valproic acid has been researched along with Acquired Encephalocele in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fetuses were examined for exencephaly, resorption, and fetal weight retardation on day 18 of gestation." | 5.28 | Methotrexate increases valproic acid-induced developmental toxicity, in particular neural tube defects in mice. ( Elmazar, MM; Nau, H, 1992) |
| " In the present work the effects of developmentally toxic doses of 2-ethylhexanoic acid (EHXA), 2-ethylhexanol (EHXO), and valproic acid (VPA) on Zn metabolism were investigated in the pregnant rat." | 1.30 | Altered zinc metabolism contributes to the developmental toxicity of 2-ethylhexanoic acid, 2-ethylhexanol and valproic acid. ( Bui, LM; Commisso, JF; Faber, WD; Keen, CL; Taubeneck, MW; Uriu-Hare, JY, 1998) |
| "Fetuses were examined for exencephaly, resorption, and fetal weight retardation on day 18 of gestation." | 1.28 | Methotrexate increases valproic acid-induced developmental toxicity, in particular neural tube defects in mice. ( Elmazar, MM; Nau, H, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bui, LM | 1 |
| Taubeneck, MW | 1 |
| Commisso, JF | 1 |
| Uriu-Hare, JY | 1 |
| Faber, WD | 1 |
| Keen, CL | 1 |
| Elmazar, MM | 1 |
| Nau, H | 1 |
2 other studies available for valproic acid and Acquired Encephalocele
| Article | Year |
|---|---|
Altered zinc metabolism contributes to the developmental toxicity of 2-ethylhexanoic acid, 2-ethylhexanol and valproic acid.
Topics: Animals; Caproates; Crown-Rump Length; Encephalocele; Female; Hexanols; Hydrocephalus; Liver; Metall | 1998 |
Methotrexate increases valproic acid-induced developmental toxicity, in particular neural tube defects in mice.
Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Encephalocele; Female; Folic Acid; Methotrexat | 1992 |