ursolic acid has been researched along with Neoplasms in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (5.88) | 29.6817 |
| 2010's | 32 (62.75) | 24.3611 |
| 2020's | 16 (31.37) | 2.80 |
| Authors | Studies |
|---|---|
| Baba, K; Bastow, KF; Itokawa, H; Lee, KH; Morris-Natschke, SL; Nakagawa-Goto, K; Taniguchi, M; Tatsuzaki, J | 1 |
| Abramson, HN | 1 |
| Arellano, ML; Boggon, TJ; Brat, DJ; Chen, GZ; Chen, J; Chen, PR; DeBerardinis, RJ; Elf, S; Fan, J; Gu, TL; He, C; Hitosugi, T; Hurwitz, SJ; Ji, Q; Jiang, L; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lee, BH; Lei, Q; Li, Y; Lin, R; Lonial, S; Mao, H; Mitsche, M; Seo, JH; Shan, C; Sudderth, J; Tucker, M; Wang, D; Wu, S; Xie, J; Ye, K; Zhang, L; Zhang, S; Zhou, L | 1 |
| Chau, VM; Do Thi, T; Doan Thi Mai, H; Litaudon, M; Nguyen, TT; Nguyen, VH; Pham, VC; Truong, BN | 1 |
| Bodige, S; Endoori, S; Gulipalli, KC; Narendra Sharath Chandra, JN; Ravula, P; Seelam, N; Suresh Babu, G; Vanaja, GR | 1 |
| Alho, DPS; Figueiredo, SAC; Gonçalves, BMF; Leal, AS; Mendes, VIS; Salvador, JAR; Silvestre, SM; Valdeira, AS | 1 |
| Borkova, L; Hodon, J; Kazakova, A; Pokorny, J; Urban, M | 1 |
| Ansari, MI; Coop, A; Johnson, CR; Kamil Hussain, M; Khatoon, S; Saquib, M | 1 |
| Daelemans, D; De Jonghe, S; Dehaen, W; Hu, H; Krasniqi, B; Li, Y; Luyten, W; Persoons, L; Wang, R | 1 |
| Hua, D; Wu, X | 1 |
| Akter, R; Bibi, P; Hassan, SSU; Mubin, S; Najda, A; Rahman, MH; Saeeda, S; Shah, M; Wesołowska, S | 1 |
| Chandramohan, V; Kunjiappan, S; Pavadai, P; Ram Kumar Pandian, S; Sundar, K; Sundarapandian, V | 1 |
| Adnan, M; Ahmed, S; Alam, M; Ali, S; Elasbali, AM; Hassan, MI; Islam, A; Yadav, DK | 1 |
| Besztercei, B; Bóta, A; Gyulavári, P; Lőrincz, A; Mihály, J; Németh, C; Peták, I; Varga, Z; Wacha, A | 1 |
| Jiang, SN; Liu, X; Piao, L; Xu, H | 1 |
| Huang, X; Law, BYK; Li, H; Li, W; Liu, Y; Luo, Z; Yu, Y; Zheng, Y | 1 |
| Lokeshwar, BL; Panda, SS; Thangaraju, M | 1 |
| Gidwani, B; Jain, V; Joshi, V; Namdeo, P; Pandey, RK; Shukla, SS; Tiwari, S; Vyas, A | 1 |
| Bahetjan, Y; Chen, H; Kang, S; Liu, W; Lu, R; Yang, G; Yang, X; Zhang, J; Zheng, N | 1 |
| Chen, Y; Liu, S; Shi, S; Wei, X; Xu, F; Xu, Y; Zhang, N | 1 |
| Guan, Q; Guo, Y; Li, Y; Lv, S; Shang, E; Shi, L; Sun, S; Xiao, H; Yu, X; Zhao, C | 1 |
| Choi, HG; Gautam, M; Jeong, JH; Khan, GM; Kim, JO; Maharjan, S; Poudel, K; Yong, CS | 1 |
| Aderibigbe, BA; Khwaza, V; Oyedeji, OO | 1 |
| Chen, F; Chen, W; He, B; Lei, J; Wang, T; Zhang, R; Zhang, T; Zhu, Z | 1 |
