valproic acid has been researched along with Acute Hepatic Failure in 19 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alpers syndrome was not clearly defined until the link between brain and liver disease was described." | 2.43 | Alpers syndrome: progressive neuronal degeneration of children with liver disease. ( Gordon, N, 2006) |
| "He developed coma and acute liver failure that were attributed to VPA toxicity, and underwent emergency orthotopic liver transplantation (OLTx)." | 1.31 | Inappropriate liver transplantation in a child with Alpers-Huttenlocher syndrome misdiagnosed as valproate-induced acute liver failure. ( Camboulives, J; Delarue, A; Guys, JM; Lethel, V; Montfort, MF; Paut, O; Pellissier, JF; Roquelaure, B; Sarles, J, 2000) |
| "We report 2 siblings with Alpers disease who were discordant for exposure to valproate (VPA)." | 1.30 | Valproate-induced liver failure in one of two siblings with Alpers disease. ( Armstrong, DL; Burke, B; Dobyns, WB; Schwabe, MJ, 1997) |
| "A 29-year-old female patient with Friedreich's ataxia and partial seizures with acute liver failure during VPA treatment is reported." | 1.30 | Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: review of valproate hepatotoxicity in adults. ( Hehlmann, R; Heubner, C; Holm, E; König, I; König, SA; Schenk, M; Sick, C; Weiss, A, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 10 (52.63) | 29.6817 |
| 2010's | 6 (31.58) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amathieu, R | 1 |
| Levesque, E | 1 |
| Merle, JC | 1 |
| Chemit, M | 1 |
| Costentin, C | 1 |
| Compagnon, P | 1 |
| Dhonneur, G | 1 |
| Hynynen, J | 1 |
| Komulainen, T | 1 |
| Tukiainen, E | 1 |
| Nordin, A | 1 |
| Arola, J | 1 |
| Kälviäinen, R | 1 |
| Jutila, L | 1 |
| Röyttä, M | 1 |
| Hinttala, R | 1 |
| Majamaa, K | 1 |
| Mäkisalo, H | 1 |
| Uusimaa, J | 1 |
| McKiernan, P | 1 |
| Schmid, MM | 1 |
| Connemann, BJ | 1 |
| Wolf, RC | 1 |
| Flechtenmacher, C | 1 |
| Eisenbach, C | 1 |
| Schönfeldt-Lecuona, C | 1 |
| Mindikoglu, AL | 1 |
| King, D | 1 |
| Magder, LS | 1 |
| Ozolek, JA | 1 |
| Mazariegos, GV | 1 |
| Shneider, BL | 1 |
| van Zoelen, MA | 1 |
| de Graaf, M | 1 |
| van Dijk, MR | 1 |
| Bogte, A | 1 |
| van Erpecum, KJ | 1 |
| Rockmann, H | 1 |
| Maarschalk-Ellerbroek, LJ | 1 |
| Bauer, MS | 1 |
| Gordon, N | 1 |
| Kakinuma, H | 1 |
| Fujiki, T | 1 |
| Nakamura, T | 1 |
| Takahashi, H | 1 |
| Hadzić, N | 1 |
| Vara, R | 1 |
| Raiman, J | 1 |
| Mieli-Vergani, G | 1 |
| Iniesta, I | 1 |
| McFarland, R | 1 |
| Hudson, G | 1 |
| Taylor, RW | 1 |
| Green, SH | 1 |
| Hodges, S | 1 |
| McKiernan, PJ | 1 |
| Chinnery, PF | 1 |
| Ramesh, V | 1 |
| Shawcross, D | 1 |
| Auzinger, G | 1 |
| Antoniuk, SA | 1 |
| Bruck, I | 1 |
| Hönnicke, LR | 1 |
| Martins, LT | 1 |
| Carreiro, JE | 1 |
| Cat, R | 1 |
| Schwabe, MJ | 1 |
| Dobyns, WB | 1 |
| Burke, B | 1 |
| Armstrong, DL | 1 |
| König, SA | 1 |
| Schenk, M | 1 |
| Sick, C | 1 |
| Holm, E | 1 |
| Heubner, C | 1 |
| Weiss, A | 1 |
| König, I | 1 |
| Hehlmann, R | 1 |
| Delarue, A | 1 |
| Paut, O | 1 |
| Guys, JM | 1 |
| Montfort, MF | 1 |
| Lethel, V | 1 |
| Roquelaure, B | 1 |
| Pellissier, JF | 1 |
| Sarles, J | 1 |
| Camboulives, J | 1 |
| Kelly, DA | 1 |
| Kayihan, N | 1 |
| Nennesmo, I | 1 |
| Ericzon, BG | 1 |
| Németh, A | 1 |
2 reviews available for valproic acid and Acute Hepatic Failure
| Article | Year |
|---|---|
[Severe toxic acute liver failure: etiology and treatment].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorde | 2013 |
Alpers syndrome: progressive neuronal degeneration of children with liver disease.
