valproic acid has been researched along with Acquired Immunodeficiency Syndrome in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Acquired Immunodeficiency Syndrome: An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS)." | 7.75 | Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid. ( Aboulafia, D; Ambinder, RF; Dezube, BJ; Dittmer, DP; Krown, SE; Lechowicz, M; Lee, JY; Ratner, L; Said, J; Wachsman, W, 2009) |
| "The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS)." | 3.75 | Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid. ( Aboulafia, D; Ambinder, RF; Dezube, BJ; Dittmer, DP; Krown, SE; Lechowicz, M; Lee, JY; Ratner, L; Said, J; Wachsman, W, 2009) |
| "Among 1345 HIV/AIDS persons in active care between 2001 and 2007, 169 individuals were exposed to AEDs for the following indications: peripheral neuropathy/neuropathic pain (60%), seizure/epilepsy (24%), mood disorder (13%) and movement disorder (2%)." | 1.36 | Clinical outcomes and immune benefits of anti-epileptic drug therapy in HIV/AIDS. ( Gill, MJ; Krentz, HB; Lee, K; Maingat, F; Power, C; Siemieniuk, RA; Vivithanaporn, P, 2010) |
| "Valproic acid is an anticonvulsant drug known to inhibit the glucuronidation of zidovudine (AZT) in human liver microsomes." | 1.30 | Valproic acid increases cerebrospinal fluid zidovudine levels in a patient with AIDS. ( Akula, SK; Dejace, PM; Dreisbach, AW; Lertora, JJ; Rege, AB, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lechowicz, M | 1 |
| Dittmer, DP | 1 |
| Lee, JY | 1 |
| Krown, SE | 1 |
| Wachsman, W | 1 |
| Aboulafia, D | 1 |
| Dezube, BJ | 1 |
| Ratner, L | 1 |
| Said, J | 1 |
| Ambinder, RF | 1 |
| Lee, K | 1 |
| Vivithanaporn, P | 1 |
| Siemieniuk, RA | 1 |
| Krentz, HB | 1 |
| Maingat, F | 1 |
| Gill, MJ | 1 |
| Power, C | 1 |
| Nesseler, N | 1 |
| Polard, E | 1 |
| Arvieux, C | 1 |
| Coquerel, N | 1 |
| Michelet, C | 1 |
| Tattevin, P | 1 |
| Dewhurst, S | 1 |
| Maggirwar, SB | 1 |
| Schifitto, G | 1 |
| Gendelman, HE | 1 |
| Gelbard, HA | 1 |
| Akula, SK | 1 |
| Rege, AB | 1 |
| Dreisbach, AW | 1 |
| Dejace, PM | 1 |
| Lertora, JJ | 1 |
| Jefferson, JW | 1 |
1 review available for valproic acid and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS.
Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; Animals; Anti-HIV Agents; Drug Delivery S | 2007 |
5 other studies available for valproic acid and Acquired Immunodeficiency Syndrome
| Article | Year |
|---|---|
Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid.
Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Herpesvirus 8, Human; Humans; Male; Middle Aged; | 2009 |
Clinical outcomes and immune benefits of anti-epileptic drug therapy in HIV/AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anticonvulsants; Calcium Channel Blockers; CD4 Antigens; | 2010 |
Aseptic meningitis associated with lamotrigine: report of two cases.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anticonvulsants; Blood; Blood Chemical Analysis; Cerebros | 2007 |
Valproic acid increases cerebrospinal fluid zidovudine levels in a patient with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; Anticonvulsants; Drug Interactions | 1997 |
Possible risks associated with valproate treatment of AIDS-related mania.
Topics: Acquired Immunodeficiency Syndrome; Bipolar Disorder; Cytomegalovirus; Drug Costs; HIV-1; Humans; In | 1998 |