| Ahmed, I; Al-Sadi, AM; Ali, I; Ali, Z; Green, IR; Hussain, H; Khan, IA | 1 |
| Abdollahi, M; Manayi, A; Nikan, M; Nobakht-Haghighi, N | 1 |
| Chen, X; Jiang, K; Shao, J; Shen, Z; Wu, P; Xu, A; Yang, X; Zheng, G | 1 |
| He, J; Lei, J; Li, C; Li, X; Liu, J; Liu, K; Liu, Y; Wang, L; Xiao, S; Zheng, D; Zhu, P | 1 |
| Fan, L; Guo, Y; Shao, JW; Shen, Z; Xu, A; Yao, H; Zhang, B; Zhao, R | 1 |
| Fan, L; Li, C; Lin, J; Shao, J; Yu, J; Zhao, R; Zou, J | 1 |
| Lei, L; Liu, Z; Meng, Q; Wang, H; Wang, W | 1 |
| Bishayee, A; Dai, X; Kumar, AP; Sethi, G; Shanmugam, MK; Tan, BK | 1 |
| Fu, L; Lin, Y; Tang, ZY; Wang, J; Wu, BN; Zang, LL | 1 |
| Lei, P; Men, X; Zhang, W | 1 |
| Chen, J; Chen, X; Chi, T; Ho, RJ; Jia, L; Ou, M; Shao, J; Tang, Q; Xiang, L; Yang, X; Yu, X | 1 |
| Qian, Z; Song, Z; Wang, H; Wang, X; Zhang, H; Zhao, J; Zhou, S | 1 |
| González-Vallinas, M; Ramírez de Molina, A; Reglero, G | 1 |
| Kashyap, D; Sharma, AK; Tuli, HS | 1 |
| Huang, L; Li, Y; Miao, L; Satterlee, AB; Wu, Y; Yao, J; Zhou, J | 1 |
| Chen, H; Jia, L; Li, T; Liu, Y; Shao, J; Tang, Q; Yang, X; Zheng, G | 1 |
| Günther, G; Morales, J; Rodríguez, L; Valdés, K | 1 |
| Bau, DT; Chang, YH; Chen, YC; Kuo, CL; Lee, HZ; Tsai, RY | 1 |
| Sultana, N | 1 |
| Ding, S; Dong, C; Nurieva, RI; Wang, X; Xu, T; Zhong, B | 1 |
| Giaginis, C; Katsargyris, A; Tampaki, EC; Theocharis, S | 1 |
| Cui, M; Gao, J; Gu, G; Li, X; Liu, S; Lou, HX | 1 |
| Jing, Y; Leal, AS; Salvador, JA; Wang, R | 1 |
| Hao, XS; Qian, ZZ; Qiu, LH; Song, Z; Wang, HQ; Wang, P; Wang, XH; Zhang, HL; Zhao, J; Zhou, SY | 1 |
| Qian, Z; Wang, H; Yan, Z; Ying, G; Zhao, C; Zhu, Z | 1 |
| Ikeda, Y; Murakami, A; Nishizawa, T; Ohigashi, H | 1 |
| Biggs, D; Novotný, L; Vachálková, A | 1 |
21 review(s) available for ursolic acid and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Protein Serine-Threonine Kinases; Ribulosephosphates; Signal Transduction | 2015 |
Oleanane-, ursane-, and quinone methide friedelane-type triterpenoid derivatives: Recent advances in cancer treatment.
Topics: Animals; Antineoplastic Agents; Chemistry Techniques, Synthetic; Humans; Indolequinones; Neoplasms; Oleanolic Acid; Structure-Activity Relationship; Triterpenes | 2017 |
Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antiviral Agents; Biomedical Research; Cell Proliferation; Drug Design; Humans; Neoplasms; Triterpenes; Viruses | 2019 |
Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment.
