Page last updated: 2024-10-26

valproic acid and Adolescent Myoclonic Epilepsy

valproic acid has been researched along with Adolescent Myoclonic Epilepsy in 86 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Research Excerpts

ExcerptRelevanceReference
"Drug-induced acute pancreatitis is a rare condition in childhood, and information about the incidence of valproic acid-induced acute pancreatitis in the pediatric population is scarce."7.79Valproic acid-induced pancreatitis in a 15-year-old boy with juvenile myoclonic epilepsy. ( Talvik, I; Talvik, T; Uibo, O; Veri, K, 2013)
"We describe four children with Dravet syndrome treated with the combination of valproic acid (VPA) and topiramate (TPM) who developed transient liver toxicity."7.74Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen? ( Ceulemans, B; Gunning, B; Leroy, PL; Nicolai, J; Vles, JS, 2008)
" For efficacy, a greater proportion of participants in the topiramate group had a 50% or greater reduction in primarily generalized tonic-clonic seizures (PGTCS), compared with participants in the placebo group (RR 4."5.12Topiramate for juvenile myoclonic epilepsy. ( Liu, J; Tai, YJ; Wang, LN, 2021)
" For efficacy, a greater proportion of participants in the topiramate group had a 50% or more reduction in primarily generalized tonic-clonic seizures (PGTCS) compared with participants in the placebo group."5.01Topiramate for juvenile myoclonic epilepsy. ( Liu, J; Wang, LN; Wang, YP, 2019)
" For efficacy, a greater proportion of participants in the topiramate group had a 50% or more reduction in primarily generalized tonic-clonic seizures (PGTCS) compared with participants in the placebo group."4.95Topiramate monotherapy for juvenile myoclonic epilepsy. ( Liu, J; Wang, LN; Wang, YP, 2017)
" For the efficacy, a greater proportion of participants in the topiramate group had a 50% or more reduction in primarily generalized tonic-clonic seizures (PGTCS) compared with participants in the placebo group."4.91Topiramate monotherapy for juvenile myoclonic epilepsy. ( Liu, J; Wang, LN; Wang, YP, 2015)
"Drug-induced acute pancreatitis is a rare condition in childhood, and information about the incidence of valproic acid-induced acute pancreatitis in the pediatric population is scarce."3.79Valproic acid-induced pancreatitis in a 15-year-old boy with juvenile myoclonic epilepsy. ( Talvik, I; Talvik, T; Uibo, O; Veri, K, 2013)
"We describe four children with Dravet syndrome treated with the combination of valproic acid (VPA) and topiramate (TPM) who developed transient liver toxicity."3.74Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen? ( Ceulemans, B; Gunning, B; Leroy, PL; Nicolai, J; Vles, JS, 2008)
"Since its initial 1957 description, juvenile myoclonic epilepsy (JME) has been recognized as a common epileptic syndrome worldwide."2.55Juvenile myoclonic epilepsy: Challenges on its 60th anniversary. ( Yacubian, EM, 2017)
"Myoclonic jerks are frequently the debut symptom, while tonic-clonic seizures appear later on."2.48[Juvenile myoclonic epilepsy]. ( Markhus, R; Nakken, KO; Selmer, KK; Syvertsen, MR, 2012)
"Juvenile myoclonic epilepsy is a common idiopathic generalized epileptic syndrome that includes generalized myoclonic seizures and commonly generalized tonic-clonic and generalized absence seizures."2.45The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent? ( Abou-Khalil, B; Montouris, G, 2009)
"Drug treatment of juvenile myoclonic epilepsy (JME) is mainly based on clinical experience and prospective and retrospective studies, with little evidence from randomized clinical trials."2.44Treatment of juvenile myoclonic epilepsy. ( Auvin, S, 2008)
"Most idiopathic generalized epilepsy (IGE) begins in childhood."2.43Management guidelines for children with idiopathic generalized epilepsy. ( Camfield, C; Camfield, P, 2005)
"Absence seizures were significantly associated with no-remission at multivariable multinomial logistic regression analysis."1.72Seizure outcome trajectories in a well-defined cohort of newly diagnosed juvenile myoclonic epilepsy patients. ( Cerulli Irelli, E; Di Bonaventura, C; Fanella, M; Fattouch, J; Giallonardo, AT; Manfredi, M; Morano, A; Orlando, B; Salamone, EM, 2022)
"Patients with juvenile myoclonic epilepsy (JME) are especially prone to having antiseizure medications (ASMs) withdrawal seizures (WS)."1.72Antiseizure Medications Withdrawal Seizures in Patients with Juvenile Myoclonic Epilepsy. ( Ekstein, D; Eyal, S; Hofi, E; Khana Levy, N; Medvedovsky, M; Nassar, M, 2022)
"This study aimed to evaluate antiseizure medication (ASM) use in patients with JME."1.72Trends in the choice of antiseizure medications in juvenile myoclonic epilepsy: A retrospective multi-center study from Turkey between 2010 and 2020. ( Aydın, K; Cansu, A; Esenülkü, G; Haspolat, Ş; İnce, T; Kılıç, B; Okuyaz, Ç; Polat, BG; Serdaroğlu, A; Serdaroğlu, E; Tekgül, H; Topçu, Y, 2022)
"Under lamotrigine, seizure aggravation was observed in 15 patients (two patients during levetiracetam, one patient during zonisamide, none during phenobarbital and valproic acid)."1.62Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy. ( Beier, CP; Gesche, J; Hjalgrim, H; Rubboli, G, 2021)
"The most common syndrome was juvenile myoclonic epilepsy (JME), diagnosed in 44."1.56Persistent treatment resistance in genetic generalized epilepsy: A long-term outcome study in a tertiary epilepsy center. ( Barone, FA; Cerulli Irelli, E; Di Bonaventura, C; Fanella, M; Fattouch, J; Fisco, G; Giallonardo, AT; Manfredi, M; Morano, A; Orlando, B, 2020)
"Only 29 (33%) were seizure-free."1.51Treatment and challenges with antiepileptic drugs in patients with juvenile myoclonic epilepsy. ( Baftiu, A; Enger, U; Fløgstad, I; Johannessen Landmark, C; Johannessen, SI; Koht, J; Syvertsen, M, 2019)
