valproic acid has been researched along with Abnormality, Heart in 22 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) exposure during pregnancy has been proven to contribute to congenital heart disease (CHD)." | 3.88 | Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice. ( Duan, HY; Hua, YM; Li, YF; Wang, C; Wang, T; Zhang, Y; Zhou, KY, 2018) |
| "The effects of antiepileptic drugs (AED) on infants during pregnancy and delivery were studied in a total of 82 epileptic mothers on various monotherapies; 29 cases receiving valproic acid (VPA), 20 receiving phenytoin (PHT), 18 on carbamazepine (CBZ) and 15 on phenobarbital (PB)." | 3.68 | [Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital]. ( Ishikawa, S; Izumi, M; Okada, H; Takeda, A; Tanaka, H, 1991) |
| "To characterize the effects of VPA on murine heart development, pregnant CD-1 mice were dosed with 400 mg/kg of VPA on gestational day (GD) 9." | 1.51 | Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development. ( Belanger, CL; Maciver, RD; Nikolovska, A; Philbrook, NA; Winn, LM, 2019) |
| "Valproic acid is an effective anti-epileptic drug; however, when taken by pregnant women to treat epilepsy, it can produce cardiac developmental defects in fetuses." | 1.43 | The Phosphorylation State of GSK3β Serine 9 Correlated to the Development of Valproic Acid-Associated Fetal Cardiac Teratogenicity, Fetal VPA Syndrome, Rescued by Folic Acid Administration. ( Chu, SL; Ho, YL; Huang, PT; Liou, HH; Tsai, HJ; Yu, WH, 2016) |
| "Valproic acid (VPA) is a teratogenic drug used in pregnant women for the treatment of epilepsy and mood disorders." | 1.37 | Severe fetal valproate syndrome: combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly. ( Cetinkaya, M; Köksal, N; Ozkan, H; Yapici, S, 2011) |
| " The frequency of withdrawal symptoms was significantly related to the dose of valproate given to the mothers in the third trimester, and there was a tendency for both the frequency of the minor abnormalities and the major malformations to be related to the valproate dosage in the first trimester." | 1.29 | Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero. ( Ebbesen, F; Thisted, E, 1993) |
| "Spina Bifida, Congenital Heart Defects, Clefts, Diaphragmatic Hernia and Trisomy 18 were more frequent than expected among babies with maternal epilepsy." | 1.27 | Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC). ( Bertollini, R; Mastroiacovo, P; Segni, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (9.09) | 18.7374 |
| 1990's | 6 (27.27) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 9 (40.91) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Philbrook, NA | 1 |
| Nikolovska, A | 1 |
| Maciver, RD | 1 |
| Belanger, CL | 1 |
| Winn, LM | 1 |
| Gandhi, M | 1 |
| Rac, MWF | 1 |
| McKinney, J | 1 |
| Duan, HY | 2 |
| Zhang, Y | 2 |
| Zhou, KY | 2 |
| Wang, C | 2 |
| Qiu, DJ | 1 |
| Hua, YM | 2 |
| Wang, T | 1 |
| Li, YF | 1 |
| Arora, V | 1 |
| Joshi, A | 1 |
| Lall, M | 1 |
| Agarwal, S | 1 |
| Bijarnia Mahay, S | 1 |
| Dua Puri, R | 1 |
| Chander Verma, I | 1 |
| Ki, S | 1 |
| Kwon, SH | 1 |
| Eum, J | 1 |
| Raslan, AA | 1 |
| Kim, KN | 1 |
| Hwang, BJ | 1 |
| Kee, Y | 1 |
| Yu, WH | 1 |
| Ho, YL | 1 |
| Huang, PT | 1 |
| Chu, SL | 1 |
| Tsai, HJ | 1 |
| Liou, HH | 1 |
| Wu, G | 1 |
| Nan, C | 1 |
| Rollo, JC | 1 |
| Huang, X | 1 |
| Tian, J | 1 |
| Ozkan, H | 1 |
| Cetinkaya, M | 1 |
| Köksal, N | 1 |
| Yapici, S | 1 |
| ten Berg, K | 1 |
| van Oppen, AC | 1 |
| Nikkels, PG | 1 |
| Gittenberger-de Groot, AC | 1 |
| van der Voet, GB | 1 |
| Brilstra, EH | 1 |
| Lindhout, D | 1 |
| Hurst, HS | 1 |
| Clothier, RH | 1 |
| Pratten, M | 1 |
| DiLiberti, JH | 1 |
| Farndon, PA | 1 |
| Dennis, NR | 1 |
| Curry, CJ | 1 |
| Sonoda, T | 2 |
| Ohdo, S | 2 |
| Ohba, K | 2 |
| Okishima, T | 2 |
| Hayakawa, K | 2 |
| Thisted, E | 1 |
| Ebbesen, F | 1 |
| Lorenzo Sanz, G | 1 |
| Serna Saugar, C | 1 |
| Quintana Castilla, A | 1 |
| Lozano Giménez, C | 1 |
| Aparicio Meix, JM | 1 |
| Alla, P | 1 |
| Philip, N | 1 |
| Azulay, JP | 1 |
| Attarian, S | 1 |
| Pouget, J | 1 |
| Gardner, RJ | 1 |
| Savarirayan, R | 1 |
| Dunne, KB | 1 |
| McLellan, JA | 1 |
| Coleman, LT | 1 |
| Suthers, GK | 1 |
| Sodhi, P | 1 |
| Poddar, B | 1 |
| Parmar, V | 1 |
| Tanaka, H | 1 |
| Takeda, A | 1 |
| Izumi, M | 1 |
| Okada, H | 1 |
| Ishikawa, S | 1 |
| Bertollini, R | 1 |
| Mastroiacovo, P | 1 |
| Segni, G | 1 |
22 other studies available for valproic acid and Abnormality, Heart
| Article | Year |
|---|---|
Characterizing the effects of in utero exposure to valproic acid on murine fetal heart development.
