valproic acid has been researched along with Abnormalities, Autosome in 16 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy." | 7.72 | Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003) |
| "Valproic acid has been previously associated with hematologic toxicity, including a reversible myelodysplasia-like syndrome without chromosomal abnormalities." | 5.33 | Acute leukemia associated with valproic acid treatment: a novel mechanism for leukemogenesis? ( Bair, AK; Coyle, TE; Mehdi, S; Stein, C; Vajpayee, N; Wright, J, 2005) |
| "This study explored whether valproic acid (VPA, a histone deacetylase inhibitor) could radiosensitize osteosarcoma and primary-culture tumor cells, and determined the mechanism of VPA-induced radiosensitization." | 3.85 | The Effect of VPA on Increasing Radiosensitivity in Osteosarcoma Cells and Primary-Culture Cells from Chemical Carcinogen-Induced Breast Cancer in Rats. ( Cai, Z; Feng, Z; Lim, D; Liu, G; Tian, Y; Tian, Z; Wang, H; Zhang, F, 2017) |
| " The mother had been treated with valproic acid (1800mg per day) and lamotrigine (100mg per day) throughout pregnancy." | 3.72 | Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality. ( Cogulu, O; Gunduz, C; Kultursay, N; Ozkinay, F; Yilmaz, D, 2003) |
| " Following treatment with antiepileptic drugs (AEDs), the patient developed several rare complications: after beginning therapy with phenytoin, the patient developed pseudolymphoma; after monotherapy with carbamazepine (CBZ), the patient thereafter developed myoclonic jerks of upper and lower limbs upon awakening; after one year of treatment with valproate (VPA) the patient developed clinical and immuno-haematological signs of SLE." | 3.69 | Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p. ( Diomedi, M; Gigli, GL; Masala, C; Placidi, F; Pomponi, MG; Scalise, A; Silvestri, G, 1996) |
| "Acute megakaryocytic leukemia (AMegL) is a biologically heterogenous subtype of acute myeloid leukemia (AML) that arises from megakaryocytes." | 2.53 | Acute megakaryocytic leukemia: What have we learned. ( Giri, S; Hahn, AW; Li, B; Martin, MG; Pathak, R; Prouet, P, 2016) |
| "Valproic acid (VPA) is a potent anticonvulsant that inhibits histone deacetylases." | 1.37 | Chromatin remodeling, cell proliferation and cell death in valproic acid-treated HeLa cells. ( Felisbino, MB; Mello, ML; Tamashiro, WM, 2011) |
| "Valproic acid has been previously associated with hematologic toxicity, including a reversible myelodysplasia-like syndrome without chromosomal abnormalities." | 1.33 | Acute leukemia associated with valproic acid treatment: a novel mechanism for leukemogenesis? ( Bair, AK; Coyle, TE; Mehdi, S; Stein, C; Vajpayee, N; Wright, J, 2005) |
| "A 25-year-old girl with mild mental retardation had a 6-year history of absence seizures, with occasional head drop." | 1.31 | Mild generalized epilepsy and developmental disorder associated with large inv dup(15). ( Canevini, MP; Canger, R; Cavani, S; Chifari, R; Elia, M; Guerrini, R; Pierluigi, M; Sgrò, V, 2002) |
| "From a series of 1,713 patients with craniosynostosis hospitalized between 1976 and 1996, 237 propositi with metopic synostosis were analyzed." | 1.30 | Syndromal and nonsyndromal primary trigonocephaly: analysis of a series of 237 patients. ( Lajeunie, E; Le Merrer, M; Marchac, D; Renier, D, 1998) |
| "Chromosome fragility was sought in a well-defined cohort of patients with Lennox-Gastaut epilepsy syndrome." | 1.28 | Chromosome fragility in the Lennox-Gastaut epilepsy syndrome. ( Beran, RG; Smith, A, 1992) |
| "Sister-chromatid exchange (SCE) and chromosome aberrations have been studied in peripheral lymphocytes of 20 epileptic children treated in monotherapy with valproic acid (VPA) for 6-52 months and in 2 matched control groups." | 1.28 | The effect of valproic acid on SCE and chromosome aberrations in epileptic children. ( Hu, LJ; Huang, YQ; Lu, BQ; Lu, XF, 1990) |
| "Spina Bifida, Congenital Heart Defects, Clefts, Diaphragmatic Hernia and Trisomy 18 were more frequent than expected among babies with maternal epilepsy." | 1.27 | Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC). ( Bertollini, R; Mastroiacovo, P; Segni, G, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, G | 1 |
| Wang, H | 1 |
| Zhang, F | 1 |
| Tian, Y | 1 |
| Tian, Z | 1 |
| Cai, Z | 1 |
| Lim, D | 1 |
| Feng, Z | 1 |
| Hahn, AW | 1 |
| Li, B | 1 |
| Prouet, P | 1 |
| Giri, S | 1 |
| Pathak, R | 1 |
| Martin, MG | 1 |
| Passeri, E | 1 |
| Wilson, AM | 1 |
| Primerano, A | 1 |
| Kondo, MA | 1 |
| Sengupta, S | 1 |
| Srivastava, R | 1 |
| Koga, M | 1 |
| Obie, C | 1 |
| Zandi, PP | 1 |
| Goes, FS | 1 |
| Valle, D | 1 |
| Rapoport, JL | 1 |
| Sawa, A | 1 |
| Kano, S | 1 |
