uridine has been researched along with Disease Models, Animal in 60 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (26.67) | 18.7374 |
| 1990's | 6 (10.00) | 18.2507 |
| 2000's | 14 (23.33) | 29.6817 |
| 2010's | 17 (28.33) | 24.3611 |
| 2020's | 7 (11.67) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Corry, KA; Juul, SE; Law, JB; Moralejo, DH; Shearlock, AE; Snyder, JM; White, OR; Wood, TR | 1 |
| Arrate, M; Azab, M; Boyd, K; Fuller, L; Gorska, AE; Keer, H; Oganesian, A; Ramsey, HE; Savona, MR | 1 |
| Al, N; Alkan, T; Çakir, A; Cansev, M; Koç, C | 1 |
| Bai, X; Liu, P; Zhou, L; Zhu, L | 1 |
| Chen, H; He, Y; Huang, R; Li, Y; Luo, Y; Wu, Q | 1 |
| Belosludtseva, NV; Bulion, VV; Evdokimova, NR; Krylova, IB; Mironova, GD; Rodionova, OM; Selina, EN; Shigaeva, MI | 1 |
| Jeengar, MK; Magnusson, M; Naidu, VGM; Thummuri, D; Uppugunduri, S | 1 |
| Alkan, T; Cakir, A; Cansev, M; Goren, B; Kahveci, N; Minbay, Z; Ocalan, B; Oy, C; Serter Kocoglu, S; Sevinc, C | 1 |
| Karimi, MR; Khoee, S; Khoei, S; Raoufi, NJ; Shakeri-Zadeh, A; Shirvalilou, S | 1 |
| Fernández, FM; Gaul, DA; Huang, D; Kim, J; Nan, H | 1 |
| Garcia, R; Hu, Z; Li, Q; Olariu, A; Pei, J; Saydoff, JA; Sheng, J; Sun, GY; von Borstel, R | 1 |
| Liu, P; Song, W; Wang, F; Wu, C; Xiang, R; Yang, J; Yang, X; Yu, L | 1 |
| Chau, JK; Chung, M; Frank, CB; Hart, DA; Heard, BJ; Mickiewicz, B; Shrive, NG; Vogel, HJ | 1 |
| Field, MS; Finkelstein, JL; Martiniova, L; Perry, CA; Stover, PJ | 1 |
| Dobolyi, Á; Juhász, G; Kékesi, KA; Kovács, Z; Lakatos, R | 1 |
| Ayata, K; Beckert, J; Cicko, S; Grimm, M; Hossfeld, M; Idzko, M; Meyer, A; Müller, T; Zissel, G | 1 |
| Alkan, T; Cansev, M; Cetinkaya, M; Goren, B; Koyuncuoglu, T; Turkyilmaz, M | 1 |
| Chalise, JP; Chenna Narendra, S; Magnusson, M; Uppugunduri, S | 1 |
| Bogatcheva, E; Einck, L; Guerrant, RL; Kolling, GL; Moore, JH; Nikonenko, B; Phipps, AJ; Protopopova, M; Shin, JH; van Opstal, E; Warren, CA | 1 |
| Chen, X; DeGracia, DJ; Tri Anggraini, F; Wang, H | 1 |
| Go, J; Hong, JT; Hwang, DY; Kim, JE; Lee, HA; Sung, JE; Yun, WB | 1 |
| Alkan, T; Cakir, A; Cansev, M; Goren, B; Kahveci, N; Ocalan, B; Serter Kocoglu, S | 1 |
| Amante, DJ; Bordiuk, OL; Carreiro, ST; Cooper, AC; Cormier, K; Edgerly, CK; Ferrante, RJ; Jones, SW; Kim, J; Li, T; Moody, JP; Rusche, J; Smith, K | 1 |
| Minami, M; Nakagawa, T; Okada, M; Satoh, M | 1 |
| Hotta, K; Jaffe, GJ; Meyer, CH; Peterson, WM; Toth, CA | 1 |
| Gukasyan, HJ; Kim, KJ; Kulkarni, AA; Lee, VH; Read, RW; Shiue, MH; Stevenson, D; Trousdale, MD | 1 |
