Page last updated: 2024-08-24

ursolic acid and Colorectal Cancer

ursolic acid has been researched along with Colorectal Cancer in 19 studies

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.26)29.6817
2010's12 (63.16)24.3611
2020's6 (31.58)2.80

Authors

AuthorsStudies
Chen, L; Liu, M; Meng, X; Ming, T; Ren, S; Sun, Q; Tang, S; Tao, Q; Xu, H; Yang, H; Zeng, S; Zhao, H1
Li, H; Lin, J; Liu, H; Liu, X; Mao, Q; Min, J; Wu, M; Zeng, R; Zhang, C; Zheng, A1
Lei, J; Liang, Y; Liu, M; Ming, T; Peng, Y; Ren, S; Tang, S; Tao, Q; Wang, M; Xu, H; Yang, H; Zhao, H1
An, HM; Chen, L; Hu, B; Huang, XW; Li, M; Peng, X; Shen, KP; Wang, SS; Zheng, J-1
An, HM; Chen, JF; Chen, L; Hu, B; Peng, X; Shen, KP; Wang, SS; Zheng, JL1
Chen, L; He, M; Liu, ML; Ren, S; Sun, Q; Xu, HB; Yang, H; Zeng, S; Zhang, M; Zhao, H1
Cai, Q; Chen, D; Lin, J; Peng, J; Wang, L; Zhang, L1
Chen, H; Huang, L; Shen, R; Shi, H; Tao, J; Wang, T; Zhang, Y1
Jung, JH; Kim, DS; Kim, K; Kim, SH; Park, JE; Shim, BS; Shin, EA1
Chan, EWC; Hui, YW; Soon, CY; Tan, JBL; Wong, SK1
Deng, W; Duan, C; He, N; Li, Q; Wang, Q; Wang, T; Wang, X; Yi, F; Zhu, L1
Chen, Y; Hong, Z; Lin, J; Peng, J; Sferra, TJ; Shen, A; Wei, L1
Chen, Y; Hong, Z; Lin, J; Peng, J; Sferra, TJ; Wei, L1
Liu, Z; Shan, J; Xuan, Y; Zhang, Q; Zhang, S; Zhu, C1
Fernandes-Ferreira, M; Lima, CF; Pereira-Wilson, C; Preto, A; Seruca, R; Xavier, CP1
Aggarwal, BB; Kannappan, R; Prasad, S; Yadav, VR1
Beneytout, JL; Cook-Moreau, J; Delage, C; Leger, DY; Liagre, B; Limami, Y; Mousseau, Y; Pinon, A; Simon, A1
Beneytout, JL; Delage, C; Leger, DY; Liagre, B; Limami, Y; Pinault, E; Pinon, A; Simon, A1
Aggarwal, BB; Baladandayuthapani, V; Deorukhkar, A; Diagaradjane, P; Guha, S; Kannappan, R; Krishnan, S; Prasad, S; Reuter, S; Sung, B; Wei, C; Yadav, VR1

Reviews

1 review(s) available for ursolic acid and Colorectal Cancer

ArticleYear
Ursolic acid: An overview on its cytotoxic activities against breast and colorectal cancer cells.
    Journal of integrative medicine, 2019, Volume: 17, Issue:3

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Colorectal Neoplasms; Drugs, Chinese Herbal; Female; Humans; Male; Triterpenes; Ursolic Acid

2019

Other Studies

18 other study(ies) available for ursolic acid and Colorectal Cancer

ArticleYear
Ursolic acid inhibits the activation of smoothened-independent non-canonical hedgehog pathway in colorectal cancer by suppressing AKT signaling cascade.
    Phytotherapy research : PTR, 2022, Volume: 36, Issue:9

    Topics: Animals; Cell Proliferation; Colorectal Neoplasms; Hedgehog Proteins; Humans; Oleanolic Acid; Proto-Oncogene Proteins c-akt; Signal Transduction; Triterpenes; Ursolic Acid; Zinc Finger Protein GLI1

2022
Self-assembled traditional Chinese nanomedicine modulating tumor immunosuppressive microenvironment for colorectal cancer immunotherapy.
    Theranostics, 2022, Volume: 12, Issue:14

    Topics: Carcinogens; China; Colorectal Neoplasms; Humans; Immunologic Factors; Immunotherapy; Lentinan; Nanomedicine; Oleanolic Acid; Tumor Microenvironment; Ursolic Acid

2022
Ursolic Acid Suppresses Colorectal Cancer by Down-Regulation of Wnt/β-Catenin Signaling Pathway Activity.
    Journal of agricultural and food chemistry, 2023, Mar-08, Volume: 71, Issue:9

    Topics: Animals; beta Catenin; Colorectal Neoplasms; Down-Regulation; Humans; Mice; Ursolic Acid; Wnt Signaling Pathway

2023
Ursolic acid potentiated oxaliplatin to induce apoptosis in colorectal cancer RKO cells.
    Die Pharmazie, 2020, 06-01, Volume: 75, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Down-Regulation; Drug Synergism; Humans; Oxaliplatin; Survivin; Triterpenes; Ursolic Acid; X-Linked Inhibitor of Apoptosis Protein

2020
Ursolic acid induces apoptosis and anoikis in colorectal carcinoma RKO cells.
    BMC complementary medicine and therapies, 2021, Feb-06, Volume: 21, Issue:1

    Topics: Anoikis; Apoptosis; Caspases; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Focal Adhesion Kinase 1; Humans; Reactive Oxygen Species; Signal Transduction; Triterpenes; Ursolic Acid

