valproic acid has been researched along with Abnormalities, Multiple in 47 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Abnormalities, Multiple: Congenital abnormalities that affect more than one organ or body structure.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy." | 7.72 | Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003) |
| "Valproic acid (VPA) is a known teratogenic drug." | 5.40 | Middle and inner ear malformations in two siblings exposed to valproic acid during pregnancy: a case report. ( Casselman, J; De Kegel, A; Dhooge, I; Janssens, S; Maes, L; Van Houtte, E, 2014) |
| "In order to establish the etiology of autism with facial palsy, research into developmental abnormalities of the peripheral facial nerves is necessary." | 5.37 | Morphological abnormalities of embryonic cranial nerves after in utero exposure to valproic acid: implications for the pathogenesis of autism with multiple developmental anomalies. ( Imura, Y; Narita, M; Narita, N; Oyabu, A; Tashiro, Y; Uchida, A, 2011) |
| "Pregnancy was otherwise uneventful." | 5.32 | Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero. ( Audeoud, F; Bernardin, A; Gaugler, C; Messer, J; Stoll, C, 2003) |
| "Valproate embryopathy is a well recognized syndrome caused by prenatal exposure to the anticonvulsant valproic acid (Depakote)." | 3.73 | Valproate embryopathy: clinical and cognitive profile in 5 siblings. ( Oppenheimer, SG; Saal, HM; Schorry, EK, 2005) |
| " The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy." | 3.72 | Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003) |
| "The use of valproic acid during pregnancy has been associated with adverse fetal outcomes, including major and minor congenital malformations, intrauterine growth retardation (IUGR), hyperbilirubinemia, hepatotoxicity, transient hyperglycemia, and fetal and neonatal distress." | 3.71 | Septo-optic dysplasia as a manifestation of valproic acid embryopathy. ( Braddock, SR; McMahon, CL, 2001) |
| "Teratogenic chemicals (2,3,7, 8-tetrachlorodibenzo-p-dioxin [TCDD], ethyl carbamate [urethane], methylnitrosourea [MNU], or valproic acid [VA]) were given to pregnant mice to induce cleft palate (TCDD, urethane), digital defects (urethane, MNU), or exencephaly (VA)." | 3.70 | Nonspecific stimulation of the maternal immune system. I. Effects On teratogen-induced fetal malformations. ( Blaylock, BL; Gogal, RM; Holladay, SD; Sharova, L; Smith, BJ; Ward, DL, 2000) |
| "Four infants who were exposed to sodium valproate or valproic acid during pregnancy are described." | 3.67 | Fetal valproate syndrome: is there a recognisable phenotype? ( Burn, J; Donnai, D; Tucker, SM; Winter, RM, 1987) |
| "Neural tube defects were seen in 3% of the sample." | 2.41 | Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature. ( Kozma, C, 2001) |
| "Valproic acid is an anticonvulsant that has been associated with open neural tube defects." | 2.38 | Valproic acid prenatal exposure. Association with lipomyelomeningocele. ( Carter, BS; Stewart, JM, 1989) |
| "Valproic acid has probable teratogenic potential in humans but the number of reported cases is few and the spectrum of anomalies is broad so it is not possible to delineate a definite fetal valproate syndrome." | 2.37 | Congenital malformations associated with maternal use of valproic acid. ( Gauthier, M; Huot, C; Larbrisseau, A; Lebel, M, 1987) |
