Compounds > valine

valine and Malignant Melanoma

valine has been researched along with Malignant Melanoma in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.25)18.7374
1990's2 (6.25)18.2507
2000's11 (34.38)29.6817
2010's17 (53.13)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
De Giorgi, V; Gori, A; Massi, D; Pazzagli, M; Pinzani, P; Salvianti, F1
Li, S; Liang, C; Nemecio, D; Quach, C; Song, Y1
Edmonds, K; Fearfield, L; Gore, M; Larkin, J; Newton-Bishop, J; Sinha, R1
D'Alonzo, D; Glatz, K1
Botella, L; Callaghan, RC; Cerda-Nicolas, M; Gil-Benso, R; Gonzalez-Darder, J; Lopez-Gines, C; Muñoz-Hidalgo, L; Navarro, L; Quilis, V; San Miguel, T1
Abildgaard, C; Basse, AL; Dahl, C; Guldberg, P; Ma, T1
Busser, B; Charles, J; de Fraipont, F; Leccia, MT; Martel, C; Robert, C1
Aktan, G; Amonkar, MM; Arance, A; Bondarenko, I; Casey, M; Chiarion-Sileni, V; de Braud, F; DeMarini, DJ; Flaherty, KT; Garbe, C; Gogas, H; Grob, JJ; Irani, JG; Larkin, J; Lebbe, C; Levchenko, E; Long, GV; Mandalà, M; Millward, M; Nathan, P; Ribas, A; Robert, C; Schadendorf, D; Stroyakovskiy, D1
Benedict, JJ; DeConti, R; Gibney, GT; Gonzalez, RJ; Kudchadkar, RR; McCardle, T; Messina, JL; Sloot, S; Smalley, KS; Sondak, VK; Turner, LM; Weber, JS; Zager, JS1
Anniciello, AM; Ascierto, PA; Botti, G; Favoino, E; Feldman, SA; Ferrone, CR; Ferrone, S; Flaherty, KT; Giannarelli, D; Nota, S; Palmieri, G; Pepe, S; Sabbatino, F; Scognamiglio, G; Simeone, E; Villani, V; Wang, Y1
Blower, PE; Durinck, S; Futreal, AP; Ikediobi, ON; Reimers, M; Stratton, MR; Weinstein, JN1
Dalla Palma, M; Desai, B; Egyhazi, S; Elder, DE; Flaherty, KT; Hansson, J; Herlyn, M; King, AJ; Lioni, M; Nathanson, KL; Smalley, KS; Van Belle, P; Wu, H; Xiao, M1
Elder, DE; Flaherty, KT; Herlyn, M; Letrero, R; Nathanson, KL; Nguyen, TK; Smalley, KS; Van Belle, P; Villanueva, J; Wang, Y; Xiao, M1
Mier, JW; Panka, DJ; Sullivan, RJ1
Coral, S; Fratta, E; Maio, M; Parisi, G; Sigalotti, L1
Chi, Z; Cui, C; Flaherty, KT; Guo, J; Kong, Y; Li, S; Mao, L; Sheng, X; Si, L; Xu, X1
Ajouaou, A; Dankort, D; Horlings, HM; Kortman, PC; McMahon, M; Meissl, K; Michaloglou, C; Mooi, WJ; Peeper, DS; Possik, PA; Smit, MA; Vredeveld, LC1
Brunet, JP; Fisher, DE; Golub, TR; Jalili, A; Lupien, M; Mertz, KD; Pashenkov, M; Pathria, G; Ramaswamy, S; Stingl, G; Wagner, C; Wagner, SN; Widlund, HR1
Clements, A; Kefford, RF; Klein, O; Long, GV; Menzies, AM; O'Toole, S1
Dudek, AZ; Elmquist, WF; Mittapalli, RK; Vaidhyanathan, S1
HULTIN, T; KARASEK, M1
Niendorf, KB; Tsao, H; Yang, G1
Barany, F; Elenitsas, R; Seykora, J; Turner, DJ; Zirvi, MA1
Abbe, P; Bahadoran, P; Bailet, O; Ballotti, R; Baron, V; Bertolotto, C; Gaggioli, C; Ortonne, JP; Robert, G; Spadafora, A; Tartare-Deckert, S1
Angel, C; Dobrovic, A; Dowling, JP; Kelly, JW; Liu, W; Magee, J; Mason, G; McArthur, GA; Murray, WK; Trivett, M; Wolfe, R1
Cui, Y; Guadagno, TM1
Cheung, M; Madhunapantula, SV; Robertson, GP; Sharma, A1
Arden, KC; Cavenee, WK; Gutzmer, R; Herbst, RA; Kapp, A; Matiaske, F; Mommert, S; Weiss, J1
Chidambaram, A; Fraser, MC; Goldstein, AM; Struewing, JP; Tucker, MA1
Peng, ZY; Zhang, B1
Green, LJ; Humphries, MJ; Komoriya, A; Mervic, M; Yamada, KM; Yamada, SS1
Doores, L; Schulman, JD; Silagi, S; Wrathall, JR1

