uridine has been researched along with Colonic Neoplasms in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (54.41) | 18.7374 |
| 1990's | 19 (27.94) | 18.2507 |
| 2000's | 8 (11.76) | 29.6817 |
| 2010's | 3 (4.41) | 24.3611 |
| 2020's | 1 (1.47) | 2.80 |
| Authors | Studies |
|---|---|
| Callan, B; Callan, JF; Gao, J; Griffith, DM; Logan, KA; Love, M; McHale, AP; McKaig, T; Nesbitt, H; Taylor, M | 1 |
| Bonaterra, GA; Farhat, A; Kinscherf, R; Malecki, E; Rosemeyer, H; Röthlein, D; Schmitt, J; Wolf, M | 1 |
| Banerjee, D; Bertino, JR; Cheng, YC; Gorlick, R; Humeniuk, R; Kemeny, N; Menon, LG; Mishra, PJ; Pizzorno, G; Rode, W; Sowers, R | 1 |
| McEvilly, M; Popelas, C; Tremmel, B | 1 |
| Gelain, A; Masciocchi, D; Meneghetti, F; Villa, S | 1 |
| Mall, JW; Myers, JA; Philipp, AW; Pollmann, C; Saclarides, TJ; Xu, X | 1 |
| HAHN, RG; MOERTEL, CG; REITEMEIER, RJ | 1 |
| Canaparo, R; Casale, F; Costa, M; Eandi, M; Fornari, G; Mairone, L; Muntoni, E; Pepa, CD; Serpe, L; Zara, GP | 1 |
| Agarwal, R; Ardalan, B; Patel, M | 1 |
| Saif, MW; von Borstel, R | 1 |
| Al Safarjalani, ON; el Kouni, MH; Naguib, FN; Rais, R; Schinazi, RF; Shi, J | 1 |
| Cricca, S; de Bruin, M; Laan, AC; Peters, GJ; Temmink, OH; Turksma, AW | 1 |
| Gustavsson, B; Hafström, L | 1 |
| Cimino, F; Cimino, L; Colonna, A; Mazzacca, G; Russo, T; Salvatore, F | 1 |
| Kraal, I; Lankelma, J; Leyva, A; Pinedo, HM | 1 |
| Björk, GR; Damber, L; Holm, SE; Jacobsson, L; Jeppsson, A; Rasmuson, T; Stigbrand, T; Westman, G | 1 |
| Houghton, JA; Houghton, PJ | 1 |
| Keppler, D; Krug, E; Schulz-Holstege, C; Zweibaum, A | 1 |
| Benvenuto, J; Drewinko, B; Freireich, EJ; Ho, DH; Loo, TL; Yang, LY | 1 |
| Glazer, RI; Hartman, KD | 1 |
| Bruno, S; Creaven, PJ; Ledesma, E; Mittelman, A; Poster, D; Yoon, J | 1 |
| Glazer, RI; Lloyd, LS | 1 |
| Martin, DS; Sawyer, RC; Spiegelman, S; Stolfi, RL; Young, CW | 1 |
| De Mello, J; Giles, GR; Higley, B; Oakes, DJ | 1 |
| Belles-Isles, M; Pagé, M | 1 |
| Anderson, LW; Cysyk, RL; Erlichman, C; Karle, JM | 1 |
| Hu, JL; Qi, CQ; Su, J; Zhen, YC | 1 |
| Allegra, CJ; Geoffroy, FJ; Grem, JL; Sinha, B | 1 |
| Chen, TB; Huzak, M; Macura, S; Vuk-Pavlović, S | 1 |
| Das, NP; Yit, CC | 1 |
| Behrens, CH; Behrens, DL; Chen, SF; Fredericks, JR; Kirshenbaum, MR; Papp, LM; Polkus, ST; Sipple, P; Stafford, MM; Sun, JH | 1 |
| Eda, H; Fujimoto, K; Ishikawa, T; Ishitsuka, H; Ohiwa, T; Tanaka, Y; Tatsuno, K; Watanabe, S | 1 |
| Allegra, CJ; Chu, E | 1 |
| Berry, SE; Boothman, DA; Davis, TW; Garces, C; Hwang, HS; Kinsella, TJ; Kunugi, K; Meyers, M | 1 |