2021
[Mechanism of ursolic acid in regulating colorectal cancer cell HCT116 autophagy through hedgehog signaling pathway].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2021, Volume: 46, Issue:5

    Topics: Apoptosis; Autophagy; Cell Line, Tumor; Colorectal Neoplasms; Hedgehog Proteins; Humans; Signal Transduction; Triterpenes; Ursolic Acid

2021
Comparative proteomics-network analysis of proteins responsible for ursolic acid-induced cytotoxicity in colorectal cancer cells.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2017, Volume: 39, Issue:3

    Topics: Apoptosis; Calreticulin; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chaperonin 60; Colorectal Neoplasms; Electrophoresis, Gel, Two-Dimensional; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Membrane Glycoproteins; Mitochondrial Proteins; Mitochondrial Proton-Translocating ATPases; Molecular Chaperones; Neoplasm Proteins; Protein Folding; Proteomics; Signal Transduction; Triterpenes; Ursolic Acid

2017
Ursolic acid enhances the therapeutic effects of oxaliplatin in colorectal cancer by inhibition of drug resistance.
    Cancer science, 2018, Volume: 109, Issue:1

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Synergism; Humans; Mice; Organoplatinum Compounds; Oxaliplatin; Reactive Oxygen Species; Treatment Outcome; Triterpenes; Ursolic Acid; Xenograft Model Antitumor Assays

2018
Ursolic Acid Induces Apoptosis in Colorectal Cancer Cells Partially via Upregulation of MicroRNA-4500 and Inhibition of JAK2/STAT3 Phosphorylation.
    International journal of molecular sciences, 2018, Dec-29, Volume: 20, Issue:1

    Topics: Apoptosis; Colorectal Neoplasms; HCT116 Cells; HT29 Cells; Humans; Janus Kinase 2; MicroRNAs; Phosphorylation; Poly(ADP-ribose) Polymerases; Signal Transduction; STAT3 Transcription Factor; Triterpenes; Up-Regulation; Ursolic Acid

2018
Ursolic Acid Inhibits Tumor Growth via Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells.
    Biological & pharmaceutical bulletin, 2019, Volume: 42, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Humans; Triterpenes; Ursolic Acid

2019
Ursolic acid promotes colorectal cancer cell apoptosis and inhibits cell proliferation via modulation of multiple signaling pathways.
    International journal of oncology, 2013, Volume: 43, Issue:4

    Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Mice; Proto-Oncogene Proteins c-akt; Signal Transduction; STAT3 Transcription Factor; Triterpenes; Ursolic Acid; Xenograft Model Antitumor Assays

2013
Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways.
    International journal of oncology, 2013, Volume: 43, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Movement; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Colorectal Neoplasms; Human Umbilical Vein Endothelial Cells; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Triterpenes; Ursolic Acid; Xenograft Model Antitumor Assays

2013
Ursolic acid synergistically enhances the therapeutic effects of oxaliplatin in colorectal cancer.
    Protein & cell, 2016, Volume: 7, Issue:8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colorectal Neoplasms; Drug Synergism; Female; Humans; Mice; Mice, Nude; Neoplasm Proteins; Organoplatinum Compounds; Oxaliplatin; Triterpenes; Ursolic Acid; Xenograft Model Antitumor Assays

2016
Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells.
    Cancer letters, 2009, Aug-28, Volume: 281, Issue:2

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Extracellular Signal-Regulated MAP Kinases; Humans; In Situ Nick-End Labeling; Luteolin; Mutation; Proto-Oncogene Proteins; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Quercetin; ras Proteins; Triterpenes; Ursolic Acid

2009
Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors: evidence for the role of reactive oxygen species and JNK.
    The Journal of biological chemistry, 2011, Feb-18, Volume: 286, Issue:7

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Caco-2 Cells; Cell Survival; Colorectal Neoplasms; Down-Regulation; Drug Synergism; Humans; MAP Kinase Kinase 4; Mice; Mice, Nude; Neoplasm Transplantation; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand; Triterpenes; Tumor Necrosis Factor Decoy Receptors; Tumor Suppressor Protein p53; Up-Regulation; Ursolic Acid; Xenograft Model Antitumor Assays

2011
HT-29 colorectal cancer cells undergoing apoptosis overexpress COX-2 to delay ursolic acid-induced cell death.
    Biochimie, 2011, Volume: 93, Issue:4

    Topics: Apoptosis; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Resistance, Neoplasm; HCT116 Cells; HT29 Cells; Humans; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; RNA, Small Interfering; Sulfonamides; Triterpenes; Ursolic Acid

2011
The P2Y2/Src/p38/COX-2 pathway is involved in the resistance to ursolic acid-induced apoptosis in colorectal and prostate cancer cells.
    Biochimie, 2012, Volume: 94, Issue:8

    Topics: Adenosine Triphosphate; Apoptosis; Arachidonic Acid; Colorectal Neoplasms; Cyclooxygenase 2; Female; Gene Expression Regulation, Neoplastic; Group II Phospholipases A2; HT29 Cells; Humans; Male; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Receptors, Purinergic P2Y2; Signal Transduction; src-Family Kinases; Triterpenes; Ursolic Acid

2012
Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Sep-15, Volume: 18, Issue:18

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; beta Catenin; Capecitabine; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Deoxycytidine; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Fluorouracil; Humans; Ki-67 Antigen; Male; Mice; Mice, Nude; Neoplasm Metastasis; NF-kappa B; Platelet Endothelial Cell Adhesion Molecule-1; Signal Transduction; STAT3 Transcription Factor; Triterpenes; Tumor Suppressor Proteins; Ursolic Acid; Xenograft Model Antitumor Assays

2012