valine and Insulin Sensitivity

valine has been researched along with Insulin Sensitivity in 72 studies

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-19905 (6.94)18.7374
1990's5 (6.94)18.2507
2000's17 (23.61)29.6817
2010's35 (48.61)24.3611
2020's10 (13.89)2.80

Authors

AuthorsStudies
Goh, HJ; Goh, JP; Govindharajulu, P; Henry, CJ; Leow, MK; Michael, N; Sadananthan, SA; Sun, L; Velan, SS; Verma, S1
Bishop, CA; Grune, T; Henkel, J; Henning, T; Klaus, S; Machate, T; Püschel, G; Weber, D; Weitkunat, K1
Chen, S; Eguchi, M; Fukunaga, A; Kabe, I; Kochi, T; Miki, T; Mizoue, T; Nanri, A1
Lenart-Lipinska, M; Matyjaszek-Matuszek, B; Szmygin, H; Szydelko, J; Wozniak, S1
Bi, Y; Chen, Y; Kong, L; Li, M; Lu, J; Ning, G; Wang, T; Wang, W; Wang, Y; Xu, M; Xu, Y; Ye, C; Zhao, Z; Zheng, J1
Alvarez, M; André Drevon, C; Birkeland, KI; Bjune, MS; Claussnitzer, M; Dankel, SN; Heinonen, S; Jersin, RÅ; Lee-Ødegård, S; McCann, A; Mellgren, G; Muniandy, M; Pajukanta, P; Pietiläinen, KH; Skartveit, L; Sri Priyanka Tallapragada, D1
Choi, HJ; Jeon, HJ; Kim, BJ; Kim, JM; Kim, YJ; Lee, HS; Oh, T; Yu, HY; Yun, JH1
Abdel Moneim, A; Mabrouk, D; Mahmoud, B; Suleiman, HA; Zaky, MY1
Johnson, MA; Lyon, ES; Rivera, ME; Sunderland, KL; Vaughan, RA1
Altıntaş, E; Ateş, F; Özdoğan, O; Sezgin, O; Üçbilek, E; Yaraş, S1
Alizadeh, A; Hafezi, M; Hajitarkhani, S; Moini, A; Shahhoseini, M1
Chen, SC; Chuang, WL; Dai, CY; Hsieh, MH; Huang, CF; Huang, CI; Huang, JF; Liang, PC; Lin, YH; Lin, ZY; Yang, JF; Yeh, ML; Yu, ML1
He, T; Ma, X; Nie, C; Zhang, G; Zhang, W1
Al-Majdoub, M; Ali, A; Carstensen, B; Ridderstråle, M; Safai, N; Spégel, P; Suvitaival, T; Vestergaard, H1
Cho, S; Park, KW; Yang, J1
Auriola, S; Giacco, R; Hanhineva, K; Jokkala, J; Kärkkäinen, O; Koistinen, V; Kolehmainen, M; Lankinen, MA; Lehtonen, M; Leppänen, J; Micard, V; Mykkänen, H; Poutanen, K; Riccardi, G; Rivellese, AAA; Rosa-Sibakov, N; Schwab, U; Uusitupa, M; Vitale, M1
Kuusisto, J; Laakso, M; Smith, U; Stancáková, A; Vangipurapu, J1
El-Bassossy, HM; El-Fawal, R; Fahmy, A; Watson, ML1
Cong, XD; Dai, DZ; Dai, Y; Shi, FH; Wu, Y; Zhang, YM1
Choi, H; Han, SH; Koh, KK; Lee, K; Lee, Y; Lim, S; Oh, PC; Quon, MJ; Sakuma, I; Shin, EK1
Araki, E; Goto, R; Igata, M; Kawasaki, S; Kawashima, J; Kitano, S; Kondo, T; Matsumura, T; Matsuyama, R; Miyagawa, K; Motoshima, H; Ono, K1
Chen, S; Deng, J; Du, Y; Guo, F; Guo, Y; Li, K; Sheng, H; Xiao, F; Yu, J; Zhu, J1
Choovichian, P; Leelasiri, K; Satirapoj, B; Supasyndh, O1
Kim, SH; Lee, JH; Park, JY; Park, S1
Arrieta-Cruz, I; Gutiérrez-Juárez, R; Su, Y1
Bao, Y; Chen, T; Hu, C; Huang, F; Jia, W; Ma, X; Ni, Y; Rajani, C; Zhao, A; Zheng, X1
Civantos, E; Egido, J; Mas, S; Peiró, C; Ruiz-Ortega, M; Sánchez, MS; Vázquez, C; Zhenyukh, O1
Kohno, N; Nakanishi, S; Nakashima, R; Nojima, H; Ohishi, W; Watanabe, H; Yamane, K; Yoneda, M1
Bergmann, A; Bornstein, SR; Fischer, S; Grässler, J; Li, J; Reimann, M; Schulze, J; Schwarz, PE; Selisko, T1
Chen, YH; Chen, YY; Qi, CJ; Yuan, L1
Bassols, J; Botas, P; Delgado, E; Fernández-Real, JM; Menéndez, JA; Moreno-Navarrete, JM; Ortega, FJ; Pardo, G; Ricart, W; Valdés, S; Vázquez-Martín, A1
