valacyclovir and Carcinoma--Squamous-Cell

Herpes simplex virus (HSV)-1 is a highly prevalent, non-oncogenic virus that has higher morbidity in immunocompromised hosts. Its most common clinical manifestation is superficial ulceration of the integument or mucus membranes.. A 65-year-old woman with a history of acute myelogenous leukemia treated with allogenic peripheral blood stem cell transplant presented for resection of an ulcerated buccal squamous cell carcinoma. We report a case of HSV-1-infected malignant cells discovered on histopathological examination of the carcinoma specimen ultimately treated with valacyclovir.. HSV-1 is not considered an oncogenic virus itself but may increase risk of malignant progression. Cancer cells are vulnerable to superimposed viral infections, including HSV-1, which likely led to the findings in this case.

Topics: Aged; Carcinoma, Squamous Cell; Female; Herpes Simplex; Herpesvirus 1, Human; Humans; Immunocompromised Host; Valacyclovir

Topics: Anti-Bacterial Agents; Antiviral Agents; Carcinoma, Squamous Cell; Clarithromycin; Diagnosis, Differential; Fingers; Herpes Simplex; Humans; Male; Middle Aged; Skin Neoplasms; Staphylococcus aureus; Valacyclovir

Topics: Aged, 80 and over; Antiviral Agents; Carcinoma, Squamous Cell; Female; Herpes Zoster; Humans; Mohs Surgery; Nose Neoplasms; Skin Neoplasms; Surgical Wound Infection; Valacyclovir