valganciclovir and Behcet-Syndrome

To report a case of cytomegalovirus (CMV) endotheliitis after insertion of an intravitreal fluocinolone acetonide (Retisert) implant.. Interventional case report.. Retrospective chart review.. A 40-year-old man received a Retisert implant in the left eye for recurrent Behçet uveitis. Although inflammation became quiescent within a month, corneal edema developed 4 months after insertion. Polymerase chain reaction analysis for aqueous humor detected 3.9 × 10(4) copies/mL of CMV DNA. After treatment with oral valganciclovir, CMV DNA nearly disappeared but visual outcome was poor due to corneal decompensation resulting from severe endothelial cell loss.. After Retisert implant, clinicians should be attentive to the potential risk of CMV endotheliitis.

Topics: Administration, Oral; Adult; Anti-Inflammatory Agents; Antiviral Agents; Behcet Syndrome; Corneal Edema; Cytomegalovirus Infections; Drug Implants; Endothelium, Corneal; Fluocinolone Acetonide; Ganciclovir; Humans; Inflammation; Male; Uveitis; Valganciclovir; Vision Disorders