Compounds > valine

valine and Acute Confusional Senile Dementia

valine has been researched along with Acute Confusional Senile Dementia in 93 studies

Research

Studies (93)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's18 (19.35)18.2507
2000's32 (34.41)29.6817
2010's32 (34.41)24.3611
2020's11 (11.83)2.80

Authors

AuthorsStudies
Assa, M; Gurevich, V; Polis, B; Samson, AO; Squillario, M; Srikanth, KD1
Jing, XJ; Ren, SJ; Therriault, J; Xiong, YL; Zhang, H1
Hu, X; Li, X; Tian, P1
Amaral, AP; Conde, R; Graça, G; Morais, E; Oliveira, N; Sousa, A; Verde, I1
Assa, M; Gurevich, V; Polis, B; Samson, AO1
Abushakra, S; Sabbagh, M; Tolar, M1
Bloch, N; Gil-Henn, H; Gurevich, V; Polis, B; Samson, AO; Srikanth, KD1
An, SSA; Bagyinszky, E; Kim, SY; Pyun, JM; Vo, VG1
Abushakra, S; Hey, JA; Porsteinsson, A; Sabbagh, M; Tolar, M1
Caselli, RJ; Chen, K; Chen, Y; Huentelman, M; Lee, W; Locke, DEC; Lu, B; Reiman, EM; Richholt, R; Stonnington, CM; Su, Y; Syed, S; Thiyyagura, P; Velgos, SN1
Gan, T; Liu, Q; Ma, X; Shi, Y; Wang, Y; Zhang, X1
Bradshaw, PC; Griffin, JWD1
Babiloni, C; Bastlund, JF; Bentivoglio, M; Bertini, G; Bordet, R; Christensen, DZ; Colavito, V; Del Percio, C; Dix, S; Drinkenburg, W; Fabene, PF; Ferri, R; Forloni, G; Frasca, A; Limatola, C; Lopez, S; Noe, FM; Pedersen, JT; Richardson, JC1
Abushakra, S; Amedio, J; Hey, JA; Kaplan, PL; Kocis, P; Power, A; Tolar, M; Versavel, M; Yu, JY1
Chen, AP; Kong, HH; Lee, CR; O'Sullivan Coyne, G; Woodring, TS1
Abushakra, S; Hey, JA; Hort, J; Kocis, P; Power, A; Tolar, M; Vyhnálek, M; Yu, JY1
Elliott, E; Gil-Henn, H; Polis, B; Samson, AO; Srikanth, KD1
Ames, D; Bourgeat, P; Bush, AI; Darby, D; Ellis, KA; Harrington, KD; Laws, SM; Lim, YY; Martins, RN; Maruff, P; Masters, CL; Nathan, PJ; Pietrzak, RH; Rowe, CC; Salvado, O; Snyder, PJ; Villemagne, VL1
Kobayashi, N; Kondo, K; Nagata, T; Nakayama, K; Shinagawa, S; Yamada, H1
Chen, QH; Fan, J; Han, YQ; Nan, SJ1
An, SS; Bagyinszky, E; Choi, BO; Kim, H; Kim, S; Youn, YC1
Normile, D1
Barik, J; Bethus, I; Chafai, M; Kootar, S; Lanté, F; Marie, H; Mouska, X; Pereira, AR; Raymond, EF1
Bali, J; Birnbaum, JH; Nitsch, RM; Rajendran, L; Tackenberg, C1
Bowers, MT; Liu, D; Roychaudhuri, R; Teplow, DB; Zheng, X1
García-Cárdenas, JM; Leone, PE; López-Cortés, A; Paz-Y-Miño, CA; Salazar, C; Serrano, M1
Antequera-Torres, M; Antúnez-Almagro, C; Gómez-Tortosa, E; Legaz-García, A; López-Motos, D; Manzanares-Sánchez, S; Marín-Muñoz, J; Martínez-Herrada, B; Noguera-Perea, MF; Rábano-Gutiérrez Del Arroyo, A; Vivancos-Moreau, L1
Allegri, R; Bateman, RJ; Benzinger, TL; Chhatwal, J; Cruchaga, C; Fagan, AM; Farlow, MR; Goate, A; Graff-Radford, NR; Hassenstab, J; Holtzman, DM; Laske, C; Levin, J; Lim, YY; Maruff, P; Masters, CL; McDade, E; Morris, JC; Ringman, JM; Rossor, M; Salloway, S; Schofield, PR; Snyder, PJ1
Feng, X; Jia, J; Wang, W; Xie, Y; Zhang, G1
Li, J; Li, JY; Ma, LP; Shen, JK; Wang, X; Xiao, K; Xiong, B; Yu, HP; Zhang, HY; Zhu, YP1
Fahrenholz, F; Schmitt, U; Schroeder, A1
Belarbi, K; Blum, D; Buée, L; Burnouf, S; Caillierez, R; Demeyer, D; Grosjean, ME; Hamdane, M; Schindowski, K; Sergeant, N1
Akatsu, H; Arboleda, H; Asada, T; Combarros, O; Comings, DE; Fujii, T; Fukumoto, N; Goto, Y; Grupe, A; Hyman, BT; Ingelsson, M; Kamboh, MI; Kunugi, H; Matsushita, S; Mattila, KM; Nacmias, B; Nakamura, S; Nishimura, AL; Rinne, J; Tsai, SJ; Zatz, M1
Tomita, T1
Barzilai, N; Derby, CA; Katz, M; Lipton, RB; Ozelius, L; Sanders, AE; Wang, C1
Krack, L; Kretzschmar, H; Meissner, B; Redyk, K; Roeber, S; Schmidt, C; von Ahsen, N; Zerr, I1
Fan, M; Jiang, T; Liu, B; Song, M; Wang, Z; Xu, C; Zhen, X1
Botta, M; Catania, M; Di Fede, G; Giaccone, G; Mazzoleni, G; Moda, F; Morbin, M; Moro, ML; Redaelli, V; Rossi, RS; Salmona, M; Spagnoli, A; Tagliavini, F; Uggetti, A1
Almkvist, O; Bogdanovic, N; Långström, B; Nordberg, A; Schöll, M; Viitanen, M; Wall, A1
Anfossi, M; Bernardi, L; Bruni, AC; Bugiani, O; Clodomiro, A; Colao, R; Curcio, SA; Di Lorenzo, R; Frangipane, F; Gallo, M; Geracitano, S; Ghidoni, E; Giaccone, G; Maletta, R; Marcello, N; Mirabelli, M; Muraca, G; Puccio, G; Smirne, N; Tagliavini, F; Vasso, F1
Bartic, C; Benilova, I; Callewaert, G; Chong, SA; De Strooper, B; Devijver, H; Eberle, W; Moechars, D; Shaban, H; Van Leuven, F1
Baker, GB; Cao, X; Chlan-Fourney, J; Gabriel, GG; Mousseau, DD; Nazarali, AJ; Pennington, PR; Rui, L; Wei, Z1
Bonasera, SJ; Boxer, AL; Cholfin, JA; Crawford, RK; Gennatas, ED; Gorno-Tempini, ML; Karydas, A; Kramer, JH; Miller, BL; Rankin, KP; Rosen, HJ; Sasaki, DA; Seeley, WW; Weiner, M; Zhou, J1
Calero, M; Calero, O; Cuadrado-Corrales, N; de Pedro-Cuesta, J; Díaz-Hurtado, M; Ipiens, JR; López-Gastón, JI; Muñoz-Nieto, M; Ramón y Cajal, S; Ramonet, N1