Reviews

1 review(s) available for valine and Malignant Melanoma

ArticleYear
[Mechanisms of resistance to anti-BRAF treatments].
    Annales de dermatologie et de venereologie, 2014, Volume: 141, Issue:11

    Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Humans; Imidazoles; Indoles; Melanoma; Molecular Targeted Therapy; Mutation; Oximes; Proto-Oncogene Proteins B-raf; Sulfonamides; Valine; Vemurafenib

2014

Trials

1 trial(s) available for valine and Malignant Melanoma

ArticleYear
Health-related quality of life impact in a randomised phase III study of the combination of dabrafenib and trametinib versus dabrafenib monotherapy in patients with BRAF V600 metastatic melanoma.
    European journal of cancer (Oxford, England : 1990), 2015, Volume: 51, Issue:7

    Topics: Amino Acid Substitution; Antineoplastic Combined Chemotherapy Protocols; Health Status; Humans; Imidazoles; Melanoma; Neoplasm Metastasis; Oximes; Pain Measurement; Proto-Oncogene Mas; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Quality of Life; Skin Neoplasms; Valine

2015

Other Studies

30 other study(ies) available for valine and Malignant Melanoma

ArticleYear
Evaluation of the liquid biopsy for the detection of BRAFV600E mutation in metastatic melanoma patients.
    Cancer biomarkers : section A of Disease markers, 2019, Volume: 26, Issue:3

    Topics: Amino Acid Substitution; Biomarkers, Tumor; Circulating Tumor DNA; DNA Mutational Analysis; Feasibility Studies; Glutamic Acid; Humans; Liquid Biopsy; Melanoma; Mutation; Neoplastic Cells, Circulating; Proto-Oncogene Proteins B-raf; Real-Time Polymerase Chain Reaction; Skin Neoplasms; Valine

2019
Revisiting the role of autophagy in melanoma.
    Autophagy, 2019, Volume: 15, Issue:10

    Topics: Amino Acid Substitution; Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Glutamic Acid; Humans; MAP Kinase Signaling System; Melanoma; Proto-Oncogene Proteins B-raf; Signal Transduction; Skin Neoplasms; Valine

2019
Erythema nodosum-like panniculitis in patients with melanoma treated with vemurafenib.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Jul-01, Volume: 31, Issue:19

    Topics: Adult; Antineoplastic Agents; Diagnosis, Differential; Erythema Nodosum; Female; Glutamic Acid; Humans; Indoles; Male; Melanoma; Middle Aged; Molecular Targeted Therapy; Panniculitis; Point Mutation; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Sulfonamides; Valine; Vemurafenib

2013
Absent response of intracranial melanoma metastases harboring BRAF V600E sequence variation to vemurafenib.
    Mayo Clinic proceedings, 2013, Volume: 88, Issue:12

    Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Fatal Outcome; Glutamic Acid; Humans; Ileal Neoplasms; Immunohistochemistry; Indoles; Magnetic Resonance Imaging; Male; Melanoma; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Sulfonamides; Treatment Failure; Valine; Vemurafenib

2013
BRAF V600E mutation in two distinct meningeal melanocytomas associated with a nevus of Ota.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014, Jul-10, Volume: 32, Issue:20