| Bajzer, Z; Chen, TB; Macura, S; Vuk-Pavlovic, S | 1 |
| Erdélyi-Tóth, V; Jeney, A; Katona, C; Kovács, P; Kralovánszky, J; Noordhuis, P; Otvös, L; Pandi, E; Peters, GJ; Van der Wilt, CL | 1 |
| Sullenger, BA; Watanabe, T | 1 |
| Danhauser, L; Rustum, YM; Wang, G | 1 |
| Borek, E; Gehrke, CW; Kuo, KC; McCune, RA; Waalkes, TP | 1 |
| Edmunds, NH; Kwong, LK; Tsuboi, KK | 1 |
| Hoshi, A; Iigo, M; Nishikata, K | 1 |
| Handschumacher, RE; Lentz, SK; Pizzorno, G; Wiegand, RA | 1 |
| Chew, BP; Luedecke, LO; Seaman, WR; Shultz, TD | 1 |
| Hendriks, HG; Koninkx, JF; Mouwen, JM; van den Ingh, TS; van Rossum, JM | 1 |
| Goldenberg, DM; Sharkey, RM; Shih, LB; Xuan, H | 1 |
| Kraal, I; Peters, GJ; Pinedo, HM | 1 |
| De Clercq, E; Iigo, M; Nakajima, Y; Nishikata, K; Szabolcs, A; Szinai, I; Veres, Z | 1 |
| Inaba, M; Mitsuhashi, J; Ozawa, S | 1 |
| de Kant, E; Laurensse, EJ; Nadal, JC; Peters, GJ; Pinedo, HM | 1 |
| Cohen, MB; Glazer, RI | 1 |
| Ford, CH; Richardson, VJ; Tsaltas, G | 1 |
| Nadal, JC; Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Chisholm, EM; Finan, PJ; Giles, GR; Woodhouse, L | 2 |
| Lankelma, J; Laurensse, EJ; Leyva, A; Peters, GJ; Pinedo, HM; van Dijk, J; van Groeningen, C | 1 |
| Aigner, KR; Danenberg, PV; Link, KH; Peschau, K; Schwemmle, K; Warthona, M | 1 |
| Beverley, PC; Kardamakis, D; Merkenschlager, M; Rawle, FC; Spurr, N | 1 |
| Lankelma, J; Laurensse, E; Leyva, A; Nadal, JC; Peters, GJ; Pinedo, HM; van Dijk, J; van Groeningen, CJ | 1 |
| Bartlett, SE; Casson, AG; Ford, CH; Gallant, ME; Marsden, CH | 1 |
| Lankelma, J; Laurensse, EJ; Leyva, A; Peters, GJ; Pinedo, HM; van Groeningen, CJ | 1 |
| Itoh, M; Kijima-Suda, I; Miyamoto, Y; Osawa, T; Toyoshima, S | 1 |
| Glazer, RI; Haines, DR; Knode, MC; Marquez, VE; Tseng, CK | 1 |
| Chan, TC; Howell, SB; King, ME; Taetle, R; Young, B | 1 |
| Glazer, RI; Knode, MC; Lim, MI; Marquez, VE | 1 |
| Darnowski, JW; Handschumacher, RE | 1 |
| Barlogie, B; Dipasquale, MA; Drewinko, B; Trujillo, JM; Yang, LY | 1 |
| Seidel, HJ | 1 |
| Wolberg, WH | 1 |
1 review(s) available for uridine and Colonic Neoplasms
| Article | Year |
|---|---|
Treatment of cultured human colon carcinoma cells with fluorinated pyrimidines.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Culture Media; Drug Evaluation, Preclinical; Fluorouracil; Humans; Tegafur; Thymidine; Uridine | 1980 |
1 trial(s) available for uridine and Colonic Neoplasms
| Article | Year |
|---|---|
Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.