| Al-Ubaidi, MR; Naash, MI; Nour, M; Peterson, WM; Quiambao, AB | 1 |
| Jung, S; Korn, T; Magnus, T; Toyka, K | 1 |
| Carlezon, WA; Cohen, BM; Mague, SD; Parow, AM; Renshaw, PF; Stoll, AL | 1 |
| Beal, MF; Browne, SE; Calingasan, NY; Gardian, G; Klivenyi, P; Saydoff, J; von Borstel, R; Yang, L | 1 |
| Holmes, GL; Marolewski, A; Rusche, JR; Zhao, Q | 1 |
| Beal, MF; Brenneman, D; Browne, SE; Burr, H; Cardin, S; Garcia, RA; Gonzalez, A; Gregorio, J; Hu, Z; Liu, L; Saydoff, JA; Sheng, J; von Borstel, RW | 1 |
| In, YS; Kim, MK; Ko, JH; Lee, HJ; Lee, JH; Lee, SM; Oh, JY; Park, M; Shin, KC; Wee, WR | 1 |
| Evaldsson, C; Rydén, I; Uppugunduri, S | 1 |
| Farjo, R; Naash, MI; Peterson, WM | 1 |
| Choi, JW; Choi, MS; El Kouni, MH; Kim, WK; Ko, KH; Lee, JC; Ryu, JH; Shin, CY; Yoon, SY | 1 |
| Casper, ES; Gralla, RJ; Kemeny, N; Wiley, RG | 1 |
| Bahgat, MM; Bandok, B; el-Aswad, M; Niesman, MR; Peyman, GA; Salah-Eldin, M | 1 |
| Clark, JM; Huang, JL; Russell, JW; Soike, KF; Stratton, LW; Sundeen, JE; Whiterock, VJ | 1 |
| Blumenkranz, M; Hartzer, M; Lin, LR; Ward, T | 1 |
| Ausserlechner, MJ; Sgonc, R; Wick, G | 1 |
| Amano, Y; Kitagawa, H; Mizushima, Y; Ogata, K | 1 |
| Bentires-Alj, M; Bours, V; Fillet, G; Gielen, J; Hellin, AC; Lechanteur, C; Lopez, M; Merville, MP; Princen, F | 1 |
| Hara, Y; Tomizawa, S | 2 |
| Middleton, PJ; Petric, M; Szymanski, MT | 1 |
| Dunkelburger, GR; Jampel, HD; Leong, KW; Quigley, HA | 1 |
| Martin, DS; Sawyer, RC; Stolfi, RL | 1 |
| Braig, HR; Diringer, H | 1 |
| Colly, LP; Edelbroek, PM; Honders, W; vd Hoorn, F; Willemze, R | 1 |
| Finkelstein, MS; Huizenga, CG; McWilliams, M | 1 |
| Ablashi, DV; Neubauer, RH; Pearson, GR; Rabin, H; Wallen, WC | 1 |
| Everson, R; Hall, TC; Kessel, D | 1 |
| Decker, K; Keppler, D | 2 |
| Roberts, CA | 1 |
| Bruzzi, G; Donzelli, MG; Testa, R | 1 |
| Hübner, G; Keppler, DO | 1 |
| Mussgay, M; Weiland, E | 1 |
2 review(s) available for uridine and Disease Models, Animal
| Article | Year |
|---|---|
Galactosamine hepatitis: key role of the nucleotide deficiency period in the pathogenesis of cell injury and cell death.
Topics: Animals; Blood Coagulation Factors; Carbohydrates; Carcinoma, Hepatocellular; Cell Survival; Chemical and Drug Induced Liver Injury; Deoxy Sugars; Disease Models, Animal; Galactosamine; Galactose; Glucosamine; Hyperbilirubinemia; Liver Neoplasms; Macromolecular Substances; Protein Biosynthesis; Pyrimidine Nucleotides; RNA; Time Factors; Uracil Nucleotides; Uridine; Uridine Diphosphate Sugars | 1974 |
Galactosamine induced liver injury.