    Topics: Adolescent; Cell Transformation, Neoplastic; Glutamic Acid; Humans; Male; Melanocytes; Melanoma; Meningeal Neoplasms; Mutation; Nevus of Ota; Proto-Oncogene Proteins B-raf; Signal Transduction; Skin Neoplasms; Valine

2014
Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAFV600E inhibition.
    Journal of translational medicine, 2014, Sep-03, Volume: 12

    Topics: Amino Acid Substitution; Cell Proliferation; Dichloroacetic Acid; Drug Resistance, Neoplasm; Drug Synergism; Energy Metabolism; Glutamic Acid; Humans; Indoles; Melanoma; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Sulfonamides; Tumor Cells, Cultured; Valine; Vemurafenib

2014
BRAF inhibition for advanced locoregional BRAF V600E mutant melanoma: a potential neoadjuvant strategy.
    Melanoma research, 2016, Volume: 26, Issue:1

    Topics: Amino Acid Substitution; Antineoplastic Combined Chemotherapy Protocols; Disease Progression; Female; Follow-Up Studies; Glutamic Acid; Humans; Imidazoles; Indoles; Male; Melanoma; Middle Aged; Molecular Targeted Therapy; Mutation, Missense; Neoadjuvant Therapy; Oximes; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Retrospective Studies; Skin Neoplasms; Sulfonamides; Treatment Outcome; Valine; Vemurafenib

2016
Antitumor Activity of BRAF Inhibitor and IFNα Combination in BRAF-Mutant Melanoma.
    Journal of the National Cancer Institute, 2016, Volume: 108, Issue:7

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Glutamic Acid; Humans; Immunohistochemistry; Interferon-alpha; MAP Kinase Signaling System; Melanoma; Mice; Mice, Inbred NOD; Mice, SCID; Mutation; Proto-Oncogene Proteins B-raf; Receptor, Interferon alpha-beta; Signal Transduction; Skin Neoplasms; Valine

2016
In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation.
    Molecular cancer therapeutics, 2008, Volume: 7, Issue:6

    Topics: Amino Acid Substitution; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Codon; Drug Screening Assays, Antitumor; Glutamic Acid; Humans; Melanoma; Mutant Proteins; Mutation; Phenothiazines; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; ras Proteins; Reproducibility of Results; Valine

2008
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.
    Molecular cancer therapeutics, 2008, Volume: 7, Issue:9

    Topics: Amino Acid Substitution; Base Sequence; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase 4; DNA Mutational Analysis; Drug Resistance, Neoplasm; Gene Amplification; Glutamic Acid; Humans; Imidazoles; Melanoma; Molecular Sequence Data; Mutation; Proto-Oncogene Proteins B-raf; Valine

2008
CRAF inhibition induces apoptosis in melanoma cells with non-V600E BRAF mutations.
    Oncogene, 2009, Jan-08, Volume: 28, Issue:1

    Topics: Apoptosis; Benzenesulfonates; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Knockdown Techniques; Glutamic Acid; Humans; Melanoma; Mitogen-Activated Protein Kinase Kinases; Mutation; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Pyridines; RNA, Small Interfering; Signal Transduction; Sorafenib; Valine

2009
An inexpensive, specific and highly sensitive protocol to detect the BrafV600E mutation in melanoma tumor biopsies and blood.
    Melanoma research, 2010, Volume: 20, Issue:5

    Topics: Amino Acid Substitution; Biopsy; Blood Chemical Analysis; Cell Line, Tumor; Cost-Benefit Analysis; Cytogenetic Analysis; DNA Mutational Analysis; Glutamic Acid; HT29 Cells; Humans; Melanoma; Models, Biological; Proto-Oncogene Proteins B-raf; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Skin Neoplasms; Valine

2010
Stability of BRAF V600E mutation in metastatic melanoma: new insights for therapeutic success?
    British journal of cancer, 2011, Jul-12, Volume: 105, Issue:2

    Topics: Amino Acid Substitution; Disease Progression; Glutamic Acid; Humans; Melanoma; Mutation, Missense; Neoplasm Metastasis; Prognosis; Proto-Oncogene Proteins B-raf; Selection, Genetic; Skin Neoplasms; Treatment Outcome; Valine