Topics: Anticonvulsants; Child; Contraindications; Diffuse Cerebral Sclerosis of Schilder; Humans; Liver Fai | 2006 |
17 other studies available for valproic acid and Acute Hepatic Failure
| Article | Year |
|---|---|
Acute liver failure after valproate exposure in patients with POLG1 mutations and the prognosis after liver transplantation.
Topics: Adolescent; Adult; Anticonvulsants; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochon | 2014 |
Acute liver failure after valproate exposure: Liver transplantation may be indicated beyond childhood.
Topics: Anticonvulsants; DNA-Directed DNA Polymerase; Female; Humans; Liver Failure, Acute; Liver Transplant | 2014 |
Can we prevent fatal liver failure under valproate?
Topics: Anticonvulsants; Bipolar Disorder; Fatal Outcome; Female; Humans; Liver; Liver Failure, Acute; Liver | 2010 |
Valproic acid-associated acute liver failure in children: case report and analysis of liver transplantation outcomes in the United States.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Follow-Up Studies; Humans; I | 2011 |
Valproic acid-induced DRESS syndrome with acute liver failure.
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Eosinophilia; | 2012 |
Fatal hepatic failure and valproate.
Topics: Anticonvulsants; Depressive Disorder; Fatal Outcome; Humans; Liver Failure, Acute; Male; Middle Aged | 2005 |
Valproate hepatotoxicity in a 5-year-old boy with cerebral palsy due to neonatal asphyxia.
Topics: Anticonvulsants; Asphyxia Neonatorum; Cerebral Palsy; Child, Preschool; Echovirus Infections; Enceph | 2006 |
Old versus new antiepileptic drugs: the SANAD study.
Topics: Adolescent; Anticonvulsants; Diagnostic Errors; Female; Humans; Kearns-Sayre Syndrome; Liver Failure | 2007 |
Lamotrigine and the risk of fulminant hepatic failure.
Topics: Anticonvulsants; Cytomegalovirus Infections; Female; Humans; Lamotrigine; Liver Failure, Acute; Risk | 2007 |
Reversible valproate hepatotoxicity due to mutations in mitochondrial DNA polymerase gamma (POLG1).
Topics: Anticonvulsants; Child, Preschool; DNA Polymerase gamma; DNA-Directed DNA Polymerase; DNA, Mitochond | 2008 |
Lamotrigine and the risk of fulminant hepatic failure.
Topics: Anticonvulsants; Cytomegalovirus Infections; Female; Humans; Lamotrigine; Liver Failure, Acute; Risk | 2008 |
[Acute hepatic failure associated with valproic acid in children. Report of 3 cases].
Topics: Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Liver Failure, Acute; Male; Risk Factor | 1996 |
Valproate-induced liver failure in one of two siblings with Alpers disease.
Topics: Anticonvulsants; Child, Preschool; Diffuse Cerebral Sclerosis of Schilder; Fatal Outcome; Female; Hu | 1997 |
Fatal liver failure associated with valproate therapy in a patient with Friedreich's disease: review of valproate hepatotoxicity in adults.
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Comorbidity; Epilepsy; Fatal Outcome; Fem | 1999 |
Inappropriate liver transplantation in a child with Alpers-Huttenlocher syndrome misdiagnosed as valproate-induced acute liver failure.
Topics: Anticonvulsants; Brain; Child, Preschool; Diagnosis, Differential; Diagnostic Errors; Diffuse Cerebr | 2000 |
Liver transplantation: to do or not to do?
Topics: Anticonvulsants; Child; Contraindications; Diffuse Cerebral Sclerosis of Schilder; Epilepsy; Female; | 2000 |
Fatal deterioration of neurological disease after orthotopic liver transplantation for valproic acid-induced liver damage.
Topics: Adolescent; Anticonvulsants; Diffuse Cerebral Sclerosis of Schilder; Electroencephalography; Epileps | 2000 |