| Ishizuka, K | 1 |
| Kini, U | 1 |
| Hurst, JA | 1 |
| Byren, JC | 1 |
| Wall, SA | 1 |
| Johnson, D | 1 |
| Wilkie, AO | 1 |
| Felisbino, MB | 1 |
| Tamashiro, WM | 1 |
| Mello, ML | 1 |
| Ohtaki, U | 1 |
| Ozawa, H | 1 |
| Ishizuka, T | 1 |
| Kamiishi, A | 1 |
| Sasaki, K | 1 |
| Nakajima, S | 1 |
| Katayama, A | 1 |
| Arimoto, K | 1 |
| Yagihashi, T | 1 |
| Kimiya, S | 1 |
| Chifari, R | 1 |
| Guerrini, R | 1 |
| Pierluigi, M | 1 |
| Cavani, S | 1 |
| Sgrò, V | 1 |
| Elia, M | 1 |
| Canger, R | 1 |
| Canevini, MP | 1 |
| Ozkinay, F | 1 |
| Cogulu, O | 1 |
| Gunduz, C | 1 |
| Yilmaz, D | 1 |
| Kultursay, N | 1 |
| Coyle, TE | 1 |
| Bair, AK | 1 |
| Stein, C | 1 |
| Vajpayee, N | 1 |
| Mehdi, S | 1 |
| Wright, J | 1 |
| Gigli, GL | 1 |
| Scalise, A | 1 |
| Silvestri, G | 1 |
| Diomedi, M | 1 |
| Placidi, F | 1 |
| Pomponi, MG | 1 |
| Masala, C | 1 |
| Lajeunie, E | 1 |
| Le Merrer, M | 1 |
| Marchac, D | 1 |
| Renier, D | 1 |
| Sharief, N | 1 |
| Adams, T | 1 |
| Butler, L | 1 |
| Gnanaratnam, J | 1 |
| Kotlarek, F | 1 |
| Faust, J | 1 |
| Smith, A | 1 |
| Beran, RG | 1 |
| Hu, LJ | 1 |
| Lu, XF | 1 |
| Lu, BQ | 1 |
| Huang, YQ | 1 |
| Bertollini, R | 1 |
| Mastroiacovo, P | 1 |
| Segni, G | 1 |
1 review available for valproic acid and Abnormalities, Autosome
| Article | Year |
|---|---|
Acute megakaryocytic leukemia: What have we learned.
Topics: Antineoplastic Agents; Aurora Kinase A; Azepines; Chromosome Aberrations; Chromosomes, Human, Pair 3 | 2016 |
15 other studies available for valproic acid and Abnormalities, Autosome
| Article | Year |
|---|---|
The Effect of VPA on Increasing Radiosensitivity in Osteosarcoma Cells and Primary-Culture Cells from Chemical Carcinogen-Induced Breast Cancer in Rats.
Topics: Animals; Cell Line, Tumor; Cells, Cultured; Chromosome Aberrations; DNA Breaks, Double-Stranded; DNA | 2017 |
Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities.
Topics: Adolescent; Adult; Azacitidine; Cell Culture Techniques; Cell Differentiation; Chromosome Aberration | 2015 |
Etiological heterogeneity and clinical characteristics of metopic synostosis: Evidence from a tertiary craniofacial unit.
Topics: Adolescent; Anticoagulants; Child; Child, Preschool; Chromosome Aberrations; Craniosynostoses; Enoxa | 2010 |
Chromatin remodeling, cell proliferation and cell death in valproic acid-treated HeLa cells.
Topics: Anticonvulsants; Cell Death; Cell Proliferation; Chromatin Assembly and Disassembly; Chromosome Aber | 2011 |
[Evaluation of serum total carnitine values in persons with severe motor and intellectual disabilities with enteral (tube) feeding].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Carnitine; Cerebral Palsy; Chromosome Aberrations; Disab | 2012 |
Mild generalized epilepsy and developmental disorder associated with large inv dup(15).
Topics: Adult; Age of Onset; Angelman Syndrome; Anticonvulsants; Chromosome Aberrations; Chromosome Inversio | 2002 |
Valproic acid and lamotrigine treatment during pregnancy. The risk of chromosomal abnormality.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anticonvulsants; Chromosome Aberrations | 2003 |
Acute leukemia associated with valproic acid treatment: a novel mechanism for leukemogenesis?
Topics: Acute Disease; Adult; Anticonvulsants; Chromosome Aberrations; Chromosomes, Human, Pair 7; Chromosom | 2005 |
Clinical case report: multiple idiosyncratic adverse effects of antiepileptic drugs in trisomy 9p.
Topics: Adult; Anticonvulsants; Brain; Carbamazepine; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1996 |
Syndromal and nonsyndromal primary trigonocephaly: analysis of a series of 237 patients.
Topics: Birth Weight; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Craniosynostose | 1998 |
A child with a DIC (15p; 22p) centric fusion and fetal Valproate syndrome.
Topics: Abnormalities, Multiple; Adult; Chromosome Aberrations; Chromosomes, Human, Pair 15; Chromosomes, Hu | 1999 |
Chromosomal investigations in children with pyknolepsy on dipropylacetate monotherapy.
Topics: Adolescent; Cells, Cultured; Child; Child, Preschool; Chromosome Aberrations; Chromosomes, Human; Ep | 1978 |
Chromosome fragility in the Lennox-Gastaut epilepsy syndrome.
Topics: Adolescent; Adult; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome | 1992 |
The effect of valproic acid on SCE and chromosome aberrations in epileptic children.
Topics: Adolescent; Child; Child, Preschool; Chromosome Aberrations; Dose-Response Relationship, Drug; Epile | 1990 |
Maternal epilepsy and birth defects: a case-control study in the Italian Multicentric Registry of Birth Defects (IPIMC).
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Chromosome Aberrations; Chromosome Disorders; Chromoso | 1985 |