2011
Prevalence of BRAF V600E mutation in Chinese melanoma patients: large scale analysis of BRAF and NRAS mutations in a 432-case cohort.
    European journal of cancer (Oxford, England : 1990), 2012, Volume: 48, Issue:1

    Topics: Adult; Aged; Amino Acid Substitution; Asian People; Cohort Studies; DNA Mutational Analysis; Female; Genes, ras; Glutamic Acid; Humans; Male; Melanoma; Middle Aged; Mutation Rate; Mutation, Missense; Prognosis; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Valine

2012
Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis.
    Genes & development, 2012, May-15, Volume: 26, Issue:10

    Topics: Amino Acid Substitution; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p15; Enzyme Activation; Fibroblasts; Glutamic Acid; Humans; Melanocytes; Melanoma; Nevus; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Skin Neoplasms; Valine

2012
Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma.
    Journal of the National Cancer Institute, 2012, Nov-07, Volume: 104, Issue:21

    Topics: Animals; Antineoplastic Agents; Aspartic Acid; Benzamides; Blotting, Western; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p18; Cyclin-Dependent Kinase Inhibitor p21; Flow Cytometry; Gene Expression Regulation, Neoplastic; Genes, ras; Glutamic Acid; Glycine; Humans; MAP Kinase Signaling System; Melanocytes; Melanoma; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-jun; RNA, Small Interfering; Transcription Factor AP-1; Transfection; Transplantation, Heterologous; Valine; Viral Vaccines

2012
BRAF inhibitor activity in V600R metastatic melanoma.
    European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Substitution; Antineoplastic Agents; Arginine; Compassionate Use Trials; Female; Humans; Imidazoles; Male; Melanoma; Middle Aged; Mutation, Missense; Neoplasm Metastasis; Oximes; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Valine; Young Adult

2013
Mechanisms limiting distribution of the threonine-protein kinase B-RaF(V600E) inhibitor dabrafenib to the brain: implications for the treatment of melanoma brain metastases.
    The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:3

    Topics: Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Brain Neoplasms; Cell Line; Dogs; Imidazoles; Indoles; Madin Darby Canine Kidney Cells; Melanoma; Mice; Mice, Knockout; Oximes; Pilot Projects; Proto-Oncogene Proteins B-raf; Sulfonamides; Valine; Vemurafenib

2013
INCORPORATION OF L-VALINE BY MELANO-PROTEIN PARTICLES IN VITRO.
    Biochimica et biophysica acta, 1963, Aug-13, Volume: 74

    Topics: Adenosine Triphosphate; Carbon Isotopes; Chromatography; Citric Acid Cycle; In Vitro Techniques; Melanoma; Mice; Neoplasm Proteins; Neoplasms, Experimental; Pharmacology; Proteins; Research; RNA; RNA, Neoplasm; Valine

1963
A novel methionine-53-valine mutation of p16 in a hereditary melanoma kindred.
    The Journal of investigative dermatology, 2004, Volume: 123, Issue:3

    Topics: Adult; Cyclin-Dependent Kinase Inhibitor p16; Female; Germ-Line Mutation; Humans; Male; Melanoma; Methionine; Pedigree; Point Mutation; Skin Neoplasms; Valine

2004
Detection of the BRAF V600E mutation in melanocytic lesions using the ligase detection reaction.
    Journal of cutaneous pathology, 2005, Volume: 32, Issue:5

    Topics: Base Sequence; DNA; DNA Mutational Analysis; Dysplastic Nevus Syndrome; Glutamic Acid; Humans; Ligases; Melanocytes; Melanoma; Molecular Sequence Data; Mutation; Nevus; Proto-Oncogene Proteins B-raf; Sensitivity and Specificity; Skin Neoplasms; Valine

2005
Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway.
    The Journal of investigative dermatology, 2007, Volume: 127, Issue:2

    Topics: Cells, Cultured; Disease Progression; Early Growth Response Protein 1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Glutamic Acid; Humans; Melanocytes; Melanoma; Mutation; Neoplasm Invasiveness; Proto-Oncogene Proteins B-raf; Signal Transduction; Valine