| " In conclusion, MDC-1112 should be further explored as a potential agent to be used in combination with GEM for treating PC." | 1.56 | Phospho-valproic acid (MDC-1112) reduces pancreatic cancer growth in patient-derived tumor xenografts and KPC mice: enhanced efficacy when combined with gemcitabine. ( Digiovanni, MG; Lacomb, JF; Luo, D; Mackenzie, GG; Rigas, B; Wei, R; Williams, JL, 2020) |
| "Valproic acid (VPA) is a known teratogenic drug." | 1.40 | Middle and inner ear malformations in two siblings exposed to valproic acid during pregnancy: a case report. ( Casselman, J; De Kegel, A; Dhooge, I; Janssens, S; Maes, L; Van Houtte, E, 2014) |
| "Valproic acid (VPA) is a teratogenic drug used in pregnant women for the treatment of epilepsy and mood disorders." | 1.37 | Severe fetal valproate syndrome: combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly. ( Cetinkaya, M; Köksal, N; Ozkan, H; Yapici, S, 2011) |
| "In order to establish the etiology of autism with facial palsy, research into developmental abnormalities of the peripheral facial nerves is necessary." | 1.37 | Morphological abnormalities of embryonic cranial nerves after in utero exposure to valproic acid: implications for the pathogenesis of autism with multiple developmental anomalies. ( Imura, Y; Narita, M; Narita, N; Oyabu, A; Tashiro, Y; Uchida, A, 2011) |
| "Non-treated homozygous polydactyly/arhinencephaly (Pdn/Pdn) mouse fetuses exhibited exencephaly in 16." | 1.33 | Exencephaly induction by valproic acid in the genetic polydactyly/arhinencephaly mouse, Pdn/Pdn. ( Katagiri, R; Maekawa, M; Naruse, I; Ohta, K; Ueta, E, 2005) |
| "Pregnancy was otherwise uneventful." | 1.32 | Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero. ( Audeoud, F; Bernardin, A; Gaugler, C; Messer, J; Stoll, C, 2003) |
| " However, there is no information available on the number of therapeutic abortions, or the different types of epilepsy or drug dosage in the two treatment groups." | 1.32 | Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study. ( Källén, B; Wide, K; Winbladh, B, 2004) |
| "Valproic acid (VPA) is an antiepileptic drug used clinically." | 1.32 | Effect of valproic acid on fetal and maternal organs in the mouse: a morphological study. ( Emmanouil-Nikoloussi, EN; Foroglou, NG; Kerameos-Foroglou, CH; Thliveris, JA, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (14.89) | 18.7374 |
| 1990's | 14 (29.79) | 18.2507 |
| 2000's | 19 (40.43) | 29.6817 |
| 2010's | 6 (12.77) | 24.3611 |
| 2020's | 1 (2.13) | 2.80 |
| Authors | Studies |
|---|---|
| Luo, D | 1 |
| Digiovanni, MG | 1 |
| Wei, R | 1 |
| Lacomb, JF | 1 |
| Williams, JL | 1 |
| Rigas, B | 1 |
| Mackenzie, GG | 1 |
| Gandhi, M | 1 |
| Rac, MWF | 1 |
| McKinney, J | 1 |
| Hesemann, J | 1 |
| Lauer, E | 1 |
| Ziska, S | 1 |
| Noonan, K | 1 |
| Nemeth, B | 1 |
| Scott-Schwoerer, J | 1 |
| McCarty, C | 1 |
| Rasmussen, K | 1 |
| Goldberg, JM | 1 |
| Sund, S | 1 |
| Eickhoff, J | 1 |
| Raggio, CL | 1 |
| Giampietro, PF | 1 |
| Van Houtte, E | 1 |
| Casselman, J | 1 |
| Janssens, S | 1 |
| De Kegel, A | 1 |
| Maes, L | 1 |
| Dhooge, I | 1 |
| Sargar, KM | 1 |
| Herman, TE | 1 |
| Siegel, MJ | 1 |
| Seidahmed, MZ | 2 |
| Miqdad, AM | 1 |
| Al-Dohami, HS | 1 |
| Shareefi, OM | 1 |
| Al-Mendalawi, MD | 1 |
| Ozkan, H | 1 |
| Cetinkaya, M | 1 |
| Köksal, N | 1 |
| Yapici, S | 1 |
| Tashiro, Y | 1 |
| Oyabu, A | 1 |
| Imura, Y | 1 |
| Uchida, A | 1 |