Topics: Adult; Aged; Area Under Curve; Chromatography, High Pressure Liquid; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Kinetics; Leucovorin; Male; Middle Aged; Uridine | 2004 |
66 other study(ies) available for uridine and Colonic Neoplasms
| Article | Year |
|---|---|
A single microbubble formulation carrying 5-fluorouridine, Irinotecan and oxaliplatin to enable FOLFIRINOX treatment of pancreatic and colon cancer using ultrasound targeted microbubble destruction.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Fluorouracil; Humans; Irinotecan; Leucovorin; Mice; Microbubbles; Oxaliplatin; Pancreatic Neoplasms; Treatment Outcome; Uridine | 2021 |
Synthesis of 5-fluorouridine nucleolipid derivatives and their cytostatic/cytotoxic activities on human HT-29 colon carcinoma cells.
Topics: Antineoplastic Agents; Cell Survival; Colonic Neoplasms; HT29 Cells; Humans; Microscopy, Confocal; Uridine | 2013 |
Decreased levels of UMP kinase as a mechanism of fluoropyrimidine resistance.
Topics: Cell Line, Tumor; Colonic Neoplasms; Down-Regulation; Drug Resistance, Neoplasm; Humans; Liver Neoplasms; Nucleoside-Phosphate Kinase; RNA Interference; Uridine | 2009 |
Use of uridine triacetate for the management of fluorouracil overdose.
Topics: Antiemetics; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Overdose; Fluorouracil; Home Infusion Therapy; Humans; Leucovorin; Male; Medication Errors; Middle Aged; Ondansetron; Organoplatinum Compounds; Uridine | 2011 |
The influence of the substitution pattern on the molecular conformation of ureido-1,2,5-oxadiazoles, related to STAT3 inhibitors: chemical behavior and structural investigation.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Female; Humans; Molecular Conformation; Oxadiazoles; STAT3 Transcription Factor; Uridine | 2012 |
[Leflunomide reduces the angiogenesis score and tumor growth of subcutaneously implanted colon carcinoma cells in the mouse model].
Topics: Administration, Oral; Animals; Capillaries; Cell Division; Colonic Neoplasms; HT29 Cells; Humans; Injections, Intraperitoneal; Isoxazoles; Leflunomide; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Random Allocation; Uridine | 2002 |
COMPARISON OF 5-FLUOROURACIL (NSC-19893) AND 2'-DEOXY-5-FLUOROURIDINE (NSC-27640) IN TREATMENT OF PATIENTS WITH ADVANCED ADENOCARCINOMA OF COLON OR RECTUM.
Topics: Adenocarcinoma; Antineoplastic Agents; Colonic Neoplasms; Deoxyuridine; Drug Therapy; Fluorouracil; Humans; Nucleosides; Palliative Care; Rectal Neoplasms; Rectum; Toxicology; Uridine | 1965 |
Effects of oxaliplatin and CPT-11 on cytotoxicity and nucleic acid incorporation of the fluoropyrimidines.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Irinotecan; Nucleic Acids; Organoplatinum Compounds; Oxaliplatin; Uridine | 2004 |
5-Fluorouracil dose escalation enabled with PN401 (triacetyluridine): toxicity reduction and increased antitumor activity in mice.
Topics: Acetates; Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Fluorouracil; Humans; Leucovorin; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Survival Rate; Tumor Burden; Uridine; Xenograft Model Antitumor Assays | 2006 |
Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorouracil; Humans; Male; Mice; Mice, SCID; Survival Analysis; Thiouracil; Uridine; Uridine Phosphorylase; Xenograft Model Antitumor Assays | 2006 |
Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines.