Frank, H; Heemann, U; Pscherer, S1
Carter, JD; Cole, BK; Keller, SR; Nadler, JL; Nunemaker, CS; Wu, R1
Kondo, K; Nomura, Y; Oiso, Y; Ozaki, N; Sobajima, H1
Kazawa, T; Kuroki, N; Kuwabara, M; Maruki, T; Odagaki, Y; Toyoshima, R; Yamashita, H; Yoda, H1
Blaak, EE; Diamant, M; Goossens, GH; Hermans, MM; Moors, CC; van der Zijl, NJ1
Jin, D; Miyazaki, M; Takai, S1
Matsuura, K; Mori, Y; Tanaka, T; Utsunomiya, K; Yokoyama, J1
Blaak, EE; Diamant, M; Goossens, GH; Ijzerman, RG; Moors, CC; Serné, EH; van der Zijl, NJ1
de Leeuw, PW1
Eringa, EC1
Akazawa, H; Asano, T; Fujishiro, M; Fukushima, T; Iwashita, M; Kamata, H; Kikuchi, T; Komuro, I; Kumamoto, S; Kurihara, H; Kushiyama, A; Nakatsu, Y; Nishimura, F; Ohno, H; Sakoda, H; Tsuchiya, Y1
Peng, XD; Yang, ZH1
Horiguchi, CS; Makino, H; Miyoshi, T; Murakami, K; Nakamura, Y; Ogawa, D; Sasaki, M; Uchida, HA; Wada, J1
Ando, H; Fujimura, A; Hosohata, K; Saito, T; Ushijima, K1
Clish, CB; Deik, AA; Fleischman, A; Gerszten, RE; Grinspoon, SK; McCarthy, MA; McCormack, SE; Mootha, VK; Shaham, O; Wang, TJ1
Ala-Korpela, M; Kähönen, M; Kangas, AJ; Lehtimäki, T; Raitakari, OT; Rönnemaa, T; Soininen, P; Viikari, JS; Würtz, P1
Ando, H; Fujimura, A; Ishikawa-Kobayashi, E; Maekawa, T; Nozawa, M; Shiga, T; Takuma, M; Ushijima, K1
Brozinick, JT; Grove, K; Hawkins, E; Hoang Bui, H; Kievit, P; Kuo, MS; Tan, B1
RIESER, CH; RIESER, P1
Cui, TX; Horiuchi, M; Iwai, M; Li, HS; Li, JM; Min, LJ; Okumura, M; Shiuchi, T; Wu, L1
Karhapää, P; Kuusisto, J; Laakso, M; Moilanen Mykkänen, L; Pihlajamäki, J; Rutanen, J; Vauhkonen, I1
Bahtyiar, G; Blendea, MC; Ferrario, CM; Jacobs, D; Kumar, P; McFarlane, SI; Ogrin, C; Sha, Q; Sowers, JR; Stas, S; Stump, CS1
Cucuianu, M; Dican, L1
Takeuchi, M; Yamagishi, S1
Derosa, G; Fogari, E; Fogari, R; Lazzari, P; Mugellini, A; Preti, P; Rinaldi, A; Zoppi, A1
Barroso, I; Cooper, C; Day, IN; Fawcett, KA; Luan, J; O'Rahilly, S; Sandhu, MS; Syddall, H; Wareham, NJ1
Acikel, C; Caglar, K; Celik, T; Eyileten, T; Oguz, Y; Sonmez, A; Vural, A; Yavuz, I; Yenicesu, M; Yilmaz, MI1
Chen, K; Clark, SE; Ferrario, CM; Habibi, J; Sowers, JR; Stump, CS; Uptergrove, GM; Wei, Y; Whaley-Connell, AT1
Acikel, C; Caglar, K; Cakir, E; Eyileten, T; Kurt, Y; Oguz, Y; Saglam, M; Sonmez, A; Tasar, M; Vural, A; Yenicesu, M; Yilmaz, MI1
Ichikawa, Y1
Boehm, TM; Bongiovanni, R; Glass, AR; Smith, CE1
Chow, L; De Gasparo, M; Levens, N1
Accili, D; Baron, V; Dolais-Kitabgi, J; Gautier, N; Kaliman, P; Lebrun, C; Taylor, S; Van Obberghen, E1
Hashimoto, N; Hatanaka, Y; Kanashiro, O; Makino, H; Notoya, Y; Nozaki, O; Shimada, F; Suzuki, Y; Taira, M; Yoshida, S1
Clausen, JO; Echwald, SM; Hansen, L; Hansen, T; Pedersen, O; Rasmussen, SK; Urhammer, SA1
Alfieri, R; Colao, A; Faggiano, A; Filippella, M; Lombardi, G; Melis, D; Pivonello, R; Salvatore, F; Spagnuolo, G1
Dunseath, G; Luzio, SD; Owens, DR1
Akanuma, Y; Izumi, T; Koshio, O; Matsuura, N; Mikami, Y; Odawara, M; Shiba, T; Shibasaki, Y; Tobe, K; Yamamoto, R1
Accili, D; Elbein, SC; Frapier, C; Lander, E; McKeon, C; Mosthaf, L; Permutt, MA; Ramos, E; Taylor, SI; Ullrich, A1
Herbertz, L; Langer, K; Schauder, P; Zavelberg, D1
Cahill, GF; Felig, P; Marliss, E1

