Page last updated: 2024-10-26

valproic acid and ADDH

valproic acid has been researched along with ADDH in 60 studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Research Excerpts

ExcerptRelevanceReference
"This case report describes two children who developed hyperammonemia together with frank manic behavior during treatment with a combination of valproic acid and risperidone."7.74Case report: valproic Acid and risperidone treatment leading to development of hyperammonemia and mania. ( Caplan, R; Carlson, T; Reynolds, CA, 2007)
" In the dosage used, l-tryptophan was tolerated well by these children, and seizure frequency, as a whole, remained unaltered."6.65l-Tryptophan in hyperactive child syndrome associated with epilepsy: a controlled study. ( Ghose, K, 1983)
"TEAM was a multi-site, 8-week, randomized clinical trial of risperidone, lithium, or divalproex in 279 medication-naïve patients, aged 6 through 15 years, with a DSM-IV diagnosis of bipolar disorder currently in manic or mixed phase."5.16Treatment moderators and predictors of outcome in the Treatment of Early Age Mania (TEAM) study. ( Axelson, DA; Birmaher, B; Emslie, G; Joshi, P; Luby, J; Riddle, MA; Robb, A; Ryan, ND; Tillman, R; Vitiello, B; Wagner, KD; Walkup, JT; Yenokyan, G, 2012)
"Findings from this explorative study strengthen the evidence for the warning against the use of valproate in pregnancy and raise concern of risks of specific psychiatric disorders associated with topiramate and levetiracetam."4.31Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders. ( Alvestad, S; Bjørk, MH; Christensen, J; Cohen, JM; Dreier, JW; Furu, K; Gissler, M; Igland, J; Leinonen, MK; Sun, Y; Tomson, T; Zoega, H, 2023)
" In this study, we examined behavioral and hippocampal neurogenesis alterations in male offspring of rats exposed to valproic acid (VPA) during pregnancy."3.91Prenatal exposure to valproic acid is associated with altered neurocognitive function and neurogenesis in the dentate gyrus of male offspring rats. ( Arai, H; Bolati, K; Fukuhara, T; Ito, M; Kinjo, T; Seki, T; Suzuki, T, 2019)
"This case report describes two children who developed hyperammonemia together with frank manic behavior during treatment with a combination of valproic acid and risperidone."3.74Case report: valproic Acid and risperidone treatment leading to development of hyperammonemia and mania. ( Caplan, R; Carlson, T; Reynolds, CA, 2007)
"Medical records were reviewed for 42 patients (ages 12-19 years) who were hospitalized for acute mania and discharged with a diagnosis of DSM-III-R or DSM-IV bipolar disorder on either lithium (N = 29) or divalproex sodium (N = 13) treatment."3.72Chart review of the impact of attention-deficit/hyperactivity disorder comorbidity on response to lithium or divalproex sodium in adolescent mania. ( Altshuler, LL; DeAntonio, M; Frye, MA; Hwang, S; Mintz, J; State, RC; Strober, M, 2004)
" We report two cases of an adverse effect of dyskinesia and bruxism when MPH was given to children maintained on valproic acid."3.70Adverse response to methylphenidate in combination with valproic acid. ( Gara, L; Roberts, W, 2000)
"We report on three cases of acutely manic prepubertal children diagnosed with bipolar disorder who were treated with olanzapine in addition to their existing mood stabilizer regimens."3.70Mood stabilizer augmentation with olanzapine in acutely manic children. ( Chang, KD; Ketter, TA, 2000)
"Effectiveness of Combined Medication Treatment for Aggression in Children With Attention Deficit With Hyperactivity Disorder (The SPICY Study); https://www."3.01Stepped Treatment for Attention-Deficit/Hyperactivity Disorder and Aggressive Behavior: A Randomized, Controlled Trial of Adjunctive Risperidone, Divalproex Sodium, or Placebo After Stimulant Medication Optimization. ( Bailey, BY; Blader, JC; Carlson, GA; Crowell, JA; Daviss, WB; Foley, CA; Kafantaris, V; Margulies, DM; Matthews, TL; Pliszka, SR; Sauder, C; Sinha, C, 2021)
" Children whose aggressive behavior persisted at the conclusion of the lead-in phase were randomly assigned to receive double-blind, flexibly dosed divalproex or a placebo adjunctive to stimulant for 8 weeks."2.74Adjunctive divalproex versus placebo for children with ADHD and aggression refractory to stimulant monotherapy. ( Blader, JC; Jensen, PS; Kafantaris, V; Pliszka, SR; Schooler, NR, 2009)
" The mechanism of this proposed interaction may involve drug-drug competition at the level of hepatic glucuronidation (conjugation), although shifts in protein binding cannot be ruled out."2.69Increased plasma valproate concentrations when coadministered with guanfacine. ( Ambrosini, PJ; Sheikh, RM, 1998)
" In the dosage used, l-tryptophan was tolerated well by these children, and seizure frequency, as a whole, remained unaltered."2.65l-Tryptophan in hyperactive child syndrome associated with epilepsy: a controlled study. ( Ghose, K, 1983)
"For patients with migraine, the pregnancy labeling of VPA will be changed from Category "D" to "X."2.50Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions. ( Gentile, S, 2014)
"Amphetamine salts have been helpful in treating bipolar children with comorbid ADHD, but no data are available on treating comorbid depression in bipolar children."2.43Recognizing and managing bipolar disorder in children. ( Wozniak, J, 2005)
"Its use in pregnancy is associated with increased risks of congenital malformations and adverse neurodevelopment in the offspring and may be associated with an increased risk of attention-deficit/hyperactivity disorder (ADHD)."1.51Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring. ( Brikell, I; Christensen, J; Dalsgaard, S; Dreier, JW; Pedersen, L; Sun, Y, 2019)
"Benign myoclonic epilepsy in infancy (BMEI) is a well-defined electro-clinical syndrome, classically associated with a good prognosis."1.40[Benign myoclonic epilepsy in infancy: natural history and behavioral and cognitive outcome]. ( Carreras-Sáez, I; Domínguez-Carral, J; Fournier-Del Castillo, MC; García-Peñas, JJ; Jiménez-Echevarría, S; Pérez-Jiménez, MÁ, 2014)
"Methylphenidate is a short-acting stimulant."1.39Methylphenidate-induced acute orofacial and extremity dyskinesia. ( Donmez, A; Isik, B; Orun, E; Sonmez, FM; Tas, T; Yilmaz, AE, 2013)