Topics: Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Floxuridine; Humans; Kinetics; Pyrimidines; Substrate Specificity; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase | 2007 |
Adjuvant and palliative treatment of colorectal cancer with fluorinated pyrimidines. A pharmacological and clinical review.
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Palliative Care; Prognosis; Pyrimidines; Rectal Neoplasms; Uridine | 1981 |
Pseudouridine determination in blood serum as tumor marker.
Topics: Breast Neoplasms; Carcinoma, Hepatocellular; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Humans; Leukemia, Lymphoid; Liver Neoplasms; Lung Neoplasms; Lymphoma; Neoplasms; Ovarian Neoplasms; Pseudouridine; Uridine | 1983 |
High uridine catabolic activity in cultured human melanoma cells.
Topics: Breast Neoplasms; Cell Line; Colonic Neoplasms; Female; Humans; Kinetics; Leukemia, Lymphoid; Melanoma; Ovarian Neoplasms; Pentosyltransferases; Phosphotransferases; Uridine; Uridine Kinase; Uridine Phosphorylase | 1984 |
Tumor markers in colorectal carcinoma. An evaluation of carcinoembryonic antigen, tissue polypeptide antigen, placental alkaline phosphatase and pseudouridine.
Topics: Adolescent; Adult; Age Factors; Aged; Alkaline Phosphatase; Antigens, Neoplasm; Carcinoembryonic Antigen; Colonic Neoplasms; Female; GPI-Linked Proteins; Humans; Isoenzymes; Male; Middle Aged; Peptides; Prognosis; Pseudouridine; Rectal Neoplasms; Sex Factors; Statistics as Topic; Tissue Polypeptide Antigen; Uridine | 1984 |
On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune-deprived mice.
Topics: Adenocarcinoma; Animals; Cell Survival; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Male; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Neoplasms, Experimental; Transplantation, Heterologous; Uridine | 1980 |
D-glucosamine-induced changes in nucleotide metabolism and growth of colon-carcinoma cells in culture.
Topics: Adenocarcinoma; Cell Division; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cytidine; Glucosamine; Humans; Nucleotides; Pyrimidine Nucleosides; Uridine; Uridine Diphosphate | 1984 |
In vitro translation of messenger RNA following exposure of human colon carcinoma cells in culture to 5-fluorouracil and 5-fluorouridine.
Topics: Cell Line; Centrifugation, Density Gradient; Colonic Neoplasms; Electrophoresis, Polyacrylamide Gel; Fluorouracil; Humans; Protein Biosynthesis; RNA, Messenger; Uridine | 1983 |
Phase II study of 3-deazauridine in advanced colorectal adenocarcinoma.
Topics: 3-Deazauridine; Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Digestive System; Drug Evaluation; Female; Humans; Male; Middle Aged; Rectal Neoplasms; Uridine | 1982 |
Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture.
Topics: Cell Nucleus; Cell Survival; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Fluorouracil; Humans; Neoplasms, Experimental; RNA, Neoplasm; Uridine | 1982 |
High-dose 5-fluorouracil with delayed uridine "rescue" in mice.
Topics: Animals; Colonic Neoplasms; Fluorouracil; Kinetics; Leukopenia; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Uridine | 1982 |
Urinary pseudouridine/creatinine ratio as an indicator of gastrointestinal cancer.
Topics: Colonic Neoplasms; Creatinine; Female; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Neoplasm Staging; Pseudouridine; Rectal Neoplasms; Reference Values; Uridine | 1982 |
Anti-oncofoetal proteins for targeting cytotoxic drugs.
Topics: Antibodies; Antineoplastic Agents; Carcinoembryonic Antigen; Cells, Cultured; Colonic Neoplasms; Daunorubicin; Humans; Neoplasms, Experimental; Stimulation, Chemical; Uridine | 1981 |
Serum uridine levels in patients receiving N-(phosphonacetyl)-L-aspartate.