Govitrapong, P; Hernandez, JF; Htoo, HH; Jargaval, MR; Javagal, MR; Narasingapa, RB; Narasingappa, RB; Pullabhatla, S; Rao, JK; Vincent, B1
Biundo, F; Cuzzoni, G; Garbin, G; Govoni, S; Lanni, C; Lisa, A; Racchi, M; Ranzani, GN; Ranzenigo, A; Sinforiani, E1
Fan, H; Fu, X; He, J; Huang, J; Li, X; Yang, J; Zhang, Y1
du Plessis, DG; Larner, AJ1
Asada, T; Goto, Y; Hachiya, NS; Kaneko, K; Kimura, H; Kinoshita, T; Mizusawa, H; Ohkubo, T; Sakasegawa, Y1
Hong, CJ; Hsu, LE; Lin, CH; Liu, HC; Liu, TY; Tsai, SJ1
Andreoli, V; Annesi, F; Cittadella, R; Gambardella, A; La Russa, A; Manna, I; Messina, D; Nicoletti, G; Quattrone, A; Romeo, N; Serra, P; Spadafora, P; Zappia, M1
Aiso, S; Chiba, T; Iwatsubo, T; Kato, S; Kawasumi, M; Kouyama, K; Matsuoka, M; Miyamae-Kaneko, M; Nakahara, J; Nishimoto, I; Tomita, T; Yamada, M1
Baron, P; Bresolin, N; Conti, G; Cutter, GR; Fenoglio, C; Forloni, G; Galimberti, D; Gatti, A; Guidi, I; Lovati, C; Mariani, C; Pettenati, C; Scarpini, E; Venturelli, E1
Asahara, H; Checler, F; Chui, DH; Furuya, H; Ikezoe, K; Iwaki, T; Kawarabayashi, T; Kikuchi, H; Kira, J; Makifuchi, T; Miyoshi, K; Murai, H; Ohyagi, Y; Sakae, N; Shoji, M; Tabira, T; Takeda, K; Taniwaki, T; Tsuruta, Y; Yamada, T1
Kaji, R; Kawakami, H; Kuno, S; Nishimura, M1
DeKosky, ST; Desai, P; Kamboh, MI; Nebes, R1
Cai, L; Chen, L; Jiang, S; Ren, D; Tang, G; Zhang, B1
Catanese, J; Goate, A; Grupe, A; Hardy, J; Li, Y; Lovestone, S; Morris, JC; Owen, M; Powell, J; Rowland, C; Sninsky, J; Tacey, K; Thal, L; Williams, J1
Kobayashi, N; Ochiai, S; Sode, K; Usuzaka, E1
Berciano, J; Combarros, O; Infante, J; Llorca, J; Mateo, I; Rodríguez, E1
Chuu, JY; Murphy, GM; Noda, A; Taylor, JL; Tinklenberg, J; Yesavage, J1
Cherubini, A; Ercolani, S; Ingegni, T; Mangialasche, F; Mariani, E; Mecocci, P; Metastasio, A; Nocentini, G; Pilotto, A; Senin, U; Seripa, D1
Archetti, S; Borroni, B; Caimi, L; Costanzi, C; Franzoni, S; Grassi, M; Padovani, A; Zanetti, M1
Gillis, T; Gusella, JF; Hakky, MM; Hayden, M; Kishikawa, S; Li, JL; MacDonald, ME; Myers, RH; Warby, S1
Bogdanovic, N; Karelson, E; Land, T; Reis, K; Zharkovsky, A1
Boeras, DI; Crespo, NC; Granic, A; Padmanabhan, J; Potter, H; Rojiani, AM1
Fioroni, G; Flex, A; Gaetani, E; Gerardino, L; Papaleo, P; Pola, P; Pola, R1
Avila, ME; Biechele, T; De Ferrari, GV; Hardy, J; Henríquez, JP; Hock, C; Major, MB; Moon, RT; Morris, CM; Myers, A; Nitsch, RM; Papassotiropoulos, A; Sáez, K; Wavrant De-Vrieze, F; Wollmer, MA; Zhao, A1
He, XM; Hong, Z; Tang, MN; Wu, CB; Zhang, JW; Zhang, ZX; Zhou, YT1
Bartholomew, S; Chen, L; Ho, L; Humala, N; Pasinetti, GM; Qian, X; Rosendorff, C; Seror, I; Wang, J; Zhao, W; Zhao, Z1
Hong, CJ; Hsieh, CH; Liou, YJ; Liu, ME; Tsai, SJ; Tsai, YL1
Bai, F; Deng, LL; Qian, Y; Shi, YM; Yu, H; Yuan, YG; Zhang, ZJ1
Benson, MD; Farlow, M; Ghetti, B; Murrell, J; Roses, AD; Zeldenrust, SR1
Capell, A; Citron, M; Haass, C; Selkoe, DJ; Teplow, DB1
Almqvist, E; Axelman, K; Johansson, K; Lake, S; Winblad, B1
Kamino, K; Kobayashi, H; Miki, T; Miyatake, T; Naruse, S; Onodera, O; Sakaki, Y; Seki, K; Shibata, A; Tanaka, H1
Frackowiak, RS; Kennedy, AM; Lantos, P; Newman, S; Rossor, MN1
Ball, J; Chartier-Harlin, MC; Frackowiak, RS; Hardy, J; Kennedy, AM; McCaddon, A; Mullan, M; Newman, S; Roques, P; Warrington, EK1
Agid, Y; Bellis, M; Brice, A; Calenda, A; Campion, D; Charbonnier, F; Clerget-Darpoux, F; Dubois, B; Frebourg, T; Hannequin, D; Martin, C; Martinez, M; Michon, A; Penet, C1
Asada, H; Ishiura, S; Iwatsubo, T; Kume, H; Maruyama, K; Obata, K; Saido, TC; Shinozaki, K; Tomita, T1
Akiyama, H; Ikeda, K; Kondo, H; McGeer, PL; Mori, H; Nishimura, T; Oda, T; Sahara, N1
Citron, M; Corcoran, C; Diehl, TS; Eckman, CB; Levesque, G; Ostaszewski, BL; Selkoe, DJ; St George Hyslop, P; Xia, W; Younkin, SG1
Albert, M; Beisiegel, U; Binetti, G; Blacker, D; Clatworthy, A; Finckh, U; Gomez-Isla, T; Greenberg, SM; Growdon, JH; Hock, C; Hyman, BT; Liao, A; Mann, U; Mueller-Thomsen, T; Nitsch, RM; Rebeck, GW; Staehelin, H; Tanzi, RE; Zuchowski, K1
Ancolio, K; Barelli, H; Brice, A; Campion, D; Checler, F; Dumanchin, C; Frébourg, T; Warter, JM1
Bagli, M; Feder, O; Heun, R; Jessen, F; Ludwig, M; Maier, W; Papassotiropoulos, A; Rao, ML; Schwab, SG1
Campion, D; Davoust, D; Dumanchin, C; Frébourg, T; Gantier, R; Gilbert, D; Toma, F1
Brice, A; Campion, D; Frebourg, T; Gantier, R; Martin, C; Pothin, Y; Raux, G1
Kuliev, A; Lederer, K; Masciangelo, C; Rechitsky, S; Verlinsky, O; Verlinsky, Y1
Ihara, Y; Miyatake, T; Yanagisawa, K1
Anderton, BH; Hanger, DP; Mann, DM; Neary, D1
Haines, JL; Huang, TL; Hyman, BT; Jenkins, BJ; Mortilla, M; Romano, DM; Tanzi, RE; Tupler, RG; Vaula, G; Wasco, W1
Katsuya, T; Miki, T; Ogihara, T; Sakaki, Y; Yoshioka, K1