Reviews

4 review(s) available for valine and Insulin Sensitivity

ArticleYear
Branched-chain amino acids as a novel biomarker of metabolic disturbances in women with polycystic ovary syndrome - literature review.
    Ginekologia polska, 2022, Volume: 93, Issue:8

    Topics: Amino Acids, Branched-Chain; Animals; Biomarkers; Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Isoleucine; Leucine; Obesity; Polycystic Ovary Syndrome; Prediabetic State; Valine

2022
Causal effect of lower birthweight on non-alcoholic fatty liver disease and mediating roles of insulin resistance and metabolites.
    Liver international : official journal of the International Association for the Study of the Liver, 2023, Volume: 43, Issue:4

    Topics: Adult; Alanine; Birth Weight; Child; Genome-Wide Association Study; Humans; Insulin Resistance; Isoleucine; Leucine; Non-alcoholic Fatty Liver Disease; Pediatric Obesity; Polymorphism, Single Nucleotide; Valine

2023
Branched Chain Amino Acids: Beyond Nutrition Metabolism.
    International journal of molecular sciences, 2018, Mar-23, Volume: 19, Issue:4

    Topics: Amino Acids, Branched-Chain; Animals; Diabetes Mellitus, Type 2; Humans; Insulin Resistance; Isoleucine; Leucine; Metabolic Diseases; Signal Transduction; Valine

2018
Coagulation factor XIII and atherothrombosis. A mini-review.
    Romanian journal of internal medicine = Revue roumaine de medecine interne, 2003, Volume: 41, Issue:4

    Topics: Arteriosclerosis; Diabetes Mellitus, Type 2; Factor XIII; Fibrinolysis; Humans; Insulin Resistance; Leucine; Metabolic Syndrome; Polymorphism, Genetic; Valine

2003

Trials

17 trial(s) available for valine and Insulin Sensitivity

ArticleYear
Brown adipose tissues mediate the metabolism of branched chain amino acids during the transitioning from hyperthyroidism to euthyroidism (TRIBUTE).
    Scientific reports, 2022, 03-07, Volume: 12, Issue:1

    Topics: Adipose Tissue, Brown; Amino Acids, Branched-Chain; Fluorodeoxyglucose F18; Humans; Hyperthyroidism; Insulin; Insulin Resistance; Isoleucine; Leucine; Valine

2022
Viral clearance ameliorates hematological and inflammatory markers among diabetic patients infected with hepatitis C genotype 4.
    Clinical and experimental medicine, 2020, Volume: 20, Issue:2

    Topics: Adult; Antiviral Agents; Biomarkers; Carbamates; Diabetes Mellitus, Type 2; Female; Genotype; Glycated Hemoglobin; Hepacivirus; Hepatitis C; Humans; Imidazoles; Inflammation; Insulin Resistance; Interleukin-1beta; Male; Middle Aged; Pyrrolidines; Sofosbuvir; Sustained Virologic Response; Treatment Outcome; Valine

2020
Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial.
    Diabetic medicine : a journal of the British Diabetic Association, 2018, Volume: 35, Issue:7

    Topics: Aged; Carnitine; Chromatography, Liquid; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin Resistance; Isoleucine; Leucine; Lysophospholipids; Male; Mass Spectrometry; Metabolome; Metabolomics; Metformin; Middle Aged; Mitochondria; Tyrosine; Valine

2018
Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
    The American journal of clinical nutrition, 2018, 11-01, Volume: 108, Issue:5

    Topics: Adult; Aged; Animals; Betaine; Blood Glucose; Chromatography, Liquid; Cohort Studies; Diet; Dietary Fiber; Feeding Behavior; Female; Finland; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Italy; Male; Metabolic Syndrome; Mice, Inbred C57BL; Middle Aged; Pipecolic Acids; Postprandial Period; Secale; Tandem Mass Spectrometry; Triticum; Valine; Whole Grains

2018
Combination pravastatin and valsartan treatment has additive beneficial effects to simultaneously improve both metabolic and cardiovascular phenotypes beyond that of monotherapy with either drug in patients with primary hypercholesterolemia.
    Diabetes, 2013, Volume: 62, Issue:10

    Topics: Angiotensin II Type 1 Receptor Blockers; Body Mass Index; Brachial Artery; C-Reactive Protein; Coronary Artery Disease; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Drug Therapy, Combination; Endothelium, Vascular; Female; Glycated Hemoglobin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Insulin Resistance; Lipids; Male; Middle Aged; Phenotype; Pravastatin; Tetrazoles; Treatment Outcome; Valine; Valsartan

2013
Short-term administration of an angiotensin II receptor blocker in patients with long-term hemodialysis patients improves insulin resistance.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2014, Volume: 97, Issue:6

    Topics: Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Blood Glucose; Female; Humans; Insulin Resistance; Kidney Failure, Chronic; Male; Middle Aged; Prospective Studies; Renal Dialysis; Tetrazoles; Valine; Valsartan

2014
Comparison of the effects of three angiotensin II receptor type 1 blockers on metabolic parameters in hypertensive patients with type 2 diabetes mellitus.
    European journal of internal medicine, 2010, Volume: 21, Issue:3

    Topics: Adiponectin; Aged; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Glucose; Blood Pressure; C-Reactive Protein; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Glycated Hemoglobin; Humans; Hypertension; Insulin Resistance; Lipids; Male; Middle Aged; Telmisartan; Tetrazoles; Treatment Outcome; Valine; Valsartan

2010
Valsartan improves {beta}-cell function and insulin sensitivity in subjects with impaired glucose metabolism: a randomized controlled trial.
    Diabetes care, 2011, Volume: 34, Issue:4

    Topics: Angiotensin Receptor Antagonists; Blood Glucose; Double-Blind Method; Female; Glucose Intolerance; Glucose Tolerance Test; Humans; Insulin Resistance; Insulin-Secreting Cells; Male; Middle Aged; Tetrazoles; Valine; Valsartan

2011
Influence of telmisartan on insulin response after glucose loading in obese patients with hypertension: ARB trial of hypertension in obese patients with hyperinsulinemia assessed by oral glucose tolerance test (ATHLETE).
    Advances in therapy, 2011, Volume: 28, Issue:8

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Blood Glucose; Blood Pressure; Female; Glucose; Glucose Tolerance Test; Humans; Hyperinsulinism; Hypertension; Insulin Resistance; Male; Obesity; Telmisartan; Tetrazoles; Valine; Valsartan

