Page last updated: 2024-10-26

valproic acid and ATLL

valproic acid has been researched along with ATLL in 4 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Research Excerpts

ExcerptRelevanceReference
"Importantly, HTLV-1 does not cause ATLL through insertional mutagenesis."2.47[Virological aspects of HTLV-1 infection and new therapeutical concepts]. ( Mahieux, R, 2011)
"Profiling of cellular miRNAs on Adult T cell Leukemia (ATL) cells by Yamagishi et al."1.43Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients. ( Belrose, G; Césaire, R; Gazon, H; Meniane, JC; Mesnard, JM; Peloponese, JM; Terol, M, 2016)
" Herein, we tested if valproic acid and the novel orally bioavailable HDACi, AR-42 reduced the proliferation of ATL cell lines by promoting apoptosis and histone hyperacetylation."1.37Efficacy of novel histone deacetylase inhibitor, AR42, in a mouse model of, human T-lymphotropic virus type 1 adult T cell lymphoma. ( Chen, CS; Fernandez, SA; Lairmore, MD; Landes, K; Sargeant, A; Zimmerman, B, 2011)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gazon, H1
Belrose, G1
Terol, M1
Meniane, JC1
Mesnard, JM1
Césaire, R1
Peloponese, JM1
Mahieux, R1
Zimmerman, B1
Sargeant, A1
Landes, K1
Fernandez, SA1
Chen, CS1
Lairmore, MD1
Tsapis, M1
Lieb, M1
Manzo, F1
Shankaranarayanan, P1
Herbrecht, R1
Lutz, P1
Gronemeyer, H1

Reviews

1 review available for valproic acid and ATLL

ArticleYear
[Virological aspects of HTLV-1 infection and new therapeutical concepts].
    Bulletin de la Societe de pathologie exotique (1990), 2011, Volume: 104, Issue:3

    Topics: Animals; Anti-Retroviral Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Genome, Vir

2011

Other Studies

3 other studies available for valproic acid and ATLL

ArticleYear
Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients.
    Oncotarget, 2016, May-24, Volume: 7, Issue:21

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Basic-Leucine Zipper Transcription Fact

2016
Efficacy of novel histone deacetylase inhibitor, AR42, in a mouse model of, human T-lymphotropic virus type 1 adult T cell lymphoma.
    Leukemia research, 2011, Volume: 35, Issue:11

    Topics: Acetylation; Adult; Animals; Blotting, Western; Cytochromes c; Enzyme Inhibitors; Female; Histone De

2011
HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway.
    The international journal of biochemistry & cell biology, 2007, Volume: 39, Issue:7-8

    Topics: Apoptosis; Benzamides; Burkitt Lymphoma; Cyclin-Dependent Kinase Inhibitor p21; Dexamethasone; Drug

2007