Topics: Amino Acids; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Fishes; Galactosamine; Gluconeogenesis; Guinea Pigs; Haplorhini; Humans; Liver; Proteins; Rabbits; Rats; RNA; Uracil Nucleotides; Uridine | 1972 |
58 other study(ies) available for uridine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Evaluating Neuroprotective Effects of Uridine, Erythropoietin, and Therapeutic Hypothermia in a Ferret Model of Inflammation-Sensitized Hypoxic-Ischemic Encephalopathy.
Topics: Animals; Disease Models, Animal; Erythropoietin; Ferrets; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Neuroprotection; Neuroprotective Agents; Uridine | 2021 |
Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Disease Models, Animal; Female; Haplorhini; Humans; Infusions, Parenteral; Mice; Treatment Outcome; Uridine | 2020 |
Antioxidative effects of uridine in a neonatal rat model of hyperoxic brain injury
Topics: Animals; Animals, Newborn; Antioxidants; Brain Injuries; Disease Models, Animal; Glutathione Peroxidase; Hyperoxia; Malondialdehyde; Neuroprotective Agents; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Uridine | 2020 |
e5NT inhibitor protects acute restraint stress-induced depression by regulating nucleoside release in mice.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Diphosphate; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Elevated Plus Maze Test; Enzyme Inhibitors; Exploratory Behavior; GPI-Linked Proteins; Hippocampus; Male; Mice; Open Field Test; Restraint, Physical; Stress, Psychological; Uridine | 2020 |
Guanosine and uridine alleviate airway inflammation via inhibition of the MAPK and NF-κB signals in OVA-induced asthmatic mice.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Guanosine; Inflammation; Mice; Mice, Inbred BALB C; NF-kappa B; Ovalbumin; Uridine | 2021 |
Uridine treatment prevents myocardial injury in rat models of acute ischemia and ischemia/reperfusion by activating the mitochondrial ATP-dependent potassium channel.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Antioxidants; Arrhythmias, Cardiac; Disease Models, Animal; Lipid Peroxidation; Male; Myocardial Reperfusion Injury; Myocardium; Potassium Channels; Rats, Wistar; Tachycardia; Uridine; Uridine Diphosphate; Uridine Triphosphate; Ventricular Fibrillation | 2021 |
Uridine Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis in Mice.
Topics: Animals; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation; Instillation, Drug; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Signal Transduction; Tumor Necrosis Factor-alpha; Uridine | 2017 |
Uridine treatment protects against neonatal brain damage and long-term cognitive deficits caused by hyperoxia.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Brain Injuries; Cell Count; Cell Survival; Cognitive Dysfunction; Disease Models, Animal; Female; Hyperoxia; Learning Disabilities; Male; Myelin Sheath; Neurons; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley; Uridine | 2017 |
Development of a magnetic nano-graphene oxide carrier for improved glioma-targeted drug delivery and imaging: In vitro and in vivo evaluations.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Proliferation; Cell Survival; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Drug Screening Assays, Antitumor; Glioma; Graphite; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Optical Imaging; Oxides; Particle Size; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Wistar; Tumor Cells, Cultured; Uridine | 2018 |
Deep Metabolomics of a High-Grade Serous Ovarian Cancer Triple-Knockout Mouse Model.
Topics: Animals; Bilirubin; Biomarkers, Tumor; Chromatography, Liquid; Cystadenocarcinoma, Serous; Disease Models, Animal; Female; Humans; Metabolomics; Mice; Mice, Knockout; Neoplasm Staging; Oligopeptides; Ovarian Neoplasms; Phospholipids; Pyrazines; Sphingomyelins; Sterols; Tandem Mass Spectrometry; Uridine | 2019 |
Uridine prodrug improves memory in Tg2576 and TAPP mice and reduces pathological factors associated with Alzheimer's disease in related models.