Reviews

6 review(s) available for valine and Acute Confusional Senile Dementia

ArticleYear
The path forward in Alzheimer's disease therapeutics: Reevaluating the amyloid cascade hypothesis.
    Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020, Volume: 16, Issue:11

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal, Humanized; Drug Discovery; Humans; Taurine; Valine

2020
Aducanumab, gantenerumab, BAN2401, and ALZ-801-the first wave of amyloid-targeting drugs for Alzheimer's disease with potential for near term approval.
    Alzheimer's research & therapy, 2020, 08-12, Volume: 12, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal, Humanized; Humans; Pharmaceutical Preparations; Taurine; Valine

2020
Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis.
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010, Jan-05, Volume: 153B, Issue:1

    Topics: Aged; Alzheimer Disease; Base Sequence; Brain-Derived Neurotrophic Factor; Case-Control Studies; DNA Primers; Female; Genetic Predisposition to Disease; Humans; Male; Methionine; Sex Characteristics; Valine

2010
[Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity].
    Rinsho shinkeigaku = Clinical neurology, 2009, Volume: 49, Issue:11

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Humans; Sulfonamides; Tetrahydronaphthalenes; Thiophenes; Valine

2009
The association between the methionine/valine (M/V) polymorphism (rs1799990) in the PRNP gene and the risk of Alzheimer disease: an update by meta-analysis.
    Journal of the neurological sciences, 2013, Mar-15, Volume: 326, Issue:1-2

    Topics: Alzheimer Disease; Case-Control Studies; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Methionine; Polymorphism, Genetic; Prion Proteins; Prions; Valine

2013
Alzheimer's disease families with amyloid precursor protein mutations.
    Annals of the New York Academy of Sciences, 1993, Sep-24, Volume: 695

    Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Brain; Glycine; Humans; Isoleucine; Point Mutation; Valine

1993

Trials

2 trial(s) available for valine and Acute Confusional Senile Dementia

ArticleYear
Clinical Pharmacokinetics and Safety of ALZ-801, a Novel Prodrug of Tramiprosate in Development for the Treatment of Alzheimer's Disease.
    Clinical pharmacokinetics, 2018, Volume: 57, Issue:3

    Topics: Administration, Oral; Adult; Aged; Alzheimer Disease; Area Under Curve; Capsules; Dose-Response Relationship, Drug; Double-Blind Method; Female; Half-Life; Humans; Male; Middle Aged; Prodrugs; Tablets; Taurine; Valine; Young Adult

2018
Discovery and Identification of an Endogenous Metabolite of Tramiprosate and Its Prodrug ALZ-801 that Inhibits Beta Amyloid Oligomer Formation in the Human Brain.
    CNS drugs, 2018, Volume: 32, Issue:9

    Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Chromatography, Liquid; Cognition Disorders; Computer Simulation; Drug Administration Routes; Female; Humans; Male; Mental Status Schedule; Middle Aged; Models, Chemical; Nonlinear Dynamics; Peptide Fragments; Prodrugs; Propionates; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Taurine; Valine

2018

Other Studies

85 other study(ies) available for valine and Acute Confusional Senile Dementia

ArticleYear
Effects of Chronic Arginase Inhibition with Norvaline on Tau Pathology and Brain Glucose Metabolism in Alzheimer's Disease Mice.
    Neurochemical research, 2022, Volume: 47, Issue:5

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arginase; Brain; Glucose; Mice; Mice, Transgenic; tau Proteins; Valine

2022
The associations of serum valine with mild cognitive impairment and Alzheimer's disease.
    Aging clinical and experimental research, 2022, Volume: 34, Issue:8

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Brain; Cognitive Dysfunction; Disease Progression; Glucose; Humans; Positron-Emission Tomography; tau Proteins; Valine

2022
Association of Met/Val polymorphism of BDNF gene with Alzheimer's disease in Chinese patients.
    Cellular and molecular biology (Noisy-le-Grand, France), 2022, Apr-30, Volume: 68, Issue:4

    Topics: Aged; Alzheimer Disease; Asian People; Brain-Derived Neurotrophic Factor; Case-Control Studies; Genotype; Humans; Methionine; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Valine

2022
NMR analysis seeking for cognitive decline and dementia metabolic markers in plasma from aged individuals.
    Journal of pharmaceutical and biomedical analysis, 2024, Jan-20, Volume: 238

    Topics: Acetone; Aged; Alzheimer Disease; Biomarkers; Cognitive Dysfunction; Glutamates; Histidine; Humans; Isobutyrates; Isoleucine; Leucine; Magnetic Resonance Spectroscopy; Tyrosine; Valine

2024
Norvaline Restores the BBB Integrity in a Mouse Model of Alzheimer's Disease.
    International journal of molecular sciences, 2019, Sep-18, Volume: 20, Issue:18