"Juvenile myoclonic epilepsy is often regarded as a benign epileptic syndrome, but in this setting, half of the individuals with JME have refractory epilepsy with only about a quarter of those seizure-free in the previous year."1.48Juvenile myoclonic epilepsy refractory to treatment in a tertiary referral center. ( Cação, G; Mannan, S; Parra, J; Sander, JW; Sisodiya, SM, 2018)
" All patients were under valproate (VPA) treatment, and the mean VPA dosage was 783."1.48Frontal lobe cognitive functions and electroencephalographic features in juvenile myoclonic epilepsy. ( Ak, PD; Ataklı, D; Keskinkılıç, C; Pulat, TA; Sezikli, S; Tekin, B, 2018)
"Children with Childhood Absence Epilepsy (CAE) may develop generalized tonic-clonic seizure or juvenile myoclonic epilepsy."1.48Childhood Absence Epilepsy evolving to Eyelid Myoclonia with Absence Epilepsy. ( Fazzi, E; Galli, J; Giordano, L; Malerba, L; Micheletti, S, 2018)
"Three study groups: - 1) juvenile myoclonic epilepsy (N=40) [drug naïve (N=20); On sodium valproate (SVA) (N=20)]; 2) symptomatic partial epilepsy (N=40) [drug naïve (N=20); On carbamazepine (CBZ) (N=20)]; 3) healthy controls (N=40) completed 3 standardized sleep questionnaires - Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and NIMHANS Comprehensive Sleep Disorders Questionnaire."1.46Comparing sleep profiles between patients with juvenile myoclonic epilepsy and symptomatic partial epilepsy: Sleep questionnaire-based study. ( Nagappa, M; Nayak, C; Saraswati, N; Sinha, S; Taly, AB; Thennarasu, K, 2017)
"Generalized tonic-clonic seizures (GTCS) were found in 150/156 patients."1.43Electroclinical aspects and therapy of Han patients with juvenile myoclonic epilepsy in northern China. ( Bai, J; Chen, BB; Dang, JX; Deng, YC; Jia, FY; Jia, SS; Jiang, Z; Jin, L; Liu, YH; Wang, B; Wang, CT; Wang, D; Wang, JX; Wang, L; Wang, TC; Zhang, L; Zhang, WJ; Zhao, G, 2016)
"Coexisting psychiatric disorders (PDs) were found in 33."1.40Factors associated with lack of response to valproic acid monotherapy in juvenile myoclonic epilepsy. ( Bana, AK; Jayalakshmi, S; Mohandas, S; Sailaja, S; Somayajula, S; Vooturi, S, 2014)
"Fifty-four patients were included, with juvenile myoclonic epilepsy (JME) in 23 (42."1.40Low-dose sodium valproate in the treatment of idiopathic generalized epilepsies. ( Aiguabella, M; Falip, M; Juvany, R; Leiva, E; Miró, J; Salas-Puig, J; Santurino, M; Veciana, M, 2014)
"A 27-year-old woman was diagnosed with juvenile myoclonic epilepsy since the age of 13 and was on valproate therapy."1.40Juvenile myoclonic epilepsy with multiple sclerosis: is there a dual role for valproate? ( Acharya, M; Kumawat, BL; Parekh, J; Sharma, C, 2014)
"She also has cerebellar ataxia in her extremities."1.35[Case of juvenile myoclonic epilepsy misdiagnosed as simple partial seizure for more than 60 years]. ( Komori, T; Mizoi, Y; Shimazu, K; Sumita, N; Tamura, N; Yamamoto, T, 2009)
"Juvenile myoclonic epilepsy developed in two patients, and cryptogenic partial epilepsy in another."1.33Benign myoclonic epilepsy in infants: electroclinical features and long-term follow-up of 34 patients. ( Auvin, S; Badinand, N; De Bellecize, J; Isnard, H; Lamblin, MD; Motte, J; Pandit, F; Vallée, L; Villeneuve, N, 2006)
"Mean dosage of valproic acid was 800 mg/d in both groups (13 mg/kg and 12."1.33Comparison of valporic acid efficacy in familial versus sporadic cases of juvenile myoclonic epilepsy. ( Mohammad Ali, S; Motamedi, M; Rahmat, M, 2006)
"Lamotrigine is an anti-epileptic drug considered as a first-line therapy in idiopathic generalised epilepsy."1.33[Exacerbation of tonicoclonic seizures in a juvenile myoclonic epileptic taking lamotrigine]. ( Guillon, B; Maiga, Y; Nogues, B, 2006)
"We studied 14 patients with juvenile myoclonic epilepsy (JME), 19 patients with refractory localization-related epilepsy (RLE) and 20 healthy volunteers who were matched for age and sex."1.32Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients. ( Keränen, T; Peltola, J; Rainesalo, S; Saransaari, P, 2003)
"Most cases of toxic epidermal necrolysis are drug induced."1.32Suspected lamotrigine-induced toxic epidermal necrolysis. ( Demiralay, E; Kilinç, M; Söğüt, A; Söğüt, AG; Uzar, H; Yilmaz, A, 2003)
"The recommended treatment for juvenile myoclonic epilepsy (JME) is valproate (VPA)."1.32Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy. ( Hardison, H; Khurana, DS; Kothare, SV; Legido, A; Melvin, JJ; Valencia, I, 2004)
"The clinical data on cases of Juvenile Myoclonic Epilepsy (JME) were analysed."1.31Juvenile myoclonic epilepsy--an experience from north western India. ( Panagariya, A; Sardana, V; Sureka, RK, 2001)
" Four of them suffered persistent seizures despite optimal VPA dosage and needed the addition of a second drug (lamotrigine in three cases, clobazam in one case)."1.31Evolution of juvenile myoclonic epilepsy treated from the outset with sodium valproate. ( Calleja, S; Lahoz, CH; Ribacoba, R; Salas-Puig, J, 2001)
"A young woman with juvenile myoclonic epilepsy had recurrent attacks of myoclonic status epilepticus related to a long history of limited compliance and irregular sleep."1.31Myoclonic status epilepticus: video presentation. ( Andermann, E; Andermann, F; Badhwar, A; Siren, A, 2002)
"Fourteen patients with juvenile myoclonic epilepsy (JME) were treated with a single low dose of a sustained-release preparation of sodium valproate (VPA, 500 mg daily)."1.31Low dose sodium valproate in the treatment of juvenile myoclonic epilepsy. ( Alexiou, D; Angelopoulos, P; Armentsoudis, P; Baloyannis, S; Delithanasis, I; Dimitrakoudi, E; Hamlatzis, P; Karlovassitou-Koniari, A, 2002)
"The PGE had characteristics of both childhood absence epilepsy (CAE) and juvenile myoclonic epilepsy (JME)."1.30Primary ciliary dyskinesia syndrome and primary generalised epilepsy. ( Shepherd, RC, 1999)

