ursolic acid has been researched along with Hepatocellular Carcinoma in 32 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (15.63) | 29.6817 |
| 2010's | 25 (78.13) | 24.3611 |
| 2020's | 2 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Dai, YC; Guo, YH; Lin, FP; Shao, JW; Wang, JC; Xue, JP | 1 |
| Lin, Y; Wang, B; Xu, Q; Zhou, C | 1 |
| Chang, SS; Kuo, YT; Lin, LT; Liu, CH; Tai, CJ | 1 |
| Kan, SY; Kang, H; Kim, GH; Kim, JH; Ko, HM; Lee, S; Lim, JH | 1 |
| Duan, J; Li, C; Li, S; Lin, J; Lin, L; Liu, T; Lv, J; Ma, H; Shi, W; Wang, Y; Zhang, C | 1 |
| Fan, L; Jiang, K; Li, T; Shao, J; Zhao, R; Zheng, G | 1 |
| Fan, L; Guo, Y; Jiang, K; Li, B; Liu, Y; Shao, J; Shen, Z; Zhao, R; Zheng, G | 1 |
| Li, Y; Shen, E | 1 |
| Bruno, M; Fontana, G; Labbozzetta, M; Notarbartolo, M; Poma, P; Rosselli, S; Spinella, A | 1 |
| Abdel-Monem, AR; Abdel-Naim, AB; Abdel-Sattar, E; Kandil, ZA | 1 |
| Chen, J; Chi, T; Dong, H; Gao, Y; Jia, L; Li, Y; Liu, Z; Ou, M; Shao, J; Xiang, L; Xie, J; Yang, X; Yu, S | 1 |
| Deng, S; Hann, SS; Tang, Q; Wu, J; Yang, L; Yie, Y; Zhao, S; Zheng, F | 1 |
| Ding, J; Li, X; Sun, W; Xu, H; Zhang, H; Zheng, D | 1 |
| Chen, J; Dai, Y; Jia, L; Jiang, Z; Li, Y; Lin, L; Lu, Y; Ou, M; Shao, J; Wang, J; Xiang, L; Yang, X | 1 |
| Fan, LM; Gong, LL; Lin, RX; Yang, SL; Zhao, ZK | 1 |
| Chen, Y; Dai, Z; Hann, SS; Tang, Q; Wu, J; Yang, LJ; Zheng, F | 1 |
| Chen, H; Huang, Q; Li, X; Ren, Y; Wang, J; Wang, Z; Zeng, P; Zheng, X | 1 |
| Chen, S; Chen, X; Fan, L; Li, T; Lin, L; Liu, Y; Shao, J; Xu, Y | 1 |
| Chang, CD; Hsu, JL; Lin, PY; Shih, WL | 1 |
| Du, J; Wu, S; Zhang, T | 1 |
| Lu, YH; Tang, C; Wang, F; Xi, T; Xie, JH; Xing, YY; Yang, JS; Zou, JN | 1 |
| Gayathri, R; Gunassekaran, GR; Priya, DK; Sakthisekaran, D | 1 |
| Kao, TC; Shyu, MH; Yen, GC | 1 |
| Fung, KP; Liu, X; Lu, Z; Wu, P; Wu, S; Yang, L; Yuet-Wa Chan, J; Zhou, L | 1 |
| Chou, WH; Gu, ZL; Kwok, CY; Liang, ZQ; Qin, ZH; Yin, JL; Yu, YX | 1 |
| Chang, CI; Hsu, JL; Liao, MH; Lin, BW; Lin, PY; Shih, WL; Wu, HY; Yen, CH; Yu, FL | 1 |
| Long, H; Mei, Y; Su, X; Wang, X; Yang, L; Zhang, F; Zhang, J; Zhang, X | 1 |
| Chang, CD; Liao, MH; Lin, PY; Shih, WL; Wu, HY; Yu, FL | 1 |
| Kim, SH; Kim, YC; Kwon, HY; Lee, JH; Sohn, EJ; Son, HS; Woo, HJ; Yun, M | 1 |
| Huang, F; Lin, G; Tian, Z; Xiao, PG; Yang, MS; Zheng, RX | 1 |
| Bartková, M; Horváthová, E; Kosíková, B; Krajcovicová, Z; Lábaj, J; Masterová, I; Slamenová, D | 1 |
| Fernandes-Ferreira, M; Lima, CF; Pereira, ML; Pereira-Wilson, C; Ramos, AA | 1 |
1 review(s) available for ursolic acid and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Anti-hepatocellular carcinoma activity and mechanism of chemopreventive compounds: ursolic acid derivatives.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Liver Neoplasms; Plant Extracts; Triterpenes; Ursolic Acid | 2016 |
31 other study(ies) available for ursolic acid and Hepatocellular Carcinoma
| Article | Year |
|---|---|
In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Crystallography, X-Ray; Fibroblasts; Gene Expression; HeLa Cells; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Triterpenes; Ursolic Acid; Xenograft Model Antitumor Assays | 2011 |
