valproic acid has been researched along with Absence of Brain, Congenital in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neural tube defects (NTDs), including anencephaly and spina bifida, are common major malformations of fetal development resulting from incomplete closure of the neural tube." | 1.91 | A Shared Pathogenic Mechanism for Valproic Acid and ( Huang, J; Luo, J; Parent, JM; Sexton, JZ; Sudyk, R; Takla, TN; Tidball, AM; Vora, NL; Walker, JC, 2023) |
| "Exencephaly/anencephaly is one of the leading causes of neonatal mortality and the most extreme open neural tube defect with no current treatments and limited mechanistic understanding." | 1.51 | Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis. ( Duru, S; Fernandez-Alonso, I; Fernandez-Martin, A; Figueira, RL; Marotta, M; Oria, M; Peiro, JL; Sbragia, L; Scorletti, F; Shaaban, AF; Turner, LE, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Takla, TN | 1 |
| Luo, J | 1 |
| Sudyk, R | 1 |
| Huang, J | 1 |
| Walker, JC | 1 |
| Vora, NL | 1 |
| Sexton, JZ | 1 |
| Parent, JM | 1 |
| Tidball, AM | 1 |
| Oria, M | 1 |
| Duru, S | 1 |
| Figueira, RL | 1 |
| Scorletti, F | 1 |
| Turner, LE | 1 |
| Fernandez-Alonso, I | 1 |
| Fernandez-Martin, A | 1 |
| Marotta, M | 1 |
| Sbragia, L | 1 |
| Shaaban, AF | 1 |
| Peiro, JL | 1 |
| Oakley, GP | 1 |
| Castilla, E | 1 |
| Koch, S | 1 |
| Göpfert-Geyer, I | 1 |
| Jäger-Roman, E | 1 |
| Jakob, S | 1 |
| Huth, H | 1 |
| Hartmann, A | 1 |
| Rating, D | 1 |
| Helge, H | 1 |
| Leck, I | 1 |
1 trial available for valproic acid and Absence of Brain, Congenital
| Article | Year |
|---|---|
[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and child development].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Akathisia, Drug-Induced; Anencephaly; Ant | 1983 |
5 other studies available for valproic acid and Absence of Brain, Congenital
| Article | Year |
|---|---|
A Shared Pathogenic Mechanism for Valproic Acid and
Topics: Anencephaly; Animals; Brain; Female; Glycogen Synthase Kinase 3 beta; Humans; Mice; Mice, Knockout; | 2023 |
Cell necrosis, intrinsic apoptosis and senescence contribute to the progression of exencephaly to anencephaly in a mice model of congenital chranioschisis.
Topics: Amniotic Fluid; Anencephaly; Animals; Apoptosis; Brain; Caspase 3; Caspase 9; Cellular Senescence; C | 2019 |
Classifying by cause and preventing the many causes of spina bifida and anencephaly.
Topics: Anencephaly; Anticonvulsants; Diabetes Mellitus; Female; Folic Acid; Folic Acid Deficiency; Food, Fo | 2020 |
Valproic acid and spina bifida.
Topics: Adult; Anencephaly; Epilepsy; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; S | 1983 |
Spina bifida and anencephaly: fewer patients, more problems.
Topics: Abnormalities, Drug-Induced; Anencephaly; Female; Humans; Infant, Newborn; Neural Tube Defects; Preg | 1983 |