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-19904 (6.67)18.7374
1990's9 (15.00)18.2507
2000's22 (36.67)29.6817
2010's18 (30.00)24.3611
2020's7 (11.67)2.80

Authors

AuthorsStudies
Błaszczyk, B1
Miziak, B1
Pluta, R1
Czuczwar, SJ1
Dreier, JW2
Bjørk, MH1
Alvestad, S1
Gissler, M1
Igland, J1
Leinonen, MK1
Sun, Y2
Zoega, H1
Cohen, JM1
Furu, K1
Tomson, T1
Christensen, J2
Kinjo, T1
Ito, M1
Seki, T1
Fukuhara, T1
Bolati, K1
Arai, H1
Suzuki, T1
Sakade, Y1
Yamanaka, K1
Soumiya, H1
Furukawa, S1
Fukumitsu, H1
Blader, JC2
Pliszka, SR2
Kafantaris, V2
Foley, CA1
Carlson, GA1
Crowell, JA1
Bailey, BY1
Sauder, C1
Daviss, WB1
Sinha, C1
Matthews, TL1
Margulies, DM1
Cortese, S1
Novins, DK1
Oh, Y1
Joung, YS1
Choi, J1
Stuver, R1
Khanna, P1
Wischhusen, JW1
Cobb, C1
Bockorny, B1
Wiggs, KK1
Rickert, ME1
Sujan, AC1
Quinn, PD1
Larsson, H1
Lichtenstein, P1
Oberg, AS1
D'Onofrio, BM1
Meador, KJ1
Pedersen, L1
Brikell, I1
Dalsgaard, S1
Kanemura, H1
Sano, F1
Tando, T1
Hosaka, H1
Sugita, K1
Aihara, M1
Allen, MB1
Baker, JC1
Nuernberger, JE1
Vargo, KK1
Santos-Cubiñá, J1
Torres-Rodríguez, A1
Castaing-Lespier, PA1
Sabaté, N1
Torres-Martin, A1
Carlo, S1
Domínguez-Carral, J1
García-Peñas, JJ1
Pérez-Jiménez, MÁ1
Fournier-Del Castillo, MC1
Carreras-Sáez, I1
Jiménez-Echevarría, S1
Gentile, S1
Ciftci, S1
Guler, A1
Deveci, E1
Celebisoy, N1
Yuceyar, N1
Miklowitz, DJ1
Chang, KD2
Kummer, A1
Teixeira, A1
Schooler, NR1
Jensen, PS1
Steiner, H2
Karnik, NS1
Torrioli, M1
Vernacotola, S1
Setini, C1
Bevilacqua, F1
Martinelli, D1
Snape, M1
Hutchison, JA1
Di Raimo, FR1
Tabolacci, E1
Neri, G1
Sahu, JK1
Bos, MJ1
de Weerd, AW1
Hagebeuk, EE1
Liu, HY1
Potter, MP1
Woodworth, KY1
Yorks, DM1
Petty, CR1
Wozniak, JR1
Faraone, SV1
Biederman, J1
Lance, EI1
Shapiro, BK1
Yilmaz, AE1
Donmez, A1
Orun, E1
Tas, T1
Isik, B1
Sonmez, FM1
Vitiello, B1
Riddle, MA1
Yenokyan, G1
Axelson, DA1
Wagner, KD1
Joshi, P1
Walkup, JT1
Luby, J1
Birmaher, B1
Ryan, ND1
Emslie, G1
Robb, A1
Tillman, R1
Levy, T1
Bloch, Y1
Kowatch, RA2
Sethuraman, G1
Hume, JH1
Kromelis, M1
Weinberg, WA1
State, RC1
Frye, MA1
Altshuler, LL1
Strober, M1
DeAntonio, M1
Hwang, S1
Mintz, J1
Scheffer, RE1
Carmody, T1
Rush, AJ1
Wozniak, J1
Kruszewski, SP1
Paczynski, R1
Mendhekar, DN1
Bebarta, VS1
Kostic, MA1
Gonzalez, MG1
Pavuluri, MN1
Schenkel, LS1
Aryal, S1
Harral, EM1
Hill, SK1
