valproic acid has been researched along with Acute Kidney Injury in 27 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The current study investigated the effects of treatment with 300 mg/kg valproic acid on rhabdomyolysis and acute kidney injury induced by intramuscular injection of hypertonic glycerol in rats." | 8.02 | Valproate attenuates hypertonic glycerol-induced rhabdomyolysis and acute kidney injury. ( Abd-Eldayem, AM; Abdelzaher, LA; Badary, DM; Hareedy, MS; Mohammed Alnasser, S, 2021) |
| " As valproic acid (VPA) treatment has been shown to improve survival in animal models of lethal trauma, we hypothesized that it would also attenuate the degree of acute kidney injury." | 8.02 | Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma. ( Alam, HB; Biesterveld, BE; Kemp, MT; O'Connell, RL; Remmer, H; Shamshad, A; Siddiqui, AZ; Smith, WM; Wakam, GK; Williams, AM, 2021) |
| " Life-threatening valproic acid toxicity is an indication for coated charcoal hemoperfusion usually accomplished without complications, but we report a case of acute severe intravascular hemolysis during the time of hemoperfusion with coated charcoal column." | 7.73 | Acute hemolysis with acute renal failure in a patient with valproic acid poisoning treated with charcoal hemoperfusion. ( Haqqie, SS; McGoldrick, MD; Rahman, MH, 2006) |
| "To quantify absolute and relative risks of chronic kidney disease (CKD) progression and acute kidney injury (AKI) in people who initiated lithium compared with valproate therapy and to investigate the association between cumulative use and elevated lithium levels and kidney outcomes." | 4.31 | Absolute and Relative Risks of Kidney Outcomes Associated With Lithium vs Valproate Use in Sweden. ( Bellocco, R; Bosi, A; Carrero, JJ; Ceriani, L; Chang, Z; Clase, CM; Elinder, CG; Fu, EL; Landén, M; Runesson, B; Sjölander, A, 2023) |
| "The current study investigated the effects of treatment with 300 mg/kg valproic acid on rhabdomyolysis and acute kidney injury induced by intramuscular injection of hypertonic glycerol in rats." | 4.02 | Valproate attenuates hypertonic glycerol-induced rhabdomyolysis and acute kidney injury. ( Abd-Eldayem, AM; Abdelzaher, LA; Badary, DM; Hareedy, MS; Mohammed Alnasser, S, 2021) |
| " As valproic acid (VPA) treatment has been shown to improve survival in animal models of lethal trauma, we hypothesized that it would also attenuate the degree of acute kidney injury." | 4.02 | Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma. ( Alam, HB; Biesterveld, BE; Kemp, MT; O'Connell, RL; Remmer, H; Shamshad, A; Siddiqui, AZ; Smith, WM; Wakam, GK; Williams, AM, 2021) |
| " The creatinine clearance, serum urea, uric acid, lactate dehydrogenase, potassium, fractional excretion of sodium, and microproteinuria were measured to assess kidney injury." | 3.80 | Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats. ( Arora, S; Brar, R; Kaur, T; Singh, AP; Singh, JP, 2014) |
| " Life-threatening valproic acid toxicity is an indication for coated charcoal hemoperfusion usually accomplished without complications, but we report a case of acute severe intravascular hemolysis during the time of hemoperfusion with coated charcoal column." | 3.73 | Acute hemolysis with acute renal failure in a patient with valproic acid poisoning treated with charcoal hemoperfusion. ( Haqqie, SS; McGoldrick, MD; Rahman, MH, 2006) |
| "The aim of this review was to evaluate current literature for dosing recommendations for the use of antiepileptic medications in patients receiving renal replacement therapy (RRT)." | 2.53 | Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. ( Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS, 2016) |
