valacyclovir and Hypertrophy

Herpes Simplex Virus type 2 is the primary cause of genital ulceration worldwide. The presence of atypical features like deep ulcerations, hypertrophic, or pseudotumoural lesions or unusual location can be a marker for co-infection with HIV. These immunocompromised patients are usually resistant to the conventional antiviral treatment. We present a case of an HIV-infected patient with hypertrophic herpes genitalis, refractory to conventional oral antiviral therapy, who was successfully treated with a combination of oral valcyclovir and topical application of 5% imiquimod.

Topics: Acyclovir; Adjuvants, Immunologic; Administration, Topical; Aminoquinolines; Antiviral Agents; Drug Therapy, Combination; Herpes Genitalis; HIV Infections; Humans; Hypertrophy; Imiquimod; Immunocompromised Host; Male; Middle Aged; Valacyclovir; Valine