Herbener, ES1
Sweeney, JA1
Miyazaki, M1
Ito, H1
Saijo, T1
Mori, K1
Kagami, S1
Kuroda, Y1
Kratochvil, CJ1
Varley, C1
Cummins, TK1
Martin, A1
Bora, E1
Vahip, S1
Akdeniz, F1
Saxena, K1
Howe, M1
Simeonova, D1
Chang, K1
Barzman, DH1
DelBello, MP1
Adler, CM1
Stanford, KE1
Strakowski, SM1
Carlson, T1
Reynolds, CA1
Caplan, R1
Tahiroglu, AY1
Avci, A1
Wammanda, RD1
Berlin, CM1
Ghose, K1
Debray-Ritzen, P1
Dubois, H1
Frank, Y1
Donovan, SJ1
Susser, ES1
Nunes, EV1
Stewart, JW1
Quitkin, FM1
Klein, DF1
Brasić, JR1
Barnett, JY1
Crumley, FE1
Steele, M1
Fisman, S1
Damore, J1
Stine, J1
Brody, L1
Schaller, JL1
Behar, D1
Ambrosini, PJ1
Sheikh, RM1
Gara, L1
Roberts, W1
Ketter, TA1
Spiel, W1
Schuch, B1
Widmer, U1
Matthews-Ferrari, K1
Karroum, N1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Adjunctive Treatment With Divalproex or Risperidone for Aggression Refractory to Stimulant Monotherapy Among Children With ADHD[NCT00794625]Phase 4270 participants (Anticipated)Interventional2008-11-30Recruiting
Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar Disorder[NCT00943085]52 participants (Anticipated)Interventional2007-04-30Completed
Early Intervention for Youth at Risk for Bipolar Disorder[NCT01483391]150 participants (Anticipated)Interventional2011-10-06Completed
Double-Blind, Placebo-Controlled Trial of Flexible Dose Divalproex Sodium Adjunctive to Stimulant Treatment for Aggressive Children With Attention-Deficit Hyperactivity Disorder[NCT00228046]Phase 440 participants (Anticipated)Interventional2004-01-31Completed
Treatment of Early Age Mania (TEAM) Study[NCT00057681]Phase 3379 participants (Actual)Interventional2003-02-28Completed
A Comparison of Omega-3 Fatty Acids vs. Placebo in Children and Adolescents With Bipolar Disorder[NCT00252486]65 participants (Actual)Interventional2001-11-30Completed
Aripiprazole Associated With Methylphenidate in Children and Adolescents With Bipolar Disorder and ADHD: A Randomized Cross-Over Placebo Controlled Trial[NCT00305370]Phase 420 participants (Anticipated)Interventional2005-08-31Completed
A Collaborative Treatment Network for Youth With or at High Risk for Bipolar Disorder[NCT05427123]80 participants (Anticipated)Observational2022-07-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Clinical Global Impressions-Bipolar Mania Improvement

