valproic acid has been researched along with Acute Lung Injury in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Acute Lung Injury: A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Valproic acid (VPA) alleviates hemorrhagic shock (HS)-induced ALI (HS/ALI) and inhibits TF expression in monocytes." | 8.31 | VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS. ( Chong, W; Liu, C; Shao, L; Wu, B, 2023) |
| "Acute lung injury was induced by producing 40 min of ischemia followed by 60 min of reperfusion in isolated perfused rat lungs." | 5.42 | Valproic acid attenuates acute lung injury induced by ischemia-reperfusion in rats. ( Chu, SJ; Huang, KL; Ko, FC; Tang, SE; Wu, GC; Wu, SY, 2015) |
| "Valproic acid (VPA) has been shown to exert anti-inflammatory and antioxidant effects in a range of diseases including septic shock." | 5.39 | Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice. ( Fan, YX; Gao, DP; Ji, MH; Jia, M; Li, GM; Wu, J; Yang, JJ; Zhu, SH, 2013) |
| " Valproic acid (VPA) alleviates hemorrhagic shock (HS)-induced ALI (HS/ALI) and inhibits TF expression in monocytes." | 4.31 | VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS. ( Chong, W; Liu, C; Shao, L; Wu, B, 2023) |
| "Acute lung injury was induced by producing 40 min of ischemia followed by 60 min of reperfusion in isolated perfused rat lungs." | 1.42 | Valproic acid attenuates acute lung injury induced by ischemia-reperfusion in rats. ( Chu, SJ; Huang, KL; Ko, FC; Tang, SE; Wu, GC; Wu, SY, 2015) |
| "Valproic acid (VPA) has been shown to exert anti-inflammatory and antioxidant effects in a range of diseases including septic shock." | 1.39 | Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice. ( Fan, YX; Gao, DP; Ji, MH; Jia, M; Li, GM; Wu, J; Yang, JJ; Zhu, SH, 2013) |
| "The valproic acid plasma level was very high (1437 μg/mL), confirming it was a severe intoxication." | 1.37 | [Acute valproic acid intoxication: interest of a treatment by extracoporeal elimination combined with L-carnitine]. ( Alluin, A; Canevet, C; Desmaretz, JL; Gauthier, N; Jezequel, J, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (88.89) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Shao, L | 3 |
| Wu, B | 3 |
| Liu, C | 3 |
| Chong, W | 6 |
| Kasotakis, G | 1 |
| Galvan, MD | 1 |
| Osathanugrah, P | 1 |
| Dharia, N | 1 |
| Bufe, L | 1 |
| Breed, Z | 1 |
| Mizgerd, JP | 1 |
| Remick, DG | 1 |
| Liu, Z | 2 |
| Li, Y | 4 |
| Liu, B | 4 |
| Deperalta, DK | 2 |
| Zhao, T | 1 |
| Duan, X | 2 |
| Zhou, P | 2 |
| Velmahos, GC | 3 |
| Alam, HB | 4 |
| Ji, MH | 1 |
| Li, GM | 1 |
| Jia, M | 1 |
| Zhu, SH | 1 |
| Gao, DP | 1 |
| Fan, YX | 1 |
| Wu, J | 1 |
| Yang, JJ | 1 |
| Halaweish, I | 1 |
| Wu, SY | 1 |
| Tang, SE | 1 |
| Ko, FC | 1 |
| Wu, GC | 1 |
| Huang, KL | 1 |
| Chu, SJ | 1 |
| Alluin, A | 1 |
| Jezequel, J | 1 |
| Gauthier, N | 1 |
| Desmaretz, JL | 1 |
| Canevet, C | 1 |
| Kim, K | 2 |
| Jin, G | 1 |
| Lu, J | 2 |
| Lee, K | 1 |
| Demoya, M | 1 |
| Fukudome, EY | 1 |
| Kochanek, AR | 1 |
| Smith, EJ | 1 |
| deMoya, MA | 1 |
9 other studies available for valproic acid and Acute Lung Injury
| Article | Year |
|---|---|
VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS.
Topics: Acute Lung Injury; Animals; Cytokines; Lung; Monocytes; Rats; Rats, Wistar; Shock, Hemorrhagic; Thro | 2023 |
VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS.
Topics: Acute Lung Injury; Animals; Cytokines; Lung; Monocytes; Rats; Rats, Wistar; Shock, Hemorrhagic; Thro | 2023 |
VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS.
Topics: Acute Lung Injury; Animals; Cytokines; Lung; Monocytes; Rats; Rats, Wistar; Shock, Hemorrhagic; Thro | 2023 |
VALPROIC ACID INHIBITS CLASSICAL MONOCYTE-DERIVED TISSUE FACTOR AND ALLEVIATES HEMORRHAGIC SHOCK-INDUCED ACUTE LUNG INJURY IN RATS.
Topics: Acute Lung Injury; Animals; Cytokines; Lung; Monocytes; Rats; Rats, Wistar; Shock, Hemorrhagic; Thro | 2023 |
Timing of valproic acid in acute lung injury: prevention is the best therapy?
Topics: Acute Lung Injury; Animals; Biomarkers; Cytokines; Drug Evaluation, Preclinical; Escherichia coli; H | 2017 |
Synergistic effects of hypertonic saline and valproic acid in a lethal rat two-hit model.
Topics: Acute Lung Injury; Animals; Blotting, Western; C-Reactive Protein; Cytokines; Disease Models, Animal | 2013 |
Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Bronchoalveolar Lavage Fluid; Do | 2013 |
Creating a prosurvival phenotype through a histone deacetylase inhibitor in a lethal two-hit model.
Topics: Acute Lung Injury; Animals; Ascitic Fluid; Histone Deacetylase Inhibitors; Interleukin-6; Male; Pero | 2014 |
Valproic acid attenuates acute lung injury induced by ischemia-reperfusion in rats.
Topics: Acetylation; Acute Lung Injury; Animals; Antioxidants; Body Weight; Capillary Permeability; Heme Oxy | 2015 |
[Acute valproic acid intoxication: interest of a treatment by extracoporeal elimination combined with L-carnitine].
Topics: Acidosis, Lactic; Acute Lung Injury; Anticonvulsants; Carnitine; Cranial Nerve Diseases; Electroence | 2011 |
Effect of valproic acid on acute lung injury in a rodent model of intestinal ischemia reperfusion.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Enzyme Inhibitors; Follow-Up Studies; Intestines | 2012 |
Pharmacologic resuscitation decreases circulating cytokine-induced neutrophil chemoattractant-1 levels and attenuates hemorrhage-induced acute lung injury.
Topics: Acute Lung Injury; Animals; Chemokine CXCL1; Histone Deacetylase Inhibitors; Lung; Peroxidase; Rats; | 2012 |