Topics: Antineoplastic Agents; Cell Proliferation; DNA Ligase ATP; Enzyme Inhibitors; Humans; Neoplasms; Structure-Activity Relationship | 2019 |
Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases.
Topics: Humans; Neoplasms; Protein Processing, Post-Translational; Small Ubiquitin-Related Modifier Proteins; Sumoylation; Ubiquitin | 2022 |
Potential Role of Natural Products to Combat Radiotherapy and Their Future Perspectives.
Topics: Berberine; Biological Products; Curcumin; Emodin; Genistein; Humans; Neoplasms; Pentacyclic Triterpenes; Radiation-Protective Agents; Radiation-Sensitizing Agents; Radiotherapy; Resveratrol; Sesquiterpenes; Triterpenes; Ursolic Acid; Vitamin D; Withanolides | 2021 |
Therapeutic Potential of Ursolic Acid in Cancer and Diabetic Neuropathy Diseases.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Diabetic Neuropathies; Humans; Neoplasms; Plants, Medicinal; Triterpenes; Ursolic Acid | 2021 |
Ursolic Acid Analogs as Potential Therapeutics for Cancer.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Humans; Neoplasms; Triterpenes; Ursolic Acid | 2022 |
Therapeutic potential and novel formulations of ursolic acid and its derivatives: an updated review.
Topics: Animals; Drug Compounding; Neoplasms; Oleanolic Acid; Solubility; Triterpenes; Ursolic Acid | 2023 |
Ursolic Acid-Based Derivatives as Potential Anti-Cancer Agents: An Update.
Topics: Animals; Antineoplastic Agents, Phytogenic; Drug Discovery; Humans; Neoplasms; Triterpenes; Ursolic Acid | 2020 |
Ursolic acid derivatives for pharmaceutical use: a patent review (2012-2016).
Topics: Animals; Antineoplastic Agents; Drug Design; Humans; Neoplasms; Patents as Topic; Structure-Activity Relationship; Triterpenes; Ursolic Acid | 2017 |
Advances in the Anticancer Value of the Ursolic Acid Through Nanodelivery.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Availability; Drug Delivery Systems; Humans; Nanoparticles; Neoplasms; Solubility; Triterpenes; Ursolic Acid | 2018 |
Ursolic Acid in Cancer Treatment and Metastatic Chemoprevention: From Synthesized Derivatives to Nanoformulations in Preclinical Studies.
Topics: Animals; Antineoplastic Agents; Drug Compounding; Humans; Nanomedicine; Neoplasm Metastasis; Neoplasms; Triterpenes; Ursolic Acid | 2019 |
Research progress of ursolic acid's anti-tumor actions.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Humans; Immunologic Surveillance; Neoplasms; Triterpenes; Ursolic Acid | 2014 |
Review on anti-tumor effect of triterpene acid compounds.
Topics: Anti-Inflammatory Agents; Apoptosis; Cell Proliferation; Humans; Neoplasms; Oleanolic Acid; Triterpenes; Ursolic Acid | 2014 |
Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy.
Topics: Abietanes; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Breast Neoplasms; Cinnamates; Depsides; Drug Interactions; Europe; Humans; Neoplasms; Phytotherapy; Plant Extracts; Rosmarinic Acid; Rosmarinus; Triterpenes; United States; United States Food and Drug Administration; Ursolic Acid | 2015 |
Ursolic acid (UA): A metabolite with promising therapeutic potential.
Topics: Animals; Antineoplastic Agents, Phytogenic; Humans; Neoplasms; Triterpenes; Ursolic Acid | 2016 |
Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments.