Liposomes co-loaded with ursolic acid and ginsenoside Rg3 in the treatment of hepatocellular carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Cell Survival; Ginsenosides; Hep G2 Cells; Humans; Liposomes; Liver Neoplasms; Triterpenes; Ursolic Acid | 2021 |
Combination of Oncolytic Measles Virus and Ursolic Acid Synergistically Induces Oncolysis of Hepatocellular Carcinoma Cells.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Hepatitis C; Humans; Liver Neoplasms; Measles virus; Oncolytic Virotherapy; Oncolytic Viruses; Ursolic Acid | 2023 |
Ursolic Acid Suppresses Cholesterol Biosynthesis and Exerts Anti-Cancer Effects in Hepatocellular Carcinoma Cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cholesterol; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Sterol Regulatory Element Binding Protein 2; Triterpenes; Ursolic Acid | 2019 |
Inhibition of STAT3 signaling pathway by ursolic acid suppresses growth of hepatocellular carcinoma.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Janus Kinase 2; Liver Neoplasms; Phosphorylation; Signal Transduction; STAT3 Transcription Factor; Triterpenes; Ursolic Acid; Xenograft Model Antitumor Assays | 2017 |
Simultaneous inhibition of growth and metastasis of hepatocellular carcinoma by co-delivery of ursolic acid and sorafenib using lactobionic acid modified and pH-sensitive chitosan-conjugated mesoporous silica nanocomplex.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chitosan; Delayed-Action Preparations; Disaccharides; Drug Synergism; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Lung Neoplasms; Male; Mice; Nanoparticles; Niacinamide; Phenylurea Compounds; Porosity; Rats; Silicon Dioxide; Sorafenib; Triterpenes; Ursolic Acid | 2017 |
A self-assembly nanodrug delivery system based on amphiphilic low generations of PAMAM dendrimers-ursolic acid conjugate modified by lactobionic acid for HCC targeting therapy.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Adhesion; Cell Proliferation; Dendrimers; Disaccharides; Drug Carriers; Drug Delivery Systems; Liver Neoplasms, Experimental; Matrix Metalloproteinase 9; Mice; Nanoparticles; Neoplasm Metastasis; Rats; Rats, Sprague-Dawley; Triterpenes; Tumor Cells, Cultured; Ursolic Acid | 2018 |
[Effect of ursolic acid on invasion and migration of hepatocellular carcinoma cells co-cultured with macrophages and the underlying mechanisms].
Topics: Cadherins; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Coculture Techniques; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Macrophages; Neoplasm Invasiveness; Triterpenes; Ursolic Acid | 2018 |
Cytotoxicity of oleanolic and ursolic acid derivatives toward hepatocellular carcinoma and evaluation of NF-κB involvement.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; Humans; Liver Neoplasms; Malus; NF-kappa B; Olea; Oleanolic Acid; Plant Extracts; Triterpenes; Tumor Cells, Cultured; Ursolic Acid | 2019 |
A new triterpene and protective effect of Periploca somaliensis Browicz fruits against CCl₄-induced injury on human hepatoma cell line (Huh7).