The Clinical Global Impressions-Bipolar (CGI-BP) assessment instrument measured improvement in mania, depression, and overall bipolar illness. The primary outcome measure was mania improvement, which measured the change in mania from baseline. Scores were 1=very much improved, 2=much improved, 3=minimally improved, 4=no change, 5=minimally worse, 6=much worse, 7=very much worse. (NCT00057681)
Timeframe: Measured at Week 8

Interventionunits on a scale (Mean)
Randomized Medication - Lithium2.49
Randomized Medication - Divalproex Sodium2.73
Randomized Medication - Risperidone1.70

K-SADS Mania Rating Scale

The K-SADS Mania Rating Scale (KMRS) is comprised of 15 items modified from WASH-U-KSADS items. The individual items are scored on a 1-6 severity scale and then these item scores are summed to create an overall KMRS score. Guidelines for interpretation are as follows: 0-11 = no or minimal mania, 12-17 = mild mania, 18-25 = moderate mania, 26+ = marked or worse mania. The maximum possible score is 64. (NCT00057681)
Timeframe: Measured at Week 8

Interventionunits on a scale (Mean)
Randomized Medication - Lithium24.06
Randomized Medication - Divalproex Sodium26.31
Randomized Medication - Risperidone14.58

Modified Side Effects Form for Children and Adolescents

The Modified Side Effects Form for Children and Adolescents includes 62 potential side effects, with measures of frequency and severity for each item. Frequencies are 0=not present, 1=1-2 days, 2=3-4 days, 3=5-7 days. Severity scores are 0=not present, 1=mild (does not interfere with functioning), 2=moderate (some interference with functioning), 3=severe (functioning is significantly impaired because of side effects). Items for cardiovascular, gastrointestinal, central nervous system, ocular, mouth and nose, genito urinary, dermatology, musculo-skeletal, and other side effects are included. For analyses, side effects that were reported at any frequency and a severity of 2 or greater were considered present. (NCT00057681)
Timeframe: Measured at Week 8

Interventionside effects at week 8 (Mean)
Randomized Medication - Lithium5.11
Randomized Medication - Divalproex Sodium4.95
Randomized Medication - Risperidone3.70

Reviews

8 reviews available for valproic acid and ADDH

ArticleYear
Epilepsy in Pregnancy-Management Principles and Focus on Valproate.
    International journal of molecular sciences, 2022, Jan-25, Volume: 23, Issue:3

    Topics: Abnormalities, Drug-Induced; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism

2022
Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions.
    CNS spectrums, 2014, Volume: 19, Issue:4

    Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Bipolar Di

2014
Prevention of bipolar disorder in at-risk children: theoretical assumptions and empirical foundations.
    Development and psychopathology, 2008,Summer, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Affect; Amygdala; Anticonvulsants; Attention Deficit Disorder with Hyperactivity;

