valproic acid has been researched along with Academic Disorder, Developmental in 17 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prenatal exposure to valproic acid (VPA) in rat offspring is capable of inducing experimental autism with neurobehavioral aberrations." | 7.83 | Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model. ( Cao, Y; Gao, J; Liang, S; Sun, H; Wang, H; Wang, X; Wang, Y; Wu, L; Yang, F; Zhang, F, 2016) |
| "Previously, we have documented that prenatal hypoxia can aggravate the cognitive impairment and Alzheimer's disease (AD) neuropathology in APP(Swe) /PS1(A246E) (APP/PS1) transgenic mice, and valproic acid (VPA) can prevent hypoxia-induced down-regulation of β-amyloid (Aβ) degradation enzyme neprilysin (NEP) in primary neurons." | 7.80 | Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin. ( Le, W; Li, J; Li, T; Tang, Y; Wang, Z; Zhang, XJ, 2014) |
| "Prenatal exposure to valproic acid (VPA) in rat offspring is capable of inducing experimental autism with neurobehavioral aberrations." | 3.83 | Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model. ( Cao, Y; Gao, J; Liang, S; Sun, H; Wang, H; Wang, X; Wang, Y; Wu, L; Yang, F; Zhang, F, 2016) |
| "Previously, we have documented that prenatal hypoxia can aggravate the cognitive impairment and Alzheimer's disease (AD) neuropathology in APP(Swe) /PS1(A246E) (APP/PS1) transgenic mice, and valproic acid (VPA) can prevent hypoxia-induced down-regulation of β-amyloid (Aβ) degradation enzyme neprilysin (NEP) in primary neurons." | 3.80 | Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin. ( Le, W; Li, J; Li, T; Tang, Y; Wang, Z; Zhang, XJ, 2014) |
| " To test the effect of antiepileptic drugs on kindled seizures and kindling-induced learning deficits we injected ethosuximide, dipropylacetate, and phenobarbital prior to each kindling stimulation or after kindling completion, and tested these animals in a shuttle-box paradigm." | 3.69 | Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments. ( Becker, A; Brosz, M; Grecksch, G, 1995) |
| "Benign myoclonic epilepsy in infancy (BMEI) is a well-defined electro-clinical syndrome, classically associated with a good prognosis." | 1.40 | [Benign myoclonic epilepsy in infancy: natural history and behavioral and cognitive outcome]. ( Carreras-Sáez, I; Domínguez-Carral, J; Fournier-Del Castillo, MC; García-Peñas, JJ; Jiménez-Echevarría, S; Pérez-Jiménez, MÁ, 2014) |
| "A diagnosis of generalized NCSE with tonic seizures was made on the basis of the clinical picture and response to barbiturate anaesthetic, although the EEG pattern was not typical of the changes previously described in tonic seizures-tonic status epilepticus." | 1.33 | Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state? ( Chattopadhyay, A; Kuc, S; Langheinrich, TC; Reuber, M, 2005) |
| "One also had features of infantile autism." | 1.29 | Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. ( Chesler, N; Christianson, AL; Kromberg, JG, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (35.29) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 8 (47.06) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Davies, P | 1 |
| Reuber, M | 2 |
| Grunewald, R | 1 |
| Howell, S | 1 |
| Dickson, J | 1 |
| Dennis, G | 1 |
| Shanmugarajah, P | 1 |
| Tsironis, T | 1 |
| Brockington, A | 1 |
| Wang, Z | 1 |
| Zhang, XJ | 1 |
| Li, T | 1 |
| Li, J | 1 |
| Tang, Y | 1 |
| Le, W | 1 |
| Domínguez-Carral, J | 1 |
| García-Peñas, JJ | 1 |
| Pérez-Jiménez, MÁ | 1 |
| Fournier-Del Castillo, MC | 1 |
| Carreras-Sáez, I | 1 |
| Jiménez-Echevarría, S | 1 |
| Galer, S | 1 |
| Urbain, C | 1 |
| De Tiège, X | 1 |
| Emeriau, M | 1 |
| Leproult, R | 1 |
| Deliens, G | 1 |
| Nonclerq, A | 1 |
| Peigneux, P | 1 |
| Van Bogaert, P | 1 |
| Gao, J | 2 |
| Wang, X | 1 |
| Sun, H | 2 |
| Cao, Y | 2 |
| Liang, S | 2 |
| Wang, H | 1 |
| Wang, Y | 1 |
| Yang, F | 1 |
| Zhang, F | 1 |
| Wu, L | 2 |
| Wu, H | 1 |
| Sun, C | 1 |
| Wang, P | 1 |
| Wang, J | 1 |
| Niquet, J | 1 |
| Baldwin, R | 1 |
| Norman, K | 1 |
| Suchomelova, L | 1 |
| Lumley, L | 1 |
| Wasterlain, CG | 1 |
| Lee, Y | 1 |
| Kim, D | 1 |
| Kim, YH | 1 |
| Lee, H | 1 |
| Lee, CJ | 1 |
| Porras-Kattz, E | 1 |
| Harmony, T | 1 |
| Ricardo-Garcell, J | 1 |
| Galán, L | 1 |
| Fernández, T | 1 |
| Prado-Alcalá, R | 1 |
| Avecilla-Ramírez, G | 1 |
| Sánchez-Moreno, L | 1 |
| Barrera-Reséndiz, J | 1 |
| Corsi-Cabrera, M | 1 |
| Valencia-Solís, E | 1 |
| Langheinrich, TC | 1 |
| Chattopadhyay, A | 1 |
| Kuc, S | 1 |
| Christianson, AL | 1 |
| Chesler, N | 1 |
| Kromberg, JG | 1 |
| Schmidt, A | 1 |
| Darius, J | 1 |
| Brosz, M | 2 |
| Roth, N | 1 |
| Meyer, FP | 1 |
| Kroker, S | 1 |
| Wien, F | 1 |
| Brett, B | 1 |
| Becker, A | 1 |