Topics: Antimetabolites, Antineoplastic; Aspartic Acid; Colonic Neoplasms; Drug Evaluation; Humans; Melanoma; Organophosphorus Compounds; Phosphonoacetic Acid; Uridine | 1980 |
Antibiotic C3368-A, a fungus-derived nucleoside transport inhibitor, potentiates the activity of antitumor drugs.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Benzofurans; Biological Transport; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Division; Colonic Neoplasms; Doxorubicin; Drug Synergism; Female; Fluorouracil; Humans; KB Cells; Liver Neoplasms; Methotrexate; Mice; Mice, Inbred BALB C; Mitomycin; Spiro Compounds; Thymidine; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine | 1995 |
Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells.
Topics: Biotransformation; Cell Division; Colonic Neoplasms; DNA, Neoplasm; Drug Synergism; Fluorouracil; Humans; Interleukin-1; Prodrugs; Receptors, Interleukin-1; Recombinant Proteins; RNA, Neoplasm; Thymidine; Thymine Nucleotides; Tumor Cells, Cultured; Tumor Stem Cell Assay; Uridine; Uridine Triphosphate | 1994 |
Somatostatin analogue octreotide modulates metabolism and effects of 5-fluorouracil and 5-fluorouridine in human colon cancer spheroids.
Topics: Adenocarcinoma; Amino Acid Sequence; Cell Cycle; Colonic Neoplasms; DNA Damage; DNA, Neoplasm; Drug Interactions; Fluorine; Fluorouracil; G1 Phase; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Octreotide; Receptors, Somatostatin; Resting Phase, Cell Cycle; RNA, Ribosomal; S Phase; Tumor Cells, Cultured; Uridine | 1994 |
Cytotoxic effect of butein on human colon adenocarcinoma cell proliferation.
Topics: Adenocarcinoma; Cell Division; Chalcone; Chalcones; Colonic Neoplasms; Flavonoids; Fluorouracil; Humans; Phenols; Polymers; Polyphenols; Tumor Cells, Cultured; Uridine | 1994 |
(R,R)-2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]- bis[5-nitro-1H-benz[de]isoquinoline-1,3-(2H)-dione] dimethanesulfonate (DMP 840), a novel bis-naphthalimide with potent nonselective tumoricidal activity in vitro.
Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Division; Clinical Trials, Phase I as Topic; Colonic Neoplasms; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Isoquinolines; KB Cells; Kinetics; Leucine; Leukemia L1210; Leukemia P388; Mammary Neoplasms, Experimental; Melanoma; Melanoma, Experimental; Mesylates; Mice; Mitoxantrone; Thymidine; Transplantation, Heterologous; Tumor Cells, Cultured; Uridine | 1994 |
Cytokines induce uridine phosphorylase in mouse colon 26 carcinoma cells and make the cells more susceptible to 5'-deoxy-5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Fibroblast Growth Factor 2; Floxuridine; Fluorouracil; Interferon-gamma; Interleukin-1; Mice; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uridine; Uridine Phosphorylase | 1993 |
The role of thymidylate synthase in cellular regulation.
Topics: Antineoplastic Agents; Blotting, Southern; Colonic Neoplasms; Electrophoresis, Polyacrylamide Gel; Fluorodeoxyuridylate; Gene Expression Regulation, Neoplastic; Humans; Polymerase Chain Reaction; Precipitin Tests; Protein Biosynthesis; RNA-Binding Proteins; RNA, Messenger; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured; Uridine; Uridine Monophosphate | 1996 |
The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Bromouracil; Carrier Proteins; Cell Survival; Colonic Neoplasms; Deoxyribonucleotides; DNA Repair; DNA, Neoplasm; Humans; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; Radiation, Ionizing; Thioguanine; Thymidine; Thymidine Kinase; Thymidylate Synthase; Tumor Cells, Cultured; Uridine | 1999 |
Differences in metabolism of 5-fluorouracil and 5-fluorouridine and regulation by glucosamine in human colon cancer multicell tumor spheroids.