2011
Valsartan-induced improvement in insulin sensitivity is not paralleled by changes in microvascular function in individuals with impaired glucose metabolism.
    Journal of hypertension, 2011, Volume: 29, Issue:10

    Topics: Adipokines; Angiotensin II Type 1 Receptor Blockers; Blood Glucose; Capillaries; Cytokines; Diabetes Mellitus, Type 2; Female; Humans; Inflammation Mediators; Insulin Resistance; Male; Microvessels; Middle Aged; Tetrazoles; Valine; Valsartan

2011
The effects of telmisartan treatment on the abdominal fat depot in patients with metabolic syndrome and essential hypertension: Abdominal fat Depot Intervention Program of Okayama (ADIPO).
    Diabetes & vascular disease research, 2013, Volume: 10, Issue:1

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Blood Glucose; Blood Pressure; Body Mass Index; Body Weight; Female; Humans; Hypertension; Insulin Resistance; Intra-Abdominal Fat; Male; Metabolic Syndrome; Middle Aged; PPAR gamma; Subcutaneous Fat; Telmisartan; Tetrazoles; Tomography, X-Ray Computed; Treatment Outcome; Valine; Valsartan; Waist Circumference

2013
Relationship between the receptor occupancy profile and pleiotropic effects of angiotensin II receptor blockers.
    British journal of clinical pharmacology, 2013, Volume: 75, Issue:2

    Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Area Under Curve; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cross-Over Studies; Dinoprost; Double-Blind Method; Enzyme-Linked Immunosorbent Assay; Humans; Hypertension; Insulin; Insulin Resistance; Irbesartan; Luminescent Measurements; Male; Middle Aged; Oxidative Stress; Radioligand Assay; Receptors, Angiotensin; Tetrazoles; Time Factors; Valine; Valsartan; Young Adult

2013
Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2005, Volume: 28, Issue:3

    Topics: Aged; Antihypertensive Agents; Felodipine; Female; Humans; Hypertension; Insulin Resistance; Leptin; Male; Middle Aged; Obesity; Tetrazoles; Treatment Outcome; Valine; Valsartan

2005
Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome.
    Nephrology (Carlton, Vic.), 2007, Volume: 12, Issue:2

    Topics: Adiponectin; Adrenergic beta-Antagonists; Adult; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Body Mass Index; Calcium Channel Blockers; Doxazosin; Female; Humans; Hypertension; Insulin Resistance; Lipids; Male; Metabolic Syndrome; Metoprolol; Middle Aged; Predictive Value of Tests; Prospective Studies; Ramipril; Tetrazoles; Time Factors; Treatment Outcome; Valine; Valsartan

2007
Improving proteinuria, endothelial functions and asymmetric dimethylarginine levels in chronic kidney disease: ramipril versus valsartan.
    Blood purification, 2007, Volume: 25, Issue:4

    Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Arginine; Biomarkers; Blood Glucose; C-Reactive Protein; Female; Glomerular Filtration Rate; Hemorheology; Humans; Insulin Resistance; Kidney Failure, Chronic; Lipids; Male; Middle Aged; Proteinuria; Ramipril; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan; Vasodilation

2007
Comparative effects of telmisartan and valsartan on insulin resistance in hypertensive patients with metabolic syndrome.
    Internal medicine (Tokyo, Japan), 2007, Volume: 46, Issue:17

    Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Female; Humans; Hypertension; Insulin Resistance; Male; Metabolic Syndrome; Middle Aged; Telmisartan; Tetrazoles; Valine; Valsartan

2007
Acute effects of valsartan on insulin sensitivity in obese, non-hypertensive subjects with and without type 2 diabetes.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2002, Volume: 34, Issue:5

    Topics: Adolescent; Adult; Antihypertensive Agents; Cross-Over Studies; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Obesity; Tetrazoles; Valine; Valsartan

2002

Other Studies

51 other study(ies) available for valine and Insulin Sensitivity

ArticleYear
Detrimental effects of branched-chain amino acids in glucose tolerance can be attributed to valine induced glucotoxicity in skeletal muscle.
    Nutrition & diabetes, 2022, 04-13, Volume: 12, Issue:1

    Topics: Amino Acids, Branched-Chain; Animals; Glucose; Insulin Resistance; Leucine; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Obesity; Valine

2022
Associations of serum amino acids with insulin resistance among people with and without overweight or obesity: A prospective study in Japan.
    Clinical nutrition (Edinburgh, Scotland), 2022, Volume: 41, Issue:8

    Topics: Alanine; Animals; Humans; Insulin; Insulin Resistance; Isoleucine; Japan; Methionine; Obesity; Overweight; Prospective Studies; Thinness; Tyrosine; Valine

2022
Impaired Adipocyte SLC7A10 Promotes Lipid Storage in Association With Insulin Resistance and Altered BCAA Metabolism.
    The Journal of clinical endocrinology and metabolism, 2023, 08-18, Volume: 108, Issue:9

    Topics: Adipocytes; Amino Acids; Amino Acids, Branched-Chain; Animals; Fatty Acids; Glucose; Humans; Insulin Resistance; Lipid Metabolism; Mice; Obesity; RNA, Messenger; Tandem Mass Spectrometry; Valine

2023
Metabolomics profiles associated with HbA1c levels in patients with type 2 diabetes.
    PloS one, 2019, Volume: 14, Issue:11

    Topics: Aged; Amino Acids; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glucose; Glycated Hemoglobin; Glycine; Hexoses; Humans; Insulin Resistance; Male; Metabolomics; Middle Aged; Phosphatidylcholines; Valine

2019
Effect of valine on myotube insulin sensitivity and metabolism with and without insulin resistance.
    Molecular and cellular biochemistry, 2020, Volume: 468, Issue:1-2

    Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Amino Acids, Branched-Chain; Animals; Cell Line; Cell Survival; Glycolysis; Insulin; Insulin Resistance; Mice; Mitochondria; Muscle Fibers, Skeletal; Muscle, Skeletal; Signal Transduction; Valine

2020
The impact of direct-acting antiviral treatment on lipid metabolism and insulin resistance in chronic hepatitis C patients: temporary? permanent?
    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 2020, Volume: 31, Issue:5

    Topics: Aged; Anilides; Antiviral Agents; Benzimidazoles; Blood Glucose; Cholesterol; Cyclopropanes; Drug Therapy, Combination; Female; Fluorenes; Hepacivirus; Hepatitis C, Chronic; Humans; Insulin Resistance; Lactams, Macrocyclic; Lipid Metabolism; Lipoproteins, LDL; Male; Middle Aged; Proline; Ribavirin; Ritonavir; Sofosbuvir; Sulfonamides; Sustained Virologic Response; Treatment Outcome; Triglycerides; Valine

2020
Differences in gene expression of enzymes involved in branched-chain amino acid metabolism of abdominal subcutaneous adipose tissue between pregnant women with and without PCOS.
    Taiwanese journal of obstetrics & gynecology, 2021, Volume: 60, Issue:2

    Topics: Adult; Amino Acids, Branched-Chain; Body Mass Index; Female; Gene Expression; Humans; Insulin Resistance; Isoleucine; Leucine; Polycystic Ovary Syndrome; Pregnancy; Pregnancy Complications; Prognosis; Real-Time Polymerase Chain Reaction; RNA, Messenger; Subcutaneous Fat, Abdominal; Valine

2021
The outcomes of glucose abnormalities in chronic hepatitis C patients receiving interferon-free direct antiviral agents.
    The Kaohsiung journal of medical sciences, 2017, Volume: 33, Issue:11

    Topics: 2-Naphthylamine; Aged; Anilides; Antiviral Agents; Carbamates; Cyclopropanes; Drug Therapy, Combination; Female; Genotype; Glucose; Hepacivirus; Hepatitis C, Chronic; Humans; Imidazoles; Insulin Resistance; Insulin-Secreting Cells; Isoquinolines; Lactams, Macrocyclic; Macrocyclic Compounds; Male; Middle Aged; Proline; Prospective Studies; Pyrrolidines; Ritonavir; Sofosbuvir; Sulfonamides; Uracil; Valine

2017
Inhibition of the CD36 receptor reduces visceral fat accumulation and improves insulin resistance in obese mice carrying the BDNF-
    The Journal of biological chemistry, 2018, 08-24, Volume: 293, Issue:34

    Topics: Animals; Benzofurans; Brain-Derived Neurotrophic Factor; CD36 Antigens; Cell Differentiation; Diet, High-Fat; Insulin Resistance; Intra-Abdominal Fat; Male; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Mutation; Obesity; Valine

2018
Nine Amino Acids Are Associated With Decreased Insulin Secretion and Elevated Glucose Levels in a 7.4-Year Follow-up Study of 5,181 Finnish Men.
    Diabetes, 2019, Volume: 68, Issue:6

    Topics: Aged; Alanine; Amino Acids; Aspartic Acid; Blood Glucose; Diabetes Mellitus, Type 2; Finland; Follow-Up Studies; Glutamic Acid; Humans; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Metabolomics; Middle Aged; Phenylalanine; Risk Factors; Tryptophan; Tyrosine; Valine

2019
Arginase inhibition alleviates hypertension in the metabolic syndrome.
    British journal of pharmacology, 2013, Volume: 169, Issue:3

    Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Arginase; Blood Pressure; Citrulline; Endothelium, Vascular; Enzyme Inhibitors; Hyperinsulinism; Hypertension; Hypertriglyceridemia; Hypolipidemic Agents; Insulin Resistance; Male; Metabolic Syndrome; Nitric Oxide; Ornithine; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Valine

2013
Hepatosteatosis and hepatic insulin resistance are blunted by argirein, an anti-inflammatory agent, through normalizing endoplasmic reticulum stress and apoptosis in diabetic liver.
    The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:6

    Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Apoptosis; Arginine; Diabetes Mellitus, Experimental; Diet, High-Fat; Drug Combinations; eIF-2 Kinase; Endoplasmic Reticulum Stress; Glucose; Glucose Transporter Type 4; Glutathione Peroxidase; Glycogen; Heat-Shock Proteins; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Liver; Male; PPAR alpha; PPAR gamma; Rats; Rats, Sprague-Dawley; Receptors, Leptin; Tetrazoles; Transcription Factor CHOP; Valine; Valsartan

2013
Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes.
    Cardiovascular diabetology, 2013, Nov-04, Volume: 12

    Topics: Adamantane; Adiponectin; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Fatty Liver; Homeodomain Proteins; Inflammation; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Nitriles; Phlorhizin; Pyrrolidines; Tetrazoles; Trans-Activators; Valine; Valsartan; Vildagliptin

2013
Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice.
    Metabolism: clinical and experimental, 2014, Volume: 63, Issue:6

    Topics: Amino Acids, Branched-Chain; AMP-Activated Protein Kinases; Animals; Blood Glucose; Blotting, Western; Cell Line; Gluconeogenesis; Glucose-6-Phosphatase; Hep G2 Cells; Hepatocytes; Humans; Insulin Resistance; Isoleucine; Male; Mice; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; TOR Serine-Threonine Kinases; Valine

2014
Plasma levels of lysine, tyrosine, and valine during pregnancy are independent risk factors of insulin resistance and gestational diabetes.
    Metabolic syndrome and related disorders, 2015, Volume: 13, Issue:2

