uroporphyrinogen iii has been researched along with Porphyrias in 31 studies
Uroporphyrinogens: Porphyrinogens which are intermediates in heme biosynthesis. They have four acetic acid and four propionic acid side chains attached to the pyrrole rings. Uroporphyrinogen I and III are formed from polypyrryl methane in the presence of uroporphyrinogen III cosynthetase and uroporphyrin I synthetase, respectively. They can yield uroporphyrins by autooxidation or coproporphyrinogens by decarboxylation.
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This work examines whether the four sequential decarboxylations occur at the same active site, and explores whether hexachlorobenzene-induced porphyria affects the behavior of the enzyme." | 7.73 | Abnormal kinetic behavior of uroporphyrinogen decarboxylase obtained from rats with hexachlorobenzene-induced porphyria. ( Cárdenas, ML; Chaufan, G; Corvi, MM; Ríos de Molina, Mdel C; San Martín de Viale, LC, 2005) |
| " Qualitative and quantitative studies of the porphyrins and the porphyrinogen carboxylyase of the liver, spleen, kidney, harderian gland and erythrocytes from normal rats and from those hexachlorobenzene-induced porphyria were carried out." | 7.65 | Porphyrins and porphyrinogen carboxy-lase in hexachlorobenzene-induced porphyria. ( De Calmanovici, RW; Ríos De Molina, MD; San Martín De Viale, LC; Tomio, JM, 1977) |
| " This work examines whether the four sequential decarboxylations occur at the same active site, and explores whether hexachlorobenzene-induced porphyria affects the behavior of the enzyme." | 3.73 | Abnormal kinetic behavior of uroporphyrinogen decarboxylase obtained from rats with hexachlorobenzene-induced porphyria. ( Cárdenas, ML; Chaufan, G; Corvi, MM; Ríos de Molina, Mdel C; San Martín de Viale, LC, 2005) |
| "The porphyrias are a heterogeneous group of clinical disorders that share a common etiologic background in that each manifests a major metabolic defect in the synthesis of heme." | 3.67 | Porphyria. Basic science aspects. ( Bickers, DR, 1986) |
| "The excretion of position isomers of type III porphyrins, not only in porphyric disorders in which the enzymatic decarboxylation of uroporphyrinogen III to coproporphyrinogen III is known to or suspected to play a role, but also in normal man and in conditions like erythropoietic protoporphyria and lead-intoxication, in which no such changes have ever been reported, or would be expected for theoretical reasons, has been described." | 3.66 | Urinary excretion of position isomers type III in normal man and a series of different types of porphyrias. ( Eriksen, L, 1980) |
| " Qualitative and quantitative studies of the porphyrins and the porphyrinogen carboxylyase of the liver, spleen, kidney, harderian gland and erythrocytes from normal rats and from those hexachlorobenzene-induced porphyria were carried out." | 3.65 | Porphyrins and porphyrinogen carboxy-lase in hexachlorobenzene-induced porphyria. ( De Calmanovici, RW; Ríos De Molina, MD; San Martín De Viale, LC; Tomio, JM, 1977) |
| "Uroporphyria was produced by injecting animals with iron-dextran and giving the porphyrin precursor 5-aminolaevulinic acid in the drinking water." | 1.30 | Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice. ( Bement, WJ; Dalton, T; Gorman, N; Nebert, DW; Sinclair, JF; Sinclair, PR; Smith, AG; Walton, HS, 1998) |
| "The porphyria is not dependent on pretreatment with iron and persists for at least 21 days after withdrawal of ALA." | 1.27 | Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid. ( Bement, WJ; Elder, GH; Gorman, N; Lambrecht, RW; Roberts, AG; Sinclair, JA; Sinclair, PR; Urquhart, AJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (70.97) | 18.7374 |
| 1990's | 7 (22.58) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakano, K | 1 |
| Ishizuka, M | 1 |
| Sakamoto, KQ | 1 |
| Fujita, S | 1 |
| Chaufan, G | 1 |
| Corvi, MM | 1 |
| San Martín de Viale, LC | 5 |
| Cárdenas, ML | 1 |
| Ríos de Molina, Mdel C | 1 |
| Cantoni, L | 1 |
| Dal Fiume, D | 1 |
| Ruggieri, R | 1 |
| Kondo, M | 1 |
| Urata, G | 1 |
| Shimizu, Y | 1 |
| Kostrzewska, E | 2 |
| Gregor, A | 2 |