Topics: Body Fluid Compartments; Colonic Neoplasms; Fluorouracil; Glucosamine; Humans; Kinetics; Magnetic Resonance Spectroscopy; Models, Biological; Nonlinear Dynamics; Phosphates; Spheroids, Cellular; Uridine | 1999 |
5-ethyl-2'-deoxyuridine, a modulator of both antitumour action and pharmacokinetics of 5-fluorouracil.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Colonic Neoplasms; Deoxyuridine; Dose-Response Relationship, Drug; Drug Synergism; Fluorodeoxyuridylate; Fluorouracil; Male; Metabolic Clearance Rate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Time Factors; Treatment Outcome; Uracil; Uridine | 1999 |
Induction of wild-type p53 activity in human cancer cells by ribozymes that repair mutant p53 transcripts.
Topics: Alternative Splicing; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neoplasms; DNA Repair; Humans; Lung Neoplasms; Mutagenesis; Osteosarcoma; RNA, Catalytic; Transcriptional Activation; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Uridine | 2000 |
Selectivity of action of 5-FU: biochemical basis.
Topics: Animals; Colonic Neoplasms; Drug Resistance; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Humans; Leukemia L1210; Mice; Mice, Inbred Strains; Rats; RNA, Neoplasm; Thymidine; Uridine | 1979 |
Rapid, quantitative high-performance liquid column chromatography of pseudouridine.
Topics: Chromatography, Affinity; Chromatography, Gel; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Humans; Male; Pseudouridine; Uridine | 1978 |
Selective inhibition of pyrimidine biosynthesis and effect on proliferative growth of colonic cancer cells.
Topics: Animals; Aspartic Acid; Cell Division; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Humans; Kinetics; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Organophosphorus Compounds; Phosphonoacetic Acid; Pyrimidines; Transplantation, Isogeneic; Uridine | 1977 |
In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Cell Division; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leucovorin; Male; Mice; Mice, Inbred Strains; Thymidylate Synthase; Uridine | 1992 |
Brequinar potentiates 5-fluorouracil antitumor activity in a murine model colon 38 tumor by tissue-specific modulation of uridine nucleotide pools.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biphenyl Compounds; Colonic Neoplasms; Digestive System; Drug Synergism; Female; Fluorouracil; Kidney; Kinetics; Liver; Mice; Mice, Inbred C57BL; Organ Specificity; Spleen; Thymidylate Synthase; Uracil Nucleotides; Uridine | 1992 |
Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells.
Topics: beta Carotene; Breast Neoplasms; Carotenoids; Cell Division; Cell Line; Colonic Neoplasms; DNA, Neoplasm; Dose-Response Relationship, Drug; Female; Humans; Leucine; Linoleic Acids; Melanoma; Neoplasm Proteins; RNA, Neoplasm; Thymidine; Tritium; Tumor Cells, Cultured; Uridine | 1992 |
Interaction of legume lectins with the cellular metabolism of differentiated Caco-2 cells.
Topics: Colonic Neoplasms; Fucose; Glucosamine; Humans; Lectins; Microvilli; Phytohemagglutinins; Plant Lectins; Soybean Proteins; Thymidine; Tumor Cells, Cultured; Uridine | 1992 |
A fluorouridine-anti-CEA immunoconjugate is therapeutically effective in a human colonic cancer xenograft model.
