urografin-76 and Lymphoma

We reviewed our experience with computerized tomography (CT) of the abdomen in 212 patients with histologically documented liver neoplasms seen during a 30-month period. The CT findings in cavernous hemangioma and focal nodular hyperplasia were specific, and permitted accurate diagnosis of this lesion before biopsy. The CT appearance of all other lesions was variable. We consider CT useful in providing an accurate evaluation of the intrahepatic and extrahepatic extent of the neoplasm.

Topics: Adenocarcinoma; Adult; Carcinoma, Hepatocellular; Child; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Drug Combinations; Hemangioma, Cavernous; Humans; Liver; Liver Neoplasms; Lymphoma; Tomography, X-Ray Computed

Large unilamellar phospholipid vesicles were prepared and loaded with various radiographic contrast media. Body CT following in vivo administration of these vesicles in the rat demonstrated opacification of organs associated with the reticuloendothelial system. Image enhancement in the spleen and liver was dose dependent and was linearly related within the dose range investigated. Contrast enhancement was observed within five minutes of intravenous administration, was maximal 60 minutes after injection, and declined during the second hour. Clearance of the radiographic contrast material was complete within 24 hours. Diffuse splenic lymphoma following intraperitoneal or intrasplenic injection of lymphoma cells, and solitary lymphoma nodules following intrahepatic injection were readily detected as nonenhanced areas following injection of liposomes.

Topics: Animals; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Drug Combinations; Iothalamate Meglumine; Liposomes; Lymphoma; Male; Metrizamide; Radiographic Image Enhancement; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Tomography, X-Ray Computed; Triiodobenzoic Acids