valproic acid has been researched along with Adrenoleukodystrophy in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Adrenoleukodystrophy: An X-linked recessive disorder characterized by the accumulation of saturated very long chain fatty acids in the LYSOSOMES of ADRENAL CORTEX and the white matter of CENTRAL NERVOUS SYSTEM. This disease occurs almost exclusively in the males. Clinical features include the childhood onset of ATAXIA; NEUROBEHAVIORAL MANIFESTATIONS; HYPERPIGMENTATION; ADRENAL INSUFFICIENCY; SEIZURES; MUSCLE SPASTICITY; and DEMENTIA. The slowly progressive adult form is called adrenomyeloneuropathy. The defective gene ABCD1 is located at Xq28, and encodes the adrenoleukodystrophy protein (ATP-BINDING CASSETTE TRANSPORTERS).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourcade, S | 1 |
| Ruiz, M | 1 |
| Guilera, C | 1 |
| Hahnen, E | 1 |
| Brichta, L | 1 |
| Naudi, A | 1 |
| Portero-Otín, M | 1 |
| Dacremont, G | 1 |
| Cartier, N | 1 |
| Wanders, R | 1 |
| Kemp, S | 1 |
| Mandel, JL | 1 |
| Wirth, B | 1 |
| Pamplona, R | 1 |
| Aubourg, P | 1 |
| Pujol, A | 1 |
| Salsano, E | 1 |
| Gambini, O | 1 |
| Giovagnoli, AR | 1 |
| Farina, L | 1 |
| Uziel, G | 1 |
| Pareyson, D | 1 |
| Brownstone, E | 1 |
| Voigtländer, T | 1 |
| Baumhackl, U | 1 |
| Finsterer, J | 1 |
1 trial available for valproic acid and Adrenoleukodystrophy
| Article | Year |
|---|---|
Valproic acid induces antioxidant effects in X-linked adrenoleukodystrophy.
Topics: Acetyltransferases; Adolescent; Adrenoleukodystrophy; Animals; Antioxidants; ATP Binding Cassette Tr | 2010 |
2 other studies available for valproic acid and Adrenoleukodystrophy
| Article | Year |
|---|---|
Effectiveness of valproate for the treatment of manic-like behavior in X-linked adrenoleukodystrophy.
Topics: Adrenoleukodystrophy; Antimanic Agents; Bipolar Disorder; Humans; Male; Valproic Acid; Young Adult | 2012 |
Epilepsy in adult X-linked adrenoleucodystrophy due to the deletion c.1415-1416delAG in exon 5 of the ABCD1-gene.
Topics: Adrenoleukodystrophy; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP- | 2013 |