| de Verneuil, H | 1 |
| Grandchamp, B | 2 |
| Nordmann, Y | 2 |
| Eriksen, L | 1 |
| Miller, DM | 1 |
| Woods, JS | 1 |
| Smith, AG | 3 |
| Francis, JE | 2 |
| Sinclair, PR | 2 |
| Gorman, N | 2 |
| Dalton, T | 1 |
| Walton, HS | 1 |
| Bement, WJ | 2 |
| Sinclair, JF | 1 |
| Nebert, DW | 1 |
| de Catabbi, SB | 1 |
| de Calmanovici, RW | 2 |
| Minutolo, C | 1 |
| Aldonatti, C | 1 |
| Jackson, AH | 1 |
| Sancovich, HA | 1 |
| Ferramola, AM | 1 |
| Evans, N | 1 |
| Games, DE | 1 |
| Matlin, SA | 1 |
| Elder, GH | 2 |
| Smith, SG | 1 |
| Brugsch, J | 1 |
| Müller, H | 1 |
| Gidari, AS | 1 |
| Levere, RD | 1 |
| Walsh, JR | 1 |
| Granick, S | 1 |
| Beale, SI | 1 |
| Traczyk, A | 1 |
| Rudowski, W | 1 |
| Ríos De Molina, MD | 1 |
| Tomio, JM | 1 |
| Moore, MR | 1 |
| Thompson, GG | 1 |
| Goldberg, A | 1 |
| Ippen, H | 1 |
| Seubert, A | 1 |
| Seubert, S | 1 |
| Herrero, C | 1 |
| Piñol Aguade, J | 1 |
| Lecha, M | 1 |
| Muniesa, MA | 1 |
| Almeida, J | 1 |
| Mallolas, J | 1 |
| Kushner, JP | 1 |
| Steinmuller, DP | 1 |
| Lee, GR | 1 |
| Billi de Catabbi, S | 1 |
| Ríos de Molina, MC | 2 |
| Luo, JL | 1 |
| Lim, CK | 1 |
| Beukeveld, GJ | 1 |
| Wolthers, BG | 1 |
| Deybach, JC | 1 |
| Wadman, SK | 1 |
| Lannfelt, L | 1 |
| Wetterberg, L | 1 |
| Gellerfors, P | 1 |
| Lilius, L | 1 |
| Floderus, Y | 1 |
| Thunell, S | 1 |
| De Matteis, F | 1 |
| Harvey, C | 1 |
| Reed, C | 1 |
| Hempenius, R | 1 |
| Urquhart, AJ | 1 |
| Roberts, AG | 1 |
| Lambrecht, RW | 1 |
| Sinclair, JA | 1 |
| Wainstok de Calmanovici, R | 1 |
| Mukerji, SK | 1 |
| Pimstone, NR | 1 |
| Bickers, DR | 1 |
3 reviews available for uroporphyrinogen iii and Porphyrias
| Article | Year |
|---|---|
Enzymatic formation and cellular regulation of heme synthesis.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Coenzyme A; Coproporphyrinogens; Enzyme | 1977 |
Hepatic porphyrias. Current concepts.
Topics: 5-Aminolevulinate Synthetase; Acute Disease; Coproporphyrinogens; Female; Genetic Diseases, Inborn; | 1977 |
Hemes, chlorophylls, and related compounds: biosynthesis and metabolic regulation.
Topics: 5-Aminolevulinate Synthetase; Aminolevulinic Acid; Animals; Bacteria; Chlorophyll; Fungi; Heme; Hemi | 1978 |
28 other studies available for uroporphyrinogen iii and Porphyrias
| Article | Year |
|---|---|
Absolute requirement for iron in the development of chemically induced uroporphyria in mice treated with 3-methylcholanthrene and 5-aminolevulinate.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A2; Iron; Male; Methylcholanthrene; Mice; Mice, I | 2009 |
Abnormal kinetic behavior of uroporphyrinogen decarboxylase obtained from rats with hexachlorobenzene-induced porphyria.
Topics: Animals; Female; Hexachlorobenzene; Kinetics; Liver; Porphyrias; Porphyrinogens; Rats; Rats, Wistar; | 2005 |
Decarboxylation of uroporphyrinogen I and III in 2,3,7,8-tetrachlorodibenzo-p-dioxin induced porphyria in mice.
Topics: Animals; Carboxy-Lyases; Decarboxylation; Dioxins; Erythrocytes; Liver; Male; Mice; Mice, Inbred C57 | 1984 |
Decreased liver delta-aminolaevulinate dehydratase activity in porphyria cutanea tarda and in alcoholism.
Topics: Adult; Alcoholism; Ferrous Compounds; Hot Temperature; Humans; Liver; Liver Extracts; Male; Middle A | 1983 |
[Normal activity of uroporphyrinogen I synthase during an attack of acute intermittent porphyria].
Topics: Acute Disease; Adult; Ammonia-Lyases; Erythrocytes; Female; Humans; Hydroxymethylbilane Synthase; Po | 1980 |
Some kinetic properties of human red cell uroporphyrinogen decarboxylase.
Topics: Carboxy-Lyases; Erythrocytes; Humans; Kinetics; Porphyrias; Structure-Activity Relationship; Substra | 1980 |
Urinary excretion of position isomers type III in normal man and a series of different types of porphyrias.
Topics: Animals; Chromatography, Paper; Coproporphyrinogens; Decarboxylation; Female; Humans; Isomerism; Mal | 1980 |
Redox activities of mercury-thiol complexes: implications for mercury-induced porphyria and toxicity.
Topics: Drug Interactions; Glutathione; Hydrogen Peroxide; In Vitro Techniques; Mercury; Oxidation-Reduction | 1993 |
Genetic variation of iron-induced uroporphyria in mice.
