vadimezan has been researched along with Colonic Neoplasms in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (45.45) | 18.2507 |
| 2000's | 18 (54.55) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Atwell, GJ; Baguley, BC; Boyd, M; Denny, WA; Rewcastle, GW; Thomsen, LL; Zhuang, L | 1 |
| Atwell, GJ; Baguley, BC; Denny, WA; Li, ZA; Rewcastle, GW | 1 |
| Ching, LM; Henare, K; Kieda, C; Palmer, BD; Reddy, C; Sutherland, R; Wang, LC; Woon, ST | 1 |
| Baguley, BC; Ching, LM; Kestell, P; Paxton, JW; Sutherland, R; Wang, LC; Zhuang, L | 1 |
| Angel, CE; Chen, CJ; Ching, LM; Dunbar, PR; Reddy, CB; Sutherland, R; Thomsen, L; Tijono, SM; Wang, LC | 1 |
| Baguley, BC; Ching, LM; Kestell, P; Zhao, L | 2 |
| Baguley, BC; Ching, LM; Newth, AL; Schooltink, MA; Woon, ST; Zwain, S | 1 |
| Baguley, BC; Ching, LM; Chung, F; Kestell, P; Man, HW; Muller, GW; Palmer, BD | 1 |
| Baguley, BC; Ching, LM; Zwain, S | 1 |
| Baguley, BC; Ching, LM; Kelland, LR; Kestell, P; Zhao, L | 1 |
| Chung, YL; Clark, S; Griffiths, JR; Kelland, LR; Madhu, B; McPhail, LD; Robinson, SP | 1 |
| Baguley, BC; Ching, LM; Drummond, CJ; Kieda, C; Reddy, CB; Schooltink, MA; Woon, ST | 1 |
| Bellnier, DA; Cheney, RT; Maiery, PG; Mazurchuk, R; Seshadri, M; Spernyak, JA | 1 |
| Baguley, BC; Ching, LM; Chung, F; Liu, J | 1 |
| Baguley, BC; Ching, LM; Gummer, BH; Joseph, WR; Palmer, BD; Xu, ZF | 1 |
| Baguley, BC; Ching, LM; Philpott, M | 1 |
| Bibby, MC; Double, JA; Laws, AL; Matthew, AM | 1 |
| Baguley, BC; Ching, LM; Joseph, WR; Zhuang, L | 1 |
| Baguley, BC; Gavin, JB; Wilson, WR; Zwi, LJ | 1 |
| Baguley, BC; Cole, G; Li, Z; Thomsen, LL | 1 |
| Baguley, BC; Li, Z; Thomsen, LL; Veszelovszky, E | 1 |
| Baguley, BC; Kestell, P; Zhuang, L | 1 |
| Baguley, BC; Browne, WL; Ching, LM; Gregory, T; Palmer, BD; Tchernegovski, R | 1 |
| Baguley, BC; Cao, Z; Ching, LM; Joseph, WR; Pang, JH | 1 |
| Baguley, BC; Browne, WL; Cao, Z; Ching, LM; Joseph, WR; Mountjoy, KG; Palmer, BD | 1 |
| Baguley, BC; Ching, LM; Goldsmith, D; Joseph, WR; Körner, H; Sedgwick, JD | 1 |
| Baguley, BC; Ching, LM; Kestell, P; Muller, G; Palmer, BD; Paxton, JW; Zhao, L | 1 |
| Baguley, BC; Cao, Z; Ching, LM | 1 |
| Baguley, BC; Ching, LM; Kestell, P; Philpott, M; Zhao, L; Zhuang, L | 1 |
| Beauregard, DA; Brindle, KM; Hill, SA; Pedley, RB | 1 |
| Baguley, BC; Cao, Z; Ching, LM; Jameson, MB; Kieda, C; Zwain, S | 1 |
| Baguley, BC; Ching, LM; Joseph, WR | 1 |
1 trial(s) available for vadimezan and Colonic Neoplasms
| Article | Year |
|---|---|
Induction of endothelial cell apoptosis by the antivascular agent 5,6-Dimethylxanthenone-4-acetic acid.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Blotting, Northern; Breast Neoplasms; Cells, Cultured; Chemokine CXCL10; Chemokines, CXC; Colonic Neoplasms; Endothelium, Vascular; Female; Humans; Interferons; Mice; Mice, Inbred C57BL; Ovarian Neoplasms; RNA, Messenger; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones | 2002 |
32 other study(ies) available for vadimezan and Colonic Neoplasms
| Article | Year |
|---|---|
Potential antitumor agents. 63. Structure-activity relationships for side-chain analogues of the colon 38 active agent 9-oxo-9H-xanthene-4-acetic acid.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Macrophages; Methylation; Mice; Nitrates; Nitrites; Structure-Activity Relationship; Xanthenes | 1991 |
Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Indicators and Reagents; Mice; Mice, Inbred Strains; Molecular Structure; Structure-Activity Relationship; Xanthenes; Xanthones | 1991 |