Topics: Acetates; Alzheimer Disease; Animals; Cell Line, Tumor; Cricetinae; Disease Models, Animal; Female; Gerbillinae; Humans; Male; Maze Learning; Memory; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Prodrugs; Stroke; Uridine | 2013 |
Uridine decreases morphine-induced behavioral sensitization by decreasing dorsal striatal dopamine release possibly via agonistic effects at GABAA receptors.
Topics: Analgesics, Opioid; Animals; Animals, Inbred Strains; beta-Alanine; Bicuculline; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Mice; Morphine; Motor Activity; Receptors, GABA-A; Time Factors; Uracil; Uridine | 2014 |
Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis.
Topics: Animals; Anterior Cruciate Ligament Reconstruction; Asparagine; Biomarkers; Disease Models, Animal; Female; Glucose; Hydroxyproline; Isobutyrates; Knee Joint; Magnetic Resonance Spectroscopy; Metabolome; Osteoarthritis, Knee; Serine; Sheep; Synovial Fluid; Uridine | 2015 |
Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects.
Topics: Animals; Deoxyuridine; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Glycine Hydroxymethyltransferase; HeLa Cells; Humans; Maternal Nutritional Physiological Phenomena; Mice; Neural Tube; Neural Tube Defects; Pregnancy; Thymidine; Uracil; Uridine | 2015 |
Absence epileptic activity changing effects of non-adenosine nucleoside inosine, guanosine and uridine in Wistar Albino Glaxo Rijswijk rats.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocorticography; Epilepsy, Absence; Guanosine; Inosine; Male; Rats, Wistar; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Uridine | 2015 |
Uridine supplementation exerts anti-inflammatory and anti-fibrotic effects in an animal model of pulmonary fibrosis.
Topics: Animals; Anti-Inflammatory Agents; Bleomycin; Bronchoalveolar Lavage Fluid; Cell Line, Tumor; Collagen; Cytokines; Disease Models, Animal; Epithelial Cells; Fibroblasts; Humans; Inflammation Mediators; Leukocytes; Lung; Male; Mice, Inbred C57BL; Pneumonia; Pulmonary Fibrosis; Reactive Oxygen Species; Time Factors; Transforming Growth Factor beta; Uridine | 2015 |
Uridine protects against hypoxic-ischemic brain injury by reducing histone deacetylase activity in neonatal rats.
Topics: Animals; Animals, Newborn; Blotting, Western; Brain; Caspase 3; Disease Models, Animal; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Hypoxia-Ischemia, Brain; Injections, Intraperitoneal; Male; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley; Treatment Outcome; Uridine | 2015 |
Local but Not Systemic Administration of Uridine Prevents Development of Antigen-Induced Arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens; Arthritis, Experimental; CD18 Antigens; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Immunoglobulin G; Immunohistochemistry; Injections, Intra-Articular; Intercellular Adhesion Molecule-1; Mice; Serum Albumin, Bovine; Synovial Membrane; Uridine | 2015 |
Treatment of Clostridium difficile infection using SQ641, a capuramycin analogue, increases post-treatment survival and improves clinical measures of disease in a murine model.
Topics: Administration, Oral; Aminoglycosides; Animals; Anti-Bacterial Agents; Bacterial Shedding; Bacterial Toxins; Clostridioides difficile; Disease Models, Animal; Enterocolitis, Pseudomembranous; Feces; Male; Mice, Inbred C57BL; Severity of Illness Index; Survival Analysis; Treatment Outcome; Uridine | 2016 |
Embryonic lethal abnormal vision proteins and adenine and uridine-rich element mRNAs after global cerebral ischemia and reperfusion in the rat.
Topics: Adenine; Animals; Brain Ischemia; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Chromatography, Liquid; Disease Models, Animal; ELAV Proteins; Electrophoresis, Polyacrylamide Gel; Male; Protein Array Analysis; Proteomics; Rats, Long-Evans; Reperfusion Injury; RNA-Binding Proteins; RNA, Messenger; Tandem Mass Spectrometry; Uridine | 2017 |
Uridine stimulate laxative effect in the loperamide-induced constipation of SD rats through regulation of the mAChRs signaling pathway and mucin secretion.