Topics: Carbon Tetrachloride; Carcinoma, Hepatocellular; Cell Line, Tumor; Fruit; Humans; Liver Neoplasms; Molecular Structure; Periploca; Triterpenes; Ursolic Acid | 2015 |
UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Dose-Response Relationship, Drug; Drug Delivery Systems; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Protein Structure, Secondary; Random Allocation; Signal Transduction; Triterpenes; Ursolic Acid; Xenograft Model Antitumor Assays | 2015 |
Ursolic acid inhibited growth of hepatocellular carcinoma HepG2 cells through AMPKα-mediated reduction of DNA methyltransferase 1.
Topics: AMP-Activated Protein Kinases; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Proliferation; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Inhibitory Concentration 50; Metformin; Phosphorylation; Protein Processing, Post-Translational; Sp1 Transcription Factor; Triterpenes; Ursolic Acid | 2015 |
Efficient delivery of ursolic acid by poly(N-vinylpyrrolidone)-block-poly (ε-caprolactone) nanoparticles for inhibiting the growth of hepatocellular carcinoma in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Delivery Systems; Liver Neoplasms; Mice; Mice, Inbred ICR; Nanoparticles; Polyesters; Pyrrolidinones; Triterpenes; Ursolic Acid | 2015 |
Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Deoxyglucose; Drug Synergism; Female; G1 Phase Cell Cycle Checkpoints; Glucokinase; Glycolysis; HeLa Cells; Hep G2 Cells; Hexokinase; Humans; Lactic Acid; Liver Neoplasms; Membrane Potential, Mitochondrial; Mice; Neoplasm Transplantation; Triterpenes; Ursolic Acid | 2014 |
Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells.
Topics: AC133 Antigen; Antigens, CD; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line, Tumor; Cell Separation; Chalcone; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glycoproteins; Humans; Liver Neoplasms; Neoplastic Stem Cells; Peptides; Triterpenes; Ursolic Acid | 2015 |
Inter-regulation of IGFBP1 and FOXO3a unveils novel mechanism in ursolic acid-inhibited growth of hepatocellular carcinoma cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Forkhead Box Protein O3; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Insulin-Like Growth Factor Binding Protein 1; Liver Neoplasms; Mice; Signal Transduction; Triterpenes; Ursolic Acid; Xenograft Model Antitumor Assays | 2016 |
pH-Sensitive mesoporous silica nanoparticles anticancer prodrugs for sustained release of ursolic acid and the enhanced anti-cancer efficacy for hepatocellular carcinoma cancer.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Survival; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Carriers; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Liver Neoplasms; Nanoparticles; Prodrugs; Silicon Dioxide; Treatment Outcome; Triterpenes; Ursolic Acid | 2017 |
Ursolic Acid Suppresses Hepatitis B Virus X Protein-mediated Autophagy and Chemotherapeutic Drug Resistance.
Topics: Autophagy; Beclin-1; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Resistance, Neoplasm; Green Fluorescent Proteins; Humans; Liver Neoplasms; Luciferases; Promoter Regions, Genetic; rho-Associated Kinases; Signal Transduction; Trans-Activators; Transcription Factor AP-1; Triterpenes; Ursolic Acid; Viral Regulatory and Accessory Proteins | 2016 |
Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway.
Topics: Antineoplastic Agents; Antioxidant Response Elements; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Drug Synergism; Drug Therapy, Combination; Hep G2 Cells; Humans; NF-E2-Related Factor 2; RNA, Small Interfering; Triterpenes; Ursolic Acid | 2016 |
Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Line, Tumor; Cell Proliferation; DNA Fragmentation; Dose-Response Relationship, Drug; Down-Regulation; Humans; Inhibitor of Apoptosis Proteins; Liver Neoplasms; Microtubule-Associated Proteins; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Survivin; Time Factors; Triterpenes; Ursolic Acid | 2009 |
Ursolic acid attenuates oxidative stress-mediated hepatocellular carcinoma induction by diethylnitrosamine in male Wistar rats.
Topics: Adenosine Triphosphatases; Alkylating Agents; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Diethylnitrosamine; Erythrocyte Membrane; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Lipid Peroxides; Liver Neoplasms, Experimental; Male; Oxidative Stress; Phenobarbital; Rats; Rats, Wistar; Triterpenes; Ursolic Acid | 2009 |
Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP.