Topics: Acetylation; Animals; Cell Differentiation; Embryonic Development; Female; Fetal Development; Fetal | 2019 |
Radial Ray Malformation.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Amniocentesis; Amniotic Band Syndrome; Anal Ca | 2019 |
[Effect of histone acetylation/deacetylation imbalances on key gene of planar cell polarity pathway].
Topics: Acetylation; Animals; Cell Polarity; Cells, Cultured; Fetal Heart; Heart Defects, Congenital; Histon | 2017 |
Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice.
Topics: Animals; Cell Polarity; Enzyme Inhibitors; Female; Fetal Heart; Heart Defects, Congenital; Histone D | 2018 |
Fetal valproate syndrome as a phenocopy of Kleefstra syndrome.
Topics: Abnormalities, Drug-Induced; Adult; Child, Preschool; Chromosome Deletion; Chromosomes, Human, Pair | 2018 |
3D light-sheet assay assessing novel valproate-associated cardiotoxicity and folic acid relief in zebrafish embryogenesis.
Topics: Animals; Biological Assay; Cardiotoxicity; Diagnostic Imaging; Embryo, Nonmammalian; Embryonic Devel | 2019 |
The Phosphorylation State of GSK3β Serine 9 Correlated to the Development of Valproic Acid-Associated Fetal Cardiac Teratogenicity, Fetal VPA Syndrome, Rescued by Folic Acid Administration.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Bradycardia; Cell Proliferation; Dose-Respo | 2016 |
Sodium valproate-induced congenital cardiac abnormalities in mice are associated with the inhibition of histone deacetylase.
Topics: Animals; Anticonvulsants; Female; Heart Defects, Congenital; Histone Deacetylase 1; Histone Deacetyl | 2010 |
Severe fetal valproate syndrome: combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Craniosynostoses; Fatal Outcome; Female; Heart | 2011 |
Complex cardiac defect with hypoplastic right ventricle in a fetus with valproate exposure.
Topics: Abortion, Induced; Adult; Anticonvulsants; Diagnosis, Differential; Epilepsy; Female; Heart Defects, | 2005 |
An evaluation of a novel chick cardiomyocyte micromass culture assay with two teratogens/embryotoxins associated with heart defects.
Topics: Animal Testing Alternatives; Animals; Anticonvulsants; Antineoplastic Agents; Cell Culture Technique | 2007 |
The fetal valproate syndrome.
Topics: Epilepsy; Face; Female; Heart Defects, Congenital; Humans; Infant, Low Birth Weight; Infant, Newborn | 1984 |
Sodium valproate-induced cardiovascular abnormalities in the Jcl:ICR mouse fetus: peak sensitivity of gestational day and dose-dependent effect.
Topics: Animals; Dose-Response Relationship, Drug; Female; Fetal Death; Fetal Resorption; Fetus; Heart Defec | 1993 |
Malformations, withdrawal manifestations, and hypoglycaemia after exposure to valproate in utero.
Topics: Drug Administration Schedule; Epilepsy; Female; Heart Defects, Congenital; Humans; Infant, Newborn; | 1993 |
[Severe bone malformations in fetal valproic acid disease].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Face; Heart Defects, Congenita | 1993 |
[Epilepsy in an adult with chromosome 22q11 micro-deletion].
Topics: Adult; Anticonvulsants; Atrophy; Brain; Chromosome Deletion; Chromosomes, Human, Pair 22; DiGeorge S | 1999 |
Valproate and other anticonvulsants for psychiatric disorders.
Topics: Abnormalities, Drug-Induced; Acetates; Adult; Amines; Anti-Anxiety Agents; Anticonvulsants; Bipolar | 2000 |
Microlissencephaly with cardiac, spinal and urogenital defects.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Brain; Fetal Diseases; Heart | 2001 |
Fatal cardiac malformation in fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Epilepsy; Fatal Outcome; Female; Heart Defects, | 2001 |
[Effects of antiepileptic drugs on delivery and early childhood--comparison among mono-therapies of valproic acid, phenytoin, carbamazepine and phenobarbital].
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Birth Weight; Carbamazepine; Embryonic and Feta | 1991 |
Teratogenic effects of sodium valproate in the Jcl: ICR mouse fetus.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Gestational Age; Heart Defects, Congenital; Hum | 1990 |
Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC).
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1985 |