valproic acid has been researched along with Abnormalities, Congenital in 22 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lamotrigine (LTG) is increasingly being prescribed in pregnancy for women with epilepsy in place of valproate (VPA), because of the teratogenic risks associated with the latter." | 7.76 | Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJ, 2010) |
| "Lamotrigine (LTG) is increasingly being prescribed in pregnancy for women with epilepsy in place of valproate (VPA), because of the teratogenic risks associated with the latter." | 3.76 | Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJ, 2010) |
| "Full seizure control in the pre-pregnancy year, and adjusting antiepileptic drug doses to maintain plasma drug concentrations throughout pregnancy at values associated with seizure control before pregnancy, have major influences in preserving seizure control during pregnancy." | 2.50 | Treating epilepsy in pregnant women. ( Eadie, MJ, 2014) |
| "Seizures and intracranial hemorrhage are possible medical diseases that any obstetrician may encounter." | 2.49 | Seizures and intracranial hemorrhage. ( Alexander, JM; Wilson, KL, 2013) |
| "Juvenile myoclonic epilepsy is a common idiopathic generalized epileptic syndrome that includes generalized myoclonic seizures and commonly generalized tonic-clonic and generalized absence seizures." | 2.45 | The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent? ( Abou-Khalil, B; Montouris, G, 2009) |
| " While women younger than 50 years of age were less likely to be prescribed valproate than men in the same age group, and at a lower dosage, it is unclear to what extent this reflects clinicians' concerns about teratogenicity or is driven by perceptions of the indication for valproate, and the dosage required, for the treatment of different phases of the disorder in men and women." | 1.48 | A UK clinical audit addressing the quality of prescribing of sodium valproate for bipolar disorder in women of childbearing age. ( Barnes, TRE; Bhatti, S; Cookson, J; Fagan, E; Ferrier, IN; Paton, C, 2018) |
| " These changes tended to parallel prescribing trends in the wider community, except for valproate, whose prescribing in the overall community increased as its prescribing, and its dosage prescribed, decreased in pregnancy." | 1.36 | Changing patterns of antiepileptic drug use in pregnant Australian women. ( Eadie, MJ; Graham, J; Hitchcock, AA; Hollingworth, S; Lander, CM; O'Brien, TJ; Vajda, FJ, 2010) |
| "The incidence of birth defects in relation to specific AEDs was: valproate (16." | 1.32 | The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months. ( Graham, J; Hitchcock, A; Lander, C; O'Brien, TJ; Vajda, FJ, 2003) |
| " It is concluded that 2-EH is not developmentally toxic by the dermal route in the Fischer 344 rat at and below treatment levels which produce maternal toxicity." | 1.28 | The developmental toxicity of 2-ethylhexanol applied dermally to pregnant Fischer 344 rats. ( Astill, BD; Fisher, LC; Gingell, R; Guest, D; Hodgson, JR; Kubena, MF; Murphy, SR; Tyl, RW; Tyler, TR; Vrbanic, MA, 1992) |