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Blood-Brain Barrier; Brain; Cerebral Amyloid Angiopathy; Disease Models, Animal; Male; Mice, Inbred C57BL; Mice, Transgenic; Valine

2019
Arginase Inhibition Supports Survival and Differentiation of Neuronal Precursors in Adult Alzheimer's Disease Mice.
    International journal of molecular sciences, 2020, Feb-08, Volume: 21, Issue:3

    Topics: Alzheimer Disease; Animals; Arginase; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Neurogenesis; Valine

2020
Identification of a Pathogenic PSEN1 Ala285Val Mutation Associated with Early-Onset Alzheimer's Disease.
    Current Alzheimer research, 2020, Volume: 17, Issue:5

    Topics: Alanine; Alzheimer Disease; Amino Acid Sequence; Female; Humans; Middle Aged; Mutation; Pedigree; Presenilin-1; Protein Structure, Secondary; Valine

2020
Interaction Between BDNF Val66Met and APOE4 on Biomarkers of Alzheimer's Disease and Cognitive Decline.
    Journal of Alzheimer's disease : JAD, 2020, Volume: 78, Issue:2

    Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Cohort Studies; Female; Hippocampus; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Methionine; Middle Aged; Positron-Emission Tomography; Protein Binding; Valine

2020
Secondary Chemical Bonding between Insoluble Calcium Oxalate and Carbonyl Oxygen Atoms of GLY and VAL Residues Triggers the Formation of Aβ Aggregates and Their Deposition in the Brain.
    ACS chemical neuroscience, 2020, 12-16, Volume: 11, Issue:24

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Calcium Oxalate; Glycine; Humans; Oxygen; Valine

2020
Residue Interaction Network Analysis Predicts a Val24-Ile31 Interaction May be Involved in Preventing Amyloid-Beta (1-42) Primary Nucleation.
    The protein journal, 2021, Volume: 40, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Databases, Protein; Humans; Hydrophobic and Hydrophilic Interactions; Isoleucine; Models, Molecular; Peptide Fragments; Protein Aggregation, Pathological; Protein Stability; Valine

2021
Ongoing Electroencephalographic Activity Associated with Cortical Arousal in Transgenic PDAPP Mice (hAPP V717F).
    Current Alzheimer research, 2018, Volume: 15, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Arousal; Brain Mapping; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Fourier Analysis; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Phenylalanine; Valine

2018
Hidradenitis Suppurativa-Like Lesions Associated with Pharmacologic Inhibition of Gamma-Secretase.
    The Journal of investigative dermatology, 2018, Volume: 138, Issue:4

    Topics: Adult; Alanine; Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Azepines; Biopsy; Female; Hidradenitis Suppurativa; Humans; Male; Mice; Mice, Knockout; Tetrahydronaphthalenes; Valine

2018
L-Norvaline Reverses Cognitive Decline and Synaptic Loss in a Murine Model of Alzheimer's Disease.
    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2018, Volume: 15, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arginase; Calcium-Binding Proteins; Cerebral Cortex; Cognition Disorders; Dendritic Spines; Hippocampus; Male; Maze Learning; Mice; Mice, Transgenic; Microfilament Proteins; Microglia; Mutation; Neurons; Presenilin-1; tau Proteins; Valine

2018
BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease.
    Neurobiology of aging, 2013, Volume: 34, Issue:11

    Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Australia; Brain-Derived Neurotrophic Factor; Cognition Disorders; Female; Genotype; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Memory, Episodic; Methionine; Neuropsychological Tests; Positron-Emission Tomography; Psychiatric Status Rating Scales; Thiazoles; Valine

2013
Plasma BDNF levels are correlated with aggressiveness in patients with amnestic mild cognitive impairment or Alzheimer disease.
    Journal of neural transmission (Vienna, Austria : 1996), 2014, Volume: 121, Issue:4

    Topics: Aged; Aged, 80 and over; Aggression; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Female; Genotype; Humans; Male; Methionine; Neuropsychological Tests; Polymorphism, Single Nucleotide; Psychiatric Status Rating Scales; Statistics as Topic; Valine

2014
Blepharospasm in familial AD secondary to an APP mutation (V715M).
    Acta neurologica Belgica, 2014, Volume: 114, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Blepharospasm; Family Health; Female; Humans; Male; Methionine; Middle Aged; Motor Cortex; Mutation; Valine

2014
Probable novel PSEN2 Val214Leu mutation in Alzheimer's disease supported by structural prediction.
    BMC neurology, 2014, May-15, Volume: 14

    Topics: Aged; Alzheimer Disease; Amino Acid Substitution; DNA Mutational Analysis; Exons; Female; Humans; Leucine; Models, Molecular; Mutation; Presenilin-2; Protein Structure, Tertiary; Valine

2014
Biomedicine. Faulty drug trials tarnish Japan's clinical research.
    Science (New York, N.Y.), 2014, Jul-04, Volume: 345, Issue:6192

    Topics: Alzheimer Disease; Antihypertensive Agents; Biomedical Research; Brain; Clinical Trials as Topic; Drug Evaluation; Drug Industry; Humans; Japan; Positron-Emission Tomography; Product Surveillance, Postmarketing; Scientific Misconduct; Tetrazoles; Valine; Valsartan

2014
Subchronic glucocorticoid receptor inhibition rescues early episodic memory and synaptic plasticity deficits in a mouse model of Alzheimer's disease.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:7

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Dexamethasone; Disease Models, Animal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glucocorticoids; Hippocampus; Hormone Antagonists; Humans; Memory Disorders; Memory, Episodic; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mifepristone; Mutation; Neuronal Plasticity; Quinoxalines; Receptors, Glucocorticoid; Recognition, Psychology; Valine

2015
Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss.
    Cell death & disease, 2015, Jun-18, Volume: 6

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Dendritic Spines; Dizocilpine Maleate; Egtazic Acid; Glutamic Acid; GTP-Binding Proteins; Hippocampus; Memantine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Valine

2015
Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and Recessive A2V Familial Alzheimer's Disease Mutation.
    ACS chemical neuroscience, 2015, Oct-21, Volume: 6, Issue:10

    Topics: Alanine; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Humans; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry; Microscopy, Electron, Transmission; Mutation; Peptide Fragments; Protein Structure, Secondary; Threonine; Valine

2015
Positive Association of the Cathepsin D Ala224Val Gene Polymorphism With the Risk of Alzheimer's Disease.
    The American journal of the medical sciences, 2015, Volume: 350, Issue:4

    Topics: Aged; Alanine; Alleles; Alzheimer Disease; Case-Control Studies; Cathepsin D; Cystatin C; Ecuador; Female; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Male; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Prevalence; Risk Factors; Valine