2008
Prevention of bipolar disorder in at-risk children: theoretical assumptions and empirical foundations.
    Development and psychopathology, 2008,Summer, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Affect; Amygdala; Anticonvulsants; Attention Deficit Disorder with Hyperactivity;

2008
Prevention of bipolar disorder in at-risk children: theoretical assumptions and empirical foundations.
    Development and psychopathology, 2008,Summer, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Affect; Amygdala; Anticonvulsants; Attention Deficit Disorder with Hyperactivity;

2008
Prevention of bipolar disorder in at-risk children: theoretical assumptions and empirical foundations.
    Development and psychopathology, 2008,Summer, Volume: 20, Issue:3

    Topics: Adolescent; Adult; Affect; Amygdala; Anticonvulsants; Attention Deficit Disorder with Hyperactivity;

2008
Pharmacologic treatments for pediatric bipolar disorder: a review and meta-analysis.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2011, Volume: 50, Issue:8

    Topics: Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivi

2011
[Pharmacotherapy for conduct disorder in children and adolescents].
    Harefuah, 2012, Volume: 151, Issue:7

    Topics: Adolescent; Aggression; Anticoagulants; Antimanic Agents; Antipsychotic Agents; Attention Deficit Di

2012
Recognizing and managing bipolar disorder in children.
    The Journal of clinical psychiatry, 2005, Volume: 66 Suppl 1

    Topics: Adolescent; Age Factors; Amphetamine; Anticonvulsants; Antipsychotic Agents; Attention Deficit Disor

2005
Managing adverse reactions to psychotropic medications.
    Pediatric annals, 2005, Volume: 34, Issue:12

    Topics: Adolescent; Anticonvulsants; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivit

2005
Advances in pediatric pharmacology and toxicology.
    Advances in pediatrics, 1983, Volume: 30

    Topics: Animals; Anti-Bacterial Agents; Aspirin; Attention Deficit Disorder with Hyperactivity; Biological A

1983

Trials

13 trials available for valproic acid and ADDH

ArticleYear
Stepped Treatment for Attention-Deficit/Hyperactivity Disorder and Aggressive Behavior: A Randomized, Controlled Trial of Adjunctive Risperidone, Divalproex Sodium, or Placebo After Stimulant Medication Optimization.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2021, Volume: 60, Issue:2

    Topics: Aggression; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child;

2021
Adjunctive divalproex versus placebo for children with ADHD and aggression refractory to stimulant monotherapy.
    The American journal of psychiatry, 2009, Volume: 166, Issue:12

    Topics: Adolescent; Aggression; Antimanic Agents; Attention Deficit and Disruptive Behavior Disorders; Atten

2009
Treatment with valproic acid ameliorates ADHD symptoms in fragile X syndrome boys.
    American journal of medical genetics. Part A, 2010, Volume: 152A, Issue:6

    Topics: Adolescent; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child; Female; Fragile X

2010
Treatment moderators and predictors of outcome in the Treatment of Early Age Mania (TEAM) study.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2012, Volume: 51, Issue:9

    Topics: Adolescent; Age Factors; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Attention Deficit

2012
Combination pharmacotherapy in children and adolescents with bipolar disorder.
    Biological psychiatry, 2003, Jun-01, Volume: 53, Issue:11

    Topics: Adolescent; Antidepressive Agents; Antimanic Agents; Antipsychotic Agents; Attention Deficit Disorde

2003
Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium.
    The American journal of psychiatry, 2005, Volume: 162, Issue:1

    Topics: Adolescent; Amphetamines; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Di

2005
Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium.
    The American journal of psychiatry, 2005, Volume: 162, Issue:1

    Topics: Adolescent; Amphetamines; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Di

2005
Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium.
    The American journal of psychiatry, 2005, Volume: 162, Issue:1

    Topics: Adolescent; Amphetamines; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Di

2005
Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium.
    The American journal of psychiatry, 2005, Volume: 162, Issue:1

    Topics: Adolescent; Amphetamines; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Di

2005
Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium.
    The American journal of psychiatry, 2005, Volume: 162, Issue:1

    Topics: Adolescent; Amphetamines; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Di

