valproic acid has been researched along with Acrocephaly in 11 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Acrocephaly: Premature closing of the lambdoid and coronal sutures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "we describe a case of trigonocephaly in a six month-old girl, daughter of a young non-smoker couple, whose mother had used phenobarbital 100 mg daily and sodium valproate 500 mg twice daily during the whole pregnancy." | 3.71 | [Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report]. ( Abraham, R; Assencio-Ferreira, VJ; Santos, KC; Veiga, JC, 2001) |
| "The prevalence of trigonocephaly increased during the last two decades both in Europe and in the United States, but no clear contributing factors have yet been identified." | 2.61 | Recent advances in trigonocephaly. ( Aillet, S; Mocquard, C; Riffaud, L, 2019) |
| "Valproic acid (VPA) is a teratogenic drug used in pregnant women for the treatment of epilepsy and mood disorders." | 1.37 | Severe fetal valproate syndrome: combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly. ( Cetinkaya, M; Köksal, N; Ozkan, H; Yapici, S, 2011) |
| "Ideally any pregnancy in a woman being treated for epilepsy should be planned, and both an obstetrician and a neurologist should be consulted." | 1.31 | Craniosynostosis and fetal exposure to sodium valproate. ( Barcik, U; Bourgeois, M; El Ghouzzi, V; Lajeunie, E; Renier, D; Thorne, JA, 2001) |
| "Metopic craniosynostosis may be an adverse effect of valproic acid exposed fetus." | 1.31 | [Metopic craniosynostosis, probable effect of intrauterine exposure to maternal valproate treatment]. ( Bensouda, B; Bruel, H; Chabrolle, JP; Degre, S; Ickowicz, V; Poinsot, J; Simon, A, 2001) |
| "From a series of 1,713 patients with craniosynostosis hospitalized between 1976 and 1996, 237 propositi with metopic synostosis were analyzed." | 1.30 | Syndromal and nonsyndromal primary trigonocephaly: analysis of a series of 237 patients. ( Lajeunie, E; Le Merrer, M; Marchac, D; Renier, D, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 6 (54.55) | 29.6817 |
| 2010's | 4 (36.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mocquard, C | 1 |
| Aillet, S | 1 |
| Riffaud, L | 1 |
| Kini, U | 1 |
| Hurst, JA | 1 |
| Byren, JC | 1 |
| Wall, SA | 1 |
| Johnson, D | 1 |
| Wilkie, AO | 1 |
| Singh, RP | 1 |
| Dhariwal, D | 1 |
| Bhujel, N | 1 |
| Shaikh, Z | 1 |
| Davies, P | 1 |
| Nishikawa, H | 1 |
| Solanki, G | 1 |
| Dover, MS | 1 |
| Ozkan, H | 1 |
| Cetinkaya, M | 1 |
| Köksal, N | 1 |
| Yapici, S | 1 |
| de Oliveira, RS | 1 |
| Lajeunie, E | 4 |
| Arnaud, E | 2 |
| Greensmith, A | 1 |
| Renier, D | 5 |
| Santos de Oliveira, R | 1 |
| Valentin, M | 1 |
| Ducarme, G | 1 |
| Yver, C | 1 |
| Vuillard, E | 1 |
| Belarbi, N | 1 |
| Luton, D | 1 |
| Le Merrer, M | 1 |
| Marchac, D | 1 |
| Assencio-Ferreira, VJ | 1 |
| Abraham, R | 1 |
| Veiga, JC | 1 |
| Santos, KC | 1 |
| Barcik, U | 1 |
| Thorne, JA | 1 |
| El Ghouzzi, V | 1 |
| Bourgeois, M | 1 |
| Chabrolle, JP | 1 |
| Bensouda, B | 1 |
| Bruel, H | 1 |
| Simon, A | 1 |
| Poinsot, J | 1 |
| Ickowicz, V | 1 |
| Degre, S | 1 |
1 review available for valproic acid and Acrocephaly
| Article | Year |
|---|---|
Recent advances in trigonocephaly.
Topics: Anticonvulsants; Child; Child, Preschool; Craniosynostoses; Humans; Infant; Infant, Newborn; Intelle | 2019 |
10 other studies available for valproic acid and Acrocephaly
| Article | Year |
|---|---|
Etiological heterogeneity and clinical characteristics of metopic synostosis: Evidence from a tertiary craniofacial unit.
Topics: Adolescent; Anticoagulants; Child; Child, Preschool; Chromosome Aberrations; Craniosynostoses; Enoxa | 2010 |
Role of parental risk factors in the aetiology of isolated non-syndromic metopic craniosynostosis.
Topics: Anticonvulsants; Chi-Square Distribution; Craniosynostoses; Epilepsy; Female; Fertility Agents, Fema | 2010 |
Severe fetal valproate syndrome: combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Craniosynostoses; Fatal Outcome; Female; Heart | 2011 |
Baller-Gerold syndrome after fetal exposure to sodium valproate.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Craniosynostoses; Female; Hum | 2005 |
Fetal exposure to sodium valproate associated with Baller-Gerold syndrome: case report and review of the literature.
Topics: Craniosynostoses; Female; Humans; Infant; Pregnancy; Prenatal Exposure Delayed Effects; Radiography; | 2006 |
Trigonocephaly and valproate: a case report and review of literature.
Topics: Adult; Anticonvulsants; Craniosynostoses; Female; Gestational Age; Humans; Magnetic Resonance Imagin | 2008 |
Syndromal and nonsyndromal primary trigonocephaly: analysis of a series of 237 patients.
Topics: Birth Weight; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Craniosynostose | 1998 |
[Metopic suture craniosynostosis: sodium valproate teratogenic effect. Case report].
Topics: Adult; Anticonvulsants; Cranial Sutures; Craniosynostoses; Female; Humans; Infant; Phenobarbital; Pr | 2001 |
Craniosynostosis and fetal exposure to sodium valproate.
Topics: Anticonvulsants; Child; Child, Preschool; Craniosynostoses; Epilepsy; Female; Fetus; Humans; Infant; | 2001 |
[Metopic craniosynostosis, probable effect of intrauterine exposure to maternal valproate treatment].
Topics: Abnormalities, Drug-Induced; Craniosynostoses; Diseases in Twins; Epilepsy, Generalized; Female; Hum | 2001 |