2015
Novel Mutation (Gly212Val) in the PS2 Gene Associated with Early-Onset Familial Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2016, 04-25, Volume: 53, Issue:1

    Topics: Age of Onset; Aged; Alzheimer Disease; DNA Mutational Analysis; Family Health; Female; Glycine; Humans; Male; Middle Aged; Mutation; Neuropsychological Tests; Phenotype; Polymorphism, Single Nucleotide; Presenilin-2; Psychiatric Status Rating Scales; Valine

2016
BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease.
    Brain : a journal of neurology, 2016, Volume: 139, Issue:Pt 10

    Topics: Adult; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Female; Heterozygote; Hippocampus; Humans; Male; Memory Disorders; Methionine; Middle Aged; tau Proteins; Valine

2016
Clinical characterization of an APP mutation (V717I) in five Han Chinese families with early-onset Alzheimer's disease.
    Journal of the neurological sciences, 2017, Jan-15, Volume: 372

    Topics: Age of Onset; Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Apolipoprotein E4; Asian People; Cognition Disorders; DNA Mutational Analysis; Family Health; Female; Humans; Isoleucine; Magnetic Resonance Imaging; Male; Middle Aged; Mood Disorders; Mutation; Neuropsychological Tests; Valine

2017
Discovery of potent beta-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids.
    Acta pharmacologica Sinica, 2009, Volume: 30, Issue:2

    Topics: Alzheimer Disease; Amides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Computer Simulation; Drug Design; Humans; Isoenzymes; Models, Molecular; Molecular Structure; Phthalic Acids; Protease Inhibitors; Protein Conformation; Structure-Activity Relationship; Sulfonamides; Valine

2009
Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease.
    Journal of Alzheimer's disease : JAD, 2009, Volume: 16, Issue:2

    Topics: ADAM Proteins; ADAM10 Protein; Age Factors; Alanine; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Behavior, Animal; Disease Models, Animal; Glutamic Acid; Humans; Isoleucine; Maze Learning; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Reaction Time; Swimming; Valine

2009
Early Tau pathology involving the septo-hippocampal pathway in a Tau transgenic model: relevance to Alzheimer's disease.
    Current Alzheimer research, 2009, Volume: 6, Issue:2

    Topics: Age Factors; Alzheimer Disease; Animals; Brain Mapping; Disease Models, Animal; Glycine; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neural Pathways; Proline; Septum of Brain; Serine; Stilbamidines; tau Proteins; Valine

2009
Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia.
    JAMA, 2010, Jan-13, Volume: 303, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholesterol Ester Transfer Proteins; Dementia; Female; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Male; Memory Disorders; New York; Polymorphism, Single Nucleotide; Prospective Studies; Valine

2010
Clinical features of rapidly progressive Alzheimer's disease.
    Dementia and geriatric cognitive disorders, 2010, Volume: 29, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Apolipoproteins E; Biomarkers; Codon; Disease Progression; Female; Gait; Gene Frequency; Heterozygote; Homozygote; Humans; Male; Methionine; Middle Aged; Muscle Rigidity; Myoclonus; Peptide Fragments; Polymorphism, Genetic; Prion Proteins; Prions; Retrospective Studies; Survival Analysis; tau Proteins; Time Factors; Valine

2010
Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer's disease.
    Neuroreport, 2010, Aug-23, Volume: 21, Issue:12

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Substitution; Basal Metabolism; Brain; Brain Mapping; Brain-Derived Neurotrophic Factor; Cognition Disorders; Female; Genetic Carrier Screening; Genetic Predisposition to Disease; Humans; Male; Methionine; Middle Aged; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Valine

2010
Neuropathology of the recessive A673V APP mutation: Alzheimer disease with distinctive features.
    Acta neuropathologica, 2010, Volume: 120, Issue:6

    Topics: Alanine; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Genes, Recessive; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Valine

2010
Time course of glucose metabolism in relation to cognitive performance and postmortem neuropathology in Met146Val PSEN1 mutation carriers.
    Journal of Alzheimer's disease : JAD, 2011, Volume: 24, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Brain Mapping; Cognition Disorders; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Mental Status Schedule; Methionine; Middle Aged; Mutation; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Postmortem Changes; Presenilin-1; Statistics as Topic; Time Factors; Valine

2011
A novel pathogenic PSEN1 mutation in a family with Alzheimer's disease: phenotypical and neuropathological features.
    Journal of Alzheimer's disease : JAD, 2011, Volume: 25, Issue:3

    Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Brain; DNA Mutational Analysis; Family Health; Female; Genetic Predisposition to Disease; Humans; Isoleucine; Male; Mental Status Schedule; Middle Aged; Mutation; Phenotype; Presenilin-1; Valine

2011
Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study.
    Neurobiology of disease, 2011, Volume: 44, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Biophysics; Disease Models, Animal; Electric Stimulation; Electrodes; Excitatory Postsynaptic Potentials; Hippocampus; Humans; In Vitro Techniques; Isoleucine; Long-Term Potentiation; Mice; Mice, Transgenic; Mutation; Synapses; tau Proteins; Time Factors; Valine

2011
Monoamine oxidase-A physically interacts with presenilin-1(M146V) in the mouse cortex.
    Journal of Alzheimer's disease : JAD, 2012, Volume: 28, Issue:2

    Topics: Alzheimer Disease; Analysis of Variance; Animals; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Clorgyline; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hydroxyindoleacetic Acid; Inositol 1,4,5-Trisphosphate Receptors; Methionine; Mice; Mice, Transgenic; Mitochondria; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Mutation; Neuroblastoma; Neurons; Neurotransmitter Agents; Organic Chemicals; Presenilin-1; Serotonin; Subcellular Fractions; Swimming; Transfection; Valine; Voltage-Dependent Anion Channels

2012
COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structures.
    Neurology, 2012, May-22, Volume: 78, Issue:21

    Topics: Aged; Alleles; Alzheimer Disease; Catechol O-Methyltransferase; Cerebral Cortex; Dementia; Dopamine; Female; Frontotemporal Dementia; Frontotemporal Lobar Degeneration; Genotype; Humans; Magnetic Resonance Imaging; Male; Methionine; Middle Aged; Polymorphism, Single Nucleotide; Prefrontal Cortex; Valine

2012
A novel mutation I215V in the PRNP gene associated with Creutzfeldt-Jakob and Alzheimer's diseases in three patients with divergent clinical phenotypes.
    Journal of neurology, 2013, Volume: 260, Issue:1

    Topics: 14-3-3 Proteins; Aged; Aged, 80 and over; Alzheimer Disease; Autopsy; Creutzfeldt-Jakob Syndrome; Glial Fibrillary Acidic Protein; Humans; Isoleucine; Male; Models, Molecular; Mutation; Phenotype; Prion Proteins; Prions; Spain; Valine