2005
Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium.
    The American journal of psychiatry, 2005, Volume: 162, Issue:1

    Topics: Adolescent; Amphetamines; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Di

2005
Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium.
    The American journal of psychiatry, 2005, Volume: 162, Issue:1

    Topics: Adolescent; Amphetamines; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Di

2005
Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium.
    The American journal of psychiatry, 2005, Volume: 162, Issue:1

    Topics: Adolescent; Amphetamines; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Di

2005
Randomized, placebo-controlled trial of mixed amphetamine salts for symptoms of comorbid ADHD in pediatric bipolar disorder after mood stabilization with divalproex sodium.
    The American journal of psychiatry, 2005, Volume: 162, Issue:1

    Topics: Adolescent; Amphetamines; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Di

2005
Favorable response of ADHD with giant SEP to extended-release valproate.
    Brain & development, 2006, Volume: 28, Issue:7

    Topics: Adolescent; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool;

2006
Divalproex sodium reduces overall aggression in youth at high risk for bipolar disorder.
    Journal of child and adolescent psychopharmacology, 2006, Volume: 16, Issue:3

    Topics: Adolescent; Affect; Aggression; Antimanic Agents; Attention Deficit and Disruptive Behavior Disorder

2006
The efficacy and tolerability of quetiapine versus divalproex for the treatment of impulsivity and reactive aggression in adolescents with co-occurring bipolar disorder and disruptive behavior disorder(s).
    Journal of child and adolescent psychopharmacology, 2006, Volume: 16, Issue:6

    Topics: Adolescent; Aggression; Antimanic Agents; Antipsychotic Agents; Attention Deficit and Disruptive Beh

2006
l-Tryptophan in hyperactive child syndrome associated with epilepsy: a controlled study.
    Neuropsychobiology, 1983, Volume: 10, Issue:2-3

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Carbamazepine; Child; Clinical Trials as

1983
Visual event related potentials after methylphenidate and sodium valproate in children with attention deficit hyperactivity disorder.
    Clinical EEG (electroencephalography), 1993, Volume: 24, Issue:1

    Topics: Attention Deficit Disorder with Hyperactivity; Child; Electroencephalography; Evoked Potentials, Vis

1993
Divalproex treatment of disruptive adolescents: a report of 10 cases.
    The Journal of clinical psychiatry, 1997, Volume: 58, Issue:1

    Topics: Adolescent; Adolescent Behavior; Aggression; Ambulatory Care; Attention Deficit Disorder with Hypera

1997
Increased plasma valproate concentrations when coadministered with guanfacine.
    Journal of child and adolescent psychopharmacology, 1998, Volume: 8, Issue:2

    Topics: Adrenergic alpha-Agonists; Anticonvulsants; Attention Deficit and Disruptive Behavior Disorders; Att

1998

Other Studies

39 other studies available for valproic acid and ADDH

ArticleYear
Prenatal Exposure to Antiseizure Medication and Incidence of Childhood- and Adolescence-Onset Psychiatric Disorders.
    JAMA neurology, 2023, 06-01, Volume: 80, Issue:6

    Topics: Adolescent; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Carbamazepine; Child; Ch

2023
Prenatal exposure to valproic acid is associated with altered neurocognitive function and neurogenesis in the dentate gyrus of male offspring rats.
    Brain research, 2019, 11-15, Volume: 1723

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Behavior, Animal;

2019
Exposure to valproic acid during middle to late-stage corticogenesis induces learning and social behavioral abnormalities with attention deficit/hyperactivity in adult mice.
    Biomedical research (Tokyo, Japan), 2019, Volume: 40, Issue:5

    Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Cerebral Cortex; Female; M

2019
Editorial: Why JAACAP Published an "Inconclusive" Trial: Optimize, Optimize, Optimize Psychostimulant Treatment.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2021, Volume: 60, Issue:2

    Topics: Aggression; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyp

2021
Incidence of Neutropenia with Valproate, Antipsychotics, and ADHD Medication Combination Treatment in Children and Adolescents.
    Journal of Korean medical science, 2020, Jul-20, Volume: 35, Issue:28