Topics: Aminolevulinic Acid; Animals; Drug Tolerance; Hydrocarbons; Iron; Liver; Mice; Mice, Hairless; Mice, | 1993 |
Uroporphyria produced in mice by iron and 5-aminolaevulinic acid does not occur in Cyp1a2(-/-) null mutant mice.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enz | 1998 |
Porphyria-induced hepatic porphyrinogen carboxy-lyase inhibitor and its interaction with the active site(s) of the enzyme.
Topics: Animals; Arginine; Binding Sites; Carboxy-Lyases; Enzyme Inhibitors; Female; Hexachlorobenzene; Huma | 1999 |
Macrocyclic intermediates in the biosynthesis of porphyrins.
Topics: Animals; Chickens; Coproporphyrinogens; Hexachlorobenzene; Humans; Porphyrias; Porphyrins; Protoporp | 1976 |
[Urinary excretion of porphyrins and their precursors. Longterm observations in acute intermittent porphyrias (author's transl)].
Topics: Aminolevulinic Acid; Coproporphyrins; Estrogens; Humans; Porphobilinogen; Porphyrias; Porphyrins; Ur | 1979 |
[Diagnosis of acute intermittent porphyria on the basis of uroporphyrinogen I synthase activity in the erythrocytes; comparison of 2 methods].
Topics: Adolescent; Adult; Ammonia-Lyases; Child; Child, Preschool; Erythrocytes; Evaluation Studies as Topi | 1979 |
Porphyrins and porphyrinogen carboxy-lase in hexachlorobenzene-induced porphyria.
Topics: Animals; Carboxy-Lyases; Chromatography, Gel; Female; Hexachlorobenzene; Porphyrias; Porphyrins; Rat | 1977 |
The biosynthesis of haem in congenital (erythropoietic) porphyria.
Topics: 5-Aminolevulinate Synthetase; Adult; Child; Child, Preschool; Coproporphyrinogens; Erythrocytes; Ery | 1978 |
In vitro studies of the metabolic pathway from 8-COOH porphyrins to 4-COOH porphyrins.
Topics: Coproporphyrinogens; Decarboxylation; Fibroblasts; Humans; Porphyrias; Porphyrinogens; Porphyrins; U | 1978 |
The role of iron in the pathogenesis of porphyria cutanea tarda. II. Inhibition of uroporphyrinogen decarboxylase.
Topics: Animals; Carboxy-Lyases; Chromatography, Paper; Depression, Chemical; In Vitro Techniques; Iron; Liv | 1975 |
Studies on the active centre of rat liver porphyrinogen carboxylase in vivo effect of hexachlorobenzene.
Topics: Animals; Arginine; Binding Sites; Carboxy-Lyases; Diethyl Pyrocarbonate; Epoxy Compounds; Female; He | 1991 |
Random decarboxylation of uroporphyrinogen III by human hepatic uroporphyrinogen decarboxylase.
Topics: Chromatography, High Pressure Liquid; Decarboxylation; Humans; Isomerism; Liver; Porphyrias; Skin Di | 1991 |
A retrospective study of a patient with homozygous form of acute intermittent porphyria.
Topics: Acute Disease; Aminolevulinic Acid; Child, Preschool; Chromatography, High Pressure Liquid; Erythroc | 1990 |
Mutations in acute intermittent porphyria detected by ELISA measurement of porphobilinogen deaminase.
Topics: Ammonia-Lyases; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Female; Heterozygo | 1989 |
Oxidation of uroporphyrinogens by hydroxyl radicals. Evidence for nonporphyrin products as potential inhibitors of uroporphyrinogen decarboxylase.
Topics: Animals; Carbon Radioisotopes; Carboxy-Lyases; Free Radicals; Humans; Hydroxides; Hydroxyl Radical; | 1988 |
Increased oxidation of uroporphyrinogen by an inducible liver microsomal system. Possible relevance to drug-induced uroporphyria.
Topics: Aminolevulinic Acid; Animals; Benzoflavones; Cells, Cultured; Chick Embryo; Cytochrome P-450 CYP1A1; | 1988 |
Uroporphyria produced in mice by 20-methylcholanthrene and 5-aminolaevulinic acid.
Topics: Aminolevulinic Acid; Animals; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Hexachloroben | 1988 |
Liver porphyrinogen carboxylase in hexachlorobenzene porphyric rats. Studies with intermediate porphyrinogens of series III and with uroporphyrinogen I.
Topics: Animals; Carboxy-Lyases; Chlorobenzenes; Female; Hexachlorobenzene; Liver; Porphyrias; Porphyrinogen | 1987 |
In vitro studies of the mechanism of inhibition of rat liver uroporphyrinogen decarboxylase activity by ferrous iron under anaerobic conditions.
Topics: Anaerobiosis; Animals; Buffers; Carboxy-Lyases; Decarboxylation; Ferrous Compounds; In Vitro Techniq | 1986 |
Porphyria. Basic science aspects.
Topics: 5-Aminolevulinate Synthetase; Bone Marrow; Complement Activation; Heme; Humans; Lipid Metabolism; Li | 1986 |