| "Valproic acid may inhibit cisplatin-induced kidney injury by suppressing apoptosis, inflammatory responses, and glomerular damage throughout the kidneys by suppressing proximal tubular cell damage." | 1.91 | Valproic acid treatment attenuates cisplatin-induced kidney injury by suppressing proximal tubular cell damage. ( Aizawa, F; Goda, M; Hamano, H; Ishizawa, K; Itobayashi, S; Izawa-Ishizawa, Y; Kanda, M; Miyata, K; Niimura, T; Sakurada, T; Sugimoto, Y; Yagi, K; Yoshioka, T; Zamami, Y, 2023) |
| "Valproic acid (VPA) is a first-line drug used for the treatment of epilepsy and migraine as well as established as a HDAC inhibitor." | 1.42 | Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat. ( Jena, G; Khan, S; Tikoo, K, 2015) |
| "Extrapulmonary manifestations of an influenza A (H1N1) virus infection are rare but have to be considered after exclusion of differential diagnosis in younger patients in particular." | 1.39 | [Difficult course of rhabdomyolysis in influenza A/H1N1]. ( Fröhlich, G; Grawe, A; Märker-Hermann, E; Roth, R; Schmidt, N, 2013) |
| "Goodpasture's syndrome is a rare autoimmune disorder characterized by rapidly progressive glomerulonephritis (RPGN) and alveolar hemorrhage in the presence of antiglomerular basement membrane (anti-GBM) antibodies." | 1.36 | [Goodpasture's syndrome with neurologic involvement and negative ANCA]. ( Cobo, M; Delgado, P; González-Posada, JM; Hernández, D; Marrero, D; Pérez-Suárez, G; Rodríguez, R, 2010) |
| "The patient developed acute renal failure, and also had fever and unilateral ear inflammation." | 1.35 | Acute renal failure following detergent ingestion. ( Lim, YC, 2009) |
| "Valproic acid is an effective antiseizure medication that is also used for other indications such as migraine prophylaxis." | 1.30 | Multiorgan system failure caused by valproic acid toxicity. ( Pinkston, R; Walker, LA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 3 (11.11) | 29.6817 |
| 2010's | 16 (59.26) | 24.3611 |
| 2020's | 6 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Licon, DA | 1 |
| Xiang, L | 1 |
| Bosi, A | 1 |
| Clase, CM | 1 |
| Ceriani, L | 1 |
| Sjölander, A | 1 |
| Fu, EL | 1 |
| Runesson, B | 1 |
| Chang, Z | 1 |
| Landén, M | 1 |
| Bellocco, R | 1 |
| Elinder, CG | 1 |
| Carrero, JJ | 1 |
| Yoshioka, T | 1 |
| Goda, M | 1 |
| Kanda, M | 1 |
| Itobayashi, S | 1 |
| Sugimoto, Y | 1 |
| Izawa-Ishizawa, Y | 1 |
| Yagi, K | 1 |
| Aizawa, F | 1 |
| Miyata, K | 1 |
| Niimura, T | 1 |
| Hamano, H | 1 |
| Sakurada, T | 1 |
| Zamami, Y | 1 |
| Ishizawa, K | 1 |
| Jiang, W | 1 |
| Yuan, X | 1 |
| Zhu, H | 1 |
| He, C | 1 |
| Ge, C | 1 |
| Tang, Q | 1 |
| Xu, C | 1 |
| Hu, B | 1 |
| Huang, C | 2 |
| Ma, T | 2 |
| Hareedy, MS | 1 |
| Abdelzaher, LA | 1 |
| Badary, DM | 1 |
| Mohammed Alnasser, S | 1 |
| Abd-Eldayem, AM | 1 |
| Biesterveld, BE | 1 |
| Siddiqui, AZ | 1 |
| O'Connell, RL | 1 |
| Remmer, H | 1 |
| Williams, AM | 1 |
| Shamshad, A | 1 |
| Smith, WM | 1 |
| Kemp, MT | 1 |
| Wakam, GK | 1 |
| Alam, HB | 1 |
| Amirzargar, MA | 1 |
| Yaghubi, F | 1 |
| Hosseinipanah, M | 1 |
| Jafari, M | 1 |
| Pourjafar, M | 1 |
| Rezaeepoor, M | 1 |
| Rezaei, H | 1 |
| Roshanaei, G | 1 |
| Hajilooi, M | 1 |
| Solgi, G | 1 |
| Kennedy, J | 1 |
| Simmonds, L | 1 |
| Orme, R | 1 |
| Doherty, W | 1 |
| Xu, Q | 1 |
| Yang, Y | 1 |
| Liu, Y | 1 |
| Meng, X | 1 |
| Li, J | 1 |
| Ye, M | 1 |
| Liang, H | 1 |
| Amathieu, R | 1 |
| Levesque, E | 1 |
| Merle, JC | 1 |
| Chemit, M | 1 |
| Costentin, C | 1 |
| Compagnon, P | 1 |
| Dhonneur, G | 1 |
| Brar, R | 1 |
| Singh, JP | 1 |
| Kaur, T | 1 |
| Arora, S | 1 |
| Singh, AP | 1 |