| Narita, N | 1 |
| Narita, M | 1 |
| Malm, H | 1 |
| Kajantie, E | 1 |
| Kivirikko, S | 1 |
| Kääriäinen, H | 1 |
| Peippo, M | 1 |
| Somer, M | 2 |
| Ozkinay, F | 1 |
| Cogulu, O | 1 |
| Gunduz, C | 1 |
| Yilmaz, D | 1 |
| Kultursay, N | 1 |
| Toomes, M | 1 |
| Maleck, WH | 1 |
| Koetter, KP | 1 |
| Petroianu, GA | 1 |
| Stoll, C | 1 |
| Audeoud, F | 1 |
| Gaugler, C | 1 |
| Bernardin, A | 1 |
| Messer, J | 1 |
| Wide, K | 1 |
| Winbladh, B | 1 |
| Källén, B | 1 |
| Emmanouil-Nikoloussi, EN | 1 |
| Foroglou, NG | 1 |
| Kerameos-Foroglou, CH | 1 |
| Thliveris, JA | 1 |
| Schorry, EK | 1 |
| Oppenheimer, SG | 1 |
| Saal, HM | 1 |
| de Oliveira, RS | 1 |
| Lajeunie, E | 1 |
| Arnaud, E | 1 |
| Greensmith, A | 1 |
| Renier, D | 1 |
| Alsdorf, R | 1 |
| Wyszynski, DF | 1 |
| Maekawa, M | 1 |
| Ohta, K | 1 |
| Katagiri, R | 1 |
| Ueta, E | 1 |
| Naruse, I | 1 |
| Nanjiani, A | 1 |
| Hossain, A | 1 |
| Mahgoub, N | 1 |
| Bailey, CJ | 1 |
| Pool, RW | 1 |
| Poskitt, EM | 1 |
| Harris, F | 1 |
| Bantz, EW | 1 |
| Okada, T | 1 |
| Tomoda, T | 1 |
| Hisakawa, H | 1 |
| Kurashige, T | 1 |
| Ylagan, LR | 1 |
| Budorick, NE | 1 |
| Sharony, R | 1 |
| Garber, A | 1 |
| Viskochil, D | 1 |
| Schreck, R | 1 |
| Platt, LD | 1 |
| Ward, R | 1 |
| Buehler, BA | 1 |
| Graham, JM | 1 |
| Lorenzo Sanz, G | 1 |
| Serna Saugar, C | 1 |
| Quintana Castilla, A | 1 |
| Lozano Giménez, C | 1 |
| Aparicio Meix, JM | 1 |
| Clayton-Smith, J | 1 |
| Donnai, D | 2 |
| Hockey, A | 1 |
| Bower, C | 1 |
| Goldblatt, J | 1 |
| Knowles, S | 1 |
| Faiella, A | 1 |
| Wernig, M | 1 |
| Consalez, GG | 1 |
| Hostick, U | 1 |
| Hofmann, C | 1 |
| Hustert, E | 1 |
| Boncinelli, E | 1 |
| Balling, R | 1 |
| Nadeau, JH | 1 |
| Sharief, N | 1 |
| Adams, T | 1 |
| Butler, L | 1 |
| Gnanaratnam, J | 1 |
| Sonoda, T | 1 |
| Holladay, SD | 1 |
| Sharova, L | 1 |
| Smith, BJ | 1 |
| Gogal, RM | 1 |
| Ward, DL | 1 |
| Blaylock, BL | 1 |
| Kozma, C | 1 |
| Gardner, RJ | 1 |
| Savarirayan, R | 1 |
| Dunne, KB | 1 |
| McLellan, JA | 1 |
| Coleman, LT | 1 |
| Suthers, GK | 1 |
| McMahon, CL | 1 |
| Braddock, SR | 1 |
| Buntinx, IM | 1 |
| Ikonen, E | 1 |
| Salo, A | 1 |
| Somer, H | 1 |
| Pääkkönen, L | 1 |
| Peltonen, L | 1 |
| Elmazar, MM | 1 |
| Thiel, R | 1 |
| Nau, H | 1 |
| Dawson, DA | 1 |
| Palea, KM | 1 |
| Verloes, A | 1 |
| Frikiche, A | 1 |
| Gremillet, C | 1 |
| Paquay, T | 1 |
| Decortis, T | 1 |
| Rigo, J | 1 |
| Senterre, J | 1 |
| Vanfleteren, M | 1 |
| Crolla, D | 1 |
| Vermeulen, J | 1 |
| Devos, E | 1 |
| Carter, BS | 1 |
| Stewart, JM | 1 |
| Durá, T | 1 |
| Moya, M | 1 |
| Muñoz, M | 1 |
| Juste, M | 1 |
| Castaño, C | 1 |
| Huot, C | 1 |
| Gauthier, M | 1 |
| Lebel, M | 1 |
| Larbrisseau, A | 1 |
| Winter, RM | 1 |
| Burn, J | 1 |
| Tucker, SM | 1 |
| Tein, I | 1 |
| MacGregor, DL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects and Consequences for Mother and Child From Treatment for Depression, A Prospective Randomized, Placebo- Controlled, Trial With Internet-based Cognitive Behavior Therapy and Sertraline or Placebo for Moderate Depression in Pregnancy[NCT02185547] | Phase 4 | 17 participants (Actual) | Interventional | 2016-02-21 | Terminated (stopped due to Difficulties in recruiting participants.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for valproic acid and Abnormalities, Multiple
| Article | Year |
|---|---|
