valproic acid has been researched along with Adenocarcinoma Of Kidney in 14 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clear cell renal cell carcinoma (ccRCC) is one of the most common cancers in the world." | 1.56 | ID1 As a Prognostic Biomarker and Promising Drug Target Plays a Pivotal Role in Deterioration of Clear Cell Renal Cell Carcinoma. ( Gu, Y; Li, Q; Ni, Y; Qiu, X, 2020) |
| "Metformin (Met) is a widely available diabetic drug and shows suppressed effects on renal cell carcinoma (RCC) metabolism and proliferation." | 1.48 | Valproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal. ( Chen, Y; Huang, Z; Lan, X; Li, L; Lu, G; Mao, S; Wei, M; Xia, Q; Zhao, M; Zhao, Y, 2018) |
| "Everolimus resistance was accompanied by significant increases in the percentage of G2/M-phase cells and in the IC50." | 1.40 | HDAC-inhibition counteracts everolimus resistance in renal cell carcinoma in vitro by diminishing cdk2 and cyclin A. ( Bartsch, G; Blaheta, RA; Haferkamp, A; Harder, S; Juengel, E; Makarevi, J; Mani, J; Natsheh, I; Nelson, K; Nowaz, S; Reiter, M; Tsaur, I; Werner, I, 2014) |
| " We assume that chronic use of an HDAC-inhibitor is associated with (re)-activation of Akt, which may be involved in resistance development." | 1.39 | Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo. ( Bartsch, G; Blaheta, RA; Haferkamp, A; Juengel, E; Makarević, J; Nelson, K; Tsaur, I, 2013) |
| " VPA was also combined with low dosed interferon-alpha (IFN-alpha) and the efficacy of the combination therapy, as opposed to VPA monotherapy, was compared." | 1.35 | Valproic acid blocks adhesion of renal cell carcinoma cells to endothelium and extracellular matrix. ( Blaheta, RA; Hintereder, G; Hudak, L; Jonas, D; Jones, J; Juengel, E; Mickuckyte, A; Wedel, S, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 10 (71.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Qiu, X | 1 |
| Gu, Y | 1 |
| Ni, Y | 1 |
| Li, Q | 1 |
| Mao, S | 2 |
| Lu, G | 2 |
| Lan, X | 2 |
| Yuan, C | 1 |
| Jiang, W | 1 |
| Chen, Y | 2 |
| Jin, X | 1 |
| Xia, Q | 2 |
| Xi, W | 1 |
| Chen, X | 1 |
| Sun, J | 1 |
| Wang, W | 1 |
| Huo, Y | 1 |
| Zheng, G | 1 |
| Wu, J | 1 |
| Li, Y | 1 |
| Yang, A | 1 |
| Wang, T | 1 |
| Wei, M | 1 |
| Li, L | 1 |
| Huang, Z | 1 |
| Zhao, M | 1 |
| Zhao, Y | 1 |
| Ozerdem, A | 1 |
| Ceylan, D | 1 |
| Targıtay, B | 1 |
| Juengel, E | 7 |
| Nowaz, S | 1 |
| Makarevi, J | 1 |
| Natsheh, I | 1 |
| Werner, I | 1 |
| Nelson, K | 2 |
| Reiter, M | 1 |
| Tsaur, I | 3 |
| Mani, J | 1 |
| Harder, S | 1 |
| Bartsch, G | 3 |
| Haferkamp, A | 3 |
| Blaheta, RA | 8 |
| Zhang, X | 2 |
| Huang, T | 1 |
| Geng, J | 1 |
| Liu, M | 1 |
| Zheng, J | 1 |
| Jones, J | 5 |
| Mickuckyte, A | 3 |
| Hudak, L | 4 |
| Wedel, S | 2 |
| Jonas, D | 5 |
| Hintereder, G | 1 |
| Engler, J | 1 |
| Bhasin, M | 1 |
| Libermann, T | 1 |
| Barth, S | 1 |
| Michaelis, M | 1 |
| Cinatl, J | 1 |
| Dauselt, A | 1 |
| Makarević, J | 3 |
| Wiesner, C | 1 |
| Oertl, A | 1 |
| Relja, B | 1 |
| Weich, E | 1 |
| Höfler, S | 1 |
| Bratzke, H | 1 |
| Baer, PC | 1 |
1 review available for valproic acid and Adenocarcinoma Of Kidney
| Article | Year |
|---|---|
The Relationship Between Lithium and Cancer Proliferation: A Case-Based Review of the Literature.