2007
Distinct clinical and pathological features are associated with the BRAF(T1799A(V600E)) mutation in primary melanoma.
    The Journal of investigative dermatology, 2007, Volume: 127, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alanine; Child; Female; Gene Frequency; Glutamic Acid; Humans; Male; Melanoma; Middle Aged; Multivariate Analysis; Mutation; Pigmentation; Proto-Oncogene Proteins B-raf; Skin Neoplasms; Threonine; Valine

2007
B-Raf(V600E) signaling deregulates the mitotic spindle checkpoint through stabilizing Mps1 levels in melanoma cells.
    Oncogene, 2008, May-15, Volume: 27, Issue:22

    Topics: Amino Acid Substitution; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Genes, cdc; Glutamic Acid; Humans; Melanoma; Phosphorylation; Polymorphism, Single Nucleotide; Protein Binding; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins B-raf; Signal Transduction; Spindle Apparatus; Transfection; Valine

2008
Akt3 and mutant V600E B-Raf cooperate to promote early melanoma development.
    Cancer research, 2008, May-01, Volume: 68, Issue:9

    Topics: Animals; Cell Adhesion; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Chromones; Disease Progression; Glutamic Acid; Humans; MAP Kinase Signaling System; Melanocytes; Melanoma; Mice; Morpholines; Mutant Proteins; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Signal Transduction; Valine

2008
Further evidence for ultraviolet light induction of CDKN2 (p16INK4) mutations in sporadic melanoma in vivo.
    The Journal of investigative dermatology, 1997, Volume: 108, Issue:6

    Topics: Alanine; Alleles; Arginine; Carrier Proteins; Cyclin-Dependent Kinase Inhibitor p16; DNA, Neoplasm; Enzyme Inhibitors; Exons; Heterozygote; Humans; Leucine; Melanoma; Mutation; Polymerase Chain Reaction; Skin; Skin Neoplasms; Ultraviolet Rays; Valine

1997
Genotype-phenotype relationships in U.S. melanoma-prone families with CDKN2A and CDK4 mutations.
    Journal of the National Cancer Institute, 2000, Jun-21, Volume: 92, Issue:12

    Topics: Adolescent; Adult; Age Factors; Aged; Arginine; Aspartic Acid; Cyclin-Dependent Kinases; Cysteine; Genes, p16; Genotype; Germ-Line Mutation; Glycine; Haplotypes; Humans; Melanoma; Middle Aged; Nevus; Pancreatic Neoplasms; Phenotype; Skin Neoplasms; Statistics, Nonparametric; Tryptophan; United States; Valine

2000
Structural consequences of tumor-derived mutations in p16INK4a probed by limited proteolysis.
    Biochemistry, 2002, May-21, Volume: 41, Issue:20

    Topics: Ankyrin Repeat; Aspartic Acid; Circular Dichroism; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinases; Endopeptidase K; Humans; Hydrolysis; Leucine; Melanoma; Mutation; Peptide Fragments; Proline; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Structure-Activity Relationship; Valine

2002
The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine.
    The Journal of biological chemistry, 1991, Aug-15, Volume: 266, Issue:23

    Topics: Amino Acid Sequence; Animals; Aspartic Acid; Cattle; Cell Adhesion; Chickens; Fibronectins; Humans; Leucine; Melanoma; Mice; Molecular Sequence Data; Molecular Weight; Rats; RNA Splicing; Sequence Homology, Nucleic Acid; Tumor Cells, Cultured; Valine

1991
Altered amino acid concentrations accompanying suppression of malignancy of mouse melanoma cells by 5-bromodeoxyuridine.
    Journal of the National Cancer Institute, 1974, Volume: 52, Issue:1

    Topics: Alanine; Amino Acids; Animals; Asparagine; Bromodeoxyuridine; Cells, Cultured; Glutamates; Glutamine; Glycine; Lysine; Melanoma; Methionine; Mice; Neoplasm Proteins; Ornithine; Phenylalanine; Pigmentation; Proline; Serine; Threonine; Valine

1974