Perignon, JL | 1 |
| Gubler, MC | 1 |
| Broyer, M | 1 |
| Smith, GC | 1 |
| Balfe, JW | 1 |
| Kooh, SW | 1 |
| Lande, MB | 1 |
| Kim, MS | 1 |
| Bartlett, C | 1 |
| Guay-Woodford, LM | 1 |
| Whitin, JC | 1 |
| Tham, DM | 1 |
| Bhamre, S | 1 |
| Ornt, DB | 1 |
| Scandling, JD | 1 |
| Tune, BM | 1 |
| Salvatierra, O | 1 |
| Avissar, N | 1 |
| Cohen, HJ | 1 |
| Yüksel, A | 1 |
| Cengiz, M | 1 |
| Seven, M | 1 |
| Cengiz, S | 1 |
| Cenani, A | 1 |
| Altunbaşak, S | 1 |
| Yildizaş, D | 1 |
| Anarat, A | 1 |
| Burgut, HR | 1 |
| Watanabe, H | 1 |
| Fukuda, Y | 1 |
| Ohtomo, Y | 1 |
| Yabuta, K | 1 |
| Hirano, K | 1 |
| Tomino, Y | 1 |
5 reviews available for valproic acid and Adult Fanconi Syndrome
| Article | Year |
|---|---|
Fanconi Syndrome Secondary to Sodium Valproate Therapy: Experience and Literature Review.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Fanconi Syndrome; Female; Humans; Ma | 2022 |
The effects of sodium valproate on the renal function of children with epilepsy.
Topics: Acetylglucosaminidase; Anticonvulsants; Child; Epilepsy; Fanconi Syndrome; Female; Humans; Kidney; M | 2014 |
Valproate-induced Fanconi syndrome in a 27-year-old woman.
Topics: Adult; Fanconi Syndrome; Female; Humans; Valproic Acid | 2011 |
Renal injury from valproic acid: case report and literature review.
Topics: Child; Epilepsy, Absence; Fanconi Syndrome; Female; Humans; Kidney; Valproic Acid | 2002 |
Tubulo-interstitial nephritis caused by sodium valproate.
Topics: Adolescent; Anticonvulsants; Biopsy; Epilepsy; Fanconi Syndrome; Female; Humans; Nephritis, Intersti | 2002 |
1 trial available for valproic acid and Adult Fanconi Syndrome
| Article | Year |
|---|---|
Renal tubular dysfunction in epileptic children on valproic acid therapy.
Topics: Acetylglucosamine; Adolescent; Anticonvulsants; beta 2-Microglobulin; Child; Cross-Sectional Studies | 2001 |
25 other studies available for valproic acid and Adult Fanconi Syndrome
| Article | Year |
|---|---|
Diabetic ketoacidosis with severe hypokalaemia and valproate-associated Fanconi syndrome.
Topics: Diabetes Mellitus; Diabetic Ketoacidosis; Fanconi Syndrome; Humans; Hypokalemia; Valproic Acid | 2023 |
Sodium valproate-induced Fanconi syndrome in two severely disabled patients receiving carnitine supplementation.
Topics: Adult; Anticonvulsants; Carnitine; Disabled Persons; Epilepsy; Fanconi Syndrome; Female; Humans; Int | 2019 |
Pathological fracture and pyogenic osteomyelitis in a patient with type 2 Gaucher disease.
Topics: Anticonvulsants; Child, Preschool; Enzyme Replacement Therapy; Fanconi Syndrome; Female; Femur; Frac | 2014 |
Fever of unknown origin as the initial manifestation of valproate-induced Fanconi syndrome.
Topics: Adolescent; Cytochrome-c Oxidase Deficiency; Enzyme Inhibitors; Fanconi Syndrome; Fever of Unknown O | 2014 |
Muscle Weakness and Pain With Profound Hypophosphatemia: Mystery Revealed.
Topics: Adolescent; Epilepsy; Fanconi Syndrome; Humans; Hypophosphatemia; Male; Muscle Weakness; Valproic Ac | 2015 |
Sodium valproate-induced Fanconi type proximal renal tubular acidosis.