2013
Activation of α-secretase by curcumin-aminoacid conjugates.
    Biochemical and biophysical research communications, 2012, Aug-10, Volume: 424, Issue:4

    Topics: ADAM Proteins; ADAM10 Protein; Alzheimer Disease; Amyloid Precursor Protein Secretases; Curcumin; Enzyme Activation; HEK293 Cells; Humans; Isoleucine; Membrane Proteins; Phenylalanine; Valine

2012
Influence of COMT Val158Met polymorphism on Alzheimer's disease and mild cognitive impairment in Italian patients.
    Journal of Alzheimer's disease : JAD, 2012, Volume: 32, Issue:4

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Catechol O-Methyltransferase; Cognitive Dysfunction; Female; Genetic Predisposition to Disease; Humans; Italy; Male; Methionine; Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Risk Factors; Valine

2012
Early-onset Alzheimer's disease with presenilin-1 M139V mutation: clinical, neuropsychological and neuropathological study.
    European journal of neurology, 2003, Volume: 10, Issue:3

    Topics: Alzheimer Disease; Cerebellar Cortex; Cerebral Cortex; Humans; Male; Membrane Proteins; Methionine; Middle Aged; Mutation; Phenotype; Presenilin-1; Thalamus; Valine

2003
Absence of association between codon 129/219 polymorphisms of the prion protein gene and Alzheimer's disease in Japan.
    Annals of neurology, 2003, Volume: 54, Issue:4

    Topics: Aged; Alzheimer Disease; Amyloid; Case-Control Studies; Codon; Female; Gene Frequency; Genotype; Humans; Japan; Male; Methionine; Polymorphism, Genetic; Prion Proteins; Prions; Protein Precursors; Valine

2003
Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset.
    Neuropsychobiology, 2004, Volume: 49, Issue:1

    Topics: Age of Onset; Aged; Alleles; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Case-Control Studies; DNA Mutational Analysis; Female; Gene Frequency; Humans; Male; Methionine; Polymorphism, Genetic; Valine

2004
Increased risk for Alzheimer disease with the interaction of MPO and A2M polymorphisms.
    Archives of neurology, 2004, Volume: 61, Issue:3

    Topics: Age of Onset; Aged; alpha-Macroglobulins; Alzheimer Disease; Apolipoproteins E; Case-Control Studies; Chi-Square Distribution; Confidence Intervals; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Isoleucine; Italy; Male; Middle Aged; Odds Ratio; Peroxidase; Polymerase Chain Reaction; Polymorphism, Genetic; Risk; Valine

2004
Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice.
    The European journal of neuroscience, 2004, Volume: 19, Issue:10

    Topics: Age Factors; Alleles; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Blotting, Southern; Brain Chemistry; Choice Behavior; Disease Models, Animal; Female; Genotype; Humans; Immunohistochemistry; Isoleucine; Male; Maze Learning; Mice; Mice, Transgenic; Molecular Sequence Data; Motor Activity; Mutation; Neurofibrillary Tangles; Peptide Fragments; Reaction Time; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sex Factors; Survival Rate; tau Proteins; Valine

2004
CCR2-64I polymorphism and CCR5Delta32 deletion in patients with Alzheimer's disease.
    Journal of the neurological sciences, 2004, Oct-15, Volume: 225, Issue:1-2

    Topics: Adult; Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Chi-Square Distribution; DNA Mutational Analysis; Female; Gene Deletion; Gene Frequency; Genotype; Humans; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Receptors, CCR2; Receptors, CCR5; Receptors, Chemokine; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Valine

2004
Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Brain; Brain Chemistry; Cells, Cultured; Cytosol; DNA; Female; Fetus; Genes, p53; Guinea Pigs; Heat-Shock Response; Humans; Hydrogen Peroxide; Intracellular Space; Leucine; Male; Membrane Proteins; Mice; Mice, Mutant Strains; Mice, Transgenic; Mutation, Missense; Nerve Degeneration; Neuroblastoma; Neurons; Peptide Fragments; Presenilin-1; Promoter Regions, Genetic; Protein Binding; Response Elements; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Valine

2005
Brain-derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy.
    Movement disorders : official journal of the Movement Disorder Society, 2005, Volume: 20, Issue:8

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Cysteine; Female; Genetic Predisposition to Disease; Humans; Japan; Male; Methionine; Middle Aged; Multiple System Atrophy; Parkinson Disease; Polymorphism, Genetic; Threonine; Valine

2005
Investigation of the effect of brain-derived neurotrophic factor (BDNF) polymorphisms on the risk of late-onset Alzheimer's disease (AD) and quantitative measures of AD progression.
    Neuroscience letters, 2005, May-13, Volume: 379, Issue:3

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Black People; Brain-Derived Neurotrophic Factor; Case-Control Studies; Disease Progression; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Methionine; Polymorphism, Genetic; Risk; Valine; White People

2005
Genetic studies of A2M and BACE1 genes in Chinese Han Alzheimer's disease patients.
    Neuroreport, 2005, Jun-21, Volume: 16, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; alpha-Macroglobulins; Alzheimer Disease; Amyloid Precursor Protein Secretases; Apolipoproteins E; Asian People; Aspartic Acid Endopeptidases; Chi-Square Distribution; China; DNA Mutational Analysis; Endopeptidases; Female; Gene Frequency; Genotype; Humans; Isoleucine; Male; Meta-Analysis as Topic; Middle Aged; Polymorphism, Genetic; Valine

2005
The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples.
    Molecular psychiatry, 2005, Volume: 10, Issue:9

    Topics: Age of Onset; Alzheimer Disease; Amino Acid Substitution; Brain-Derived Neurotrophic Factor; Brazil; Case-Control Studies; China; Humans; Italy; Methionine; Polymorphism, Single Nucleotide; Reference Values; Spain; Valine; White People

2005
Engineered alpha-synuclein prevents wild type and familial Parkin variant fibril formation.
    Biochemical and biophysical research communications, 2005, Sep-23, Volume: 335, Issue:2

    Topics: alpha-Synuclein; Alzheimer Disease; Amino Acid Sequence; Amyloid; Bone Marrow Cells; Circular Dichroism; DNA; DNA, Complementary; Gene Library; Humans; Light; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nerve Tissue Proteins; Parkinson Disease; Peptides; Polymerase Chain Reaction; Proline; Protein Binding; Protein Conformation; Protein Engineering; Protein Structure, Secondary; Scattering, Radiation; Synucleins; Time Factors; Ubiquitin-Protein Ligases; Ultraviolet Rays; Valine