    Topics: Adult; Aging; Asian People; Blood Glucose; Blood Pressure; Diabetes, Gestational; Diet; Energy Intake; Female; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Lysine; Pregnancy; Risk Factors; Tyrosine; Valine

2015
Suppression of Endogenous Glucose Production by Isoleucine and Valine and Impact of Diet Composition.
    Nutrients, 2016, Feb-15, Volume: 8, Issue:2

    Topics: Animals; Blood Glucose; Diet; Diet, High-Fat; Dietary Fats; Dietary Proteins; Gluconeogenesis; Hypothalamus; Insulin Resistance; Isoleucine; Liver; Male; Rats, Sprague-Dawley; Valine

2016
Tryptophan Predicts the Risk for Future Type 2 Diabetes.
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Adult; Aged; Biomarkers; Blood Glucose; Case-Control Studies; China; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Insulin; Insulin Resistance; Isoleucine; Leucine; Longitudinal Studies; Male; Middle Aged; Phenylalanine; Predictive Value of Tests; Prognosis; Risk Factors; Tryptophan; Tyrosine; Valine

2016
High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation.
    Free radical biology & medicine, 2017, Volume: 104

    Topics: Amino Acids, Branched-Chain; Cell Movement; Humans; Inflammation; Insulin Resistance; Interleukin-6; Isoleucine; Leucine; Leukocytes, Mononuclear; Mechanistic Target of Rapamycin Complex 1; Mitochondria; NF-kappa B; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha; Valine

2017
Manganese superoxide dismutase Ala16Val polymorphism is associated with the development of type 2 diabetes in Japanese-Americans.
    Diabetes research and clinical practice, 2008, Volume: 81, Issue:3

    Topics: Alanine; Amino Acid Substitution; Diabetes Mellitus, Type 2; Female; Glucose Intolerance; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Japan; Male; Middle Aged; Polymorphism, Genetic; Reactive Oxygen Species; Superoxide Dismutase; United States; Valine

2008
The A98V single nucleotide polymorphism (SNP) in hepatic nuclear factor 1 alpha (HNF-1alpha) is associated with insulin sensitivity and beta-cell function.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2008, Volume: 116 Suppl 1

    Topics: Adult; Alanine; Diabetes Mellitus, Type 2; Female; Genetic Linkage; Genotype; Hepatocyte Nuclear Factor 1-alpha; Humans; Insulin; Insulin Resistance; Insulin-Secreting Cells; Male; Middle Aged; Polymorphism, Single Nucleotide; Valine

2008
[The effects of renin-angiotensin system blockade on the liver steatosis in rats on long-term high-fat diet].
    Zhonghua nei ke za zhi, 2008, Volume: 47, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Dietary Fats; Fatty Liver; Immunohistochemistry; Insulin Resistance; Ion Channels; Liver; Male; Mitochondrial Proteins; Perindopril; Rats; Rats, Wistar; Renin-Angiotensin System; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazoles; Time Factors; Transforming Growth Factor beta1; Uncoupling Protein 2; Valine; Valsartan

2008
Val1483Ile in FASN gene is linked to central obesity and insulin sensitivity in adult white men.
    Obesity (Silver Spring, Md.), 2009, Volume: 17, Issue:9

    Topics: Adipose Tissue; Adiposity; Adult; Age Factors; Blood Glucose; Blood Pressure; Body Mass Index; Case-Control Studies; Down-Regulation; Fatty Acid Synthase, Type I; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Insulin Resistance; Isoleucine; Male; Middle Aged; Obesity; Phenotype; Polymorphism, Single Nucleotide; Risk Factors; Sex Factors; Time Factors; Valine; Waist-Hip Ratio; Weight Gain

2009
Effect of Renin-Angiotensin system blockade on insulin resistance and inflammatory parameters in patients with impaired glucose tolerance.
    Diabetes care, 2010, Volume: 33, Issue:4

    Topics: Adiponectin; Adult; Angiotensin II Type 1 Receptor Blockers; C-Reactive Protein; Glucose Intolerance; Humans; Insulin Resistance; Male; Middle Aged; Prospective Studies; Renin-Angiotensin System; Retinol-Binding Proteins, Plasma; Tetrazoles; Valine; Valsartan

2010
Valsartan protects pancreatic islets and adipose tissue from the inflammatory and metabolic consequences of a high-fat diet in mice.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 55, Issue:3

    Topics: Adipocytes; Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animal Feed; Animals; Body Weight; Cytokines; Diabetes Mellitus, Type 2; Dietary Fats; Disease Models, Animal; Gene Expression; Glucose Intolerance; Inflammation; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Macrophages; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mitochondria; Tetrazoles; Valine; Valsartan

2010
Angiotensin II type 1 receptor blockers improve insulin sensitivity in patients with schizophrenia being treated with olanzapine.
    Psychopharmacology, 2011, Volume: 213, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Antipsychotic Agents; Benzimidazoles; Benzoates; Benzodiazepines; Female; Humans; Hyperinsulinism; Insulin Resistance; Male; Middle Aged; Olanzapine; Receptor, Angiotensin, Type 1; Schizophrenia; Telmisartan; Tetrazoles; Valine; Valsartan

2011
Irbesartan prevents metabolic syndrome in rats via activation of peroxisome proliferator-activated receptor γ.
    Journal of pharmacological sciences, 2011, Volume: 116, Issue:3

    Topics: Adiponectin; Adipose Tissue; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Gene Expression Regulation; Glucose Transporter Type 4; Hypertension; Hypertriglyceridemia; Hypoglycemic Agents; Insulin Resistance; Irbesartan; Male; Metabolic Syndrome; Pioglitazone; PPAR gamma; Rats; Rats, Inbred SHR; RNA, Messenger; Tetrazoles; Thiazolidinediones; Valine; Valsartan