Teratogenicity of sodium valproate.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Animals; Autistic Disorder; Cleft Lip; | 2005 |
[Fetal valproate syndrome].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Diagnosis, Differential; Fema | 2000 |
Valproic acid embryopathy: report of two siblings with further expansion of the phenotypic abnormalities and a review of the literature.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Epilepsy; Face; Female | 2001 |
Valproic acid prenatal exposure. Association with lipomyelomeningocele.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Cleft Palate; Female; | 1989 |
Congenital malformations associated with maternal use of valproic acid.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Epilepsy; Facial Bones; Female | 1987 |
42 other studies available for valproic acid and Abnormalities, Multiple
| Article | Year |
|---|---|
Phospho-valproic acid (MDC-1112) reduces pancreatic cancer growth in patient-derived tumor xenografts and KPC mice: enhanced efficacy when combined with gemcitabine.
Topics: Abnormalities, Multiple; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Li | 2020 |
Radial Ray Malformation.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Amniocentesis; Amniotic Band Syndrome; Anal Ca | 2019 |
Analysis of maternal risk factors associated with congenital vertebral malformations.
Topics: Abnormalities, Multiple; Adolescent; Adult; Alcohol Drinking; Child; Clomiphene; Diabetes Mellitus, | 2013 |
Middle and inner ear malformations in two siblings exposed to valproic acid during pregnancy: a case report.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Developmental Disabil | 2014 |
Valproate fetopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Diagnostic Imaging; Epilepsy; Female; Fetal Di | 2015 |
A case of fetal valproate syndrome with new features expanding the phenotype.
Topics: Abnormalities, Multiple; Anticonvulsants; Epilepsy, Post-Traumatic; Female; Fetus; Humans; Infant; P | 2009 |
A case of fetal valproate syndrome with new features expanding the phenotype.
Topics: Abnormalities, Multiple; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant; Phenotype; Pregna | 2009 |
Severe fetal valproate syndrome: combination of complex cardiac defect, multicystic dysplastic kidney, and trigonocephaly.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Craniosynostoses; Fatal Outcome; Female; Heart | 2011 |
Morphological abnormalities of embryonic cranial nerves after in utero exposure to valproic acid: implications for the pathogenesis of autism with multiple developmental anomalies.
Topics: Abnormalities, Multiple; Animals; Anticonvulsants; Autistic Disorder; Cranial Nerves; Disease Models | 2011 |
Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Developmental Disabil | 2002 |
Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Chromosome Aberrations | 2003 |
Out-of-hospital management of benzodiazepine-resistant status epilepticus in a child with Wolf-Hirschhorn syndrome.
Topics: Abnormalities, Multiple; Anticonvulsants; Apnea; Child; Chromosome Deletion; Chromosomes, Human, Pai | 2003 |
Multiple congenital malformations including generalized hypertrichosis with gum hypertrophy in a child exposed to valproic acid in utero.
Topics: Abnormalities, Multiple; Anticonvulsants; Dermatoglyphics; Epilepsy; Fatal Outcome; Female; Gingiva; | 2003 |
Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study.