Synthesis and biological activity of azido analogues of 5,6-dimethylxanthenone-4-acetic acid for use in photoaffinity labeling.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Azides; Cells, Cultured; Colonic Neoplasms; Hemorrhage; Mice; Mice, Inbred C57BL; Necrosis; NF-kappa B; Photoaffinity Labels; Protein Binding; Spleen; Structure-Activity Relationship; Transplantation, Heterologous; Tumor Necrosis Factor-alpha; Xanthones | 2007 |
Enhancement of the action of the antivascular drug 5,6-dimethylxanthenone-4-acetic acid (DMXAA; ASA404) by non-steroidal anti-inflammatory drugs.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Cyclooxygenase Inhibitors; Diclofenac; Drug Screening Assays, Antitumor; Drug Therapy, Combination; Mice; Mice, Inbred C57BL; Xanthones | 2009 |
Neutrophil influx and chemokine production during the early phases of the antitumor response to the vascular disrupting agent DMXAA (ASA404).
Topics: Animals; Antineoplastic Agents; B-Lymphocytes; Colonic Neoplasms; Cytokines; Flow Cytometry; Fluorescent Antibody Technique; Humans; Killer Cells, Natural; Lymphocytes, Tumor-Infiltrating; Macrophages; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; T-Lymphocytes; Xanthones | 2009 |
The antitumour activity of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF receptor-1 knockout mice.
Topics: Animals; Antigens, CD; Antineoplastic Agents; Colonic Neoplasms; Dose-Response Relationship, Drug; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Neoplasm Transplantation; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; Serotonin; Time Factors; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones | 2002 |
NF-kappa B activation in vivo in both host and tumour cells by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; NF-kappa B; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Xanthenes; Xanthones | 2003 |
Effect of 3-fluorothalidomide and 3-methylthalidomide enantiomers on tumor necrosis factor production and antitumor responses to the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).
Topics: Angiogenesis Inhibitors; Animals; Colonic Neoplasms; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Female; Injections, Intraperitoneal; Maximum Tolerated Dose; Mice; Mice, Inbred C57BL; Molecular Structure; Neoplasm Transplantation; Stereoisomerism; Structure-Activity Relationship; Thalidomide; Treatment Outcome; Tumor Necrosis Factor-alpha; Xanthones | 2003 |
Relationship between tumour endothelial cell apoptosis and tumour blood flow shutdown following treatment with the antivascular agent DMXAA in mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Colonic Neoplasms; Endothelial Cells; In Situ Nick-End Labeling; Mice; Mice, Knockout; Neoplasms, Experimental; Regional Blood Flow; Tumor Necrosis Factor-alpha; Xanthones | 2004 |
Mechanisms of tumor vascular shutdown induced by 5,6-dimethylxanthenone-4-acetic acid (DMXAA): Increased tumor vascular permeability.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Capillary Permeability; Colonic Neoplasms; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neoplasms, Experimental; Neovascularization, Pathologic; Receptors, Tumor Necrosis Factor, Type I; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Xanthones | 2005 |
Tumor dose response to the vascular disrupting agent, 5,6-dimethylxanthenone-4-acetic acid, using in vivo magnetic resonance spectroscopy.