Research

Studies (86)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (1.16)18.2507
2000's34 (39.53)29.6817
2010's40 (46.51)24.3611
2020's11 (12.79)2.80

Authors

AuthorsStudies
Baheti, N1
Rathore, C1
Bansal, AR1
Shah, S1
Veedu, HK1
Prakash, S1
Kanhere, K1
Jaiswal, SK1
Jukkarwala, A1
Murthy, JMK1
Radhakrishnan, K1
Cerulli Irelli, E2
Morano, A2
Orlando, B2
Salamone, EM1
Fanella, M2
Fattouch, J2
Manfredi, M2
Giallonardo, AT2
Di Bonaventura, C2
Liu, J4
Tai, YJ1
Wang, LN4
Moon, JU1
Lee, JY1
Kim, KY1
Eom, TH1
Kim, YH1
Lee, IG1
Hofi, E1
Medvedovsky, M1
Nassar, M1
Khana Levy, N1
Eyal, S1
Ekstein, D1
Kılıç, B1
Serdaroğlu, E1
Polat, BG1
İnce, T1
Esenülkü, G1
Topçu, Y1
Serdaroğlu, A1
Haspolat, Ş1
Tekgül, H1
Okuyaz, Ç1
Cansu, A1
Aydın, K1
Tabrizi, N1
Zarvani, A1
Rezaei, P1
Cheraghmakani, H1
Alizadeh-Navaei, R1
Liguori, S1
Barone, FA1
Fisco, G1
Gesche, J1
Hjalgrim, H1
Rubboli, G1
Beier, CP1
Milano, C1
Turco, F1
Pizzanelli, C1
Bonanni, E1
Siciliano, G1
Fornai, F1
Giorgi, FS1
Ascoli, M1
Mastroianni, G1
Gasparini, S1
Striano, P1
Cianci, V1
Neri, S1
Bova, V1
Mammì, A1
Gambardella, A1
Labate, A1
Aguglia, U1
Ferlazzo, E1
Wang, YP3
Mekky, JF1
Elbhrawy, SM1
Boraey, MF1
Omar, HM1
Xu, L1
Guo, D1
Liu, YY1
Qiao, DD1
Ye, JY1
Xue, R1
Cação, G1
Parra, J1
Mannan, S1
Sisodiya, SM1
Sander, JW1
Sezikli, S1
Pulat, TA1
Tekin, B1
Ak, PD1
Keskinkılıç, C1
Ataklı, D1
Galli, J1
Micheletti, S1
Malerba, L1
Fazzi, E1
Giordano, L2
Huang, Q1
Yu, L1
Ma, M1
Qi, H1
Wu, Y1
Johannessen Landmark, C2
Fløgstad, I2
Baftiu, A2
Syvertsen, M2
Enger, U2
Koht, J2
Johannessen, SI2
Gürer, R1
Aydın, Ş1
Özkara, Ç1
Park, KM1
Kim, SH1
Nho, SK1
Shin, KJ1
Park, J1
Ha, SY1
Kim, SE1
Papadavid, E1
Evangelia, P1
Panayiotides, I1
Ioannis, P1
Makris, M1
Michael, M1
Giatrakou, S1
Sophia, G1
Dalamaga, M1
Maria, D1
Stavrianeas, N2
Rigopoulos, D1
Dimitrios, R1
Machado, RA1
García, VF1
Astencio, AG1
Cuartas, VB1
Shetty, A1
Khardenavis, S1
Deshpande, A1
Miró, J1
Aiguabella, M1
Veciana, M1
Juvany, R1
Santurino, M1
Leiva, E1
Salas-Puig, J2
Falip, M1
Krishnan, P2
Sinha, S4
Taly, AB4
Ramachandraiah, CT2
Rao, S2
Satishchandra, P2
Jayalakshmi, S1
Vooturi, S1
Bana, AK1
Sailaja, S1
Somayajula, S1
Mohandas, S1
Veri, K1
Uibo, O1
Talvik, I1
Talvik, T1
Sharma, C1
Parekh, J1
Kumawat, BL1
Acharya, M1
Asadi-Pooya, AA1
Hashemzehi, Z1
Emami, M1
Gélisse, P1
Crespel, A1
Kandemir, M1
Gündüz, A1
Uzun, N1
Yeni, N1
Kızıltan, M1
Chowdhury, A1
Brodie, MJ2
Nayak, CS1
Nagappa, M2
Kandavel, T1
Hernández-Vanegas, LE1
Jara-Prado, A1
Ochoa, A1
Rodríguez Y Rodríguez, N1
Durón, RM1
Crail-Meléndez, D1
Alonso, ME1
Delgado-Escueta, AV1
Martínez-Juárez, IE1
Wang, L1
Jiang, Z1
Chen, BB1
Wang, CT1
Wang, JX1
Bai, J1
Wang, B1
Jin, L1
Zhang, WJ1
Deng, YC1
Zhao, G1
Dang, JX1
Wang, D1
Jia, SS1
Wang, TC1
Jia, FY1
Zhang, L1
Liu, YH1
Yacubian, EM2
Saraswati, N1
Nayak, C1
Thennarasu, K1
Auvin, S2
Mizoi, Y1
Sumita, N1
Yamamoto, T1
Komori, T1
Tamura, N1
Shimazu, K1
Montouris, G1
Abou-Khalil, B1