Topics: Angiomyolipoma; Antimanic Agents; Apoptosis; Bipolar Disorder; Carcinoma, Renal Cell; Cell Prolifera | 2018 |
13 other studies available for valproic acid and Adenocarcinoma Of Kidney
| Article | Year |
|---|---|
ID1 As a Prognostic Biomarker and Promising Drug Target Plays a Pivotal Role in Deterioration of Clear Cell Renal Cell Carcinoma.
Topics: Biomarkers, Tumor; Carcinoma, Renal Cell; DNA, Neoplasm; Down-Regulation; Drug Delivery Systems; Gen | 2020 |
Valproic acid inhibits epithelial‑mesenchymal transition in renal cell carcinoma by decreasing SMAD4 expression.
Topics: Cadherins; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition | 2017 |
Combined Treatment with Valproic Acid and 5-Aza-2'-Deoxycytidine Synergistically Inhibits Human Clear Cell Renal Cell Carcinoma Growth and Migration.
Topics: Apoptosis; Azacitidine; Carcinoma, Renal Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Moveme | 2018 |
Valproic acid sensitizes metformin-resistant human renal cell carcinoma cells by upregulating H3 acetylation and EMT reversal.
Topics: Acetylation; Apoptosis; Carcinoma, Renal Cell; Cell Cycle; Cell Line, Tumor; Cell Movement; Drug Res | 2018 |
HDAC-inhibition counteracts everolimus resistance in renal cell carcinoma in vitro by diminishing cdk2 and cyclin A.
Topics: Carcinoma, Renal Cell; Cell Line, Tumor; Cyclin A; Cyclin-Dependent Kinase 2; Drug Resistance, Neopl | 2014 |
Combination of metformin and valproic acid synergistically induces cell cycle arrest and apoptosis in clear cell renal cell carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Renal Cell; Cell Cycle Checkpo | 2015 |
The histone deacetylase inhibitor valproic acid alters growth properties of renal cell carcinoma in vitro and in vivo.
Topics: Animals; Carcinoma, Renal Cell; Cell Division; Histone Deacetylase Inhibitors; Humans; Kidney Neopla | 2009 |
Valproic acid blocks adhesion of renal cell carcinoma cells to endothelium and extracellular matrix.
Topics: Carcinoma, Renal Cell; Cell Adhesion; Cell Line, Tumor; Endothelium; Extracellular Matrix; Humans; K | 2009 |
Effects of combined valproic acid and the epidermal growth factor/vascular endothelial growth factor receptor tyrosine kinase inhibitor AEE788 on renal cell carcinoma cell lines in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Carcinoma, Renal Cell; Cell Adhes | 2010 |
Alterations of the gene expression profile in renal cell carcinoma after treatment with the histone deacetylase-inhibitor valproic acid and interferon-alpha.
Topics: Carcinoma, Renal Cell; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Surv | 2011 |
Acetylation of histone H3 prevents resistance development caused by chronic mTOR inhibition in renal cell carcinoma cells.
Topics: Acetylation; Apoptosis; Carcinoma, Renal Cell; Cell Cycle; Cell Differentiation; Cell Line, Tumor; C | 2012 |
Resistance after chronic application of the HDAC-inhibitor valproic acid is associated with elevated Akt activation in renal cell carcinoma in vivo.
Topics: Acetylation; Animals; Carcinoma, Renal Cell; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinases; | 2013 |
Altered expression of beta1 integrins in renal carcinoma cell lines exposed to the differentiation inducer valproic acid.
Topics: Carcinoma, Renal Cell; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Disea | 2006 |