Topics: Animals; Antineoplastic Agents; Carcinoma; Cell Membrane; Colonic Neoplasms; Dose-Response Relationship, Drug; Energy Metabolism; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Nude; Neovascularization, Pathologic; Transplantation, Heterologous; Xanthones | 2005 |
A comparison of the ability of DMXAA and xanthenone analogues to activate NF-kappaB in murine and human cell lines.
Topics: Animals; Antineoplastic Agents; Biological Assay; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Lymphoma, B-Cell; Mice; Necrosis; NF-kappa B; Structure-Activity Relationship; Xanthenes; Xanthones | 2005 |
Visualizing the acute effects of vascular-targeted therapy in vivo using intravital microscopy and magnetic resonance imaging: correlation with endothelial apoptosis, cytokine induction, and treatment outcome.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Capillary Permeability; Colonic Neoplasms; Contrast Media; Drug Delivery Systems; Drug Screening Assays, Antitumor; Endothelium, Vascular; Female; Hemorrhage; Magnetic Resonance Imaging; Mice; Mice, Inbred BALB C; Microscopy; Neoplasm Proteins; Neoplasm Transplantation; Pentetic Acid; Polylysine; RNA, Messenger; RNA, Neoplasm; Skin Window Technique; Transplantation, Heterotopic; Transplantation, Isogeneic; Tumor Necrosis Factor-alpha; Xanthones | 2007 |
Consequences of increased vascular permeability induced by treatment of mice with 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and thalidomide.
Topics: Animals; Antineoplastic Agents; Body Temperature; Capillary Permeability; Colonic Neoplasms; Coloring Agents; Drug Synergism; Evans Blue; Hematocrit; Liver Circulation; Mice; Mice, Inbred C57BL; Thalidomide; Xanthones | 2008 |
Effect of thalidomide on tumour necrosis factor production and anti-tumour activity induced by 5,6-dimethylxanthenone-4-acetic acid.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Interactions; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Thalidomide; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones | 1995 |
Induction of tumour necrosis factor-alpha by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid.
Topics: Aging; Animals; Antineoplastic Agents; Colonic Neoplasms; Crosses, Genetic; Dose-Response Relationship, Drug; Drug Administration Schedule; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones | 1995 |
Preclinical in vitro and in vivo activity of 5,6-dimethylxanthenone-4-acetic acid.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Colonic Neoplasms; Hemorrhage; Humans; Lung Neoplasms; Mice; Mice, Inbred Strains; Mice, Nude; Necrosis; Species Specificity; Tumor Cells, Cultured; Xanthenes; Xanthones | 1995 |
Interaction between endotoxin and the antitumour agent 5,6-dimethylxanthenone-4-acetic acid in the induction of tumour necrosis factor and haemorrhagic necrosis of colon 38 tumours.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Endotoxins; Lipopolysaccharides; Mice; Necrosis; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones | 1994 |
The morphological effects of the anti-tumor agents flavone acetic acid and 5,6-dimethyl xanthenone acetic acid on the colon 38 mouse tumor.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Apoptosis; Colonic Neoplasms; Flavonoids; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Microscopy, Electron; Necrosis; Phosphocreatine; Xanthenes; Xanthones | 1994 |
Serotonin involvement in the antitumour and host effects of flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Cyproheptadine; Flavonoids; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Necrosis; Nitrates; Nitric Oxide; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones | 1993 |
Flavone acetic acid and 5,6-dimethylxanthenone-4-acetic acid: relationship between plasma nitrate elevation and the induction of tumour necrosis.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Arginine; Canavanine; Colonic Neoplasms; Flavonoids; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Necrosis; Nitrates; Nitric Oxide; Nitroarginine; omega-N-Methylarginine; Xanthenes; Xanthones | 1993 |
Increased plasma serotonin following treatment with flavone-8-acetic acid, 5,6-dimethylxanthenone-4-acetic acid, vinblastine, and colchicine: relation to vascular effects.