Somerville, ER1
Cook, MJ1
O'Brien, TJ1
Piccinelli, P1
Beghi, E1
Borgatti, R1
Ferri, M1
Romeo, A1
Termine, C1
Viri, M1
Zucca, C1
Balottin, U1
Choi, KH1
Nam, TS1
Kim, JT1
Choi, SM1
Park, MS1
Kim, BC1
Kim, MK1
Cho, KH1
Katshu, MZ1
Bhattacharya, A1
Nizamie, SH1
Morrison, N1
Thomas, R1
Smith, P1
Angus-Leppan, H1
Syvertsen, MR1
Markhus, R1
Selmer, KK1
Nakken, KO1
Karlov, VA1
Freĭdkova, NV1
Rusanova, LV1
Erdem, H1
Yiğit, A1
Culcuoğlu, A1
Mutluer, N1
Mehndiratta, MM1
Aggarwal, P1
Aiba, H1
Rainesalo, S1
Saransaari, P1
Peltola, J1
Keränen, T1
King, M1
Söğüt, A1
Yilmaz, A1
Kilinç, M1
Söğüt, AG1
Demiralay, E1
Uzar, H1
Chifari, R1
Piazzini, A1
Turner, K1
Canger, R1
Canevini, MP1
Wolf, P1
Morris, GL1
Hammer, AE1
Kustra, RP1
Messenheimer, JA1
Kothare, SV1
Valencia, I1
Khurana, DS1
Hardison, H1
Melvin, JJ1
Legido, A1
Camfield, C1
Camfield, P1
Trost, LF1
Wender, RC1
Suter, CC1
Rosenberg, JH1
Brixner, DI1
Von Worley, AM1
Gunter, MJ1
Pandit, F1
De Bellecize, J1
Badinand, N1
Isnard, H1
Motte, J1
Villeneuve, N1
Lamblin, MD1
Vallée, L1
de Araujo Filho, GM1
Pascalicchio, TF1
Lin, K1
Sousa, PS1
Fregni, F1
Boggio, PS1
Valle, AC1
Otachi, P1
Thut, G1
Rigonatti, SP1
Marcolin, MA1
Fecteau, S1
Pascual-Leone, A1
Fiore, L1
Valente, K1
Motamedi, M1
Mohammad Ali, S1
Rahmat, M1
Welty, TE1
Maiga, Y1
Nogues, B1
Guillon, B1
Chakravarty, A1
Mukherjee, A1
Roy, D1
Plattner, B1
Pahs, G1
Kindler, J1
Williams, RP1
Hall, RE1
Mayer, H1
Steiner, H1
Feucht, M1
Levisohn, PM1
Holland, KD1
Nicolai, J1
Gunning, B1
Leroy, PL1
Ceulemans, B1
Vles, JS1
Tóth, V1
Rásonyi, G1
Fogarasi, A1
Kovács, N1
Auer, T1
Janszky, J1
Grewal, HK1
Almullahassani, A1
Grewal, J1
Slater, JD1
Alfradique, I1
Vasconcelos, MM1
Shepherd, RC1
Fernando-Dongas, MC1
Radtke, RA1
VanLandingham, KE1
Husain, AM1
Biraben, A1
Allain, H1
Scarabin, JM1
Schück, S1
Edan, G1
Panagariya, A1
Sureka, RK1
Sardana, V1
Calleja, S1
Ribacoba, R1
Lahoz, CH1
Badhwar, A1
Siren, A1
Andermann, E1
Andermann, F1
Karlovassitou-Koniari, A1
Alexiou, D1
Angelopoulos, P1
Armentsoudis, P1
Dimitrakoudi, E1
Delithanasis, I1
Hamlatzis, P1
Baloyannis, S1

Reviews

16 reviews available for valproic acid and Adolescent Myoclonic Epilepsy

ArticleYear
Topiramate for juvenile myoclonic epilepsy.
    The Cochrane database of systematic reviews, 2021, 11-24, Volume: 11

    Topics: Anticonvulsants; Humans; Myoclonic Epilepsy, Juvenile; Randomized Controlled Trials as Topic; Seizur

2021
Diagnostic and therapeutic approach to drug-resistant juvenile myoclonic epilepsy.
    Expert review of neurotherapeutics, 2021, Volume: 21, Issue:11

    Topics: Anticonvulsants; Female; Humans; Levetiracetam; Myoclonic Epilepsy, Juvenile; Pharmaceutical Prepara

2021
Topiramate monotherapy for juvenile myoclonic epilepsy.
    The Cochrane database of systematic reviews, 2017, 04-23, Volume: 4

    Topics: Adolescent; Anticonvulsants; Child; Fructose; Humans; Myoclonic Epilepsy, Juvenile; Randomized Contr