Topics: Animals; Colon, Transverse; Constipation; Disease Models, Animal; Feeding Behavior; Inositol Phosphates; Intestinal Mucosa; Laxatives; Mucins; Muscle, Smooth; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Signal Transduction; Uridine | 2017 |
Long-term cognitive effects of uridine treatment in a neonatal rat model of hypoxic-ischemic encephalopathy.
Topics: Animals; Animals, Newborn; Apoptosis; Caspase 3; Cognition; Disease Models, Animal; Drug Evaluation, Preclinical; Hypoxia-Ischemia, Brain; Male; Maze Learning; Motor Activity; Nootropic Agents; Rats, Sprague-Dawley; Uridine | 2017 |
Uridine ameliorates the pathological phenotype in transgenic G93A-ALS mice.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amyotrophic Lateral Sclerosis; Animals; Anterior Horn Cells; Behavior, Animal; Body Weight; Deoxyguanosine; Disease Models, Animal; Dose-Response Relationship, Drug; Energy Metabolism; Humans; Kaplan-Meier Estimate; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Spinal Cord; Superoxide Dismutase; Survival Rate; Uridine | 2010 |
Analgesic effects of intrathecal administration of P2Y nucleotide receptor agonists UTP and UDP in normal and neuropathic pain model rats.
Topics: Adenosine Triphosphate; Analgesics; Animals; Disease Models, Animal; Hot Temperature; Injections, Spinal; Male; Neuralgia; Pain; Posture; Pressure; Purinergic P2 Receptor Agonists; Rats; Rats, Sprague-Dawley; Time Factors; Uridine; Uridine Diphosphate; Uridine Monophosphate; Uridine Triphosphate | 2002 |
Effect of INS37217, a P2Y(2) receptor agonist, on experimental retinal detachment and electroretinogram in adult rabbits.
Topics: Absorption; Animals; Body Fluids; Deoxycytosine Nucleotides; Disease Models, Animal; Electroretinography; In Situ Hybridization; Injections; Ophthalmoscopy; Pigment Epithelium of Eye; Purinergic P2 Receptor Agonists; Rabbits; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Retina; Retinal Detachment; RNA, Messenger; Tomography; Uridine | 2002 |
Nucleotide-induced restoration of conjunctival chloride and fluid secretion in adenovirus type 5-infected pigmented rabbit eyes.
Topics: Adenosine; Adenoviridae; Adenoviridae Infections; Animals; Body Fluids; Chlorides; Conjunctiva; Disease Models, Animal; Eye Infections; Pigmentation; Purinergic Agonists; Rabbits; Uridine; Uridine Triphosphate | 2003 |
P2Y(2) receptor agonist INS37217 enhances functional recovery after detachment caused by subretinal injection in normal and rds mice.
Topics: Animals; Dark Adaptation; Deoxycytosine Nucleotides; Disease Models, Animal; DNA Fragmentation; Electroretinography; Female; Fluorescent Antibody Technique, Indirect; In Situ Nick-End Labeling; Injections; Mice; Mice, Inbred C57BL; Mice, Knockout; Microspheres; Photoreceptor Cells, Vertebrate; Purinergic P2 Receptor Agonists; Receptors, Purinergic P2Y2; Recovery of Function; Retinal Detachment; Retinitis Pigmentosa; Uridine | 2003 |
Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide--mechanisms independent of pyrimidine depletion.
