valproic acid has been researched along with Acquired-Immune Deficiency Syndrome Dementia Complex in 7 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid is an anticonvulsant drug known to inhibit the glucuronidation of zidovudine (AZT) in human liver microsomes." | 1.30 | Valproic acid increases cerebrospinal fluid zidovudine levels in a patient with AIDS. ( Akula, SK; Dejace, PM; Dreisbach, AW; Lertora, JJ; Rege, AB, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davidson, DC | 1 |
| Hirschman, MP | 1 |
| Spinelli, SL | 1 |
| Morrell, CN | 1 |
| Schifitto, G | 3 |
| Phipps, RP | 1 |
| Maggirwar, SB | 3 |
| Dou, H | 1 |
| Birusingh, K | 1 |
| Faraci, J | 1 |
| Gorantla, S | 1 |
| Poluektova, LY | 1 |
| Dewhurst, S | 2 |
| Gelbard, HA | 2 |
| Gendelman, HE | 3 |
| Peterson, DR | 1 |
| Zhong, J | 1 |
| Ni, H | 1 |
| Cruttenden, K | 1 |
| Gaugh, M | 1 |
| Boska, M | 1 |
| Gelbard, H | 1 |
| Akula, SK | 1 |
| Rege, AB | 1 |
| Dreisbach, AW | 1 |
| Dejace, PM | 1 |
| Lertora, JJ | 1 |
| RachBeisel, JA | 1 |
| Weintraub, E | 1 |
| Shulman, KI | 1 |
| Herrmann, N | 1 |
2 reviews available for valproic acid and Acquired-Immune Deficiency Syndrome Dementia Complex
| Article | Year |
|---|---|
Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS.
Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; Animals; Anti-HIV Agents; Drug Delivery S | 2007 |
Bipolar disorder in old age.
Topics: Acute Disease; Adult; Age Factors; Aged; AIDS Dementia Complex; Antidepressive Agents; Antimanic Age | 1999 |
1 trial available for valproic acid and Acquired-Immune Deficiency Syndrome Dementia Complex
| Article | Year |
|---|---|
Valproic acid adjunctive therapy for HIV-associated cognitive impairment: a first report.
Topics: Adult; AIDS Dementia Complex; Anti-Retroviral Agents; CD4 Lymphocyte Count; Double-Blind Method; Dru | 2006 |
4 other studies available for valproic acid and Acquired-Immune Deficiency Syndrome Dementia Complex
| Article | Year |
|---|---|
Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals.
Topics: AIDS Dementia Complex; Animals; Blood Platelets; CD40 Ligand; Down-Regulation; Female; Glycogen Synt | 2011 |
Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis.
Topics: AIDS Dementia Complex; Animals; Basal Ganglia; Biomarkers; Cell Differentiation; Cells, Cultured; Co | 2003 |
Valproic acid increases cerebrospinal fluid zidovudine levels in a patient with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; Anticonvulsants; Drug Interactions | 1997 |
Valproic acid treatment of AIDS-related mania.
Topics: Adult; AIDS Dementia Complex; Drug Administration Schedule; Humans; Male; Quality of Life; Valproic | 1997 |