urografin-76 and Seizures

Radiographic contrast agents are associated with a number of adverse effects, including central nervous system effects and seizures. Almost all contrast agents are primarily filtered and excreted by the kidneys, and they accumulate in patients with end-stage renal disease. Brain retention of contrast associated with high doses is a rare event, having been reported only twice in the literature. We report a case of a 49-year-old male on chronic hemodialysis who developed brain retention of contrast resulting in seizures and encephalopathy after receiving large doses of meglumine/sodium diatrizoate during coronary angiography. He was treated successfully with hemodialysis and suffered no permanent neurologic sequelae. Patients with end-stage renal disease may be at increased risk of adverse effects from contrast when administered in high doses.

Topics: Brain Diseases; Contrast Media; Coronary Angiography; Diatrizoate; Diatrizoate Meglumine; Drug Combinations; Follow-Up Studies; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Seizures; Tomography, X-Ray Computed

A patient received an overdose of intravascular contrast medium and experienced protracted seizures associated with radiographic evidence of prolonged retention of the contrast agent in the cerebral cortex, basal ganglia, and thalami. This is only the second report and the first survivor of a similar neurologic syndrome occurring in a patient after contrast agent overdose. After the seizures resolved, there was a transient period of parkinsonism probably due to the toxic effect of contrast on the basal ganglia.

Topics: Aged; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Drug Combinations; Drug Overdose; Humans; Male; Parkinson Disease, Secondary; Seizures