| "Spina Bifida, Congenital Heart Defects, Clefts, Diaphragmatic Hernia and Trisomy 18 were more frequent than expected among babies with maternal epilepsy." | 1.27 | Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC). ( Bertollini, R; Mastroiacovo, P; Segni, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 5 (22.73) | 18.2507 |
| 2000's | 6 (27.27) | 29.6817 |
| 2010's | 10 (45.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Paton, C | 1 |
| Cookson, J | 1 |
| Ferrier, IN | 1 |
| Bhatti, S | 1 |
| Fagan, E | 1 |
| Barnes, TRE | 1 |
| Morris, JK | 1 |
| Garne, E | 1 |
| Loane, M | 1 |
| Addor, MC | 1 |
| Barisic, I | 1 |
| Bianchi, F | 1 |
| Gatt, M | 1 |
| Lanzoni, M | 1 |
| Lynch, C | 1 |
| Mokoroa, O | 1 |
| Nelen, V | 1 |
| Neville, A | 1 |
| O'Mahony, MT | 1 |
| Randrianaivo-Ranjatoelina, H | 1 |
| Rissmann, A | 1 |
| Tucker, D | 1 |
| de Walle, HEK | 1 |
| Zymak-Zakutnia, N | 1 |
| Rankin, J | 1 |
| Galappatthy, P | 1 |
| Liyanage, CK | 1 |
| Lucas, MN | 1 |
| Jayasekara, DTLM | 1 |
| Abhayaratna, SA | 1 |
| Weeraratne, C | 1 |
| De Abrew, K | 1 |
| Gunaratne, PS | 1 |
| Gamage, R | 1 |
| Wijeyaratne, CN | 1 |
| Wilson, KL | 1 |
| Alexander, JM | 1 |
| Miller, MW | 1 |
| Church, CC | 1 |
| Adedinsewo, DA | 1 |
| Thurman, DJ | 1 |
| Luo, YH | 1 |
| Williamson, RS | 1 |
| Odewole, OA | 1 |
| Oakley, GP | 1 |
| Onishi, Y | 1 |
| Okada, A | 2 |
| Noyori, H | 1 |
| Okamura, A | 1 |
| Hen, N | 1 |
| Yagen, B | 1 |
| Bialer, M | 1 |
| Fujiwara, M | 2 |
| Eadie, MJ | 3 |
| Veiby, G | 1 |
| Daltveit, AK | 1 |
| Engelsen, BA | 1 |
| Gilhus, NE | 1 |
| Montouris, G | 1 |
| Abou-Khalil, B | 1 |
| Vajda, FJ | 3 |
| Hollingworth, S | 1 |
| Graham, J | 2 |
| Hitchcock, AA | 2 |
| O'Brien, TJ | 3 |
| Lander, CM | 2 |
| Graham, JE | 1 |
| Hitchcock, A | 1 |
| Lander, C | 1 |
| Van Maele-Fabry, G | 1 |
| Clotman, F | 1 |
| Gofflot, F | 1 |
| Bosschaert, J | 1 |
| Picard, JJ | 1 |
| Barnes, GL | 1 |
| Alexander, PG | 1 |
| Hsu, CW | 1 |
| Mariani, BD | 1 |
| Tuan, RS | 1 |
| Prieto, L | 1 |
| Martínez-Frías, ML | 1 |
| Canger, R | 1 |
| Battino, D | 1 |
| Canevini, MP | 1 |
| Fumarola, C | 1 |
| Guidolin, L | 1 |
| Vignoli, A | 1 |
| Mamoli, D | 1 |
| Palmieri, C | 1 |
| Molteni, F | 1 |
| Granata, T | 1 |
| Hassibi, P | 1 |
| Zamperini, P | 1 |
| Pardi, G | 1 |
| Avanzini, G | 1 |
| Bauer, J | 1 |
| Holmes, LB | 1 |
| Harvey, EA | 1 |
| Coull, BA | 1 |
| Huntington, KB | 1 |
| Khoshbin, S | 1 |
| Hayes, AM | 1 |
| Ryan, LM | 1 |
| Tyl, RW | 1 |
| Fisher, LC | 1 |
| Kubena, MF | 1 |
| Vrbanic, MA | 1 |
| Gingell, R | 1 |
| Guest, D | 1 |
| Hodgson, JR | 1 |
| Murphy, SR | 1 |
| Tyler, TR | 1 |
| Astill, BD | 1 |
| Bertollini, R | 1 |
| Mastroiacovo, P | 1 |
| Segni, G | 1 |
5 reviews available for valproic acid and Abnormalities, Congenital
| Article | Year |
|---|---|
Seizures and intracranial hemorrhage.
Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; H | 2013 |
Arrhenius thermodynamics and birth defects: chemical teratogen synergy. Untested, testable, and projected relevance.