Topics: Animals; Antineoplastic Agents; Betulinic Acid; Biological Availability; Drug Delivery Systems; Drug Liberation; Humans; Nanocapsules; Neoplasms; Oleanolic Acid; Pentacyclic Triterpenes; Solubility; Triterpenes; Unilamellar Liposomes; Ursolic Acid; Water | 2016 |
Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dermatologic Agents; Humans; Neoplasms; Pharmaceutical Preparations; Plants, Medicinal; Triterpenes; Ursolic Acid | 2011 |
Cranberry as promising natural source of potential anticancer agents: current evidence and future perspectives.
Topics: Anthocyanins; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Cell Proliferation; Flavonoids; Humans; Neoplasms; Oxidative Stress; Plant Extracts; Triterpenes; Ursolic Acid; Vaccinium macrocarpon | 2012 |
Ursolic acid: an anti-tumorigenic and chemopreventive activity. Minireview.
Topics: Animals; Anticarcinogenic Agents; Antimutagenic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Differentiation; Enzyme Inhibitors; HIV Protease Inhibitors; Humans; Mice; Neoplasm Invasiveness; Neoplasms; Plant Extracts; Triterpenes; Ursolic Acid | 2001 |
3 trial(s) available for ursolic acid and Neoplasms
| Article | Year |
|---|---|
A phase I trial to evaluate the multiple-dose safety and antitumor activity of ursolic acid liposomes in subjects with advanced solid tumors.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Phytogenic; Female; Humans; Male; Middle Aged; Neoplasms; Triterpenes; Ursolic Acid | 2015 |
Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors.
Topics: Adult; Antineoplastic Agents, Phytogenic; Chemical and Drug Induced Liver Injury; Cohort Studies; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Gastrointestinal Diseases; Humans; Infusions, Intravenous; Liposomes; Male; Middle Aged; Neoplasms; Triterpenes; Ursolic Acid; Young Adult | 2013 |
A phase I pharmacokinetic study of ursolic acid nanoliposomes in healthy volunteers and patients with advanced solid tumors.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Area Under Curve; Chromatography, High Pressure Liquid; Female; Humans; Liposomes; Male; Middle Aged; Nanomedicine; Neoplasms; Statistics, Nonparametric; Tandem Mass Spectrometry; Triterpenes; Ursolic Acid | 2013 |
27 other study(ies) available for ursolic acid and Neoplasms
| Article | Year |
|---|---|
Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents.
Topics: Antineoplastic Agents; Cytotoxins; Drug Screening Assays, Antitumor; Glycyrrhetinic Acid; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Styrenes; Tumor Cells, Cultured | 2007 |
The lipogenesis pathway as a cancer target.
Topics: Acetyl-CoA Carboxylase; Animals; Antineoplastic Agents; ATP Citrate (pro-S)-Lyase; Biosynthetic Pathways; Fatty Acid Synthases; Fatty Acids; Humans; Lipogenesis; Models, Chemical; Molecular Structure; Neoplasms | 2011 |
Cytotoxic dammarane-type triterpenoids from the leaves of Viburnum sambucinum.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Dammaranes; Drug Screening Assays, Antitumor; Humans; Neoplasms; Plant Leaves; Triterpenes; Viburnum | 2017 |
Design, synthesis, in silico and in vitro evaluation of thiophene derivatives: A potent tyrosine phosphatase 1B inhibitor and anticancer activity.
Topics: Antineoplastic Agents; Cell Survival; Computer Simulation; Drug Design; Enzyme Inhibitors; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; Neoplasms; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Structure-Activity Relationship; Thiophenes | 2017 |
Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell Proliferation; HL-60 Cells; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Triterpenes | 2021 |
Delivery of Ursolic Acid by Polyhydroxybutyrate Nanoparticles for Cancer Therapy: in silico and in vitro Studies.
Topics: Drug Carriers; Drug Delivery Systems; Humans; Molecular Docking Simulation; Nanoparticles; Neoplasms; Triterpenes; Ursolic Acid | 2022 |
Combination of multifunctional ursolic acid with kinase inhibitors for anti-cancer drug carrier vesicles.