2005
Cholesteryl ester transfer protein (CETP) polymorphism modifies the Alzheimer's disease risk associated with APOE epsilon4 allele.
    Journal of neurology, 2006, Volume: 253, Issue:2

    Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Carrier Proteins; Cholesterol Ester Transfer Proteins; Confidence Intervals; DNA Mutational Analysis; Exons; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glycoproteins; Humans; Isoleucine; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; Promoter Regions, Genetic; Retrospective Studies; Risk Factors; Spain; Valine

2006
The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease.
    Journal of Alzheimer's disease : JAD, 2006, Volume: 9, Issue:1

    Topics: Aged; Alzheimer Disease; Amino Acid Substitution; Brain-Derived Neurotrophic Factor; Cohort Studies; Female; Humans; Longitudinal Studies; Male; Methionine; Middle Aged; Polymorphism, Single Nucleotide; Valine

2006
Interaction of CTSD and A2M polymorphisms in the risk for Alzheimer's disease.
    Journal of the neurological sciences, 2006, Sep-25, Volume: 247, Issue:2

    Topics: Aged; Aged, 80 and over; Alanine; alpha-Macroglobulins; Alzheimer Disease; Cathepsin D; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Isoleucine; Male; Odds Ratio; Polymorphism, Genetic; Risk; Valine

2006
Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease.
    Neurobiology of aging, 2007, Volume: 28, Issue:8

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Catechol O-Methyltransferase; Chi-Square Distribution; Cognition; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Humans; Linkage Disequilibrium; Male; Methionine; Neuropsychological Tests; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Psychotic Disorders; Risk; Valine

2007
Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease.
    Neurobiology of disease, 2006, Volume: 24, Issue:2

    Topics: Age of Onset; Alzheimer Disease; Amino Acid Substitution; Brain-Derived Neurotrophic Factor; DNA Mutational Analysis; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Haplotypes; Huntington Disease; Introns; Methionine; Polymorphism, Single Nucleotide; Trinucleotide Repeat Expansion; Valine

2006
Critical role of methionine-722 in the stimulation of human brain G-proteins and neurotoxicity induced by London familial Alzheimer's disease (FAD) mutated V717G-APP(714-723).
    Neuroscience, 2007, Jan-19, Volume: 144, Issue:2

    Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Case-Control Studies; Cell Differentiation; Cells, Cultured; Deferoxamine; Dose-Response Relationship, Drug; Estradiol; Female; Glutathione; Glycine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Melatonin; Methionine; Middle Aged; Peptides; Protein Binding; Rats; Temporal Lobe; Valine

2007
Alzheimer's presenilin 1 causes chromosome missegregation and aneuploidy.
    Neurobiology of aging, 2008, Volume: 29, Issue:3

    Topics: Alzheimer Disease; Aneuploidy; Animals; Cells, Cultured; Chromosome Segregation; Humans; Lysine; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurons; Platelet-Derived Growth Factor; Presenilin-1; Spindle Apparatus; Spleen; Transfection; Valine

2008
Coagulation factor XIII Val34Leu gene polymorphism and Alzheimer's disease.
    Neurological research, 2006, Volume: 28, Issue:8

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Chi-Square Distribution; DNA Mutational Analysis; Factor XIII; Female; Humans; Leucine; Logistic Models; Male; Polymorphism, Genetic; Valine

2006
Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, May-29, Volume: 104, Issue:22

    Topics: Age of Onset; Aging; Alleles; Alzheimer Disease; Amino Acid Sequence; Animals; beta Catenin; Cell Line; Cells, Cultured; Chromosomes, Human, Pair 12; Conserved Sequence; Gene Expression Regulation; Genes, Reporter; Haplotypes; Hippocampus; Humans; LDL-Receptor Related Proteins; Low Density Lipoprotein Receptor-Related Protein-6; Molecular Sequence Data; Polymorphism, Single Nucleotide; Sequence Alignment; Valine

2007
Lack of association between the BDNF gene Val66Met polymorphism and Alzheimer disease in a Chinese Han population.
    Neuropsychobiology, 2007, Volume: 55, Issue:3-4

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Brain-Derived Neurotrophic Factor; Chi-Square Distribution; China; DNA Mutational Analysis; Female; Gene Frequency; Genotype; Humans; Male; Methionine; Middle Aged; Polymorphism, Genetic; Valine

2007
Valsartan lowers brain beta-amyloid protein levels and improves spatial learning in a mouse model of Alzheimer disease.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:11

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antihypertensive Agents; Behavior, Animal; Brain; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Memory; Mice; Mice, Transgenic; Protein Structure, Quaternary; Random Allocation; Space Perception; Tetrazoles; Valine; Valsartan

2007
Association study of a functional catechol-O-methyltransferase polymorphism and executive function in elderly males without dementia.
    Neuroscience letters, 2008, May-09, Volume: 436, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Attention; Catechol O-Methyltransferase; Cognition Disorders; Genetic Predisposition to Disease; Genotype; Geriatric Assessment; Humans; Male; Methionine; Neuropsychological Tests; Polymorphism, Genetic; Problem Solving; Psychomotor Performance; Valine

2008
[Cognitive function, serum BDNF levels and BDNF gene Val66Met polymorphism in amnestic mild cognitive impairment].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2008, Volume: 33, Issue:4

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amnesia; Brain-Derived Neurotrophic Factor; Cognition Disorders; Female; Humans; Male; Methionine; Polymorphism, Genetic; Valine

2008
RFLP analysis for APP 717 mutations associated with Alzheimer's disease.
    Journal of medical genetics, 1993, Volume: 30, Issue:6

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Base Sequence; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA Mutational Analysis; Electrophoresis, Agar Gel; Humans; Molecular Sequence Data; Phenylalanine; Point Mutation; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Valine

1993
The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein.
    The Journal of biological chemistry, 1995, Mar-17, Volume: 270, Issue:11

    Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anti-Bacterial Agents; Cell Line; Cell Membrane; Cells, Cultured; DNA, Complementary; Fibroblasts; Humans; Kidney; Kinetics; Macrolides; Methionine; Molecular Sequence Data; Mutation; Phenylalanine; Protein Processing, Post-Translational; Proton-Translocating ATPases; Recombinant Proteins; Reference Values; Skin; Sulfur Radioisotopes; Sulfuric Acid Esters; Sweden; Transfection; Vacuoles; Valine

1995
Screening of amyloid precursor protein gene mutation (APP 717 Val-->Ile) in Swedish families with Alzheimer's disease.
    Journal of neural transmission. Parkinson's disease and dementia section, 1993, Volume: 6, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Chromosomes, Human, Pair 21; Down Syndrome; Genetic Testing; Humans; Isoleucine; Middle Aged; Mutation; Polymerase Chain Reaction; Sweden; Valine