Topics: Animals; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Cell Survival; Colonic Neoplasms; Dextrans; Drug Carriers; Humans; Immunoglobulin Fc Fragments; Mice; Mice, Nude; Neoplasm Transplantation; Tissue Distribution; Transplantation, Heterologous; Tumor Cells, Cultured; Uridine | 1990 |
In vitro and in vivo studies on the combination of Brequinar sodium (DUP-785; NSC 368390) with 5-fluorouracil; effects of uridine.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Colonic Neoplasms; Drug Administration Schedule; Drug Interactions; Drug Screening Assays, Antitumor; Female; Fluorouracil; In Vitro Techniques; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Pyrimidines; Tumor Cells, Cultured; Uridine | 1992 |
Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Drug Interactions; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Pentosyltransferases; Thymidine Phosphorylase; Tumor Cells, Cultured; Uridine; Uridine Phosphorylase | 1990 |
Kinetic analysis of 5-fluorouracil action against various cancer cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Kidney Neoplasms; Leukemia P388; Mice; RNA, Ribosomal; S Phase; Time Factors; Uridine | 1990 |
Retention of in vivo antipyrimidine effects of Brequinar sodium (DUP-785; NSC 368390) in murine liver, bone marrow and colon cancer.
Topics: Animals; Antineoplastic Agents; Biphenyl Compounds; Bone Marrow; Colonic Neoplasms; Dihydroorotate Oxidase; Female; Liver; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oxidoreductases; Pyrimidine Nucleotides; Uridine; Uridine Triphosphate | 1990 |
Comparison of the cellular and RNA-dependent effects of sangivamycin and toyocamycin in human colon carcinoma cells.
Topics: Antibiotics, Antineoplastic; Cell Survival; Colonic Neoplasms; Humans; In Vitro Techniques; Leucine; Methylation; Protein Biosynthesis; Pyrimidine Nucleosides; Ribonucleosides; RNA; RNA, Ribosomal; Time Factors; Toyocamycin; Uridine | 1985 |
Comparison of tetrazolium colorimetric and [3H]-uridine assays for in vitro chemosensitivity testing.
Topics: Carcinoma; Cell Line; Colonic Neoplasms; Colorimetry; Coloring Agents; Doxorubicin; Drug Screening Assays, Antitumor; Female; Humans; Immunoglobulin G; Immunotoxins; Lung Neoplasms; Tetrazolium Salts; Thiazoles; Tritium; Tumor Cells, Cultured; Uridine; Uterine Cervical Neoplasms; Vindesine | 1989 |
Schedule-dependency of in vivo modulation of 5-fluorouracil by leucovorin and uridine in murine colon carcinoma.
Topics: Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Hematologic Diseases; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Time Factors; Uridine | 1989 |
Incorporation of intermediary products of 5-FU anabolism into colorectal cancer.
Topics: Aged; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Intestinal Mucosa; Male; Rectal Neoplasms; Uridine | 1986 |
Toxicity and antitumor effect of 5-fluorouracil and its rescue by uridine.
Topics: Animals; Body Temperature Regulation; Carcinoma; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Hematopoiesis; Leukocyte Count; Mice; Uridine | 1986 |
The relationship between plasma pharmacokinetics and tissue metabolites of 5-fluorouracil (5-FU) in patients with colorectal cancer.
Topics: Aged; Aged, 80 and over; Colon; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Middle Aged; Rectal Neoplasms; Uridine | 1987 |
Concentration and time dependence of the toxicity of fluorinated pyrimidines to HT 29 colorectal carcinoma cells.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Rectal Neoplasms; Time Factors; Tumor Cells, Cultured; Uridine | 1988 |
Rate of incorporation of radiolabelled nucleosides does not necessarily reflect the metabolic state of cells in culture: effects of latent mycoplasma contamination.
Topics: Cell Line; Colonic Neoplasms; Humans; Lung Neoplasms; Mycoplasma Infections; Pyrimidine Nucleosides; Thymidine; Tritium; Tumor Cells, Cultured; Uridine; Urinary Bladder Neoplasms | 1988 |
In vitro biochemical and in vivo biological studies of the uridine 'rescue' of 5-fluorouracil.
Topics: Animals; Bone Marrow; Colonic Neoplasms; Drug Interactions; Female; Fluorouracil; Humans; Intestinal Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Tumor Cells, Cultured; Uridine | 1988 |
Efficacy and specificity of vindesine monoclonal anti-carcinoembryonic antigen conjugate with nine human cancer cell lines.