Topics: Adoptive Transfer; Animals; Animals, Newborn; Antigens, CD; B7-2 Antigen; Cells, Cultured; Chemotaxis, Leukocyte; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Guinea Pigs; Immunosuppressive Agents; Interferon-gamma; Interleukin-10; Interleukin-2; Isoxazoles; Leflunomide; Membrane Glycoproteins; Microglia; Multiple Sclerosis; Myelin Basic Protein; Pyrimidines; Rats; Rats, Inbred Lew; STAT6 Transcription Factor; T-Lymphocytes, Helper-Inducer; Trans-Activators; Uridine | 2004 |
Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Synergism; Drug Therapy, Combination; Fatty Acids, Omega-3; Immobility Response, Tonic; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Reaction Time; Swimming; Time Factors; Uridine | 2005 |
Neuroprotective effects of oral administration of triacetyluridine against MPTP neurotoxicity.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Acetates; Animals; Dietary Supplements; Disease Models, Animal; Dopamine; Homovanillic Acid; Mice; MPTP Poisoning; Neuroprotective Agents; Neurotoxins; Uridine | 2004 |
Effects of uridine in models of epileptogenesis and seizures.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Electroencephalography; Hippocampus; Kindling, Neurologic; Lithium; Male; Maze Learning; Pilocarpine; Rats; Rats, Sprague-Dawley; Status Epilepticus; Uridine; Water | 2006 |
Oral uridine pro-drug PN401 is neuroprotective in the R6/2 and N171-82Q mouse models of Huntington's disease.
Topics: Acetates; Administration, Oral; Analysis of Variance; Animals; Cerebral Cortex; Disease Models, Animal; Female; Huntingtin Protein; Huntington Disease; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Neurologic Mutants; Mice, Transgenic; Motor Activity; Neostriatum; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Nuclear Proteins; Prodrugs; Rotarod Performance Test; Uridine | 2006 |
Protective effect of uridine on cornea in a rabbit dry eye model.
Topics: Animals; Apoptosis; Cell Count; Cell Survival; Cells, Cultured; Conjunctiva; Disease Models, Animal; Dry Eye Syndromes; Epithelium, Corneal; Fibroblasts; Flow Cytometry; Glycosaminoglycans; Goblet Cells; Humans; Hyaluronic Acid; Male; Matrix Metalloproteinase 9; Nitric Oxide; Ophthalmic Solutions; Rabbits; Uridine; Wound Healing | 2007 |
Anti-inflammatory effects of exogenous uridine in an animal model of lung inflammation.
Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage; Dextrans; Disease Models, Animal; Granuloma; Intubation, Intratracheal; Leukocyte Count; Macrophages; Male; Microspheres; Pneumonia; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Uridine | 2007 |
Expression profiling after retinal detachment and reattachment: a possible role for aquaporin-0.
Topics: Animals; Aquaporins; Deoxycytosine Nucleotides; Disease Models, Animal; Electroretinography; Eye Proteins; Fluorescent Antibody Technique, Indirect; Gene Expression Profiling; Gene Expression Regulation; Immunoblotting; Immunoprecipitation; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Retinal Detachment; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Up-Regulation; Uridine | 2008 |
Uridine protects cortical neurons from glucose deprivation-induced death: possible role of uridine phosphorylase.
Topics: Adenosine Triphosphate; Administration, Oral; Animals; Astrocytes; Brain Infarction; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Glucose; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred ICR; Nerve Degeneration; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; RNA, Messenger; Uridine; Uridine Phosphorylase | 2008 |
Neurotoxicity of the pyrimidine synthesis inhibitor N-phosphonoacetyl-L-aspartate.
Topics: Adult; Aged; Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Brain Diseases; Disease Models, Animal; Epilepsy; Female; Humans; Male; Middle Aged; Organophosphorus Compounds; Phosphonoacetic Acid; Rats; Rats, Inbred Strains; Seizures; Uridine | 1982 |
Evaluation of toxicity and efficacy of a combination of antineoplastic agents in the prevention of PVR.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cells, Cultured; Disease Models, Animal; Drug Carriers; Drug Evaluation; Fibroblasts; Liposomes; Rabbits; Retina; Retinal Detachment; Retinal Neovascularization; RNA, Ribosomal; Uridine; Vitreoretinopathy, Proliferative | 1994 |
Pharmacokinetics and antiviral activity of a novel isonucleoside, BMS-181165, against simian varicella virus infection in African green monkeys.