    Topics: Adolescent; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Child; Female; Huma

2020
Isolated severe thrombocytopenia in the setting of extreme hyperthermia.
    Annals of hematology, 2020, Volume: 99, Issue:10

    Topics: Adult; Amphetamine-Related Disorders; Attention Deficit Disorder with Hyperactivity; Blood Platelets

2020
Antiseizure medication use during pregnancy and risk of ASD and ADHD in children.
    Neurology, 2020, 12-15, Volume: 95, Issue:24

    Topics: Adolescent; Adult; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism Spectrum D

2020
Fetal Valproate Exposure and Attention-Deficit/Hyperactivity Disorder.
    JAMA network open, 2019, 01-04, Volume: 2, Issue:1

    Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Female; Humans; Pregnancy; Prenatal

2019
Association of Prenatal Exposure to Valproate and Other Antiepileptic Drugs With Risk for Attention-Deficit/Hyperactivity Disorder in Offspring.
    JAMA network open, 2019, 01-04, Volume: 2, Issue:1

    Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child; Cohort Studies; Denmark; Epil

2019
EEG improvements with antiepileptic drug treatment can show a high correlation with behavioral recovery in children with ADHD.
    Epilepsy & behavior : E&B, 2013, Volume: 27, Issue:3

    Topics: Adolescent; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Brain Waves; Child; Elec

2013
Precursor manic behavior in the assessment and treatment of episodic problem behavior for a woman with a dual diagnosis.
    Journal of applied behavior analysis, 2013,Fall, Volume: 46, Issue:3

    Topics: Antimanic Agents; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Behavioral Sy

2013
Exacerbation of mood symptoms associated to primary and secondary carnitine deficiency: a case report.
    Boletin de la Asociacion Medica de Puerto Rico, 2013, Volume: 105, Issue:3

    Topics: Adult; Antidepressive Agents; Antimanic Agents; Attention Deficit Disorder with Hyperactivity; Benzo

2013
[Benign myoclonic epilepsy in infancy: natural history and behavioral and cognitive outcome].
    Revista de neurologia, 2014, Feb-01, Volume: 58, Issue:3

    Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child Behavior Disorders; Cognition

2014
A case with hyperammonemic encephalopathy triggered by single dose valproate.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2016, Volume: 37, Issue:12

    Topics: Attention Deficit Disorder with Hyperactivity; Brain Diseases; Female; GABA Agents; Humans; Hyperamm

2016
Methylphenidate in attention deficit hyperactivity disorder and bipolar disorder.
    Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists, 2008, Volume: 16, Issue:6

    Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Central Nervous Sy

2008
Integrated treatment of aggression in the context of ADHD in children refractory to stimulant monotherapy: a window into the future of child psychopharmacology.
    The American journal of psychiatry, 2009, Volume: 166, Issue:12

    Topics: Adolescent; Aggression; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimul

2009
Valproic acid and ADHD symptoms in fragile X syndrome: more evidence is needed.
    American journal of medical genetics. Part A, 2010, Volume: 152A, Issue:10

    Topics: Attention Deficit Disorder with Hyperactivity; Electroencephalography; Female; Fragile X Syndrome; H

2010
[Staring episodes in children with developmental disorders: epilepsy or behaviour?].
    Nederlands tijdschrift voor geneeskunde, 2011, Volume: 155

    Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Child Behavior; Diagnosis,

2011
Confounding diagnoses in the neurodevelopmental disabilities population: a child with hearing loss, absence epilepsy, and attention-deficit hyperactivity disorder (ADHD).
    Journal of child neurology, 2013, Volume: 28, Issue:5

    Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Audiometry, Pure-Tone; Central Nervo

2013
Methylphenidate-induced acute orofacial and extremity dyskinesia.
    Journal of child neurology, 2013, Volume: 28, Issue:6

    Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; C

2013
Chart review of the impact of attention-deficit/hyperactivity disorder comorbidity on response to lithium or divalproex sodium in adolescent mania.
    The Journal of clinical psychiatry, 2004, Volume: 65, Issue:8

    Topics: Adolescent; Adult; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder;

