valproic acid has been researched along with Abnormalities, Congenital, Nervous System in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the general population, it is well established that periconceptual folic acid reduces the risk of neural tube defects (NTDs) and possibly other congenital abnormalities." | 5.05 | Valproate and folate: Congenital and developmental risks. ( Green, R; Reynolds, EH, 2020) |
| "Valproic acid (VPA) is a broad-spectrum anticonvulsant with well-documented teratogenic effects, but whose mechanism of action is largely unknown." | 1.31 | A role for protein kinase C and its substrates in the action of valproic acid in the brain: implications for neural plasticity. ( Lenox, RH; Meyer, EM; Watson, DG; Watterson, JM, 2002) |
| " Nulliparous female CD-1 mice were dosed intraperitoneally on day 8 of gestation with 340 mg/kg of sodium valproate." | 1.28 | Teratogenic effects on the neuroepithelium of the CD-1 mouse embryo exposed in utero to sodium valproate. ( De Philip, RM; Paulson, RB; Sucheston, ME; Turner, S, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Reynolds, EH | 1 |
| Green, R | 1 |
| Meador, KJ | 1 |
| Main, SL | 1 |
| Kulesza, RJ | 1 |
| Penovich, P | 1 |
| Gaily, E | 1 |
| Grewal, HK | 1 |
| Almullahassani, A | 1 |
| Grewal, J | 1 |
| Slater, JD | 1 |
| García-Herrero, D | 1 |
| Fernández-Torre, JL | 1 |
| Barrasa, J | 1 |
| Calleja, J | 1 |
| Pascual, J | 1 |
| Watterson, JM | 1 |
| Watson, DG | 1 |
| Meyer, EM | 1 |
| Lenox, RH | 1 |
| Turner, S | 1 |
| Sucheston, ME | 1 |
| De Philip, RM | 1 |
| Paulson, RB | 1 |
1 review available for valproic acid and Abnormalities, Congenital, Nervous System
| Article | Year |
|---|---|
Valproate and folate: Congenital and developmental risks.
Topics: Anticonvulsants; Brain; Female; Folic Acid; Humans; Nervous System Malformations; Neural Tube Defect | 2020 |
7 other studies available for valproic acid and Abnormalities, Congenital, Nervous System
| Article | Year |
|---|---|
Comment: valproate dose effects differ across congenital malformations.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Female; Humans; Nervous System Malformations; Pre | 2013 |
Repeated prenatal exposure to valproic acid results in cerebellar hypoplasia and ataxia.
Topics: Administration, Oral; Animals; Ataxia; Calbindins; Cell Size; Cerebellum; Developmental Disabilities | 2017 |
What can we say to women of reproductive age with epilepsy?
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; E | 2005 |
Partial agenesis of the corpus callosum in a patient with juvenile myoclonic epilepsy.
Topics: Adolescent; Agenesis of Corpus Callosum; Anticonvulsants; Chromosomes, Human, Pair 15; Corpus Callos | 2007 |
Abdominal epilepsy in an adolescent with bilateral perisylvian polymicrogyria.
Topics: Abdominal Pain; Adolescent; Adult; Cerebral Cortex; Electroencephalography; Epilepsy, Temporal Lobe; | 1998 |
A role for protein kinase C and its substrates in the action of valproic acid in the brain: implications for neural plasticity.
Topics: Animals; Anticonvulsants; Brain; Cell Differentiation; Cell Division; Cell Line, Transformed; Cytosk | 2002 |
Teratogenic effects on the neuroepithelium of the CD-1 mouse embryo exposed in utero to sodium valproate.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Electrophoresis, Gel, Two-Dimensional; Epithelium; Fema | 1990 |