valproic acid has been researched along with AIDS Dementia Complex in 7 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
AIDS Dementia Complex: A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid is an anticonvulsant drug known to inhibit the glucuronidation of zidovudine (AZT) in human liver microsomes." | 1.30 | Valproic acid increases cerebrospinal fluid zidovudine levels in a patient with AIDS. ( Akula, SK; Dejace, PM; Dreisbach, AW; Lertora, JJ; Rege, AB, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Davidson, DC | 1 |
| Hirschman, MP | 1 |
| Spinelli, SL | 1 |
| Morrell, CN | 1 |
| Schifitto, G | 3 |
| Phipps, RP | 1 |
| Maggirwar, SB | 3 |
| Dou, H | 1 |
| Birusingh, K | 1 |
| Faraci, J | 1 |
| Gorantla, S | 1 |
| Poluektova, LY | 1 |
| Dewhurst, S | 2 |
| Gelbard, HA | 2 |
| Gendelman, HE | 3 |
| Peterson, DR | 1 |
| Zhong, J | 1 |
| Ni, H | 1 |
| Cruttenden, K | 1 |
| Gaugh, M | 1 |
| Boska, M | 1 |
| Gelbard, H | 1 |
| Akula, SK | 1 |
| Rege, AB | 1 |
| Dreisbach, AW | 1 |
| Dejace, PM | 1 |
| Lertora, JJ | 1 |
| RachBeisel, JA | 1 |
| Weintraub, E | 1 |
| Shulman, KI | 1 |
| Herrmann, N | 1 |
2 reviews available for valproic acid and AIDS Dementia Complex
| Article | Year |
|---|---|
Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS.
Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; Animals; Anti-HIV Agents; Drug Delivery S | 2007 |
Bipolar disorder in old age.
Topics: Acute Disease; Adult; Age Factors; Aged; AIDS Dementia Complex; Antidepressive Agents; Antimanic Age | 1999 |
1 trial available for valproic acid and AIDS Dementia Complex
| Article | Year |
|---|---|
Valproic acid adjunctive therapy for HIV-associated cognitive impairment: a first report.
Topics: Adult; AIDS Dementia Complex; Anti-Retroviral Agents; CD4 Lymphocyte Count; Double-Blind Method; Dru | 2006 |
4 other studies available for valproic acid and AIDS Dementia Complex
| Article | Year |
|---|---|
Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals.
Topics: AIDS Dementia Complex; Animals; Blood Platelets; CD40 Ligand; Down-Regulation; Female; Glycogen Synt | 2011 |
Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis.
Topics: AIDS Dementia Complex; Animals; Basal Ganglia; Biomarkers; Cell Differentiation; Cells, Cultured; Co | 2003 |
Valproic acid increases cerebrospinal fluid zidovudine levels in a patient with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; Anticonvulsants; Drug Interactions | 1997 |
Valproic acid treatment of AIDS-related mania.
Topics: Adult; AIDS Dementia Complex; Drug Administration Schedule; Humans; Male; Quality of Life; Valproic | 1997 |