valproic acid has been researched along with Addison Disease in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Addison Disease: An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Neither a single dose nor long term administration of sodium valproate resulted in a significant decrease of plasma ACTH levels in patients with Cushing's disease and Nelson's syndrome." | 2.66 | The effect of sodium valproate in Cushing's disease, Nelson's syndrome and Addison's disease. ( Allolio, B; Jaursch-Hancke, C; Kaulen, D; Reincke, M; Winkelmann, W, 1988) |
| " The effect of a long term administration of sodium valproate (600-1000 mg/day) was evaluated in 2 patients with active Cushing's disease and in 1 patient with Nelson's syndrome (3 weeks, 3, 9 months respectively); in the 2 patients with Cushing's disease ACTH and cortisol secretion, 17-hydroxy-corticosteroids (17-OHCS) urinary excretion did not change during DPA treatment." | 2.65 | Lack of ACTH lowering effect of sodium valproate in patients with ACTH hypersecretion. ( Berselli, ME; Frascatani, F; Loli, P; Muratori, F; Tagliaferri, M, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ambrosi, B | 1 |
| Bochicchio, D | 1 |
| Riva, E | 1 |
| Faglia, G | 1 |
| Loli, P | 1 |
| Berselli, ME | 1 |
| Frascatani, F | 1 |
| Muratori, F | 1 |
| Tagliaferri, M | 1 |
| Reincke, M | 1 |
| Allolio, B | 1 |
| Kaulen, D | 1 |
| Jaursch-Hancke, C | 1 |
| Winkelmann, W | 1 |
2 trials available for valproic acid and Addison Disease
| Article | Year |
|---|---|
Lack of ACTH lowering effect of sodium valproate in patients with ACTH hypersecretion.
Topics: Addison Disease; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Humans | 1984 |
The effect of sodium valproate in Cushing's disease, Nelson's syndrome and Addison's disease.
Topics: Addison Disease; Adrenocorticotropic Hormone; Cushing Syndrome; Humans; Hydrocortisone; Lypressin; N | 1988 |
1 other study available for valproic acid and Addison Disease
| Article | Year |
|---|---|
Effects of sodium-valproate administration on plasma ACTH levels in patients with ACTH hypersecretion.
Topics: Addison Disease; Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Male; Nelson Syndrom | 1983 |