2017
Juvenile myoclonic epilepsy and sleep.
    Epilepsy & behavior : E&B, 2018, Volume: 80

    Topics: Adolescent; Adult; Circadian Rhythm; Electroencephalography; Epilepsy, Reflex; Female; Humans; Male;

2018
Topiramate for juvenile myoclonic epilepsy.
    The Cochrane database of systematic reviews, 2019, 01-28, Volume: 1

    Topics: Adolescent; Anticonvulsants; Child; Humans; Myoclonic Epilepsy, Juvenile; Randomized Controlled Tria

2019
Topiramate monotherapy for juvenile myoclonic epilepsy.
    The Cochrane database of systematic reviews, 2015, Dec-23, Issue:12

    Topics: Adolescent; Anticonvulsants; Child; Fructose; Humans; Myoclonic Epilepsy, Juvenile; Randomized Contr

2015
Modern management of juvenile myoclonic epilepsy.
    Expert review of neurotherapeutics, 2016, Volume: 16, Issue:6

    Topics: Electroencephalography; Female; Frontal Lobe; Humans; Male; Myoclonic Epilepsy, Juvenile; Phenotype;

2016
Juvenile myoclonic epilepsy: Challenges on its 60th anniversary.
    Seizure, 2017, Volume: 44

    Topics: Age of Onset; Aging; Anniversaries and Special Events; Anticonvulsants; Humans; Myoclonic Epilepsy,

2017
Treatment of juvenile myoclonic epilepsy.
    CNS neuroscience & therapeutics, 2008,Fall, Volume: 14, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Lamotrigine; Le

2008
The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent?
    Epilepsia, 2009, Volume: 50 Suppl 8

    Topics: Anticonvulsants; Congenital Abnormalities; Delayed-Action Preparations; Drug Design; Epilepsy, Gener

2009
Efficacy of paroxetine in primary palmoplantar hyperhidrosis occurring with juvenile myoclonic epilepsy.
    Dermatology (Basel, Switzerland), 2011, Volume: 223, Issue:3

    Topics: Adolescent; Anticonvulsants; Drug Therapy, Combination; Female; Hand; Humans; Hyperhidrosis; Myoclon

2011
[Juvenile myoclonic epilepsy].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2012, Aug-07, Volume: 132, Issue:14

    Topics: Adolescent; Anticonvulsants; Diagnosis, Differential; Electroencephalography; Female; Humans; Lamotr

2012
[Juvenile myoclonic epilepsy].
    Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6

    Topics: Adolescent; Child; Diagnosis, Differential; Humans; Myoclonic Epilepsy, Juvenile; Prognosis; Valproi

2002
Management guidelines for children with idiopathic generalized epilepsy.
    Epilepsia, 2005, Volume: 46 Suppl 9

    Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized

2005
Juvenile myoclonic epilepsy: epidemiology, pathophysiology, and management.
    Paediatric drugs, 2006, Volume: 8, Issue:5

    Topics: Adolescent; Anticonvulsants; Child; Humans; Myoclonic Epilepsy, Juvenile; Valproic Acid

2006
Juvenile myoclonic epilepsy.
    Arquivos de neuro-psiquiatria, 2007, Volume: 65, Issue:4B

    Topics: Adolescent; Adult; Anticonvulsants; Child; Diagnosis, Differential; Electroencephalography; Humans;

2007

Trials

7 trials available for valproic acid and Adolescent Myoclonic Epilepsy

ArticleYear
Levetiracetam in genetic generalized epilepsy: A prospective unblinded active-controlled trial.
    Epilepsy research, 2019, Volume: 157

    Topics: Adolescent; Adult; Anticonvulsants; Epilepsy, Generalized; Female; Humans; Levetiracetam; Male; Myoc

2019
A randomized open-label observational study to compare the efficacy and tolerability between topiramate and valproate in juvenile myoclonic epilepsy.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2013, Volume: 20, Issue:8

    Topics: Adolescent; Adult; Electroencephalography; Female; Fructose; Humans; Male; Myoclonic Epilepsy, Juven

2013
Efficacy and tolerability of lamotrigine in juvenile myoclonic epilepsy in adults: a prospective, unblinded randomized controlled trial.
    Seizure, 2013, Volume: 22, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Female; Humans; Lamotrigine; Male; Middle Aged; Myoclonic Epilep

2013
Effect of sodium valproate on somatosensory evoked potentials in juvenile myoclonic epilepsy.
    Upsala journal of medical sciences, 2001, Volume: 106, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Evoked Potentials, Somatosensory; Female;

2001
Lamotrigine for patients with juvenile myoclonic epilepsy following prior treatment with valproate: results of an open-label study.
    Epilepsy & behavior : E&B, 2004, Volume: 5, Issue:4

    Topics: Adolescent; Anticonvulsants; Child; Drug Evaluation; Humans; Lamotrigine; Myoclonic Epilepsy, Juveni

2004
Homeostatic effects of plasma valproate levels on corticospinal excitability changes induced by 1Hz rTMS in patients with juvenile myoclonic epilepsy.
    Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2006, Volume: 117, Issue:6

    Topics: Adolescent; Adult; Anticonvulsants; Combined Modality Therapy; Homeostasis; Humans; Myoclonic Epilep

2006
Topiramate or valproate in patients with juvenile myoclonic epilepsy: a randomized open-label comparison.
    Epilepsy & behavior : E&B, 2007, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Double-Blind Method; Female; Fructose; Humans; Magn

2007

Other Studies

63 other studies available for valproic acid and Adolescent Myoclonic Epilepsy

ArticleYear
Treatment outcomes in drug resistant juvenile myoclonic epilepsy: Valproate resistance may not be the end of the road.
    Seizure, 2021, Volume: 92