Topics: Animals; Antineoplastic Agents; Drug Carriers; Mice; Neoplasms; Triterpenes; Ursolic Acid | 2021 |
Ursolic acid-enriched kudingcha extract enhances the antitumor activity of bacteria-mediated cancer immunotherapy.
Topics: Animals; Bacteria; Disease Models, Animal; Ilex; Immunotherapy; Mice; Neoplasms; Plant Extracts; Triterpenes; Ursolic Acid | 2022 |
Ursolic acid enhances the antitumor effects of sorafenib associated with Mcl-1-related apoptosis and SLC7A11-dependent ferroptosis in human cancer.
Topics: Amino Acid Transport System y+; Apoptosis; Cell Line, Tumor; Ferroptosis; Humans; Neoplasms; Sorafenib; Triterpenes; Ursolic Acid | 2022 |
A composition of ursolic acid derivatives from Ludwigia hyssopifolia induces apoptosis in throat cancer cells via the Akt/mTOR and mitochondrial signaling pathways and by modulating endoplasmic reticulum stress.
Topics: Animals; Apoptosis; China; Humans; Mice; Mice, Nude; Neoplasms; Pharynx; Proto-Oncogene Proteins c-akt; Signal Transduction; TOR Serine-Threonine Kinases; Ursolic Acid | 2024 |
Solubilization and delivery of Ursolic-acid for modulating tumor microenvironment and regulatory T cell activities in cancer immunotherapy.
Topics: Animals; Immunotherapy; Mice; Neoplasms; T-Lymphocytes, Regulatory; Triterpenes; Tumor Microenvironment; Ursolic Acid | 2020 |
Hyaluronic acid-coated nanostructured lipid carriers for loading multiple traditional Chinese medicine components for liver cancer treatment.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Drug Carriers; Drug Liberation; Female; Ginsenosides; Hyaluronic Acid; Lipids; Mice; Nanostructures; Neoplasms; Oleanolic Acid; Particle Size; Static Electricity; Tissue Distribution; Triterpenes; Ursolic Acid | 2020 |
Dual stimuli-responsive ursolic acid-embedded nanophytoliposome for targeted antitumor therapy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Compounding; Drug Liberation; Female; Humans; Hyaluronan Receptors; Hyaluronic Acid; Liposomes; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasms; Polylysine; Stimuli Responsive Polymers; Tissue Distribution; Triterpenes; Ursolic Acid | 2020 |
Synthesis and antitumor potential of new arylidene ursolic acid derivatives via caspase-8 activation.
Topics: Antineoplastic Agents; Apoptosis; Caspase 8; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Humans; Neoplasms; Nitric Oxide Donors; Prodrugs; Structure-Activity Relationship; Triterpenes; Ursolic Acid | 2021 |
Synergistic Chemopreventive and Therapeutic Effects of Co-drug UA-Met: Implication in Tumor Metastasis.
Topics: Animals; Cadherins; Cell Line, Tumor; Drug Synergism; Female; Humans; Metformin; Mice; Neoplasm Metastasis; Neoplasms; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Triterpenes; Ursolic Acid; Vimentin; Xenograft Model Antitumor Assays | 2017 |
A novel self-assembled nanoparticle platform based on pectin-eight-arm polyethylene glycol-drug conjugates for co-delivery of anticancer drugs.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; Drug Carriers; Drug Liberation; Female; Half-Life; Hemolysis; Humans; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasms; Particle Size; Pectins; Polyethylene Glycols; Transplantation, Heterologous; Triterpenes; Ursolic Acid | 2018 |
Carrier-Free, Pure Nanodrug Formed by the Self-Assembly of an Anticancer Drug for Cancer Immune Therapy.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Drug Design; Female; Humans; Immunotherapy; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles; Neoplasms; T-Lymphocytes; Triterpenes; Ursolic Acid; Xenograft Model Antitumor Assays | 2018 |
Design, Synthesis, and Biological Evaluation of Novel Nitrogen Heterocycle-Containing Ursolic Acid Analogs as Antitumor Agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; HeLa Cells; Heterocyclic Compounds; Humans; Mice; Molecular Structure; Neoplasms; Nitrogen; Structure-Activity Relationship; Triterpenes; Ursolic Acid; Xenograft Model Antitumor Assays | 2019 |
Ursolic acid in cancer prevention and treatment: molecular targets, pharmacokinetics and clinical studies.