Topics: Acidosis, Renal Tubular; Anticonvulsants; Child; Child, Preschool; Diagnosis, Differential; Fanconi | 2016 |
Outcome of renal proximal tubular dysfunction with Fanconi syndrome caused by sodium valproate.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Fanconi Syndrome; Female; Follow-Up Studies; Hum | 2016 |
Mechanism of valproic acid-induced Fanconi syndrome involves mitochondrial dysfunction and oxidative stress in rat kidney.
Topics: Adenosine Triphosphate; Animals; Atrophy; Disease Models, Animal; Fanconi Syndrome; Glutathione; Kid | 2018 |
[Correlation between renal tubular dysfunction and serum carnitine deficiency in cases with valproate therapy].
Topics: Adult; Anticonvulsants; Carnitine; Child; Child, Preschool; Fanconi Syndrome; Female; Humans; Male; | 2009 |
Fanconi syndrome caused by valproic acid.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Fanconi Syndrome; Female; Humans; Male; Time Factors; | 2010 |
[Three cases of Fanconi syndrome associated with valproate sodium treatment].
Topics: Anticonvulsants; Child; Child, Preschool; Disabled Children; Fanconi Syndrome; Female; Humans; Male; | 2011 |
Fractures and Fanconi syndrome due to prolonged sodium valproate use.
Topics: Child; Disabled Children; Epilepsies, Myoclonic; Fanconi Syndrome; Female; Femoral Fractures; Humans | 2011 |
Anticonvulsant-induced rickets and nephrocalcinosis.
Topics: Anticonvulsants; Child; Diagnosis, Differential; Fanconi Syndrome; Female; Fructose; Humans; Nephroc | 2012 |
Fanconi syndrome caused by sodium valproate: report of three severely disabled children.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Disabled Children; Epilepsy; Fanconi Syndrome; | 2002 |
Fanconi syndrome caused by antiepileptic therapy with valproic Acid.
Topics: Anticonvulsants; Child; Epilepsy; Fanconi Syndrome; Hand; Humans; Male; Radiography; Valproic Acid | 2004 |
Autoimmune haemolytic anaemia and renal Fanconi syndrome caused by valproate therapy.
Topics: Anemia, Hemolytic, Autoimmune; Anticonvulsants; Child, Preschool; Epilepsy; Fanconi Syndrome; Female | 2005 |
Secondary renal Fanconi syndrome caused by valproate therapy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Fanconi Syndrome; Female; Humans; Kidney Disea | 2005 |
Valproate-induced proximal renal tubular dysfunction: clinically relevant in the severely disabled epileptic population.
Topics: Adolescent; Adult; Anticonvulsants; Disabled Persons; Epilepsy; Fanconi Syndrome; Female; Humans; Ma | 2005 |
[A severe disabled case of incomplete Fanconi syndrome after discontinuation of carnitine supplementation during valproate sodium therapy].
Topics: Anticonvulsants; Carnitine; Child; Disabled Children; Fanconi Syndrome; Female; Humans; Valproic Aci | 2007 |
Valproic acid: a possible cause of proximal tubular renal syndrome.
Topics: Child; Fanconi Syndrome; Humans; Male; Valproic Acid | 1981 |
Anticonvulsants as a cause of Fanconi syndrome.
Topics: Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Child; Clobazam; Drug Therapy, Combination; | 1995 |
Reversible Fanconi syndrome associated with valproate therapy.
Topics: Child; Child, Preschool; Developmental Disabilities; Fanconi Syndrome; Female; Humans; Male; Valproi | 1993 |
Plasma glutathione peroxidase and its relationship to renal proximal tubule function.
Topics: Adult; Animals; Antibodies; Cephaloglycin; Child; Creatinine; Fanconi Syndrome; Glutathione Peroxida | 1998 |
N-acetyl-beta-glucosaminidase and beta-galactosidase activity in children receiving antiepileptic drugs.
Topics: Acetylglucosaminidase; Anticonvulsants; beta-Galactosidase; Biomarkers; Carbamazepine; Case-Control | 1999 |
[A case report of chronic tubulo-interstitial nephritis].
Topics: CD4 Antigens; Child; Complement C3; Fanconi Syndrome; Humans; Immunoglobulin G; Kidney; Male; Nephri | 1992 |