| Grecksch, G | 1 |
| Gordon, K | 1 |
| Bawden, H | 1 |
| Camfield, P | 1 |
| Mann, S | 1 |
| Orlik, P | 1 |
| Duane, DD | 1 |
| Ronen, GM | 1 |
| Richards, JE | 1 |
| Cunningham, C | 1 |
| Secord, M | 1 |
| Rosenbloom, D | 1 |
| Calandre, EP | 1 |
| Dominguez-Granados, R | 1 |
| Gomez-Rubio, M | 1 |
| Molina-Font, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigating the Effect of Closed-loop Auditory Stimulation on Sleep and Behavior in Patients With Epilepsy and Healthy Controls: a Developmental Study[NCT04716673] | 120 participants (Anticipated) | Interventional | 2020-07-29 | Recruiting | |||
| Efficacy of Combined Ketamine and Midazolam for Treatment of Generalized Convulsive Status Epilepticus in Children .[NCT05779657] | Phase 2/Phase 3 | 144 participants (Anticipated) | Interventional | 2023-03-21 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for valproic acid and Academic Disorder, Developmental
| Article | Year |
|---|---|
Magnesium valproate in learning disabled children with interictal paroxysmal EEG patterns: Preliminary report.
Topics: Brain Mapping; Child; Electroencephalography; Enzyme Inhibitors; Female; Humans; Learning Disabiliti | 2011 |
Valproic acid treatment of learning disorder and severely epileptiform EEG without clinical seizures.
Topics: Anticonvulsants; Child; Electroencephalography; Epilepsy; Frontal Lobe; Humans; Learning Disabilitie | 1996 |
Can sodium valproate improve learning in children with epileptiform bursts but without clinical seizures?
Topics: Anticonvulsants; Attention; Child; Child Behavior Disorders; Cross-Over Studies; Double-Blind Method | 2000 |
14 other studies available for valproic acid and Academic Disorder, Developmental
| Article | Year |
|---|---|
The impact and challenges of the 2018 MHRA statement on the use of sodium valproate in women of childbearing age during the first year of implementation, in a UK epilepsy centre.
Topics: Adolescent; Adult; Anticonvulsants; Contraception; Contraindications, Drug; Cross-Sectional Studies; | 2020 |
Valproic acid reduces neuritic plaque formation and improves learning deficits in APP(Swe) /PS1(A246E) transgenic mice via preventing the prenatal hypoxia-induced down-regulation of neprilysin.
Topics: Amyloid beta-Protein Precursor; Animals; Chromatin Immunoprecipitation; Down-Regulation; Female; Hum | 2014 |
[Benign myoclonic epilepsy in infancy: natural history and behavioral and cognitive outcome].
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child Behavior Disorders; Cognition | 2014 |
Impaired sleep-related consolidation of declarative memories in idiopathic focal epilepsies of childhood.
Topics: Anticonvulsants; Child; Electroencephalography; Epilepsies, Partial; Epilepsy, Rolandic; Female; Hum | 2015 |
Neuroprotective effects of docosahexaenoic acid on hippocampal cell death and learning and memory impairments in a valproic acid-induced rat autism model.
Topics: Animals; Anticonvulsants; Autistic Disorder; Caspase 3; Cell Death; Disease Models, Animal; Docosahe | 2016 |
Maternal DHA supplementation protects rat offspring against impairment of learning and memory following prenatal exposure to valproic acid.
Topics: Animals; Anticonvulsants; Behavior, Animal; CA1 Region, Hippocampal; Dietary Supplements; Docosahexa | 2016 |
Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits.
Topics: Animals; Anticonvulsants; Brain; Cholinergic Agents; Disease Models, Animal; Drug Synergism; Drug Th | 2016 |
Improvement of pentylenetetrazol-induced learning deficits by valproic acid in the adult zebrafish.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Dose-Response Relationship, D | 2010 |
Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state?
Topics: Adult; Anticonvulsants; Benzodiazepines; Coma; Diagnosis, Differential; Electroencephalography; Epil | 2005 |
Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs.
Topics: Adult; Autistic Disorder; Child, Preschool; Clonazepam; Developmental Disabilities; Epilepsy; Family | 1994 |
[The effect of valproic acid monotherapy on behavior and cognitive performance of children with idiopathic generalized epilepsy].
Topics: Adolescent; Anticonvulsants; Child; Child Behavior Disorders; Dose-Response Relationship, Drug; Elec | 1995 |
Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Ethosuxim | 1995 |
Valproic acid treatment of learning disorder: a comment.
Topics: Anticonvulsants; Child; Electroencephalography; Humans; Learning Disabilities; Male; Underachievemen | 1996 |
Cognitive effects of long-term treatment with phenobarbital and valproic acid in school children.
Topics: Child; Epilepsy; Female; Follow-Up Studies; Humans; Intelligence; Learning Disabilities; Male; Pheno | 1990 |