| Fröhlich, G | 1 |
| Grawe, A | 1 |
| Schmidt, N | 1 |
| Roth, R | 1 |
| Märker-Hermann, E | 1 |
| Zheng, Q | 1 |
| Liu, W | 1 |
| Liu, Z | 1 |
| Zhao, H | 1 |
| Han, X | 1 |
| Zhao, M | 1 |
| Khan, S | 1 |
| Jena, G | 1 |
| Tikoo, K | 1 |
| Laliberté, V | 1 |
| Yu, C | 1 |
| Rej, S | 1 |
| Costalonga, EC | 1 |
| Silva, FM | 1 |
| Noronha, IL | 1 |
| Smetana, KS | 1 |
| Cook, AM | 1 |
| Bastin, ML | 1 |
| Oyler, DR | 1 |
| Kanofsky, JD | 1 |
| Woesner, ME | 1 |
| Lim, YC | 1 |
| Deras, P | 1 |
| Gignon, L | 1 |
| Toumi, M | 1 |
| Louart, G | 1 |
| Muller, L | 1 |
| Boyer, JC | 1 |
| Lefrant, JY | 1 |
| Pérez-Suárez, G | 1 |
| Marrero, D | 1 |
| Rodríguez, R | 1 |
| Delgado, P | 1 |
| Cobo, M | 1 |
| González-Posada, JM | 1 |
| Hernández, D | 1 |
| Shang, Y | 1 |
| Jiang, YX | 1 |
| Ding, ZJ | 1 |
| Shen, AL | 1 |
| Xu, SP | 1 |
| Yuan, SY | 1 |
| Yao, SL | 1 |
| Van Beneden, K | 1 |
| Geers, C | 1 |
| Pauwels, M | 1 |
| Mannaerts, I | 1 |
| Verbeelen, D | 1 |
| van Grunsven, LA | 1 |
| Van den Branden, C | 1 |
| Rahman, MH | 1 |
| Haqqie, SS | 1 |
| McGoldrick, MD | 1 |
| Pinkston, R | 1 |
| Walker, LA | 1 |
| Rengstorff, DS | 1 |
| Milstone, AP | 1 |
| Seger, DL | 1 |
| Meredith, TJ | 1 |
| Roodhooft, AM | 1 |
| Van Dam, K | 1 |
| Haentjens, D | 1 |
| Verpooten, GA | 1 |
| Van Acker, KJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Valproic Acid (VPA) as Adjunctive Therapy for Liver Transplant Patients With Moderate to Severe Hemorrhage at Risk of Ischemia Reperfusion (I/R) Injury[NCT04531592] | Phase 2 | 0 participants (Actual) | Interventional | 2022-01-31 | Withdrawn (stopped due to Study terminated by the Sponsor) | ||
| Evaluation of Valproic Acid (VPA) as Adjunctive Therapy for Trauma Patients With Moderate to Severe Hemorrhage at Risk of Ischemia Reperfusion (I/R) Injury[NCT04531579] | Phase 2 | 0 participants (Actual) | Interventional | 2022-01-31 | Withdrawn (stopped due to Study terminated by the Sponsor.) | ||
| The Study of Pharmacokinetics of Levetiracetam in Patients Undergoing Intermittent Hemodialysis[NCT04511676] | 12 participants (Actual) | Observational | 2018-11-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for valproic acid and Acute Kidney Injury
| Article | Year |
|---|---|
[Severe toxic acute liver failure: etiology and treatment].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorde | 2013 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanec | 2016 |
25 other studies available for valproic acid and Acute Kidney Injury
| Article | Year |
|---|---|
Letter Regarding: Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma.
Topics: Acute Kidney Injury; Hemorrhage; Humans; Valproic Acid | 2022 |
Absolute and Relative Risks of Kidney Outcomes Associated With Lithium vs Valproate Use in Sweden.
Topics: Acute Kidney Injury; Adult; Albuminuria; Cohort Studies; Creatinine; Female; Humans; Kidney; Lithium | 2023 |
Valproic acid treatment attenuates cisplatin-induced kidney injury by suppressing proximal tubular cell damage.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cisplatin; Humans; Kidney; Mice; Mice, Inbred C57BL; Prospe | 2023 |
Inhibition of Histone H3K27 Acetylation Orchestrates Interleukin-9-Mediated and Plays an Anti-Inflammatory Role in Cisplatin-Induced Acute Kidney Injury.
Topics: Acetylation; Acute Kidney Injury; Animals; Cell Line; Cisplatin; Culture Media, Conditioned; Cytokin | 2020 |
Valproate attenuates hypertonic glycerol-induced rhabdomyolysis and acute kidney injury.
Topics: Acute Kidney Injury; Animals; Glycerol; Humans; Kidney; Male; Rats; Rhabdomyolysis; Valproic Acid | 2021 |
Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma.
