valproic acid has been researched along with Adenoma in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Adenoma: A benign epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Di-n-propylacetic acid (valproic acid) has been reported to lower plasma ACTH concentration after both acute and chronic administration of the drug." | 5.27 | Failure of valproic acid to inhibit the growth of an ACTH-secreting pituitary adenoma. ( Choi, B; Elias, AN; Gwinup, G, 1984) |
| "The toxicity of an agent or the therapeutic effect of a drug may be assessed by a dose-response study." | 1.29 | Exact power computation for dose-response studies. ( Hirji, KF; Tang, ML; Vollset, SE, 1995) |
| "Di-n-propylacetic acid (valproic acid) has been reported to lower plasma ACTH concentration after both acute and chronic administration of the drug." | 1.27 | Failure of valproic acid to inhibit the growth of an ACTH-secreting pituitary adenoma. ( Choi, B; Elias, AN; Gwinup, G, 1984) |
| "We describe herein the reduction in the size of an ACTH-secreting pituitary macroadenoma in a patient with Nelson's syndrome during chronic administration of sodium valproate, and the changes in tumour volume after withdrawal and re-institution of treatment." | 1.27 | Size reduction of an ACTH-secreting pituitary macroadenoma in Nelson's syndrome by sodium valproate: effect of withdrawal and re-institution of treatment. ( Berselli, ME; De Grandi, C; Loli, P; Tagliaferri, M; Vignati, F, 1988) |
| "189 patients with secretory pituitary adenomas underwent medical therapy for the hypersecretory state." | 1.27 | The medical treatment of the hypersecreting pituitary gland. ( Corenblum, B, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (77.78) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, P | 1 |
| Martin, E | 1 |
| Mengwasser, J | 1 |
| Schlag, P | 1 |
| Janssen, KP | 1 |
| Göttlicher, M | 1 |
| Koppeschaar, HP | 1 |
| Croughs, RJ | 1 |
| van't Verlaat, JW | 1 |
| Hendriks, MJ | 1 |
| Arts, CJ | 1 |
| Thijssen, JH | 1 |
| Schwarz, F | 1 |
| Gwinup, G | 1 |
| Elias, AN | 1 |
| Choi, B | 1 |
| Melis, GB | 1 |
| Paoletti, AM | 1 |
| Mais, V | 1 |
| Mastrapasqua, NM | 1 |
| Strigini, F | 1 |
| Fruzzetti, F | 1 |
| Guarnieri, G | 1 |
| Gambacciani, M | 1 |
| Fioretti, P | 1 |
| Tang, ML | 1 |
| Hirji, KF | 1 |
| Vollset, SE | 1 |
| Loli, P | 1 |
| Berselli, ME | 1 |
| Vignati, F | 1 |
| De Grandi, C | 1 |
| Tagliaferri, M | 1 |
| Corenblum, B | 1 |
| Yoshida, H | 1 |
| Takeda, F | 1 |
| Kinouchi, T | 1 |
| Shimizu, N | 1 |
| Burch, WM | 1 |
2 reviews available for valproic acid and Adenoma
| Article | Year |
|---|---|
[Drug and radiotherapy of pituitary tumors].
Topics: Acromegaly; Adenoma; Adrenocorticotropic Hormone; Bromocriptine; Cushing Syndrome; Cyproheptadine; G | 1986 |
Cushing's disease. A review.
Topics: Adenoma; Adolescent; Adrenalectomy; Adult; Animals; Bromocriptine; Child; Combined Modality Therapy; | 1985 |
7 other studies available for valproic acid and Adenoma
| Article | Year |
|---|---|
Induction of HDAC2 expression upon loss of APC in colorectal tumorigenesis.
Topics: Adenoma; Adenomatous Polyposis Coli Protein; Animals; Apoptosis; beta Catenin; Cell Cycle; Cell Tran | 2004 |
Successful treatment with sodium valproate of a patient with Cushing's disease and gross enlargement of the pituitary.
Topics: 17-Hydroxycorticosteroids; Adenoma; Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; H | 1984 |
Failure of valproic acid to inhibit the growth of an ACTH-secreting pituitary adenoma.
Topics: Adenoma; Adrenocorticotropic Hormone; Cytoplasmic Granules; Drug Therapy, Combination; Female; Human | 1984 |
The effects of the gabaergic drug, sodium valproate, on prolactin secretion in normal and hyperprolactinemic subjects.
Topics: Adenoma; Adult; Female; Follicular Phase; gamma-Aminobutyric Acid; Humans; Kinetics; Male; Middle Ag | 1982 |
Exact power computation for dose-response studies.
Topics: Adenoma; Algorithms; Animals; Dose-Response Relationship, Drug; Embryonic and Fetal Development; Fem | 1995 |
Size reduction of an ACTH-secreting pituitary macroadenoma in Nelson's syndrome by sodium valproate: effect of withdrawal and re-institution of treatment.
Topics: Adenoma; Adrenocorticotropic Hormone; Brain; Humans; Middle Aged; Nelson Syndrome; Pituitary Neoplas | 1988 |
The medical treatment of the hypersecreting pituitary gland.
Topics: Adenoma; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Bromocriptine; Cyproheptadine; Ergoli | 1985 |