    Topics: Anticonvulsants; Female; Humans; Male; Myoclonic Epilepsy, Juvenile; Pharmaceutical Preparations; Tr

2021
Seizure outcome trajectories in a well-defined cohort of newly diagnosed juvenile myoclonic epilepsy patients.
    Acta neurologica Scandinavica, 2022, Volume: 145, Issue:3

    Topics: Anticonvulsants; Female; Humans; Myoclonic Epilepsy, Juvenile; Retrospective Studies; Seizures; Valp

2022
Comparative analysis of background EEG activity in juvenile myoclonic epilepsy during valproic acid treatment: a standardized, low-resolution, brain electromagnetic tomography (sLORETA) study.
    BMC neurology, 2022, Feb-09, Volume: 22, Issue:1

    Topics: Brain; Child; Electroencephalography; Electromagnetic Phenomena; Frontal Lobe; Humans; Myoclonic Epi

2022
Antiseizure Medications Withdrawal Seizures in Patients with Juvenile Myoclonic Epilepsy.
    The Israel Medical Association journal : IMAJ, 2022, Volume: 24, Issue:4

    Topics: Anticonvulsants; Female; Humans; Myoclonic Epilepsy, Juvenile; Seizures; Substance Withdrawal Syndro

2022
Trends in the choice of antiseizure medications in juvenile myoclonic epilepsy: A retrospective multi-center study from Turkey between 2010 and 2020.
    Seizure, 2022, Volume: 99

    Topics: Adolescent; Anticonvulsants; Child; Female; Humans; Lamotrigine; Levetiracetam; Male; Myoclonic Epil

2022
Is topiramate effective and tolerated in young people with juvenile myoclonic epilepsy? A Cochrane Review summary with commentary.
    Developmental medicine and child neurology, 2020, Volume: 62, Issue:8

    Topics: Adolescent; Anticonvulsants; Humans; Myoclonic Epilepsy, Juvenile; Topiramate; Valproic Acid

2020
Persistent treatment resistance in genetic generalized epilepsy: A long-term outcome study in a tertiary epilepsy center.
    Epilepsia, 2020, Volume: 61, Issue:11

    Topics: Adult; Anticonvulsants; Cohort Studies; Drug Resistant Epilepsy; Electroencephalography; Epilepsy, G

2020
Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy.
    Epilepsy research, 2021, Volume: 170

    Topics: Adult; Anticonvulsants; Epilepsy, Generalized; Humans; Lamotrigine; Levetiracetam; Myoclonic Epileps

2021
Response to levetiracetam or lamotrigine in subjects with Juvenile Myoclonic Epilepsy previously treated with valproic acid: A single center retrospective study.
    Epilepsy & behavior : E&B, 2021, Volume: 115

    Topics: Anticonvulsants; Female; Humans; Lamotrigine; Levetiracetam; Myoclonic Epilepsy, Juvenile; Retrospec

2021
Sleep architecture in patients with Juvenile Myoclonic Epilepsy.
    Sleep medicine, 2017, Volume: 38

    Topics: Adolescent; Adult; Anticonvulsants; Electroencephalography; Female; Humans; Male; Myoclonic Epilepsy

2017
Juvenile myoclonic epilepsy refractory to treatment in a tertiary referral center.
    Epilepsy & behavior : E&B, 2018, Volume: 82

    Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Resistant Epilepsy; Electroencephalography; Female;

2018
Frontal lobe cognitive functions and electroencephalographic features in juvenile myoclonic epilepsy.
    Epilepsy & behavior : E&B, 2018, Volume: 86

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Attention; Cognition; Electroencephalography; Exec

2018
Childhood Absence Epilepsy evolving to Eyelid Myoclonia with Absence Epilepsy.
    Seizure, 2018, Volume: 61

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Disease Progression; Electroencephalography; E

2018
Novel SCN2A mutation in a family associated with juvenile-onset myoclonus: Case report.
    Medicine, 2019, Volume: 98, Issue:8

    Topics: Adult; Anticonvulsants; Ataxia; Carbamazepine; Disease Progression; Drug Resistant Epilepsy; Electro

2019
Long-term follow-up with therapeutic drug monitoring of antiepileptic drugs in patients with juvenile myoclonic epilepsy.
    Epilepsy research, 2019, Volume: 155

    Topics: Adolescent; Adult; Anticonvulsants; Drug Monitoring; Female; Follow-Up Studies; Humans; Lamotrigine;

2019
Outcomes of low-dose valproic acid treatment in patients with juvenile myoclonic epilepsy.
    Seizure, 2019, Volume: 70

    Topics: Adolescent; Adult; Anticonvulsants; Cross-Sectional Studies; Dose-Response Relationship, Drug; Femal

2019
Treatment and challenges with antiepileptic drugs in patients with juvenile myoclonic epilepsy.
    Epilepsy & behavior : E&B, 2019, Volume: 98, Issue:Pt A

    Topics: Adolescent; Adult; Anticonvulsants; Cohort Studies; Female; Humans; Lamotrigine; Levetiracetam; Male

2019
Pityriasis rosea-like eruption associated with lamotrigine.
    Journal of the American Academy of Dermatology, 2013, Volume: 68, Issue:6

    Topics: Adult; Anticonvulsants; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Lamotrigine; Myocloni

2013
Ophthalmoplegic migraine with isolated third cranial nerve palsy in a known case of juvenile myoclonic epilepsy.
    BMJ case reports, 2013, Dec-02, Volume: 2013

    Topics: Adult; Analgesics; Anticonvulsants; Female; Humans; Myoclonic Epilepsy, Juvenile; Ophthalmoplegic Mi

2013
Low-dose sodium valproate in the treatment of idiopathic generalized epilepsies.
    Acta neurologica Scandinavica, 2014, Volume: 129, Issue:5

    Topics: Adult; Anticonvulsants; Epilepsy, Absence; Epilepsy, Generalized; Female; Follow-Up Studies; Humans;