Topics: Acute Kidney Injury; Animals; Creatinine; Drug Evaluation, Preclinical; Hemorrhage; Histone Deacetyl | 2021 |
Anti-inflammatory Effects of Valproic Acid in a Rat Model of Renal Ischemia/Reperfusion Injury: Alteration in Cytokine Profile.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Creatinine; Cytokines; Interleukin-10; Inter | 2017 |
An unusual case of
Topics: Abdominal Pain; Acute Kidney Injury; Aged; Anti-Bacterial Agents; Anticonvulsants; Critical Care; En | 2017 |
Suppression of BMP-7 by histone deacetylase 2 promoted apoptosis of renal tubular epithelial cells in acute kidney injury.
Topics: Acute Kidney Injury; Animals; Bone Morphogenetic Protein 7; Cell Line; Cisplatin; Epithelial Cells; | 2017 |
Role of GABAergic activity of sodium valproate against ischemia-reperfusion-induced acute kidney injury in rats.
Topics: Acute Kidney Injury; Animals; Catalase; Creatinine; GABA Agents; Glutathione; Kidney; L-Lactate Dehy | 2014 |
[Difficult course of rhabdomyolysis in influenza A/H1N1].
Topics: Acute Kidney Injury; Adult; Anticonvulsants; Combined Modality Therapy; Diagnosis, Differential; Hum | 2013 |
Valproic acid protects septic mice from renal injury by reducing the inflammatory response.
Topics: Acute Kidney Injury; Animals; Cecum; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Histone | 2014 |
Valproic acid protects septic mice from renal injury by reducing the inflammatory response.
Topics: Acute Kidney Injury; Animals; Cecum; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Histone | 2014 |
Valproic acid protects septic mice from renal injury by reducing the inflammatory response.
Topics: Acute Kidney Injury; Animals; Cecum; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Histone | 2014 |
Valproic acid protects septic mice from renal injury by reducing the inflammatory response.
Topics: Acute Kidney Injury; Animals; Cecum; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Histone | 2014 |
Sodium valproate ameliorates diabetes-induced fibrosis and renal damage by the inhibition of histone deacetylases in diabetic rat.
Topics: Acetylation; Acute Kidney Injury; Animals; Cytokines; Diabetes Mellitus, Experimental; Diabetic Neph | 2015 |
Acute renal and neurotoxicity in older lithium users: How can we manage and prevent these events in patients with late-life mood disorders?
Topics: Acute Kidney Injury; Aged; Bipolar Disorder; Humans; Lithium Compounds; Male; Neurotoxicity Syndrome | 2015 |
Valproic Acid Prevents Renal Dysfunction and Inflammation in the Ischemia-Reperfusion Injury Model.
Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Male; Nephritis; Rats; Rats, Wistar; Reperfu | 2016 |
Clozapine-Valproate Adverse Drug Reactions and the Need for a Clozapine Rechallenge Case File.
Topics: Acute Kidney Injury; Antimanic Agents; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; H | 2017 |
Acute renal failure following detergent ingestion.
Topics: Acetaminophen; Acute Kidney Injury; Adult; Depression; Detergents; Eating; Female; Fluoxetine; Human | 2009 |
[Lactic acidosis after voluntary intoxication with valproic acid].
Topics: Acidosis, Lactic; Acute Kidney Injury; Adult; Combined Modality Therapy; Depressive Disorder; Emerge | 2010 |
[Goodpasture's syndrome with neurologic involvement and negative ANCA].
Topics: Acute Kidney Injury; Anti-Glomerular Basement Membrane Disease; Antibodies, Antineutrophil Cytoplasm | 2010 |
Valproic acid attenuates the multiple-organ dysfunction in a rat model of septic shock.
Topics: Acute Kidney Injury; Animals; Blotting, Western; Chemical and Drug Induced Liver Injury; Lung Injury | 2010 |
Valproic acid attenuates proteinuria and kidney injury.
Topics: Acute Kidney Injury; Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Doxorubicin; Drug | 2011 |
Acute hemolysis with acute renal failure in a patient with valproic acid poisoning treated with charcoal hemoperfusion.
Topics: Acute Kidney Injury; Charcoal; Female; Hemolysis; Hemoperfusion; Humans; Middle Aged; Valproic Acid | 2006 |
Multiorgan system failure caused by valproic acid toxicity.
Topics: Acute Kidney Injury; Anticonvulsants; Emergencies; Humans; Liver Failure; Male; Middle Aged; Migrain | 1997 |
Felbamate overdose complicated by massive crystalluria and acute renal failure.
Topics: Acute Kidney Injury; Adult; Anticonvulsants; Chromatography, Gas; Crystallization; Drug Interactions | 2000 |
Acute sodium valproate intoxication: occurrence of renal failure and treatment with haemoperfusion-haemodialysis.
Topics: Acute Disease; Acute Kidney Injury; Drug Overdose; Female; Hemoperfusion; Humans; Infant; Renal Dial | 1990 |