Topics: Abnormalities, Drug-Induced; Animals; Congenital Abnormalities; Drug Synergism; Female; Fever; Human | 2013 |
Treating epilepsy in pregnant women.
Topics: Anticonvulsants; Congenital Abnormalities; Epilepsy; Female; Humans; Intellectual Disability; Matern | 2014 |
The first line of therapy in a girl with juvenile myoclonic epilepsy: should it be valproate or a new agent?
Topics: Anticonvulsants; Congenital Abnormalities; Delayed-Action Preparations; Drug Design; Epilepsy, Gener | 2009 |
Epilepsy therapy: issues for women and men.
Topics: Anticonvulsants; Congenital Abnormalities; Epilepsy; Epilepsy, Temporal Lobe; Female; Humans; Infert | 2001 |
17 other studies available for valproic acid and Abnormalities, Congenital
| Article | Year |
|---|---|
A UK clinical audit addressing the quality of prescribing of sodium valproate for bipolar disorder in women of childbearing age.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Age Factors; Antimanic Agents; Bipolar Disorder; Cli | 2018 |
Prevalence of valproate syndrome in Europe from 2005 to 2014: A registry based multi-centre study.
Topics: Adult; Anticonvulsants; Cognitive Dysfunction; Congenital Abnormalities; Epilepsy; Europe; Female; H | 2018 |
Obstetric outcomes and effects on babies born to women treated for epilepsy during pregnancy in a resource limited setting: a comparative cohort study.
Topics: Abortion, Spontaneous; Adolescent; Adult; Anticonvulsants; Body Height; Body Weight; Carbamazepine; | 2018 |
Valproate prescriptions for nonepilepsy disorders in reproductive-age women.
Topics: Adolescent; Adult; Anticonvulsants; Bipolar Disorder; Congenital Abnormalities; Drug Prescriptions; | 2013 |
Teratology study of amide derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide in NMRI mice.
Topics: Animals; Body Weight; Bone and Bones; Carboxylic Acids; Congenital Abnormalities; Embryo, Mammalian; | 2013 |
Pregnancy, delivery, and outcome for the child in maternal epilepsy.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Apgar Score; Birth Weight; Congenital Abnormali | 2009 |
Changing patterns of antiepileptic drug use in pregnant Australian women.
Topics: Anticonvulsants; Australia; Congenital Abnormalities; Epilepsy; Female; Humans; Linear Models; Pract | 2010 |
Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Australia; Congenital Abnormalities; Dose-Response Rel | 2010 |
The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months.
Topics: Abortion, Induced; Anticonvulsants; Australia; Carbamazepine; Cohort Studies; Congenital Abnormaliti | 2003 |
Molecular approaches to developmental malformations using analogous forms of valproic acid.
Topics: Animals; Anticonvulsants; Congenital Abnormalities; Embryo, Mammalian; Gene Expression Regulation, D | 2006 |
Postimplantation mouse embryos cultured in vitro. Assessment with whole-mount immunostaining and in situ hybridization.
Topics: Animals; Congenital Abnormalities; Culture Techniques; Embryo, Mammalian; Embryonic and Fetal Develo | 1997 |
Cloning and characterization of chicken Paraxis: a regulator of paraxial mesoderm development and somite formation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Basic Helix-Loop-Helix Transcription Factors; Chick Emb | 1997 |
Case-control studies using only malformed infants: are we interpreting the results correctly?
Topics: Abnormalities, Drug-Induced; Case-Control Studies; Congenital Abnormalities; Data Interpretation, St | 1999 |
Malformations in offspring of women with epilepsy: a prospective study.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Comorbidity; Congenital Abnormalities; | 1999 |
The teratogenicity of anticonvulsant drugs.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Case-Control Studies; Congenital Abnorm | 2001 |
The developmental toxicity of 2-ethylhexanol applied dermally to pregnant Fischer 344 rats.
Topics: Administration, Cutaneous; Animals; Body Weight; Congenital Abnormalities; Dose-Response Relationshi | 1992 |
Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC).
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1985 |