Topics: Animals; Antineoplastic Agents; Colchicine; Colonic Neoplasms; Dose-Response Relationship, Drug; Flavonoids; Hydroxyindoleacetic Acid; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Serotonin; Time Factors; Vinblastine; Xanthenes; Xanthones | 1997 |
Interaction of thalidomide, phthalimide analogues of thalidomide and pentoxifylline with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid: concomitant reduction of serum tumour necrosis factor-alpha and enhancement of anti-tumour activity.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Synergism; Mice; Neoplasm Transplantation; Pentoxifylline; Phthalimides; Thalidomide; Time Factors; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones | 1998 |
Antitumour activity of the novel immune modulator 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice lacking the interferon-gamma receptor.
Topics: Animals; Colonic Neoplasms; Cyclosporine; Enzyme-Linked Immunosorbent Assay; Immunosuppressive Agents; Interferon gamma Receptor; Interferon-gamma; Lipopolysaccharides; Mice; Nitric Oxide; Receptors, Interferon; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones | 1998 |
Thalidomide increases both intra-tumoural tumour necrosis factor-alpha production and anti-tumour activity in response to 5,6-dimethylxanthenone-4-acetic acid.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Synergism; Female; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; RNA, Messenger; Spleen; Thalidomide; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones | 1999 |
Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Gene Expression Regulation, Neoplastic; Hemorrhage; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis; Neoplasm Proteins; Neovascularization, Pathologic; RNA, Messenger; RNA, Neoplasm; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones | 1999 |
Modulation of the pharmacokinetics of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice by thalidomide.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Bile; Colonic Neoplasms; Female; Half-Life; Mice; Mice, Inbred C57BL; Stereoisomerism; Thalidomide; Time Factors; Tissue Distribution; Xanthenes; Xanthones | 2000 |
Interferon-inducible protein 10 induction and inhibition of angiogenesis in vivo by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).
Topics: Animals; Antibodies; Antineoplastic Agents; Chemokine CCL4; Chemokine CXCL10; Chemokines, CXC; Collagen; Colonic Neoplasms; Drug Combinations; Endothelium, Vascular; Female; Fibroblast Growth Factor 2; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Interferons; Interleukin-12; Laminin; Macrophage Inflammatory Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Neovascularization, Physiologic; Proteoglycans; RNA, Messenger; Spleen; Up-Regulation; Xanthenes; Xanthones | 2001 |
Effects of the serotonin receptor antagonist cyproheptadine on the activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA).
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Cyproheptadine; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Female; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Serotonin Antagonists; Tissue Distribution; Xanthenes; Xanthones | 2001 |
Oral activity and pharmacokinetics of 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in mice.
Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Colonic Neoplasms; Female; Half-Life; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Nitric Oxide; Tumor Necrosis Factor-alpha; Xanthenes; Xanthones | 2002 |
Differential sensitivity of two adenocarcinoma xenografts to the anti-vascular drugs combretastatin A4 phosphate and 5,6-dimethylxanthenone-4-acetic acid, assessed using MRI and MRS.
Topics: Adenocarcinoma; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Contrast Media; Gadolinium DTPA; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Mice; Mice, SCID; Stilbenes; Transplantation, Heterologous; Xanthenes; Xanthones | 2002 |
Antitumour responses to flavone-8-acetic acid and 5,6-dimethylxanthenone-4-acetic acid in immune deficient mice.
Topics: Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Flavonoids; Mice; Mice, Inbred Strains; Mice, Nude; Necrosis; T-Lymphocytes; Thymectomy; Xanthenes; Xanthones | 1992 |