Topics: Abnormalities, Multiple; Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Fetal Diseases; Hu | 2004 |
Effect of valproic acid on fetal and maternal organs in the mouse: a morphological study.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Female; Fetus; Gestational Age; Growt | 2004 |
Valproate embryopathy: clinical and cognitive profile in 5 siblings.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child; Child Behavior; Child, | 2005 |
Baller-Gerold syndrome after fetal exposure to sodium valproate.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Craniosynostoses; Female; Hum | 2005 |
Exencephaly induction by valproic acid in the genetic polydactyly/arhinencephaly mouse, Pdn/Pdn.
Topics: Abnormalities, Multiple; Animals; Craniofacial Abnormalities; Down-Regulation; Fibroblast Growth Fac | 2005 |
Patau syndrome.
Topics: Abnormalities, Multiple; Antipsychotic Agents; Chromosomes, Human, Pair 13; Delusions; Face; Female; | 2007 |
Valproic acid and fetal abnormality.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Female; Humans; Infant, Newbo | 1983 |
Valproic acid and congenital malformations. A case report.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Epilepsy; Female; Humans; Infant, Newbo | 1984 |
Fetal valproate syndrome with reduction deformity of limb.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Arm; Face; Female; Humans; Infant, Newborn; Va | 1995 |
Radial ray aplasia in utero: a prenatal finding associated with valproic acid exposure.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Carbamazepine; Epilepsy, Absence; Female; Huma | 1994 |
Preaxial ray reduction defects as part of valproic acid embryofetopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Therapeutic; Adolescent; Adult; Extr | 1993 |
[Severe bone malformations in fetal valproic acid disease].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Face; Heart Defects, Congenita | 1993 |
Fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Epilepsy; Face; Female; Human | 1995 |
Fetal valproate embryopathy in twins: genetic modification of the response to a teratogen.
Topics: Abnormalities, Multiple; Adult; Anticonvulsants; Diseases in Twins; Epilepsy; Female; Humans; Infant | 1996 |
A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Anticonvulsants; Carcinoma, Embryonal | 2000 |
A child with a DIC (15p; 22p) centric fusion and fetal Valproate syndrome.
Topics: Abnormalities, Multiple; Adult; Chromosome Aberrations; Chromosomes, Human, Pair 15; Chromosomes, Hu | 1999 |
Nonspecific stimulation of the maternal immune system. I. Effects On teratogen-induced fetal malformations.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adjuvants, Immunologic; Animals; BCG Vaccine; | 2000 |
Microlissencephaly with cardiac, spinal and urogenital defects.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Brain; Fetal Diseases; Heart | 2001 |
Septo-optic dysplasia as a manifestation of valproic acid embryopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adolescent; Antimanic Agents; Child, Preschool | 2001 |
Preaxial polydactyly in the fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Face; Female; Fingers; Humans; Infant, Newborn | 1992 |
Terminal deletion of chromosome 4p (4p16.3) shows a breakpoint between loci linked to Huntington disease.
Topics: Abnormalities, Multiple; Adolescent; Chromosome Banding; Chromosome Deletion; Chromosomes, Human, Pa | 1992 |
Effect of supplementation with folinic acid, vitamin B6, and vitamin B12 on valproic acid-induced teratogenesis in mice.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Drug Interactions; Embryo, Mammalian; | 1992 |
Additive incidence of developmental malformation for Xenopus embryos exposed to a mixture of ten aliphatic carboxylic acids.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Butyrates; Butyric Acid; Caproates; C | 1991 |
The fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child, Preschool; Face; Female; Humans; Male; | 1991 |
Proximal phocomelia and radial ray aplasia in fetal valproic syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Ectromelia; Female; Humans; In | 1990 |
Depakine-induced embryopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Bone and Bones; Humans; Infant, Newborn; Radio | 1990 |
[Combination of hydantoins and valproate. Evidence of its teratogenic effect in 4 consecutive gestations].
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Drug Therapy, Combina | 1986 |
Fetal valproate syndrome: is there a recognisable phenotype?
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Epilepsy, Tonic-Clonic; Female; Humans; Infant | 1987 |
Possible valproate teratogenicity.
Topics: Abnormalities, Multiple; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fetal Exchange; Neural | 1985 |