1993
Absence of linkage disequilibrium at amyloid precursor protein gene locus in Japanese familial Alzheimer's disease with 717Val-->Ile mutation.
    Neuroscience letters, 1993, Nov-12, Volume: 162, Issue:1-2

    Topics: Alleles; Alzheimer Disease; Amyloid beta-Protein Precursor; Humans; Isoleucine; Japan; Linkage Disequilibrium; Mutation; Polymorphism, Genetic; Valine

1993
Familial Alzheimer's disease. A pedigree with a mis-sense mutation in the amyloid precursor protein gene (amyloid precursor protein 717 valine-->glycine).
    Brain : a journal of neurology, 1993, Volume: 116 ( Pt 2)

    Topics: Adult; Aged; Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Protein Precursor; Female; Glycine; Humans; Male; Middle Aged; Mutation; Pedigree; Valine

1993
No founder effect in three novel Alzheimer's disease families with APP 717 Val-->Ile mutation. Clerget-darpoux. French Alzheimer's Disease Study Group.
    Journal of medical genetics, 1996, Volume: 33, Issue:8

    Topics: Adult; Age of Onset; Alzheimer Disease; Amyloid beta-Protein Precursor; Apolipoproteins E; DNA Mutational Analysis; Exons; Female; Founder Effect; France; Genes, Dominant; Genotype; Haplotypes; Humans; Male; Middle Aged; Pedigree; Valine

1996
Familial Alzheimer's disease-linked mutations at Val717 of amyloid precursor protein are specific for the increased secretion of A beta 42(43).
    Biochemical and biophysical research communications, 1996, Oct-23, Volume: 227, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; COS Cells; Point Mutation; Protein Processing, Post-Translational; Valine

1996
Variable deposition of amyloid beta-protein (A beta) with the carboxy-terminus that ends at residue valine40 (A beta 40) in the cerebral cortex of patients with Alzheimer's disease: a double-labeling immunohistochemical study with antibodies specific for
    Neurochemical research, 1997, Volume: 22, Issue:12

    Topics: Aged; Aged, 80 and over; Alanine; Alzheimer Disease; Amyloid beta-Peptides; Antibodies; Antibody Specificity; Cerebral Cortex; Female; Humans; Immunohistochemistry; Male; Neurofibrillary Tangles; Peptide Fragments; Staining and Labeling; Threonine; Valine

1997
Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
    Neurobiology of disease, 1998, Volume: 5, Issue:2

    Topics: Age of Onset; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cell Line; Gene Expression Regulation; Humans; Leucine; Membrane Proteins; Methionine; Mutagenesis, Site-Directed; Peptide Fragments; Presenilin-1; Valine

1998
Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.
    Human molecular genetics, 1998, Volume: 7, Issue:12

    Topics: Alleles; alpha-Macroglobulins; Alzheimer Disease; Amyloid beta-Peptides; DNA; Female; Gene Frequency; Genotype; Humans; Isoleucine; Logistic Models; Male; Multivariate Analysis; Neurofibrillary Tangles; Odds Ratio; Polymorphism, Genetic; Valine

1998
Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Mar-30, Volume: 96, Issue:7

    Topics: Age of Onset; Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cell Line; Female; Humans; Male; Methionine; Mutagenesis, Site-Directed; Pedigree; Phenotype; Point Mutation; Recombinant Proteins; Transfection; Valine

1999
Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease.
    Neuroscience letters, 1999, Mar-12, Volume: 262, Issue:3

    Topics: Aged; Aged, 80 and over; Alanine; Alzheimer Disease; Amino Acid Substitution; Apolipoprotein E4; Apolipoproteins E; Cathepsin D; Depression; Exons; Female; Genetic Carrier Screening; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Reference Values; Risk Factors; Valine

1999
The pathogenic L392V mutation of presenilin 1 decreases the affinity to glycogen synthase kinase-3 beta.
    Neuroscience letters, 2000, Apr-14, Volume: 283, Issue:3

    Topics: Alzheimer Disease; Amino Acid Substitution; Calcium-Calmodulin-Dependent Protein Kinases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Humans; Leucine; Membrane Proteins; Mutation; Presenilin-1; Protein Binding; Recombinant Proteins; Surface Plasmon Resonance; Valine

2000
A novel presenilin 1 missense mutation (L153V) segregating with early-onset autosomal dominant Alzheimer's disease.
    Human mutation, 2000, Volume: 16, Issue:1

    Topics: Adult; Alzheimer Disease; Amino Acid Substitution; Female; France; Genes, Dominant; Humans; Leucine; Male; Membrane Proteins; Mutation, Missense; Presenilin-1; Valine

2000
Preimplantation diagnosis for early-onset Alzheimer disease caused by V717L mutation.
    JAMA, 2002, Feb-27, Volume: 287, Issue:8

    Topics: Adult; Alzheimer Disease; Amyloid beta-Protein Precursor; DNA Mutational Analysis; Female; Genes, Dominant; Genetic Testing; Humans; Leucine; Mutation; Pedigree; Pregnancy; Pregnancy Outcome; Preimplantation Diagnosis; Valine

2002
Split verdict on schizophrenia.
    Nature genetics, 1992, Volume: 1, Issue:4

    Topics: Alanine; Alzheimer Disease; Amyloid beta-Protein Precursor; Chromosomes, Human, Pair 11; Codon; DNA; Humans; Mutation; Schizophrenia; Valine

1992
Secretory pathway of beta/A4 amyloid protein precursor in familial Alzheimer's disease with Val717 to Ile mutation.
    Neuroscience letters, 1992, Sep-14, Volume: 144, Issue:1-2

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Blotting, Western; Cells, Cultured; Humans; Isoleucine; Mutation; Nervous System Diseases; Valine

1992
Tau pathology in a case of familial Alzheimer's disease with a valine to glycine mutation at position 717 in the amyloid precursor protein.
    Neuroscience letters, 1992, Oct-12, Volume: 145, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Antibodies, Monoclonal; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Female; Glycine; Humans; Middle Aged; Mutation; tau Proteins; Valine

1992
Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.
    American journal of human genetics, 1992, Volume: 51, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Base Sequence; DNA; DNA Mutational Analysis; Humans; Isoleucine; Male; Middle Aged; Molecular Sequence Data; Mutation; Pedigree; Polymerase Chain Reaction; Recombination, Genetic; Valine

1992
The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.
    Biochemical and biophysical research communications, 1991, Aug-15, Volume: 178, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Base Sequence; Ethnicity; Exons; Female; Humans; Isoleucine; Japan; Male; Molecular Sequence Data; Mutation; Oligonucleotide Probes; Pedigree; Polymerase Chain Reaction; Protein Precursors; Valine; White People

1991