valganciclovir and Iron-Overload

Intrauterine transfusion is one of the mainstays of treatment in isoimmunised pregnancies guided by the changes in middle cerebral artery Doppler of the fetus. The common postnatal complications associated with Rh isoimmunisation are high unconjugated bilirubin requiring blood exchange transfusions, cholestasis due to bile inspissation, thrombocytopenia and anaemia. Hyperferritinaemia is an uncommon adverse effect observed in Rh isoimmunised pregnancies. In this case report, we describe the clinical course of a Rh isoimmunised neonate with hyperferritinaemia and transfusion acquired cytomegalovirus disease which resolved. Iron chelation therapy was not necessary.

Topics: Adult; Antiviral Agents; Bilirubin; Blood Flow Velocity; Blood Transfusion, Intrauterine; Failure to Thrive; Female; Ferritins; Humans; Infant, Newborn; Iron Overload; Middle Cerebral Artery; Phototherapy; Pregnancy; Pregnancy Complications, Hematologic; Rh Isoimmunization; Treatment Outcome; Valganciclovir