Topics: Antineoplastic Agents; Clinical Trials as Topic; Humans; Neoplasms; Triterpenes; Ursolic Acid | 2013 |
A pentacyclic triterpene natural product, ursolic acid and its prodrug US597 inhibit targets within cell adhesion pathway and prevent cancer metastasis.
Topics: Animals; Biological Products; Cell Adhesion; Cells, Cultured; Hep G2 Cells; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; MCF-7 Cells; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasms; Pentacyclic Triterpenes; Prodrugs; Signal Transduction; Triterpenes; Ursolic Acid | 2015 |
Sigma receptor-mediated targeted delivery of anti-angiogenic multifunctional nanodrugs for combination tumor therapy.
Topics: Angiogenesis Inhibitors; Animals; Anticoagulants; Antineoplastic Combined Chemotherapy Protocols; Drug Delivery Systems; Female; Heparin, Low-Molecular-Weight; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred C57BL; Nanostructures; Neoplasms; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Receptors, sigma; Triterpenes; Ursolic Acid; Vascular Endothelial Growth Factor Receptor-2 | 2016 |
A novel co-drug of aspirin and ursolic acid interrupts adhesion, invasion and migration of cancer cells to vascular endothelium via regulating EMT and EGFR-mediated signaling pathways: multiple targets for cancer metastasis prevention and treatment.
Topics: Animals; Aspirin; Biomarkers; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Disease Models, Animal; Endothelium, Vascular; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Gene Expression; Heterografts; Humans; Mice; Models, Biological; Neoplasm Metastasis; Neoplasms; Rats; RNA, Messenger; Signal Transduction; Triterpenes; Ursolic Acid | 2016 |
Clarification of the phenotypic characteristics and anti-tumor activity of Hedyotis diffusa.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Proliferation; Chromatography, High Pressure Liquid; Drug Contamination; Hedyotis; Humans; Neoplasms; Oleanolic Acid; Phenotype; Phytotherapy; Plant Extracts; Quality Control; Species Specificity; Triterpenes; Ursolic Acid | 2011 |
Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein.
Topics: Animals; Anti-Infective Agents; Cell Differentiation; Cell Line; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; Humans; Interleukin-17; Mice; Neoplasms; Nuclear Receptor Subfamily 1, Group F, Member 3; Th17 Cells; Triterpenes; Ursolic Acid | 2011 |
Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Survival; Disaccharides; Flow Cytometry; Glycyrrhetinic Acid; Humans; Membrane Potential, Mitochondrial; Molecular Structure; Neoplasms; Reactive Oxygen Species; Saponins; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Triterpenes; Ursolic Acid | 2012 |
Semisynthetic ursolic acid fluorolactone derivatives inhibit growth with induction of p21(waf1) and induce apoptosis with upregulation of NOXA and downregulation of c-FLIP in cancer cells.
Topics: Antineoplastic Agents; Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; G1 Phase; Halogenation; Humans; Lactones; Neoplasms; Pancreatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Triterpenes; Up-Regulation; Ursolic Acid | 2012 |
Ursolic acid enhances cyclooxygenases and tumor necrosis factor-alpha expression in mouse skin.
Topics: Animals; Carcinogenicity Tests; Cyclooxygenase 1; Cyclooxygenase 2; Gene Expression Regulation; Inflammation Mediators; Mice; Mice, Inbred ICR; Neoplasms; RNA, Messenger; Skin; Tetradecanoylphorbol Acetate; Triterpenes; Tumor Necrosis Factor-alpha; Ursolic Acid | 2006 |