Topics: Antibodies, Monoclonal; Antibody Specificity; Carcinoembryonic Antigen; Cell Line; Colonic Neoplasms; Enzyme-Linked Immunosorbent Assay; Evaluation Studies as Topic; Fluorescent Antibody Technique; Humans; Lung Neoplasms; Neoplasms; Rectal Neoplasms; Uridine; Vindesine | 1987 |
Uridine-induced hypothermia in mice and rats in relation to plasma and tissue levels of uridine and its metabolites.
Topics: Animals; Body Temperature; Brain; Colonic Neoplasms; Cytidine; Cytidine Deaminase; Dose-Response Relationship, Drug; Female; Hypothermia; Liver; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Rats; Rats, Inbred Strains; Tetrahydrouridine; Thymidine; Uracil; Uridine; Uridine Phosphorylase | 1987 |
Inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid:nucleoside conjugate having sialyltransferase inhibiting activity.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Female; Glycosides; Lung Neoplasms; Mice; Neoplasm Metastasis; Sialyltransferases; Transferases; Uridine | 1986 |
3-Deazaneplanocin A: a new inhibitor of S-adenosylhomocysteine synthesis and its effects in human colon carcinoma cells.
Topics: Adenosine; Adenosylhomocysteinase; Cell Line; Colonic Neoplasms; Humans; Hydrolases; Kinetics; Methionine; Methylation; RNA, Ribosomal; RNA, Transfer; S-Adenosylhomocysteine; Uridine | 1986 |
Modulation of the activity of PALA by dipyridamole.
Topics: Animals; Aspartic Acid; Biological Transport; Cell Line; Colonic Neoplasms; Dipyridamole; Drug Interactions; Humans; In Vitro Techniques; Lethal Dose 50; Leukemia, Myeloid; Melanoma; Mice; Mice, Nude; Organophosphorus Compounds; Phosphonoacetic Acid; Pyrimidine Nucleosides; Tritium; Uridine | 1985 |
Cyclopentenyl cytidine analogue. An inhibitor of cytidine triphosphate synthesis in human colon carcinoma cells.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Colonic Neoplasms; Cytidine; Cytidine Triphosphate; Cytosine Nucleotides; DNA, Neoplasm; Humans; RNA, Neoplasm; Uridine | 1985 |
Tissue-specific enhancement of uridine utilization and 5-fluorouracil therapy in mice by benzylacyclouridine.
Topics: Animals; Colonic Neoplasms; Female; Fluorouracil; Lethal Dose 50; Mice; Mice, Inbred C57BL; Uracil; Uridine | 1985 |
The synergistic lethal interaction of cis-diamminedichloroplatinum and natural nucleosides is related to increased DNA cross-links.
Topics: Adenosine; Carcinoma; Cell Line; Cell Survival; Cisplatin; Colonic Neoplasms; Cytidine; DNA; Drug Synergism; Humans; Nucleosides; Thymidine; Uridine | 1985 |
[Estimation of tumor sensitivity in vitro. II. Studies with the solid Ehrlich carcinoma of the mouse and the GW 77, a heterotransplanted human carcinoma].
Topics: Animals; Antibiotics, Antineoplastic; Autoradiography; Carcinoma; Carcinoma, Ehrlich Tumor; Colonic Neoplasms; Cricetinae; Culture Media; Cytarabine; Dactinomycin; DNA, Neoplasm; Humans; Hydroxyurea; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Nucleosides; RNA, Neoplasm; Thymidine; Triaziquone; Tritium; Uridine | 1970 |
Biochemical approaches to prediction of response in solid tumors.
Topics: Adenocarcinoma; Antineoplastic Agents; Carbon Isotopes; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Drug Resistance; Formates; Head and Neck Neoplasms; Humans; In Vitro Techniques; Liver Neoplasms; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Prognosis; Thymidine; Thymine; Tritium; Uridine | 1971 |