Topics: Administration, Oral; Animals; Antiviral Agents; Biological Availability; Chlorocebus aethiops; Disease Models, Animal; Herpesviridae Infections; Herpesvirus 1, Cercopithecine; Treatment Outcome; Uridine; Viremia | 1994 |
A comparison of 5-fluorouridine and 5-fluorouracil in an experimental model for the treatment of vitreoretinal scarring.
Topics: Animals; Cell Division; Cells, Cultured; Disease Models, Animal; Eye Diseases; Fibroblasts; Fluorouracil; Incidence; Injections; Rabbits; Retinal Detachment; Retinal Diseases; RNA, Ribosomal; Uridine; Vitreous Body | 1993 |
Chemiluminescence-based RNase protection assays for simultaneous quantification of procollagen mRNAs containing AU-rich regions.
Topics: Adenosine; Animals; Base Sequence; Chickens; Dinucleotide Repeats; Disease Models, Animal; Humans; Procollagen; Ribonucleases; RNA, Messenger; Scleroderma, Systemic; Uridine | 1998 |
Oral administration of leflunomide (HWA486) results in prominent suppression of immunoglobulin E formation in a rat type 1 allergy model.
Topics: Administration, Oral; Aniline Compounds; Animals; Antibody Specificity; Crotonates; Disease Models, Animal; Drug Administration Schedule; Female; Hydroxybutyrates; Hypersensitivity, Immediate; Immunoglobulin E; Immunoglobulin G; Immunoglobulin M; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Nitriles; Ovalbumin; Rats; Rats, Inbred BN; Toluidines; Uridine | 1999 |
Cytosine deaminase suicide gene therapy for peritoneal carcinomatosis.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma; Colorectal Neoplasms; Cytosine Deaminase; Disease Models, Animal; Feasibility Studies; Flucytosine; Genetic Therapy; Humans; Male; Neoplasm Transplantation; Nucleoside Deaminases; Peritoneal Neoplasms; Rats; Tumor Cells, Cultured; Uridine | 2000 |
[Paper disk granuloma method for experimental granuloma in rats (author's transl)].
Topics: Absorption; Age Factors; Animals; Anti-Inflammatory Agents; Disease Models, Animal; DNA; Drug Evaluation, Preclinical; Female; Fluocinolone Acetonide; Gossypium; Granuloma; In Vitro Techniques; Male; Paper; Proteins; Rats; RNA; Sex Factors; Thymidine; Uridine; Water | 1977 |
[The antigranuloma effect of fluocinolone acetonide by paper disk granuloma in rats (author's transl)].
Topics: Adrenalectomy; Animals; Disease Models, Animal; DNA; Female; Fluocinolone Acetonide; Granuloma; In Vitro Techniques; Leucine; Methods; Orotic Acid; Paper; Protein Biosynthesis; Puromycin; Rats; RNA; Thymidine; Uridine | 1977 |
Propagation of infantile gastroenteritis virus (orbi-group) in conventional and germfree piglets.
Topics: Animals; Animals, Newborn; Antibody Formation; Antigens, Viral; Cross Infection; Disease Models, Animal; Gastroenteritis; Germ-Free Life; Humans; Infant; Intestinal Mucosa; Swine; Thymidine; Tritium; Uridine | 1975 |
Glaucoma filtration surgery in monkeys using 5-fluorouridine in polyanhydride disks.
Topics: Animals; Cells, Cultured; Cornea; Decanoic Acids; Disease Models, Animal; Drug Carriers; Fibroblasts; Fistula; Glaucoma; Haplorhini; Humans; Intraocular Pressure; Polyesters; Postoperative Complications; Prognosis; Uridine | 1990 |
Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Disease Models, Animal; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Pentosyltransferases; Uracil; Uridine; Uridine Phosphorylase | 1989 |
Scrapie: concept of a virus-induced amyloidosis of the brain.
Topics: Amyloidosis; Animals; Brain Diseases; Cricetinae; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Leucine; Nerve Tissue Proteins; Prions; PrP 27-30 Protein; RNA, Viral; Scrapie; Uridine | 1985 |
In vivo studies on high-dose 1-beta-D-arabinofuranosylcytosine (HDara-C) and 1-beta-D-arabinofuranosyluracil (ara-U) with respect to pharmacokinetics, cell kinetics, and cytotoxicity in a rat myelocytic leukemia model (BNML).