Topics: Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Cycle; Cell Division; Cell Line, Tumor; Down-Regulation; Humans; Liver Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; NF-kappa B; Oleanolic Acid; Triterpenes; Ursolic Acid; X-Linked Inhibitor of Apoptosis Protein | 2010 |
Ursolic acid induces doxorubicin-resistant HepG2 cell death via the release of apoptosis-inducing factor.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis Inducing Factor; Carcinoma, Hepatocellular; Cell Growth Processes; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Immunohistochemistry; Liver Neoplasms; Mice; Mice, Nude; Signal Transduction; Triterpenes; Ursolic Acid | 2010 |
Ursolic acid induces human hepatoma cell line SMMC-7721 apoptosis via p53-dependent pathway.
Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Flow Cytometry; Humans; Liver Neoplasms; Microscopy, Electron, Transmission; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Triterpenes; Tumor Suppressor Protein p53; Ursolic Acid | 2010 |
Suppression of hepatitis B virus x protein-mediated tumorigenic effects by ursolic Acid.
Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Hepatocellular; Cell Division; Cell Line; Cell Line, Tumor; Flavones; Hepatocytes; Humans; Liver Neoplasms; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Oleanolic Acid; Signal Transduction; Trans-Activators; Transcriptional Activation; Transfection; Triterpenes; Ursolic Acid; Viral Regulatory and Accessory Proteins | 2011 |
Ursolic acid inhibits proliferation and induces apoptosis of cancer cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Caspases; Cell Line, Tumor; Cell Proliferation; Drugs, Chinese Herbal; Female; Humans; Liver Neoplasms; Male; Mice; Stomach Neoplasms; Triterpenes; Ursolic Acid; Xenograft Model Antitumor Assays | 2011 |
Suppression of AMF/PGI-mediated tumorigenic activities by ursolic acid in cultured hepatoma cells and in a mouse model.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Adhesion; Cell Movement; Cell Proliferation; Cisplatin; Disease Models, Animal; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Flavones; Fluorescent Antibody Technique; Glucose-6-Phosphate Isomerase; Humans; Immunoprecipitation; Liver Neoplasms; Luciferases; Lung Neoplasms; Male; Matrix Metalloproteinase 3; Mice; Mice, Nude; Neovascularization, Pathologic; Oleanolic Acid; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; rhoA GTP-Binding Protein; Signal Transduction; Transforming Growth Factor beta; Triterpenes; Tumor Cells, Cultured; Ursolic Acid | 2013 |
Activation of AMP-activated protein kinase and phosphorylation of glycogen synthase kinase3 β mediate ursolic acid induced apoptosis in HepG2 liver cancer cells.
Topics: AMP-Activated Protein Kinases; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Cell Adhesion Molecules; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hep G2 Cells; Humans; Indoles; Leupeptins; Liver Neoplasms; Maleimides; Membrane Proteins; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; RNA-Binding Proteins; TOR Serine-Threonine Kinases; Triterpenes; Ubiquitination; Ursolic Acid | 2013 |
Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana.
Topics: Aralia; Carcinoma, Hepatocellular; Cell Division; Cell Line, Tumor; Humans; Liver Neoplasms; Phytotherapy; Plant Extracts; Triterpenes; Ursolic Acid | 2006 |
Reduction of DNA-damaging effects of anti-HIV drug 3'-azido-3'-dideoxythymidine on human cells by ursolic acid and lignin biopolymer.
Topics: Anti-HIV Agents; Biopolymers; Caco-2 Cells; Carcinoma, Hepatocellular; Comet Assay; DNA Breaks, Double-Stranded; DNA Breaks, Single-Stranded; DNA Damage; DNA Repair; DNA, Neoplasm; Humans; Lignin; Liver Neoplasms; Triterpenes; Ursolic Acid; Zidovudine | 2006 |
Antigenotoxic effects of quercetin, rutin and ursolic acid on HepG2 cells: evaluation by the comet assay.
Topics: Antimutagenic Agents; Antioxidants; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Formazans; Hepatocytes; HSP70 Heat-Shock Proteins; Humans; Quercetin; Rutin; Tetrazolium Salts; Triterpenes; Ursolic Acid | 2008 |