urmc-099 and Delirium
urmc-099 has been researched along with Delirium* in 1 studies
Other Studies
1 other study(ies) available for urmc-099 and Delirium
| Article | Year |
|---|---|
URMC-099 prophylaxis prevents hippocampal vascular vulnerability and synaptic damage in an orthopedic model of delirium superimposed on dementia.
Systemic perturbations can drive a neuroimmune cascade after surgical trauma, including affecting the blood-brain barrier (BBB), activating microglia, and contributing to cognitive deficits such as delirium. Delirium superimposed on dementia (DSD) is a particularly debilitating complication that renders the brain further vulnerable to neuroinflammation and neurodegeneration, albeit these molecular mechanisms remain poorly understood. Here, we have used an orthopedic model of tibial fracture/fixation in APPSwDI/mNos2 Topics: Animals; Delirium; Dementia; Hippocampus; Mice; Pyridines; Pyrroles | 2022 |