2014
Altered polysomnographic profile in juvenile myoclonic epilepsy.
    Epilepsy research, 2014, Volume: 108, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Brain Waves; Case-Control Studies; Cross-Sectional Studies; Elec

2014
Factors associated with lack of response to valproic acid monotherapy in juvenile myoclonic epilepsy.
    Seizure, 2014, Volume: 23, Issue:7

    Topics: Adolescent; Adult; Anticonvulsants; Electroencephalography; Female; Humans; Longitudinal Studies; Ma

2014
Valproic acid-induced pancreatitis in a 15-year-old boy with juvenile myoclonic epilepsy.
    Medicina (Kaunas, Lithuania), 2013, Volume: 49, Issue:11

    Topics: Acute Disease; Adolescent; Anticonvulsants; Estonia; Humans; Male; Myoclonic Epilepsy, Juvenile; Pan

2013
Juvenile myoclonic epilepsy with multiple sclerosis: is there a dual role for valproate?
    BMJ case reports, 2014, Jul-04, Volume: 2014

    Topics: Adult; Anticonvulsants; Brain; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging;

2014
Predictors of seizure control in patients with juvenile myoclonic epilepsy (JME).
    Seizure, 2014, Volume: 23, Issue:10

    Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Child; Electroencephalography; Female; Fol

2014
Mixed myoclonic-absence status epilepticus in juvenile myoclonic epilepsy.
    Epileptic disorders : international epilepsy journal with videotape, 2015, Volume: 17, Issue:1

    Topics: Anticonvulsants; Bipolar Disorder; Catatonia; Clonazepam; Electroencephalography; Epilepsies, Myoclo

2015
Auditory startle response is normal in juvenile myoclonic epilepsy.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2015, Volume: 36, Issue:7

    Topics: Acoustic Stimulation; Adolescent; Adult; Anticonvulsants; Case-Control Studies; Chi-Square Distribut

2015
Pharmacological outcomes in juvenile myoclonic epilepsy: Support for sodium valproate.
    Epilepsy research, 2016, Volume: 119

    Topics: Adolescent; Adult; Anticonvulsants; Child; Comorbidity; Drug Resistant Epilepsy; Female; Follow-Up S

2016
Effect of valproate on the sleep microstructure of juvenile myoclonic epilepsy patients - a cross-sectional CAP based study.
    Sleep medicine, 2016, Volume: 17

    Topics: Adolescent; Adult; Anticonvulsants; Arousal; Case-Control Studies; Cross-Sectional Studies; Female;

2016
High-dose versus low-dose valproate for the treatment of juvenile myoclonic epilepsy: Going from low to high.
    Epilepsy & behavior : E&B, 2016, Volume: 61

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Dose-Response Relationship, Drug; Electroen

2016
Electroclinical aspects and therapy of Han patients with juvenile myoclonic epilepsy in northern China.
    Epilepsy & behavior : E&B, 2016, Volume: 62

    Topics: Adolescent; Adult; Anticonvulsants; Brain; Child; Child, Preschool; China; Electroencephalography; F

2016
Comparing sleep profiles between patients with juvenile myoclonic epilepsy and symptomatic partial epilepsy: Sleep questionnaire-based study.
    Epilepsy & behavior : E&B, 2017, Volume: 66

    Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Female; Humans; Male; Myoclo

2017
[Case of juvenile myoclonic epilepsy misdiagnosed as simple partial seizure for more than 60 years].
    Brain and nerve = Shinkei kenkyu no shinpo, 2009, Volume: 61, Issue:1

    Topics: Aged; Cerebellar Ataxia; Diagnostic Errors; Electroencephalography; Electromyography; Epilepsies, Pa

2009
Pregnancy treatment guidelines: throwing the baby out with the bath water.
    Epilepsia, 2009, Volume: 50, Issue:9

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Femal

2009
Neuropsychological and behavioural aspects in children and adolescents with idiopathic epilepsy at diagnosis and after 12 months of treatment.
    Seizure, 2010, Volume: 19, Issue:9

    Topics: Adolescent; Anticonvulsants; Attention; Carbamazepine; Chi-Square Distribution; Child; Child, Presch

2010
Valproate associated diffuse alveolar hemorrhage.
    European journal of neurology, 2011, Volume: 18, Issue:8

    Topics: Adolescent; Anticonvulsants; Hemorrhage; Humans; Lung Diseases; Male; Myoclonic Epilepsy, Juvenile;

2011
Juvenile myoclonic epilepsy.
    BMJ (Clinical research ed.), 2012, Jan-26, Volume: 344

    Topics: Adaptation, Psychological; Adult; Anticonvulsants; Female; Health Knowledge, Attitudes, Practice; Hu

2012
Sleep disturbances in juvenile myoclonic epilepsy: a sleep questionnaire-based study.
    Epilepsy & behavior : E&B, 2012, Volume: 23, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Cross-Sectional Studies; Electroencephalography; Female; Humans;

2012
We must warn women about the risks of untreated, or ineffectively treated, epilepsy.
    BMJ (Clinical research ed.), 2012, Mar-06, Volume: 344

    Topics: Anticonvulsants; Female; Health Knowledge, Attitudes, Practice; Humans; Myoclonic Epilepsy, Juvenile

2012
[Complex therapy of idiopathic forms of epilepsy with small doses of valproates and levetiracetam].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:6 Pt 2

    Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy, Absence;

2012
Clinical expression and EEG features of patients with juvenile myoclonic epilepsy (JME) from North India.
    Seizure, 2002, Volume: 11, Issue:7

    Topics: Adult; Anticonvulsants; Electroencephalography; Female; Humans; Male; Myoclonic Epilepsy, Juvenile;

2002
Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients.
    Epilepsy research, 2003, Volume: 53, Issue:3