Topics: Animals; Arabinofuranosyluracil; Cell Cycle; Colony-Forming Units Assay; Cytarabine; Cytidine Deaminase; Disease Models, Animal; Half-Life; Humans; Kinetics; Leukemia, Myeloid, Acute; Nucleoside Deaminases; Rats; Uridine | 1985 |
Use of chicken tracheal organ cultures for studying resistance of respiratory epithelium to viral infection.
Topics: Animals; Antibodies; Autoradiography; Chickens; Culture Techniques; Cytopathogenic Effect, Viral; Disease Models, Animal; Endotoxins; Escherichia coli; Fibroblasts; Fluorescent Antibody Technique; gamma-Globulins; Immune Sera; Immunization; Interferons; Microscopy, Electron; Newcastle disease virus; Polymers; Pyrans; Sindbis Virus; Trachea; Tritium; Uridine; Vesicular stomatitis Indiana virus; Virus Cultivation; Virus Diseases | 1972 |
Virological investigations of Herpesvirus saimiri-infected owl monkeys.
Topics: Animals; Antigens, Viral; Cells, Cultured; Centrifugation, Density Gradient; Culture Media; Cytopathogenic Effect, Viral; Disease Models, Animal; Fluorescent Antibody Technique; Haplorhini; Herpesviridae; Iodine Radioisotopes; Kidney; Lymphoma; Monkey Diseases; Oncogenic Viruses; Retroviridae; RNA-Directed DNA Polymerase; Tritium; Uridine; Virus Replication | 1974 |
Enzymatic determinants of responsiveness of the LPC-1 plasma cell neoplasm to fluorouracil and fluorodeoxyuridine.
Topics: Animals; Cell Line; Disease Models, Animal; Floxuridine; Fluorouracil; Intestinal Neoplasms; Mice; Neoplasms, Experimental; Nucleotides; Phosphotransferases; Plasmacytoma; Thymidine Kinase; Transferases; Uridine | 1970 |
Anticonvulsant effects of uridine: comparative analysis of metrazol and penicillin induced foci.
Topics: Animals; Anticonvulsants; Anura; Autoradiography; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Ergothioneine; Male; Penicillins; Pentylenetetrazole; Pyrans; Rana catesbeiana; RNA; Seizures; Tritium; Uridine | 1973 |
[Changes caused by uridine amphetamine induced hyperthermia in mice and rats].
Topics: Amphetamine; Animals; Body Temperature Regulation; Disease Models, Animal; Female; Fever; Male; Mice; Rats; Uridine | 1973 |
Liver injury induced by 2-deoxy-D-galactose.
Topics: Alcohol Oxidoreductases; Animals; Aspartate Aminotransferases; Bilirubin; Chemical and Drug Induced Liver Injury; Deoxy Sugars; Disease Models, Animal; Female; Galactose; Glucose; Glutamate Dehydrogenase; Guanine Nucleotides; Guinea Pigs; Histocytochemistry; Injections, Intraperitoneal; Liver; Liver Diseases; Microscopy, Electron; Sorbitol; Time Factors; Uracil Nucleotides; Uridine; Uridine Diphosphate Sugars | 1973 |
Preparation of inactivated vaccines against alphaviruses using Semliki Forest virus-white mouse as a model. II. Evaluation of formalin-inactivated vaccines treated with tri(n-butyl)phosphate and-or saponin and properties of the inactivated virus.
Topics: Amino Acids; Animals; Arbovirus Infections; Carbon Radioisotopes; Centrifugation, Density Gradient; Disease Models, Animal; Evaluation Studies as Topic; Formaldehyde; Immunochemistry; Lipids; Methods; Mice; RNA, Viral; Saponins; Semliki forest virus; Stearic Acids; Surface-Active Agents; Tritium; Uridine; Vaccination; Viral Vaccines | 1973 |