valproic acid has been researched along with ATLL in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Excerpt | Relevance | Reference |
---|---|---|
"Importantly, HTLV-1 does not cause ATLL through insertional mutagenesis." | 2.47 | [Virological aspects of HTLV-1 infection and new therapeutical concepts]. ( Mahieux, R, 2011) |
"Profiling of cellular miRNAs on Adult T cell Leukemia (ATL) cells by Yamagishi et al." | 1.43 | Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients. ( Belrose, G; Césaire, R; Gazon, H; Meniane, JC; Mesnard, JM; Peloponese, JM; Terol, M, 2016) |
" Herein, we tested if valproic acid and the novel orally bioavailable HDACi, AR-42 reduced the proliferation of ATL cell lines by promoting apoptosis and histone hyperacetylation." | 1.37 | Efficacy of novel histone deacetylase inhibitor, AR42, in a mouse model of, human T-lymphotropic virus type 1 adult T cell lymphoma. ( Chen, CS; Fernandez, SA; Lairmore, MD; Landes, K; Sargeant, A; Zimmerman, B, 2011) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (25.00) | 29.6817 |
2010's | 3 (75.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Gazon, H | 1 |
Belrose, G | 1 |
Terol, M | 1 |
Meniane, JC | 1 |
Mesnard, JM | 1 |
Césaire, R | 1 |
Peloponese, JM | 1 |
Mahieux, R | 1 |
Zimmerman, B | 1 |
Sargeant, A | 1 |
Landes, K | 1 |
Fernandez, SA | 1 |
Chen, CS | 1 |
Lairmore, MD | 1 |
Tsapis, M | 1 |
Lieb, M | 1 |
Manzo, F | 1 |
Shankaranarayanan, P | 1 |
Herbrecht, R | 1 |
Lutz, P | 1 |
Gronemeyer, H | 1 |
1 review available for valproic acid and ATLL
Article | Year |
---|---|
[Virological aspects of HTLV-1 infection and new therapeutical concepts].
Topics: Animals; Anti-Retroviral Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Genome, Vir | 2011 |
3 other studies available for valproic acid and ATLL
Article | Year |
---|---|
Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Basic-Leucine Zipper Transcription Fact | 2016 |
Efficacy of novel histone deacetylase inhibitor, AR42, in a mouse model of, human T-lymphotropic virus type 1 adult T cell lymphoma.
Topics: Acetylation; Adult; Animals; Blotting, Western; Cytochromes c; Enzyme Inhibitors; Female; Histone De | 2011 |
HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway.
Topics: Apoptosis; Benzamides; Burkitt Lymphoma; Cyclin-Dependent Kinase Inhibitor p21; Dexamethasone; Drug | 2007 |