    Topics: 4-Aminobutyrate Transaminase; Adult; Anticonvulsants; Blood Platelets; Case-Control Studies; Dose-Re

2003
The new patient with a first seizure.
    Australian family physician, 2003, Volume: 32, Issue:4

    Topics: Adult; Anticonvulsants; Causality; Diagnosis, Differential; Electroencephalography; Genetic Counseli

2003
Suspected lamotrigine-induced toxic epidermal necrolysis.
    Acta neurologica Belgica, 2003, Volume: 103, Issue:2

    Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Female; Humans; Lamotrigine; Myoclonic Epilepsy,

2003
Reflex writing seizures in two siblings with juvenile myoclonic epilepsy.
    Acta neurologica Scandinavica, 2004, Volume: 109, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Attention; Electroencephalography; Epilepsy, Reflex; Evoked Pote

2004
Efficacy and tolerability of zonisamide in juvenile myoclonic epilepsy.
    Epileptic disorders : international epilepsy journal with videotape, 2004, Volume: 6, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Child; Dose-Response Relationship, Drug; Drug Interactions; Drug

2004
Management of epilepsy in adults. Diagnosis guidelines.
    Postgraduate medicine, 2005, Volume: 118, Issue:6

    Topics: Adolescent; Adult; Algorithms; Anticonvulsants; Child; Diagnosis, Differential; Electroencephalograp

2005
Benign myoclonic epilepsy in infants: electroclinical features and long-term follow-up of 34 patients.
    Epilepsia, 2006, Volume: 47, Issue:2

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Cerebral Cortex; Child; Child, Preschool; Comorbid

2006
Neuropsychiatric profiles of patients with juvenile myoclonic epilepsy treated with valproate or topiramate.
    Epilepsy & behavior : E&B, 2006, Volume: 8, Issue:3

    Topics: Adolescent; Anticonvulsants; Anxiety Disorders; Cross-Sectional Studies; Depressive Disorder; Female

2006
Comparison of valporic acid efficacy in familial versus sporadic cases of juvenile myoclonic epilepsy.
    Neurology India, 2006, Volume: 54, Issue:2

    Topics: Adolescent; Adult; Anticonvulsants; Child; Electroencephalography; Female; Humans; Magnetic Resonanc

2006
[Exacerbation of tonicoclonic seizures in a juvenile myoclonic epileptic taking lamotrigine].
    Revue neurologique, 2006, Volume: 162, Issue:11

    Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsy, Tonic-Clonic; Humans; Lamotrigine; Male; M

2006
Observations on juvenile myoclonic epilepsy amongst ethnic Bengalees in West Bengal--an Eastern Indian State.
    Seizure, 2007, Volume: 16, Issue:2

    Topics: Abnormalities, Drug-Induced; Age of Onset; Anticonvulsants; Benzodiazepines; Clobazam; Electroenceph

2007
Juvenile myoclonic epilepsy: a benign disorder? Personality traits and psychiatric symptoms.
    Epilepsy & behavior : E&B, 2007, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Anticonvulsants; Child; Ethosuximide; Female; Fructose; Humans; Lamotrigine; Leve

2007
Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen?
    Seizure, 2008, Volume: 17, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anticonvulsants; Chemical and Drug Induced Liver Injury; De

2008
Juvenile myoclonic epilepsy starting in the eighth decade.
    Epileptic disorders : international epilepsy journal with videotape, 2007, Volume: 9, Issue:3

    Topics: Aged; Anticonvulsants; Electroencephalography; Epilepsy, Tonic-Clonic; Female; Humans; Magnetic Reso

2007
Partial agenesis of the corpus callosum in a patient with juvenile myoclonic epilepsy.
    Epileptic disorders : international epilepsy journal with videotape, 2007, Volume: 9, Issue:4

    Topics: Adolescent; Agenesis of Corpus Callosum; Anticonvulsants; Chromosomes, Human, Pair 15; Corpus Callos

2007
Primary ciliary dyskinesia syndrome and primary generalised epilepsy.
    Scottish medical journal, 1999, Volume: 44, Issue:3

    Topics: Adult; Anticonvulsants; Child; Child, Preschool; Ciliary Motility Disorders; Electroencephalography;

1999
Characteristics of valproic acid resistant juvenile myoclonic epilepsy.
    Seizure, 2000, Volume: 9, Issue:6

    Topics: Adolescent; Anticonvulsants; Drug Resistance; Electroencephalography; Female; Humans; Magnetic Reson

2000
Exacerbation of juvenile myoclonic epilepsy with lamotrigine.
    Neurology, 2000, Dec-12, Volume: 55, Issue:11

    Topics: Adolescent; Adult; Anticonvulsants; Female; Humans; Lamotrigine; Male; Myoclonic Epilepsy, Juvenile;

2000
Juvenile myoclonic epilepsy--an experience from north western India.
    Acta neurologica Scandinavica, 2001, Volume: 104, Issue:1

    Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Administration Schedule; Female; Humans; India; Male

2001
Evolution of juvenile myoclonic epilepsy treated from the outset with sodium valproate.
    Seizure, 2001, Volume: 10, Issue:6

    Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Dose-Response Relationship, Drug; Electroen

2001
Myoclonic status epilepticus: video presentation.
    Movement disorders : official journal of the Movement Disorder Society, 2002, Volume: 17, Issue:2

    Topics: Adult; Combined Modality Therapy; Female; Humans; Myoclonic Epilepsy, Juvenile; Psychotherapy; Statu

2002
Low dose sodium valproate in the treatment of juvenile myoclonic epilepsy.
    Journal of neurology, 2002, Volume: 249, Issue:4

    Topics: Adolescent; Adult; Delayed-Action Preparations; Female; Humans; Male; Myoclonic Epilepsy, Juvenile;

2002