2011
Resistance to antihypertensive treatment: reality or artifact of reasoning?
    Journal of hypertension, 2011, Volume: 29, Issue:10

    Topics: Angiotensin II Type 1 Receptor Blockers; Female; Humans; Insulin Resistance; Male; Microvessels; Tetrazoles; Valine; Valsartan

2011
To PRESERVE and protect: targeting the microcirculation in prevention of diabetes and its complications.
    Journal of hypertension, 2011, Volume: 29, Issue:10

    Topics: Angiotensin II Type 1 Receptor Blockers; Female; Humans; Insulin Resistance; Male; Microvessels; Tetrazoles; Valine; Valsartan

2011
Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.
    American journal of physiology. Endocrinology and metabolism, 2012, Feb-01, Volume: 302, Issue:3

    Topics: 3T3-L1 Cells; Adipocytes, White; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cells, Cultured; Coculture Techniques; Humans; Insulin Resistance; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; PPAR gamma; Receptor, Angiotensin, Type 1; RNA Interference; RNA, Small Interfering; Tetrazoles; Valine; Valsartan

2012
Effects of valsartan on diabetic cardiomyopathy in rats with type 2 diabetes mellitus.
    Chinese medical journal, 2010, Volume: 123, Issue:24

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Collagen Type I; Collagen Type III; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Hydroxyproline; Insulin Resistance; Male; Myocardium; Rats; Rats, Wistar; Tetrazoles; Valine; Valsartan

2010
Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents.
    Pediatric obesity, 2013, Volume: 8, Issue:1

    Topics: Adolescent; Amino Acids, Branched-Chain; Biomarkers; Blood Glucose; Body Mass Index; Child; Child Nutrition Disorders; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Fasting; Female; Humans; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Longitudinal Studies; Male; Massachusetts; Obesity; Predictive Value of Tests; Valine

2013
Branched-chain and aromatic amino acids are predictors of insulin resistance in young adults.
    Diabetes care, 2013, Volume: 36, Issue:3

    Topics: Adult; Amino Acids; Female; Humans; Insulin Resistance; Isoleucine; Leucine; Male; Phenylalanine; Tyrosine; Valine; Young Adult

2013
Effects of telmisartan and valsartan on insulin sensitivity in obese diabetic mice.
    European journal of pharmacology, 2013, Jan-05, Volume: 698, Issue:1-3

    Topics: Adiponectin; Adipose Tissue; Animals; Benzimidazoles; Benzoates; Body Weight; Diabetes Mellitus; Eating; Fatty Acid Synthases; Fatty Acid-Binding Proteins; Gene Expression Regulation; Homeostasis; Insulin Resistance; Interleukin-6; Male; Mice; Mice, Obese; PPAR gamma; RNA, Messenger; Telmisartan; Tetrazoles; Tumor Necrosis Factor-alpha; Valine; Valsartan

2013
Plasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a Western-style diet.
    International journal of obesity (2005), 2013, Volume: 37, Issue:8

    Topics: Animals; Biomarkers; Ceramides; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Disease Progression; Fructose; Insulin Resistance; Macaca mulatta; Male; Metabolic Syndrome; Obesity; Risk Factors; Serine C-Palmitoyltransferase; Sphingolipids; Valine

2013
REVERSAL OF INSULIN RESISTANCE IN RED CELL SUGAR TRANSPORT.
    Archives of biochemistry and biophysics, 1964, Volume: 105

    Topics: Arabinose; Biological Transport; Carbohydrate Metabolism; Chymotrypsin; Erythrocytes; Fructose; Galactose; Glycerol; Insulin; Insulin Resistance; Lipase; Mannose; Permeability; Pharmacology; Phospholipases; Research; Ribose; Sorbose; Threonine; Urea; Valine; Xylose

1964
Angiotensin II type-1 receptor blocker valsartan enhances insulin sensitivity in skeletal muscles of diabetic mice.
    Hypertension (Dallas, Tex. : 1979), 2004, Volume: 43, Issue:5

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Crosses, Genetic; Deoxyglucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Intake; Gene Expression Regulation; Glucose Transporter Type 4; Imidazoles; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Obese; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Protein Transport; Pyridines; Signal Transduction; Superoxides; Tetrazoles; Tumor Necrosis Factor-alpha; Valine; Valsartan

2004
The Val103Ile polymorphism of melanocortin-4 receptor regulates energy expenditure and weight gain.
    Obesity research, 2004, Volume: 12, Issue:7

    Topics: Adult; Aged; Alleles; Blood Glucose; Calorimetry, Indirect; Energy Metabolism; Fatty Acids, Nonesterified; Finland; Gene Frequency; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Isoleucine; Middle Aged; Oxidation-Reduction; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Prospective Studies; Receptor, Melanocortin, Type 4; Sequence Analysis, DNA; Valine; Weight Gain

2004
Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression.
    American journal of physiology. Endocrinology and metabolism, 2005, Volume: 288, Issue:2

    Topics: Administration, Oral; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cyclic N-Oxides; Disease Models, Animal; Glucose; Hypertension; Insulin; Insulin Resistance; Male; Muscle, Skeletal; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Spin Labels; Tetrazoles; Valine; Valsartan

2005
Telmisartan is a promising cardiometabolic sartan due to its unique PPAR-gamma-inducing property.
    Medical hypotheses, 2005, Volume: 64, Issue:3

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Benzimidazoles; Benzoates; Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Humans; Hypertension; Insulin Resistance; PPAR gamma; Renin-Angiotensin System; Telmisartan; Tetrazoles; Valine; Valsartan