2004
Conclusions inconsistent with results with amphetamines and divalproex.
    The American journal of psychiatry, 2005, Volume: 162, Issue:11

    Topics: Amphetamines; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Cent

2005
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:12

    Topics: Age Factors; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Comor

2005
Neurocognitive function in unmedicated manic and medicated euthymic pediatric bipolar patients.
    The American journal of psychiatry, 2006, Volume: 163, Issue:2

    Topics: Adolescent; Anticonvulsants; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Bi

2006
Less is more: inpatient management of a child with complex pharmacotherapy.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2006, Volume: 45, Issue:5

    Topics: Aggression; Amphetamines; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Depressio

2006
Sustained attention deficits in manic and euthymic patients with bipolar disorder.
    Progress in neuro-psychopharmacology & biological psychiatry, 2006, Aug-30, Volume: 30, Issue:6

    Topics: Adult; Anticonvulsants; Antimanic Agents; Arousal; Attention Deficit Disorder with Hyperactivity; Bi

2006
Case report: valproic Acid and risperidone treatment leading to development of hyperammonemia and mania.
    Journal of the American Academy of Child and Adolescent Psychiatry, 2007, Volume: 46, Issue:3

    Topics: Antipsychotic Agents; Asperger Syndrome; Attention Deficit Disorder with Hyperactivity; Bipolar Diso

2007
Polypharmacy and EPS in a child; a case report.
    Psychopharmacology bulletin, 2007, Volume: 40, Issue:2

    Topics: Attention Deficit Disorder with Hyperactivity; Benztropine; Bipolar Disorder; Child; Comorbidity; Do

2007
Hyperactivity and inattention--a successful response to table coffee.
    Nigerian journal of clinical practice, 2007, Volume: 10, Issue:2

    Topics: Attention Deficit Disorder with Hyperactivity; Caffeine; Central Nervous System Stimulants; Child, P

2007
[Simple tic disease in children. A report on 93 cases (author's transl)].
    Revue neurologique, 1980, Volume: 136, Issue:1

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child, Preschool; Female; Humans;

1980
Hyperkinesias in a prepubertal boy with autistic disorder treated with haloperidol and valproic acid.
    Psychological reports, 1997, Volume: 80, Issue:1

    Topics: Anti-Dyskinesia Agents; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autistic Dis

1997
Valproic acid for Kleine-Levin syndrome.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1997, Volume: 36, Issue:7

    Topics: Adolescent; Anger; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder;

1997
Bipolar disorder in children and adolescents: current challenges.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1997, Volume: 42, Issue:6

    Topics: Adolescent; Aggression; Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Child; Clom

1997
Medication-induced hypomania in Asperger's disorder.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1998, Volume: 37, Issue:3

    Topics: Antimanic Agents; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Bipolar Disorder

1998
Treatment of a case of comorbid bipolar disorder and attention-deficit/hyperactivity disorder.
    The Journal of neuropsychiatry and clinical neurosciences, 1998,Spring, Volume: 10, Issue:2

    Topics: Adult; Antidepressive Agents, Second-Generation; Antimanic Agents; Attention Deficit Disorder with H

1998
Adverse response to methylphenidate in combination with valproic acid.
    Journal of child and adolescent psychopharmacology, 2000,Spring, Volume: 10, Issue:1

    Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Bruxism; Central Nervous System Stim

2000
Mood stabilizer augmentation with olanzapine in acutely manic children.
    Journal of child and adolescent psychopharmacology, 2000,Spring, Volume: 10, Issue:1

    Topics: Antimanic Agents; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Benzodiazepin

2000
[Therapy with convulex in patients with disorders of concentration and of the visual motor system].
    Wiener medizinische Wochenschrift. Supplement, 1979, Volume: 57

    Topics: Attention; Attention Deficit Disorder with Hyperactivity; Child; Female; Humans; Male; Psychological

1979
Mania and anticonvulsant therapy.
    Journal of the American Academy of Child and Adolescent Psychiatry, 1992, Volume: 31, Issue:6

    Topics: Attention Deficit Disorder with Hyperactivity; Bipolar Disorder; Child; Epilepsy, Absence; Ethosuxim

1992