valproic acid and ATLL
valproic acid has been researched along with ATLL in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Importantly, HTLV-1 does not cause ATLL through insertional mutagenesis." | 2.47 | [Virological aspects of HTLV-1 infection and new therapeutical concepts]. ( Mahieux, R, 2011) |
| "Profiling of cellular miRNAs on Adult T cell Leukemia (ATL) cells by Yamagishi et al." | 1.43 | Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients. ( Belrose, G; Césaire, R; Gazon, H; Meniane, JC; Mesnard, JM; Peloponese, JM; Terol, M, 2016) |
| " Herein, we tested if valproic acid and the novel orally bioavailable HDACi, AR-42 reduced the proliferation of ATL cell lines by promoting apoptosis and histone hyperacetylation." | 1.37 | Efficacy of novel histone deacetylase inhibitor, AR42, in a mouse model of, human T-lymphotropic virus type 1 adult T cell lymphoma. ( Chen, CS; Fernandez, SA; Lairmore, MD; Landes, K; Sargeant, A; Zimmerman, B, 2011) |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Gazon, H | 1 |
| Belrose, G | 1 |
| Terol, M | 1 |
| Meniane, JC | 1 |
| Mesnard, JM | 1 |
| Césaire, R | 1 |
| Peloponese, JM | 1 |
| Mahieux, R | 1 |
| Zimmerman, B | 1 |
| Sargeant, A | 1 |
| Landes, K | 1 |
| Fernandez, SA | 1 |
| Chen, CS | 1 |
| Lairmore, MD | 1 |
| Tsapis, M | 1 |
| Lieb, M | 1 |
| Manzo, F | 1 |
| Shankaranarayanan, P | 1 |
| Herbrecht, R | 1 |
| Lutz, P | 1 |
| Gronemeyer, H | 1 |
Reviews
1 review available for valproic acid and ATLL
| Article | Year |
|---|---|
[Virological aspects of HTLV-1 infection and new therapeutical concepts].
Topics: Animals; Anti-Retroviral Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Genome, Vir | 2011 |
Other Studies
3 other studies available for valproic acid and ATLL
| Article | Year |
|---|---|
Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Basic-Leucine Zipper Transcription Fact | 2016 |
Efficacy of novel histone deacetylase inhibitor, AR42, in a mouse model of, human T-lymphotropic virus type 1 adult T cell lymphoma.
Topics: Acetylation; Adult; Animals; Blotting, Western; Cytochromes c; Enzyme Inhibitors; Female; Histone De | 2011 |
HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway.
Topics: Apoptosis; Benzamides; Burkitt Lymphoma; Cyclin-Dependent Kinase Inhibitor p21; Dexamethasone; Drug | 2007 |