2005
PARL Leu262Val is not associated with fasting insulin levels in UK populations.
    Diabetologia, 2006, Volume: 49, Issue:11

    Topics: Aged; Amino Acid Substitution; Body Mass Index; Cohort Studies; Fasting; Genotype; Humans; Insulin; Insulin Resistance; Leucine; Male; Metalloproteases; Middle Aged; Mitochondrial Proteins; Models, Genetic; United Kingdom; Valine

2006
NADPH oxidase contributes to vascular inflammation, insulin resistance, and remodeling in the transgenic (mRen2) rat.
    Hypertension (Dallas, Tex. : 1979), 2007, Volume: 50, Issue:2

    Topics: Animals; Animals, Genetically Modified; Apoptosis; Blood Pressure; Blotting, Western; C-Reactive Protein; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Insulin Resistance; Male; Muscle, Smooth, Vascular; NADPH Oxidases; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sensitivity and Specificity; Superoxide Dismutase; Tetrazoles; Valine; Valsartan; Vasculitis

2007
Normal valine disposal in obese subjects with impaired glucose disposal: evidence for selective insulin resistance.
    Metabolism: clinical and experimental, 1981, Volume: 30, Issue:6

    Topics: Blood Glucose; Female; Glucose; Humans; Insulin; Insulin Resistance; Male; Metabolic Clearance Rate; Obesity; Valine

1981
Improved glucose metabolism following blockade of angiotensin converting enzyme but not angiotensin AT1 receptors.
    European journal of pharmacology, 1995, Aug-25, Volume: 282, Issue:1-3

    Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzazepines; Blood Glucose; Blood Pressure; Body Weight; Drug Tolerance; Glucose Intolerance; Hypertension; Insulin Resistance; Lipids; Rats; Rats, Inbred SHR; Tetrazoles; Valine; Valsartan

1995
Antibodies to the extracellular receptor domain restore the hormone-insensitive kinase and conformation of the mutant insulin receptor valine 382.
    The Journal of biological chemistry, 1993, May-25, Volume: 268, Issue:15

    Topics: 3T3 Cells; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Humans; Insulin; Insulin Resistance; Kinetics; Mice; Mutagenesis, Site-Directed; Peptides; Phosphorylation; Protein Conformation; Protein-Tyrosine Kinases; Receptor, Insulin; Recombinant Proteins; Transfection; Valine

1993
A glycine-1008 to valine mutation in the insulin receptor in a woman with type A insulin resistance.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 77, Issue:1

    Topics: Adult; Female; Glucose Tolerance Test; Glycine; Humans; Insulin; Insulin Resistance; Japan; Mutation; Pedigree; Polymerase Chain Reaction; Protein-Tyrosine Kinases; Receptor, Insulin; Valine

1993
The Val985Met insulin-receptor variant in the Danish Caucasian population: lack of associations with non-insulin-dependent diabetes mellitus or insulin resistance.
    American journal of human genetics, 1997, Volume: 60, Issue:6

    Topics: Blood Glucose; C-Peptide; Denmark; Diabetes Mellitus, Type 2; Genetic Variation; Genotype; Heterozygote; Homozygote; Humans; Insulin; Insulin Resistance; Methionine; Point Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Receptor, Insulin; Reference Values; Valine; White People

1997
Evaluation of circulating levels and renal clearance of natural amino acids in patients with Cushing's disease.
    Journal of endocrinological investigation, 2002, Volume: 25, Issue:2

    Topics: Adult; Alanine; Amino Acids; Blood Glucose; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Creatinine; Cushing Syndrome; Cystine; Cystinuria; Fasting; Female; Glucose Tolerance Test; Humans; Hydrocortisone; Insulin; Insulin Resistance; Isoleucine; Kidney; Leucine; Male; Middle Aged; Valine

2002
Defect in tyrosine kinase activity of the insulin receptor from a patient with insulin resistance and acanthosis nigricans.
    The Journal of clinical endocrinology and metabolism, 1990, Volume: 70, Issue:4

    Topics: Acanthosis Nigricans; Adenosine Triphosphate; Adolescent; Alleles; B-Lymphocytes; Binding Sites; Cell Transformation, Viral; Cloning, Molecular; DNA; Glycine; Humans; Insulin; Insulin Resistance; Male; Mutation; Peptide Mapping; Phosphorylation; Protein-Tyrosine Kinases; Receptor, Insulin; Valine

1990
A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes.
    The EMBO journal, 1989, Volume: 8, Issue:9

    Topics: Cells, Cultured; Cloning, Molecular; Diabetes Mellitus; Female; Genetic Linkage; Homozygote; Humans; Insulin Resistance; Mutation; Pedigree; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Protein Processing, Post-Translational; Receptor, Insulin; Transfection; Valine

1989
Sex-specific differences in plasma branched-chain keto acid levels in obesity.
    The American journal of clinical nutrition, 1987, Volume: 46, Issue:1

    Topics: Blood Glucose; Body Composition; Female; Hemiterpenes; Humans; Insulin; Insulin Resistance; Isoleucine; Keto Acids; Leucine; Male; Middle Aged; Obesity; Sex Characteristics; Valine

1987
Plasma amino acid levels and insulin secretion in obesity.
    The New England journal of medicine, 1969, Oct-09, Volume: 281, Issue:15

    Topics: Adolescent; Adult; Amino Acids; Blood Glucose; Fasting; Feedback; Female; Glucose; Glycine; Humans; Insulin; Insulin Resistance; Insulin Secretion; Isoleucine; Leucine; Male; Middle Aged; Obesity; Pancreas; Phenylalanine; Tyrosine; Valine

1969